Abstract:
PURPOSE:To investigate orbital biomechanical properties in patients with thyroid orbitopathy and in age- and gender-matched healthy subjects using the Corvis-ST (CST, Oculus Wetzlar, Germany). METHODS:The CST allows a non-contact tonometry with an ultra-high-speed Scheimpflug device to record the deformation of the cornea during an air pulse. Biomechanical response parameters (intraocular pressure (IOP), whole eye movement length (WEMl) and time (WEMt), deflection amplitude 2 mm ratio max, deflection amplitude max, stiffness parameter, and biomechanically corrected IOP were measured in 39 patients with thyroid orbitopathy (= group I) and in 33 age- and gender-matched healthy subjects (= group II) using the CST. RESULTS:Mean age in group I was 54.3 ± 11.6 years and in group II 54.2 ± 12.3 years with no statistical significant difference between the groups (P = 0.98). The gender distribution between the groups was not statistically significantly different (P = 0.51). Mean central corneal thickness was 571 ± 30 µm in group I and 563 ± 36 µm in group II (P = 0.306). There were statistically significant differences (P < 0.001) between groups I and II in mean IOP (19.3 ± 4.5 vs. 14.8 ± 2.3 mmHg, mean biomechanically corrected IOP (17.1 ± 3.4 vs. 13.4 ± 2.1 mmHg), mean WEMl (207 ± 57 vs. 322 ± 50 µm), mean WEMt (20.5 ± 1.0 vs. 21.9 ± 0.7 ms), mean IOP-adjusted WEMl (213 ± 56 vs. 314 ± 62 µm), and in mean stiffness parameter (132.5 ± 29.6 vs. 107.8 ± 23.3 mmHg/mm), respectively. CONCLUSION:Biomechanical parameters as measured by the CST were significantly reduced in patients with thyroid orbitopathy compared to age- and gender-matched healthy subjects, indicating a reduction in orbital compliance in thyroid orbitopathy. The parameters WEMl and WEMt might be a useful diagnostic tool to evaluate the condition of the eyeball within the orbit.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Leszczynska A,Moehler K,Spoerl E,Ramm L,Herber R,Pillunat LE,Terai Ndoi
10.1080/02713683.2017.1405044subject
Has Abstractpub_date
2018-03-01 00:00:00pages
289-292issue
3eissn
0271-3683issn
1460-2202journal_volume
43pub_type
杂志文章abstract:PURPOSE:Predicting the toxic potential of compounds to the ocular surface has depended on the Draize test for the past half century. Alternatives to Draize testing have recently been sought for a number of reasons. Stress gene expression has emerged as a means of quantifying cellular reaction and, thus, the toxic poten...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.19.2.115.5325
更新日期:1999-08-01 00:00:00
abstract:PURPOSE:A retrospective study was developed to evaluate risk factors in adult-onset myopia. METHODS:Subjects included were 25 to 35 years old. There were 116 non-myopic subjects in the control group and 66 myopic subjects with first lens prescription at age 17 or later. Subjects received a questionnaire about academic...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.25.5.309.13494
更新日期:2002-11-01 00:00:00
abstract:PURPOSE:To determine the cellular mechanisms involved in the hypoxia-induced alteration of the retinal pigment epithelium (RPE) potentials and the light-evoked responses of the RPE in chicks. In addition, to determine the mechanisms involved in the recovery of the RPE during the post-hypoxic period. METHODS:In vitro p...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713689808951219
更新日期:1998-04-01 00:00:00
abstract::The aim of this study was to determine whether or not alpha neoprotein formation can occur in the lens in response to a photolytic process. Alpha crystallin from young calf and aged bovine lenses was irradiated for up to 22 hours with UV light. After cortical alpha crystallin had been irradiated, it completely preserv...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688809001882
更新日期:1988-11-01 00:00:00
abstract:PURPOSE:To evaluate differences of phagocytic capacities in rat retinal pigment epithelial (RPE) cells, iris pigment epithelial (IPE) cells, and basic fibroblast growth factor (bFGF) cDNA-transfected IPE (bFGF-IPE) cells in vitro. METHODS:The RPE cells and IPE cells were isolated from adult Long Evans rats' eyes. The ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.23.3.185.5465
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:There is a clinical need for biomimetic corneas that are as effective, preferably superior, to cadaveric donor tissue. Decellularized tissues are advantageous compared to synthetic or semi-synthetic engineered tissues in that the native matrix ultrastructure and intrinsic biological cues including growth fac...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1062114
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:We wished to establish which matrix metalloproteinases (MMPs) and metalloproteinase inhibitors (TIMPs) were present in human interphotoreceptor matrix (IPM) and vitreous. METHODS:IPM and vitreous were obtained from postmortem human eyebank eyes. Western immunoblots were probed with antibodies against human MMP...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.17.2.132.5610
更新日期:1998-02-01 00:00:00
abstract:PURPOSE:Based on the relationship between keratoconus and dry eye, the aim of this study was to evaluate changes in signs and symptoms of dry eye in keratoconus patients before and after intrastromal corneal ring surgery. METHODS:Fifteen keratoconus patients were enrolled in Fundación Jiménez-Díaz of Madrid and Univer...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1200098
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:To study the association of cell proliferation in uveal melanoma with the mean of the 10 largest nucleoli (MLN), microvascular prognostic factors, and survival. METHODS:Population-based, retrospective cohort study of 167 choroidal and ciliary body melanomas enucleated from 1972 to 1981. Mouse monoclonal antibo...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680500478535
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:A pilot study was conducted to evaluate human corneal epithelial cell shedding in response to wearing a silicone hydrogel contact lens/solution combination inducing corneal staining. The nature of ex vivo collected cells staining with fluorescein was also examined. METHODS:A contralateral eye study was conduct...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.3109/02713683.2013.841255
更新日期:2014-03-01 00:00:00
abstract:PURPOSE:To investigate the therapeutic role of topical and oral fluconazole treatment using a rabbit model of Aspergillus fumigatus keratitis. METHODS:Aspergillus fumigatus spores were injected into the corneal stroma of the right eye of 20 rabbits. Forty-eight hours later the rabbits were randomly divided into three ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.26.2.113.14514
更新日期:2003-02-01 00:00:00
abstract:PURPOSE:Taurolidine is a broad-spectrum, non antibiotic antimicrobial agent, not previously tested against the common causes of bacterial keratitis. This study, employing an experimental rabbit model of Staphylococcus aureus keratitis, investigated the effectiveness of topical taurolidine in reducing the number of bact...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680490908733
更新日期:2005-03-01 00:00:00
abstract:PURPOSE:Intrastromal epithelial migration occurs following deep excimer annular keratectomy. Our purpose is to determine the localization of gelatinase B expression and its relationship to migrating intrastromal epithelial cells following deep annular excimer keratectomy. METHODS:Rabbit corneas were treated with deep ...
journal_title:Current eye research
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract:PURPOSE:Phoria is used in the diagnosis of binocular dysfunctions, such as convergence insufficiency. A common treatment for convergence insufficiency is vision therapy, yet it is controversial whether the phoria changes as a result of rehabilitation. Phoria can vary due to the duration and/or the type of prior visual ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.694551
更新日期:2012-11-01 00:00:00
abstract::Goggles that degrade the retinal image produce axial enlargement of the ocular globe and large myopic refractive errors. Many authors have assumed that visual image degradation itself leads to myopia. Hodos and co-authors have shown, however, that goggled eyes in chicks are considerably warmer than normal. Such temper...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689308999467
更新日期:1993-03-01 00:00:00
abstract:PURPOSE:RPE65, a retinal pigment epithelium-specific 65-kDa protein, plays a critical role in the visual cycle of the eye. Rpe65(-/-) mice develop vision loss due to a lack of 11-cis-retinal, degradation of M-opsin and mislocalization of S-opsin. Several studies have suggested that 9-cis-β-carotene, a precursor of 9-ci...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2014.907430
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:The mechanisms involved in the reported beneficial effects of Calcium dobesilate monohydrate (CaD) for the treatment of diabetic retinopathy (DR) remain to be elucidated. The main aim of the present study is to examine whether CaD prevents early events in the pathogenesis of DR such as neurodegeneration and vas...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2017.1302591
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:To evaluate indocyanine green angiography (ICGA) for the identification and characterization of afferent (feeding) and efferent (draining) vessels in patients with ocular surface neoplasia. MATERIALS AND METHODS:Consecutive patients with biopsy-proven benign, pre-invasive, or invasive ocular surface tumors of ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2017.1387273
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:Matrix metalloproteinases (MMPs) are involved in posterior capsule opacification (PCO), but the mechanisms that promote MMP expression are yet to be determined. In this study, we investigated whether type I collagen, which is only detected in aged or cataractous lens capsules, affects the expression and activat...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2013.853194
更新日期:2014-05-01 00:00:00
abstract:PURPOSE:Previous studies showed that lutein and zeaxanthin, the major human retinal carotenoids, are concentrated in the macula. In this study, the carotenoids in human macular and peripheral retina and the retinal pigment epithelium (RPE) were analyzed. They were also determined in the rod outer segments (ROS) before ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.19.6.491.5276
更新日期:1999-12-01 00:00:00
abstract:PURPOSE:To quantitatively measure the flow, nonflow, density, and foveal avascular zone (FAZ) assessment tool parameters of optical coherence tomography angiography (OCTA) in patients with nonocular Behcet's Disease (BD), and to compare the results with those obtained in healthy controls. METHODS:FAZ parameters, flow ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1530361
更新日期:2019-02-01 00:00:00
abstract:PURPOSE:Alternative splicing of the last exon (exon 8) of vascular endothelial growth factor (VEGF) pre-mRNA is a key element in the balance of pro- and anti-angiogenic VEGF isoforms in exudative age-related macular degeneration (exAMD) and proliferative diabetic retinopathy (PDR). Three splicing factors, SRp40, ASF/SF...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2010.548892
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:To evaluate the ultrastructure of the cut edge and associated endothelial cell loss following donor cornea trephination with a standard punch, vacuum punch, and vacuum trephine and artificial anterior chamber system. MATERIALS AND METHODS:This laboratory investigation compared trephinations (8.0 mm) performed ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713680903222779
更新日期:2009-11-01 00:00:00
abstract:PURPOSE:To evaluate "in vivo" the effect of topical travoprost on the central corneal thickness (CCT) of rabbit eyes, and the changes in the CCT after acute increases of intraocular pressure (IOP) in these eyes. MATERIALS AND METHODS:This is an interventional, prospective, case-control, masked study. Topical travopros...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2011.608239
更新日期:2011-11-01 00:00:00
abstract:PURPOSE:To evaluate the immediate effect of 3% diquafosol ophthalmic solution on tear MUC5AC concentration, periodic acid-Schiff (PAS)-positive goblet cells, and tear film stability in normal and keratoconjunctivitis sicca (KCS) rat models. METHODS:Rats were divided into normal and KCS groups. 3% of diquafosol solutio...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1233986
更新日期:2017-05-01 00:00:00
abstract:PURPOSE:To investigate the effects of rapamycin on the TNF-α-induced secretion of interleukin-6 (IL-6) and IL-8 in orbital fibroblasts and its possible mechanism. MATERIALS AND METHODS:Orbital fibroblasts were obtained from patients with thyroid-associated ophthalmopathy. IL-6 and IL-8 levels were measured by enzyme-l...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.750368
更新日期:2013-06-01 00:00:00
abstract:PURPOSES:To investigate whether valproic acid (VPA) has a neuroprotective effect against ischemia/reperfusion (I/R) injury in the rat retina, and to elucidate the potential antioxidant mechanisms involved. METHODS:Adult male Wistar rats were randomly divided into four groups: sham (group A), sham plus VPA (group B), I...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2011.653616
更新日期:2012-05-01 00:00:00
abstract::3-aminotriazole (3AT) is known to reduce catalase levels in ocular tissues when given intravenously or orally. Rabbits were given either 4 ml/kg of a 3M solution of 3AT intravenously or a 2% solution as drinking fluid. Intravenous 3AT administration was followed at 4 hrs by an intracameral injection of hydrogen peroxi...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688709044504
更新日期:1987-12-01 00:00:00
abstract::In the unsutured partial thickness penetrating wounds of the cornea, the epithelium migrates over the wounded stromal surface prior to the onset of stromal regeneration. To determine the possible affects of the epithelial ingrowth on the organization of the stromal scar tissues, the healing of unsutured and sutured wo...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689508995803
更新日期:1995-09-01 00:00:00
abstract::In primates, ciliary muscle contraction causes accommodation and facilitates aqueous outflow. In living rhesus monkeys, accommodative, outflow facility, and ciliary muscle movement responses to cholinergic agonists all decline with age. We developed an apparatus to determine in vitro whether the latter is related to i...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689309024623
更新日期:1993-05-01 00:00:00