Abstract:
PURPOSE:Phoria is used in the diagnosis of binocular dysfunctions, such as convergence insufficiency. A common treatment for convergence insufficiency is vision therapy, yet it is controversial whether the phoria changes as a result of rehabilitation. Phoria can vary due to the duration and/or the type of prior visual tasks. The variability potentially observed within phoria measurements leads to difficulties in confidently assessing changes within longitudinal studies. Hence, we propose to measure phoria and vergence peak velocities on separate days to evaluate whether a more robust measurement can be attained. METHODS:Eleven subjects with normal binocular vision participated in two identical experimental sessions. Four-degree convergence and divergence steps stimulated from targets at far, middle, and near initial vergence positions were recorded using a limbus tracking system. Near dissociated phoria was measured after a set of step stimuli. The vergence ratio was defined as the convergence peak velocity divided by the divergence peak velocity. Linear regression analyses calculated the correlation between the phoria and the vergence ratio, and the difference between phoria measurements and vergence ratio measurements, recorded on different days. RESULTS:Near dissociated phoria measurements and vergence ratios were highly correlated for all three initial vergence positions (r > 0.85, p < 0.005). The change in phoria was significantly correlated to the change in vergence ratio (r > 0.94, p = 0.0001). The slope of the linear regression analysis between the phoria and the vergence ratio using individual subject data was repeatable between the sessions (r = 0.99, p < 0.00001) despite large changes in phoria observed in a few individuals. CONCLUSIONS:The change in phoria is significantly correlated to the change in vergence ratio. For longitudinal studies including the efficacy of vision therapies for patients with binocular dysfunctions, we suggest assessing both phoria and vergence velocities to reduce the variability potentially observed from different days.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Kim EH,Alvarez TLdoi
10.3109/02713683.2012.694551subject
Has Abstractpub_date
2012-11-01 00:00:00pages
1054-65issue
11eissn
0271-3683issn
1460-2202journal_volume
37pub_type
杂志文章abstract:PURPOSE:C5a anaphylatoxin is a potent inflammatory mediator that acts on polymorphonuclear cells (PMN) and monocytes via C5a receptors (C5aR). It mediates chemotaxis of both cell types and stimulates cytokine release from the latter. To investigate whether C5a can act on retinal pigment epithelial (RPE) cells, we exami...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.23.5.320.5437
更新日期:2001-11-01 00:00:00
abstract:PURPOSE:To study early signs of neuronal and glial differentiation in the human embryonic retina. MATERIALS AND METHODS:6.5-to 8-week-old human embryos were obtained from elective abortions. The neuroretinas were kept in culture as full-thickness sheets for 7-42 days. RESULTS:The control retinas consisted of a neurob...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680701843784
更新日期:2008-02-01 00:00:00
abstract::Forty-five patients with virologically confirmed dendritic keratitis were treated in a randomized, double-blind controlled study with a basic therapy of trifluorothymidine (TFT) eye drops. In addition they received different human recombinant interferon (rHu IFN) eye drops. The following results were obtained for aver...
journal_title:Current eye research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/02713688709020104
更新日期:1987-01-01 00:00:00
abstract::The variation of central corneal thickness with age was measured weekly at 10am by ultrasound pachometry in 10 normal (5 to 19 weeks of age) and 10 alloxan-induced diabetic (9 to 19 weeks of age) rabbits. The diurnal variation of corneal thickness was also measured at 2 hour intervals for a period of 24 hours on both ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689008999611
更新日期:1990-05-01 00:00:00
abstract:PURPOSE:To evaluate the predictive association between the horizontal anterior chamber diameter (HACD) and other measurements using Scheimpflug imaging, and to assess whether a method superior to using fixed constants can be proposed. METHODS:This hospital-based study was performed in the Cornea and Refractive Surgery...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2016.1151529
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:Choroidal neovascularization (CNV) is a major cause of vision loss in patients with age-related macular degeneration (AMD). Stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) plays a critical role in homing of bone marrow-derived cells (BMCs) to choroidal neovascularization (CNV). In this st...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2011.593107
更新日期:2011-09-01 00:00:00
abstract::Arachidonic acid metabolism via the cyclooxygenase pathway and the effects of aspirin and indomethacin were studied in whole retinas of rats with streptozotocin-induced diabetes. Diabetes was induced by intravenous injection of streptozotocin (60 mg/kg) and the animals were examined 5-6 weeks later. Whole retinas of n...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409000813
更新日期:1984-09-01 00:00:00
abstract:PURPOSE:Form-deprivation myopia (FDM) is believed to result principally from actions of substances that modulate information processing in the retina. We used a chick model to investigate what role nitric oxide (NO), a gaseous neuromodulator, might play in the development of FDM. METHODS:We injected different concentr...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.10.992.9021
更新日期:1997-10-01 00:00:00
abstract::Experiments were conducted to test the influence of thapsigargin on the NaK-ATPase activity of cultured cells (ODM2) derived from human nonpigmented ciliary epithelium. The rate of ouabain-sensitive ATP hydrolysis (Na,K-ATPase activity) was diminished in cells that had been pretreated with thapsigargin then permeabili...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689508998492
更新日期:1995-08-01 00:00:00
abstract:PURPOSE:To optimize cultured human corneal endothelial cell (cHCEC) sheet transplantation technique for maintenance of cHCEC viability. MATERIALS AND METHODS:cHCEC sheets cultured on a collagen scaffold were covered with or without Viscoat® and exposed to humidified air in the incubator. cHCEC sheets with or without V...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1101774
更新日期:2016-09-01 00:00:00
abstract::Rabbits have circadian rhythms of intraocular pressure (IOP) and aqueous flow. The dark phase increases of IOP and flow are associated with increased aqueous cyclic AMP. If the daily rhythm of aqueous cyclic AMP reflects changes of tissue levels of cyclic AMP which mediate one of the mechanisms which control the rhyth...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689209033491
更新日期:1992-09-01 00:00:00
abstract::Phosphorylated proteins of the chick lens were identified following incubation of lenses in a medium containing 32P and subsequent analysis by gel electrophoresis. The acidic variant of the vimentin and both subunits of fodrin were phosphorylated, as were the 95 Kd and 49 Kd proteins associated with the beaded-chain f...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409167214
更新日期:1984-07-01 00:00:00
abstract:PURPOSE:The expression of human leukocyte antigen (HLA) class II molecules on the cell surface is necessary for the presentation of peptide antigens to helper CD4 T lymphocytes of the immune system. We studied the immunoexpression of HLA class II antigen in conjunctival precursor lesions and conjunctival squamous cell ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.27.3.151.16052
更新日期:2003-09-01 00:00:00
abstract:PURPOSE:To investigate the biomechanical effect induced by radial keratotomy on outflow facility in paired, enucleated whole porcine eyes. METHODS:Freshly enucleated porcine eyes were perfused at a constant pressure of 10 mm Hg. Radial keratotomy (RK), with a 3.5 mm central clear zone and eight radial incisions, was p...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.12.1193.5027
更新日期:1997-12-01 00:00:00
abstract::The full length cDNA sequence for the lens-specific intermediate filament protein, CP49, from chicken is presented. The sequence contains features typical of the other intermediate filament proteins, including two major alpha-helical regions, helix I and II and appropriate linker regions. CP49 lacks a C-terminal non-a...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689508998401
更新日期:1995-07-01 00:00:00
abstract:PURPOSE:To examine the effect of elevated extracellular glucose, thus simulating diabetes, on migration, adhesion and proliferation of SV40 transformed human corneal epithelial (HCE) cells. METHODS:HCE cells were maintained in serum supplemented media containing 5 mM, 17.5 mM or 38 mM D-glucose. Cell migration was det...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.17.9.924.5133
更新日期:1998-09-01 00:00:00
abstract:PURPOSE:Post-surgical macular edema is an important clinical problem resulting from breakdown of the blood-retinal barrier (BRB) after surgery. This study was designed to develop a mouse model of post-surgical BRB breakdown. METHODS:Two 25-gauge needles, one for infusion and one for aspiration, were inserted through t...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680490503769
更新日期:2004-06-01 00:00:00
abstract:PURPOSE:Unoprostone isopropyl is an ocular hypotensive that was originally produced as a prostaglandin F2alpha analogue and is eventually recognized as a synthetic docosanoid. The compound is recently suggested to have potent neuroprotective ability in the retina. The purpose of this study is to test whether and how th...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680490889465
更新日期:2004-12-01 00:00:00
abstract:PURPOSE:The repair of the corneal epithelium is modulated by matrix metalloproteinases. The present study examined the effects of recombinant (r-) tissue inhibitors of metalloproteinases-1 and -2 (TIMP-1 and -2) on the proliferation of cultured epithelial cells from rabbit cornea, and on the spreading of a sheet of squ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.17.1.47.5247
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:To compare the intensity of posterior capsule opacification (PCO) between two intraocular lenses (IOLs) of the same optic material, but with different haptic design (1-piece vs. 3-piece). METHODS:This prospective intraindividual controlled cohort study comprised eighty eyes of 40 patients with bilateral age...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.3109/02713683.2012.717242
更新日期:2013-01-01 00:00:00
abstract::We adapted a previously described procedure to quantitate collagen in corneal tissue sections prepared from paraffin-embedded samples. The method entailed staining the deparaffinized tissue sections with Sirius red, eluting the bound dye with NaOH-methanol, and estimating the color in a spectrophotometer as an indicat...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688609015119
更新日期:1986-08-01 00:00:00
abstract:PURPOSE:Whether there is an interaction between eyes of individual subjects in refractive development is an important issue to guide experimental designs and help understand mechanisms involved in development of refractive errors. This study investigated whether spontaneous high myopia in one eye will affect refractive...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2011.568660
更新日期:2011-06-01 00:00:00
abstract::The corneal endothelium is known to contain gap junctions on its lateral borders. Here we show that the endothelial cells of the rabbit cornea are highly dye coupled. Lucifer Yellow CH introduced into a single cell through either an intracellular glass microelectrode or a patch electrode rapidly spreads into its neigh...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688909000876
更新日期:1989-08-01 00:00:00
abstract:PURPOSE:To validate the more easily applicable "flush" tear collection technique as a viable alternative to basal and reflex tear collection. MATERIALS AND METHODS:Total protein content (TPC) and immunoglobulin A (IgA) concentrations were determined in the basal, reflex, and flush tears of 16 healthy non-contact lens ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2010.542867
更新日期:2011-03-01 00:00:00
abstract::Purpose: Dual wavelength retinal oximetry allows the quantification of oxygen saturation in the larger retinal vessels. However, the technique might be refined further by identifying factors that are responsible for the different oxygen saturations in first order arterioles from the same eye shortly after their branch...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1524015
更新日期:2019-01-01 00:00:00
abstract::After the debridement of the entire corneal epithelium of the rabbit eye, epithelial cells of conjunctival origin cover the denuded corneal surface. Under such experimental conditions, the rate of wound healing is considerably delayed and total regeneration is completed within 15 to 20 days, allowing evaluation of var...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688709025230
更新日期:1987-10-01 00:00:00
abstract:PURPOSE:This study was designed to investigate whether synthetic small interference RNA (siRNA) targeting VEGF-A could inhibit mouse corneal neovascularization or not. METHODS:First, the effect of synthetic siRNA targeting VEGF-A on the expression of VEGF in human retinal pigment epithelial line ARPE-19 cells was exam...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713681003597230
更新日期:2010-05-01 00:00:00
abstract:PURPOSE:To test if nicotine counteracts the dampening effect of human cytomegalovirus (HCMV) infection of NF-kappaB in retinal pigment epithelial (RPE) cells, thereby increasing the permissiveness of RPE cells for HCMV replication. METHODS:Human ARPE-19 cells were transfected with NF-kappaB luciferase DNA, inoculated ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680500514651
更新日期:2006-02-01 00:00:00
abstract::Although experimental models of autoimmune uveitis predict pinealitis coincident with uveitis, there is no direct evidence of pineal pathology accompanying a human uveitis. Horses with naturally occurring uveitis are a potential source of eye and pineal tissues that are not available from human patients with active uv...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689208999525
更新日期:1992-01-01 00:00:00
abstract::The effects of 4% epinephrine bitartrate and 0.5% timolol on ocular and optic nerve blood flow were studied in phakic and aphakic rabbit eyes using a radioactive microsphere (85Sr) technique. Either epinephrine or timolol was given topically as eight drops in the hour immediately preceding blood flow measurements (one...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409000822
更新日期:1984-10-01 00:00:00