Increasing cell density down-regulates the expression of acidic FGF by human RPE cells in vitro.

abstract：:After the debridement of the entire corneal epithelium of the rabbit eye, epithelial cells of conjunctival origin cover the denuded corneal surface. Under such experimental conditions, the rate of wound healing is considerably delayed and total regeneration is completed within 15 to 20 days, allowing evaluation of var...

journal_title：Current eye research

authors： Fredj-Reygrobellet D,Plouet J,Delayre T,Baudouin C,Bourret F,Lapalus P

更新日期：1987-10-01 00:00:00

abstract：:Purpose: The purpose of this study is to present the study design and one month's preliminary results of a 2-year randomized trial, Combined Atropine with Orthokeratology (AOK), for myopia control study. Methods: Children aged 6 to <11 years and with 1.00-4.00 D myopia were randomly assigned to AOK group or ortho-k al...

journal_title：Current eye research

authors： Tan Q,Ng AL,Cheng GP,Woo VC,Cho P

更新日期：2019-06-01 00:00:00

abstract：PURPOSE/AIM:To quantitatively analyse the evolution of TUNEL-labeling, after in vivo exposure to UVB. METHODS:Altogether, 16 Sprague Dawley rats were unilaterally exposed in vivo for 15 min to close to threshold dose, 5 kJ/m(2), of ultraviolet radiation in the 300 nm wavelength region. Animals were sacrificed in group...

journal_title：Current eye research

authors： Kronschläger M,Yu Z,Talebizadeh N,Meyer LM,Hallböök F,Söderberg PG

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:Retinoblastoma (RB) is the most common intraocular malignancy in children. Deregulation of several miRNAs has been identified in RB, suggesting a potential role in tumorigenesis. Recent evidence suggests that many dietary components like folate, retinoids and curcumin act as potential anticancer/antiproliferati...

journal_title：Current eye research

authors： Sreenivasan S,Thirumalai K,Danda R,Krishnakumar S

更新日期：2012-05-01 00:00:00

abstract：PURPOSE:To measure the cell size and cell density in five layers of the central cornea in the widely used inbred C57BL/6 mouse strain using in vivo three-dimensional (3D) two-photon (2PH) imaging. METHODS:Corneas were scanned using a 2PH laser scanning fluorescence microscope after staining with plasma membrane stain ...

journal_title：Current eye research

authors： Zhang H,He S,Liu S,Xie Y,Chen G,Zhang J,Sun S,Liang D,Wang L

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Previously we established a strong association of systemic hypertension with cataract formation. In the present study, we investigated the role of nitric oxide (NO) in the development of cataract formation in CdCl2-induced hypertensive animals. MATERIALS AND METHODS:Hypertension was induced in male albino rats...

journal_title：Current eye research

authors： Yadav A,Choudhary R,Bodakhe SH

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:Recent advances in technology now provide tools capable of tracking genome-wide expression changes occurring in progressive pathological processes. The present experiments were carried out to determine if acetylcholine receptor α 6 subunit (Chrna6) is a reliable retinal ganglion cell (RGC) marker in adult mouse...

journal_title：Current eye research

authors： Munguba GC,Geisert EE,Williams RW,Tapia ML,Lam DK,Bhattacharya SK,Lee RK

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:To assess the distribution of dark-light changes in iris features and associated factors amongst American Caucasians, American Chinese and mainland Chinese aged 40 years and over. METHODS:Four gender- and age-matched cohorts: Caucasians, American Chinese, Southern Chinese and Northern Chinese comprised the stu...

journal_title：Current eye research

authors： Wang D,He M,Wu L,Kao A,Pekmezci M,Singh K,Lin S

更新日期：2012-07-01 00:00:00

abstract：PURPOSE:To determine if the Schirmer I test (without anesthesia) cut-off value is a predictor of dry eye severity in a large Norwegian cohort of dry eye disease (DED) patients, which are grouped into six levels of tear production. METHODS:Patients (n = 1090) with DED of different etiologies received an extensive dry e...

journal_title：Current eye research

authors： Yazdani M,Chen X,Tashbayev B,Utheim ØA,Ræder S,Lagali N,Stojanovic A,Dartt DA,Utheim TP

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:To investigate orbital biomechanical properties in patients with thyroid orbitopathy and in age- and gender-matched healthy subjects using the Corvis-ST (CST, Oculus Wetzlar, Germany). METHODS:The CST allows a non-contact tonometry with an ultra-high-speed Scheimpflug device to record the deformation of the co...

journal_title：Current eye research

authors： Leszczynska A,Moehler K,Spoerl E,Ramm L,Herber R,Pillunat LE,Terai N

更新日期：2018-03-01 00:00:00

abstract：:In uveal vessels of isolated arterially perfused rabbit eyes there is direct evidence for the presence of post-junctional alpha 1-receptors and indirect evidence for alpha 2-receptors. Since vasoconstriction by epinephrine could not be blocked by an alpha 1-antagonist, only 30% by an alpha 2-antagonist and almost full...

journal_title：Current eye research

authors： van Pinxteren PC,van Alphen GW

更新日期：1985-01-01 00:00:00

abstract：:Purpose: To evaluate the efficacy of polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate containing sustained-release thalidomide for delayed adjustable strabismus surgery. Methods: This is a prospective, masked-observer, controlled study using 50 eyes of 25 rabbits. After superior rectus muscle (SRM...

journal_title：Current eye research

authors： Han SB,Kim JH,Yang HK,Hwang JM

更新日期：2019-07-01 00:00:00

abstract：:Experiments were conducted to test the influence of thapsigargin on the NaK-ATPase activity of cultured cells (ODM2) derived from human nonpigmented ciliary epithelium. The rate of ouabain-sensitive ATP hydrolysis (Na,K-ATPase activity) was diminished in cells that had been pretreated with thapsigargin then permeabili...

journal_title：Current eye research

authors： Mito T,Kuwahara S,Delamere NA

更新日期：1995-08-01 00:00:00

abstract：:Purpose: To evaluate the long-term efficacy and safety of the modified canaloplasty technique with additional suprachoroidal drainage in patients with pseudoexfoliation glaucoma. Methods: This retrospective clinical trial included 131 patients with pseudoexfoliation glaucoma who underwent canaloplasty with suprachoroi...

journal_title：Current eye research

authors： Seuthe AM,Szurman P,Januschowski K

更新日期：2021-02-01 00:00:00

abstract：PURPOSE:To compare objective optical quality, ocular scattering and aberrations of eyes implanted with an aspheric monofocal intraocular lens (IOL) or an aspheric apodized diffractive multifocal IOL three months after surgery. METHODS:Prospective consecutive nonrandomized comparative cohort study. A total of 80 eyes f...

journal_title：Current eye research

authors： Liao X,Lin J,Tian J,Wen B,Tan Q,Lan C

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:To investigate the multifocal electroretinogram (mfERG) and subjective function in early age-related maculopathy (ARM). METHODS:Seventeen subjects with early ARM with visual acuity (VA) of 6/12 or better and 20 age-matched control subjects were examined. We assessed mfERGs, high and low contrast distance VA, n...

journal_title：Current eye research

authors： Feigl B,Brown B,Lovie-Kitchin J,Swann P

更新日期：2004-10-01 00:00:00

abstract：PURPOSE:Both HSV-1 and HSV-2 express LAT during viral latency. Previous studies indicated that deletion of either LAT impairs viral reactivation from latency, but that the HSV-1 LAT confers the ability to reactivate efficiently from trigeminal ganglia onto HSV-2. We sought to determine whether the HSV-2 LAT could funct...

journal_title：Current eye research

authors： Hill J,Patel A,Bhattacharjee P,Krause P

更新日期：2003-03-01 00:00:00

abstract：:Purpose/Aim: Many genes have been associated with primary open-angle glaucoma (POAG). Knowing exactly where they are expressed in the eye helps to unravel POAG pathology and to select optimal targets for intervention. We investigated whether RNA in situ hybridization (RNA-ISH) is a convenient technique to obtain detai...

journal_title：Current eye research

authors： Hubens WHG,Breddels EM,Walid Y,Ramdas WD,Webers CAB,Gorgels TGMF

更新日期：2019-09-01 00:00:00

abstract：:The effects of 4% epinephrine bitartrate and 0.5% timolol on ocular and optic nerve blood flow were studied in phakic and aphakic rabbit eyes using a radioactive microsphere (85Sr) technique. Either epinephrine or timolol was given topically as eight drops in the hour immediately preceding blood flow measurements (one...

journal_title：Current eye research

authors： Jay WM,Aziz MZ,Green K

更新日期：1984-10-01 00:00:00

abstract：PURPOSE:The purpose of this work is to describe and review the technology of plasma rich in growth factors (PRGF), a novel blood derivative product, in the treatment of ocular surface disorders. METHODS:To demonstrate the importance of this technology in the treatment of ocular pathologies, a thorough review of the pr...

journal_title：Current eye research

authors： Anitua E,Muruzabal F,de la Fuente M,Merayo J,Durán J,Orive G

更新日期：2016-07-01 00:00:00

abstract：:Serum zinc and copper levels were analyzed in 26 retinitis pigmentosa patients and compared with serum zinc levels of a control group. Serum zinc levels were documented to be decreased with a mean concentration of 0.735 +/- 0.167 micrograms/ml (p less than 0.001). Serum copper levels, on the other hand, were found to ...

journal_title：Current eye research

authors： Karcioglu ZA,Stout R,Hahn HJ

更新日期：1984-08-01 00:00:00

abstract：PURPOSE:To study early signs of neuronal and glial differentiation in the human embryonic retina. MATERIALS AND METHODS:6.5-to 8-week-old human embryos were obtained from elective abortions. The neuroretinas were kept in culture as full-thickness sheets for 7-42 days. RESULTS:The control retinas consisted of a neurob...

journal_title：Current eye research

authors： Engelsberg K,Ehinger B,Ghosh F

更新日期：2008-02-01 00:00:00

abstract：PURPOSE:Nitric oxide production can cause either apoptotic or necrotic cell death through oxidative stress. We aimed to investigate the nitrite oxide metabolites (NOx) and nitrite levels in the aqueous humor of rabbit eyes after different methods of corneal collagen cross-linking (CXL). MATERIALS AND METHODS:Twenty-fo...

journal_title：Current eye research

authors： Yuksel N,Ozel-Turkcu U,Yalinbas D,Novruzlu S,Bilgihan A,Bilgihan K

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:This study aims to evaluate and correlate the levels of interleukin-6 (IL-6) and thrombin-antithrombin III complex (TAT) in the vitreous of patients with different vitreoretinal pathologies. METHODS:Vitreous samples were collected from 78 patients scheduled for pars plana vitrectomy at a tertiary medical cente...

journal_title：Current eye research

authors： Ehrlich R,Zahavi A,Axer-Siegel R,Budnik I,Dreznik A,Dahbash M,Nisgav Y,Megiddo E,Kenet G,Weinberger D,Livnat T

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:Corneal ulceration may be treated with human amniotic membrane (HAM) while neovascularization remains a common complication of corneal ulceration. As several factors contained within HAM may contribute to reduced corneal scarring, we investigated if HAM may be additionally loaded with bevacizumab and potentiall...

journal_title：Current eye research

authors： Mayer WJ,Grüterich M,Kook D,Sigg W,Kernt M,Messmer EM,Haritoglou C,Kampik A,Wolf A

更新日期：2013-04-01 00:00:00

abstract：:5-Fluorouracil (5-FU) and Mitomycin C (MMC) are used as adjunct chemotherapy during glaucoma filtering surgery to suppress conjunctival fibroblast proliferation. Since part of these agents may gain access to the anterior chamber and cause cytotoxicity to the corneal endothelium we set up an in vitro system to establis...

journal_title：Current eye research

authors： Nuyts RM,Pels E,Greve EL

更新日期：1992-06-01 00:00:00

abstract：:Prorenin (PR) was localized by electron microscopic (EM) immunostaining of cryo-ultramicrotomy sections of human ciliary body and correlated with light microscopic immunostaining. Both layers of the ciliary epithelium contained the prohormone. However, density was much higher in the adjacent extracellular spaces, part...

journal_title：Current eye research

authors： Wallow IH,Sramek SJ,Bindley CD,Darjatmoko SR,Gange SJ

更新日期：1993-10-01 00:00:00

abstract：PURPOSE:To optimise the high efficiency, non-viral transfer of DNA to retinal pigment epithelial (RPE) cells in vitro. METHODS:A mammalian expression vector (pcDNA3.1) containing a firefly luciferase (luc) cDNA was used to transfect RPE cells using different chemical methods; calcium phosphate, DEAE-dextran and, lipos...

journal_title：Current eye research

authors： Abul-Hassan K,Walmsley R,Boulton M

更新日期：2000-05-01 00:00:00

abstract：:A major glycoprotein of relative molecular weight of 130,000 daltons of chick lens cell membranes was identified by Concanavalin-A staining and enriched for by Con A-Sepharose chromatography. Using both Con A binding and immunological analyses with a specific polyclonal antibody, the glycoprotein was detected in chick...

journal_title：Current eye research

authors： Heslip J,Bagchi M,Zhang S,Alousi S,Maisel H

更新日期：1986-12-01 00:00:00

abstract：PURPOSE:To detect the immunohistochemical changes in the main lacrimal glands of patients suffering from chronic ocular sequelae of Stevens-Johnson syndrome (SJS). METHODS:Histological sections of biopsies from the lacrimal gland of three chronic SJS patients (mean age, 33 years; 2 males) with severe dry eye disease (...

journal_title：Current eye research

authors： Singh S,Ali MJ,Mittal V,Brabletz S,Paulsen F

更新日期：2020-10-18 00:00:00