Abstract：
:The selective DA2 agonist, N-0437, produced an acute reduction in intraocular pressure (IOP) and pupil diameter (PD) when applied topically to the eyes of normal monkeys. Ocular hypotension and miosis were primarily unilateral in nature, dose-related and lasted 3 to 5 hours following drug instillation. In normal monkeys, 24 to 48 hours following drug administration, a secondary chronic (greater than 24 hrs) reduction in pressure was observed. Once-a-day topical administration of N-0437 (250 micrograms), to normal monkeys, for 4 days produced a chronic unilateral reduction in IOP that persisted for 18 days. Associated with this reduction in pressure on day 2 through 6 were miosis and ptosis of the treated eye. Although topical administration did not lower IOP in rabbits, intracameral injection of N-0437 significantly depressed IOP for 3 days when compared to control injected eyes. Evaluation of ocular sympathetic innervation in N-0437 treated rabbits indicated that these fibers were not functional. In rabbits, intracameral administration of the active (S,-) and inactive (R,+) enantiomer of N-0437 produced equivalent reductions in pressure. These data provide further support for the hypothesis that DA2 receptor agonists can produce acute reductions in IOP. In addition, N-0437 appears to have a second non-receptor mediated mechanism of action that produces a chronic reduction in IOP. This chronic reduction in pressure appears, in part, to result from an interruption of ocular sympathetic nerves function.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Crosson CE,Burke JA,Chan MF,Potter DEdoi
10.3109/02713688708997557subject
Has Abstractpub_date
1987-11-01 00:00:00pages
1319-26issue
11eissn
0271-3683issn
1460-2202journal_volume
6pub_type
杂志文章abstract：:A method is described for the preparation of plasma membrane enriched fractions from bovine retinal pigment epithelium (RPE) by means of differential centrifugation followed by the use of self forming gradients of Percoll. A detailed analysis of the distribution of organelle specific markers (nuclei, mitochondria, lys...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713688409000806
更新日期：1984-09-01 00:00:00
abstract：:Severe retinopathy of prematurity (ROP) occurs in the smallest and sickest of premature infants. We hypothesized that, in a rat model of oxygen induced retinopathy, abnormal neovascularization would occur more frequently in larger litters where the pups are subject to postnatal growth retardation. Four litters of newb...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713689608995831
更新日期：1996-04-01 00:00:00
abstract：PURPOSE:To examine the effects of calcitonin gene-related peptide (CGRP) on intraocular pressure (IOP). METHODS:IOP was periodically measured in rabbits treated with intravitreal injection (20 ael) of either: 1) CGRP (10(-4) approximately 10(-7) M) into one eye; 2) CGRP (10(-4) or 10(-6) M) into both eyes 30 min after...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1076/ceyr.19.5.432.5291
更新日期：1999-11-01 00:00:00
abstract：PURPOSE:To evaluate changes in biometric parameters in myopic eyes. MATERIALS AND METHODS:412 eyes of 412 young myopic patients underwent ophthalmic examinations including assessments of refractive error, axial length (AL), anterior chamber depth (ACD), and central corneal thickness (CCT). By using spectral domain opt...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713683.2015.1130229
更新日期：2016-12-01 00:00:00
abstract：PURPOSE:Corneal autofluorescence is related to advanced glycation end products formed by glucose that reaches the cornea via the aqueous humour. The aim of the study was to examine the influence on autofluorescence of changes in permeability of the blood aqueous barrier. METHODS:Corneal autofluorescence was measured i...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1076/ceyr.26.4.307.15433
更新日期：2003-05-01 00:00:00
abstract：PURPOSE:We located immunohistochemically the matrix metalloproteinases (MMP) -1, -2, -3 and -9 and the tissue inhibitors of matrix metalloproteinases (TIMP) -1 and -2 in the fibrous capsule of patients with intraocular lenses (IOLs). METHODS:During vitreoretinal surgery in 10 patients we obtained post-cataract surgery...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1076/ceyr.21.6.962.6989
更新日期：2000-12-01 00:00:00
abstract：:Purpose/Aim: To assess the changes in anterior eye segment biometrics and intraocular pressure during and after wearing swimming goggles.Materials and methods: Anterior segment biometry and intraocular pressure were assessed in 20 healthy young adults (22.2 ± 4.7 years) during the wearing of a drilled swimming goggle....
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1080/02713683.2019.1662056
更新日期：2020-05-01 00:00:00
abstract：PURPOSE:To evaluate the effect of anterior migration of triamcinolone acetonide on intraocular pressure (IOP) elevation after posterior subtenon injection of triamcinolone acetonide (PSTA) for macular edema. METHODS:One hundred and ten eyes from 89 patients who received PSTA for macular edema were prospectively enroll...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1080/02713683.2020.1826979
更新日期：2020-09-27 00:00:00
abstract：SIGNIFICANCE:Adopting a risk stratification system and appropriate listing of cases reduces the rates of intraoperative complications during phacoemulsification. Such listing would allow both safe surgery and enhance training, by ensuring an appropriately experienced surgeon is available to operate on a case or supervi...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1080/02713683.2020.1801759
更新日期：2020-07-30 00:00:00
abstract：:Processing of visual information within the retina depends in large measure upon a complement of chemical neurotransmitters which are released at synaptic contacts between individual neurons. Numerous investigators have participated in the identification of many of these transmitters and their assignment to specific n...
journal_title：Current eye research
pub_type： 杂志文章,评审
doi：10.3109/02713689609003465
更新日期：1996-07-01 00:00:00
abstract：:It has been shown that illumination of rod outer segment suspension in the presence of photosensitizers (methylene blue lambda greater than or equal to 620 nm; retinal 370 less than or equal to lambda less than or equal to 390 nm) results in chemical modification of the lipid and protein components of the photo-recept...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713688209019997
更新日期：1982-01-01 00:00:00
abstract：PURPOSE:Maintaining mature and viable retinal pigment epithelial cells (RPE) in vitro has proven challenging. Investigating compounds that can promote RPE-viability and maturation is motivated by RPE transplantation research, the quest to understand RPE physiology, and a desire to modulate RPE in pathological states. W...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1080/02713683.2020.1809001
更新日期：2020-09-01 00:00:00
abstract：:Spontaneous ocular shedding and adrenergic induction of ocular shedding were examined in rabbits infected with ten strains of herpes simplex virus type 1 (HSV-1): McKrae, KOS, F, Rodanus, 17 Syn+, RE, E-43, SC-16, MacIntyre, and CGA-3. All ocular inoculations were with 50 microliter of HSV-1 with titers between 1-10 X...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713688709020074
更新日期：1987-01-01 00:00:00
abstract：PURPOSE:The present study was aimed to investigate the expression of purinergic P2 receptors in oxygen-induced retinal neovascularization. METHODS:Immunohistochemistry was used to study the expression of purinergic P2Y2 and P2X2 receptors in the neonatal mouse retina during normal vascular development and after oxygen...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1080/02713680701885470
更新日期：2008-03-01 00:00:00
abstract：PURPOSE:Predicting the toxic potential of compounds to the ocular surface has depended on the Draize test for the past half century. Alternatives to Draize testing have recently been sought for a number of reasons. Stress gene expression has emerged as a means of quantifying cellular reaction and, thus, the toxic poten...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1076/ceyr.19.2.115.5325
更新日期：1999-08-01 00:00:00
abstract：PURPOSE:The purpose of this study was to determine the retinal expression of angiogenic chemokines/cytokines in a mouse model of oxygen-induced retinopathy. METHODS:C57BL/6 (B6) mice were exposed to 75% oxygen from postnatal day 7 (P7) to P12 and then recovered in room air. Reverse transcription-polymerase chain react...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1080/02713680590923276
更新日期：2005-04-01 00:00:00
abstract：PURPOSE:Taurolidine is a broad-spectrum, non antibiotic antimicrobial agent, not previously tested against the common causes of bacterial keratitis. This study, employing an experimental rabbit model of Staphylococcus aureus keratitis, investigated the effectiveness of topical taurolidine in reducing the number of bact...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1080/02713680490908733
更新日期：2005-03-01 00:00:00
abstract：PURPOSE:Previous studies have suggested that corneal fibrosis controlled by a TGFbeta-mediated cytocrine pathway underlies the development of clinical corneal haze and associated regression of photoablative effect following excimer laser PRK. Using a unique blocking antibody, we evaluated the role of TGFbeta in post-PR...
journal_title：Current eye research
pub_type： 杂志文章
doi：
更新日期：1998-07-01 00:00:00
abstract：PURPOSE:Oxidative damage of lens tissue contributes to the formation of age-related cataract. Pi-class glutathione-S-transferase (GSTP1) plays a role in the removal of oxidative adducts by transferring them to glutathione. To assess epigenetic regulation of GSTP1 and its potential role in age-related nuclear cataract (...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1080/02713683.2016.1185129
更新日期：2017-03-01 00:00:00
abstract：:Four days after corneal inoculation of mice with herpes simplex (type 1) virus (HSV), infected trigeminal ganglion cells with and without calcitonin gene-related peptide (CGRP) antigenicity were examined by electron microscopy in sections treated with colloidal gold labeled antibodies. Cells that contain CGRP were ide...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713689109020354
更新日期：1991-01-01 00:00:00
abstract：PURPOSE:To quantify the impact of posterior cornea on toric IOL calculation accuracy using Placido-topography of anterior corneal surface and Scheimpflug measurements of corneal thickness. MATERIALS AND METHODS:Three-hundred seventy-nine non-selected eyes undergoing cataract surgery with non-toric intraocular lens (IO...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713683.2014.959708
更新日期：2015-01-01 00:00:00
abstract：PURPOSE:Matrix metalloproteinases (MMPs) are involved in posterior capsule opacification (PCO), but the mechanisms that promote MMP expression are yet to be determined. In this study, we investigated whether type I collagen, which is only detected in aged or cataractous lens capsules, affects the expression and activat...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713683.2013.853194
更新日期：2014-05-01 00:00:00
abstract：AIMS:To elucidate the intramuscular distribution and branching patterns of the abducens nerve in the lateral rectus (LR) muscle so as to provide anatomical confirmation of the presence of compartmentalization, including for use in clinical applications such as botulinum toxin injections. METHODS:Thirty whole-mount hum...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1080/02713683.2018.1438631
更新日期：2018-06-01 00:00:00
abstract：:The short and long term response of the trabecular meshwork to a phagocytic challenge and the response of the meshwork to different types of foreign particles was studied by injecting one eye of 25 adult cats with a phagocytic agent (zymosan, blood, or latex microspheres) while the fellow eye received a control soluti...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713688909000037
更新日期：1989-11-01 00:00:00
abstract：:Posterior subcapsular cataracts (PSC) are associated with hereditary retinal dystrophy in the Royal College of Surgeons (RCS) rat model and with human retinitis pigmentosa. The relationship of lens and retinal pathology has never been explained. Previous studies of pink-eyed RCS rats aged 2.5 to 11 months had shown an...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713688209011629
更新日期：1982-01-01 00:00:00
abstract：:A major glycoprotein of relative molecular weight of 130,000 daltons of chick lens cell membranes was identified by Concanavalin-A staining and enriched for by Con A-Sepharose chromatography. Using both Con A binding and immunological analyses with a specific polyclonal antibody, the glycoprotein was detected in chick...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713688608995176
更新日期：1986-12-01 00:00:00
abstract：PURPOSE:To compare the differences in higher-order aberrations (HOAs) after laser subepithelial keratomileusis (LASEK) between two different laser platforms. METHODS:One hundred and seven eyes of 107 patients were included in this study. Fifty-six eyes underwent LASEK with the Triple-A profile (an ablation profile of ...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.1080/02713683.2020.1726404
更新日期：2020-09-01 00:00:00
abstract：:Retinal pigment epithelia (RPE) and retinal neurons (RN) arise from the same underlying precursor cell population. It is worthwhile to explore the transdifferentiation potential of RPE cells, given the benefits that could accrue from turning RPE into neural retina containing all its normal cellular subpopulations. Fac...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713683.2012.664673
更新日期：2012-07-01 00:00:00
abstract：PURPOSE:To investigate the roles of adherence and matrix metalloproteinases (MMPs) in growth patterns of major fungal pathogens in cornea. METHODS:Ninety-six eyes in 96 rabbits were equally divided into four groups receiving inoculation of fungal conidia of Aspergillus fumigatus, Candida albicans, Fusarium solani, and...
journal_title：Current eye research
pub_type： 杂志文章,收录出版
doi：10.1080/02713680590968196
更新日期：2005-08-01 00:00:00
abstract：PURPOSE:To evaluate the length of the trabecular meshwork (TM) from the scleral spur (SS) to Schwalbe's line (SL) and assess the detectability of the SS in histopathology specimens. METHODS:This study included 158 angle images from 79 cross-sectional slides derived from eyes enucleated for melanoma. The slides were st...
journal_title：Current eye research
pub_type： 杂志文章
doi：10.3109/02713683.2012.700757
更新日期：2013-01-01 00:00:00
