Early development of retinal subtypes in long-term cultures of human embryonic retina.

abstract：AIM:To test the feasibility of implanting human anterior lens capsules (HALCs) with porcine corneal endothelial cells (pCEC) in vivo in Göttingen minipigs and at the same time test the suitability of Göttingen minipig as model for endothelial keratoplasty. MATERIALS AND METHODS:Cell-carrier constructs of decellularize...

journal_title：Current eye research

authors： Telinius N,Spinozzi D,Rasic D,Dapena I,Baandrup U,Miron A,Oellerich S,Hjortdal J

更新日期：2020-08-01 00:00:00

abstract：:3-aminotriazole (3AT) is known to reduce catalase levels in ocular tissues when given intravenously or orally. Rabbits were given either 4 ml/kg of a 3M solution of 3AT intravenously or a 2% solution as drinking fluid. Intravenous 3AT administration was followed at 4 hrs by an intracameral injection of hydrogen peroxi...

journal_title：Current eye research

authors： Birnbaum D,Csukas S,Costarides A,Forbes E,Green K

更新日期：1987-12-01 00:00:00

abstract：PURPOSE:To determine the plasma levels of the sulfur-containing amino-acids homocysteine, cysteine, cysteinylglycine, glutamylcysteine, glutathione, and taurine in patients with central retinal vein occlusion (CRVO) and in healthy subjects and to ascertain whether there are statistically significant differences between...

journal_title：Current eye research

authors： Pinna A,Zinellu A,Franconi F,Carru C

更新日期：2010-07-01 00:00:00

abstract：:Goggles that degrade the retinal image produce axial enlargement of the ocular globe and large myopic refractive errors. Many authors have assumed that visual image degradation itself leads to myopia. Hodos and co-authors have shown, however, that goggled eyes in chicks are considerably warmer than normal. Such temper...

journal_title：Current eye research

authors： Shih YF,Fitzgerald ME,Norton TT,Gamlin PD,Hodos W,Reiner A

更新日期：1993-03-01 00:00:00

abstract：:A method is described for the preparation of plasma membrane enriched fractions from bovine retinal pigment epithelium (RPE) by means of differential centrifugation followed by the use of self forming gradients of Percoll. A detailed analysis of the distribution of organelle specific markers (nuclei, mitochondria, lys...

journal_title：Current eye research

authors： Ottonello S,Maraini G

更新日期：1984-09-01 00:00:00

abstract：PURPOSE:This study was designed to investigate whether synthetic small interference RNA (siRNA) targeting VEGF-A could inhibit mouse corneal neovascularization or not. METHODS:First, the effect of synthetic siRNA targeting VEGF-A on the expression of VEGF in human retinal pigment epithelial line ARPE-19 cells was exam...

journal_title：Current eye research

authors： Zuo L,Fan Y,Wang F,Gu Q,Xu X

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:To study changes in the morphometric characteristics of the whole brain visual-related cortex in various stages of primary open angle glaucoma (POAG) in vivo. MATERIALS AND METHODS:Thirty POAG patients (nine early stage cases and 21 advanced-late stage cases) and 30 gender-, education-, and age-matched healthy...

journal_title：Current eye research

authors： Li C,Cai P,Shi L,Lin Y,Zhang J,Liu S,Xie B,Shi Y,Yang H,Li S,Du H,Wang J

更新日期：2012-09-01 00:00:00

abstract：:Intraocular synthesis of IgG antibodies against HSV (herpes simplex virus), CMV (cytomegalovirus) and VZV (varicella zoster virus) is considered as an indirect proof of uveoretinal infection. Paired serum and aqueous samples obtained from 16 patients with retinitis associated with AIDS, 3 patients with ARN, 8 patients...

journal_title：Current eye research

authors： Luyendijk L,vd Horn GJ,Visser OH,Suttorp-Schulten MS,vd Biesen PR,Rothova A,Kijlstra A

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:To evaluate postnatal developmental changes in the amounts of retinal glutamate, glutamine and GABA, and in the distribution of retinal glutamine in the rat. METHODS:Free amino acids were extracted from rat retinas of different postnatal stages, and the concentrations of glutamate, glutamine and GABA were dete...

journal_title：Current eye research

authors： Ishikawa A,Shiono T,Ishiguro S,Tamai M

更新日期：1996-06-01 00:00:00

abstract：PURPOSE:The purpose of this work is to describe and review the technology of plasma rich in growth factors (PRGF), a novel blood derivative product, in the treatment of ocular surface disorders. METHODS:To demonstrate the importance of this technology in the treatment of ocular pathologies, a thorough review of the pr...

journal_title：Current eye research

authors： Anitua E,Muruzabal F,de la Fuente M,Merayo J,Durán J,Orive G

更新日期：2016-07-01 00:00:00

abstract：:A prototype automated flicker perimeter was used to investigate flicker luminance thresholds in glaucoma patients (n = 11), ocular hypertensives (high risk n = 10, low and intermediate risk n = 21) and normal controls (n = 10). Differential light sensitivity was measured for one eye of each subject using a flickering ...

journal_title：Current eye research

authors： Austin MW,O'Brien CJ,Wishart PK

更新日期：1994-10-01 00:00:00

abstract：PURPOSE:Androgens are thought to play a role in the regulation of the human lacrimal gland. Androgen receptor mRNA has been isolated from human lacrimal tissue; however, it is not known which cell(s) in human lacrimal tissue may contain androgen receptors. This study is an immunohistochemical investigation of the locat...

journal_title：Current eye research

authors： Smith RE,Taylor CR,Rao NA,Young LL,Rife LL

更新日期：1999-04-01 00:00:00

abstract：:Purpose: To evaluate the long-term efficacy and safety of the modified canaloplasty technique with additional suprachoroidal drainage in patients with pseudoexfoliation glaucoma. Methods: This retrospective clinical trial included 131 patients with pseudoexfoliation glaucoma who underwent canaloplasty with suprachoroi...

journal_title：Current eye research

authors： Seuthe AM,Szurman P,Januschowski K

更新日期：2021-02-01 00:00:00

abstract：PURPOSE:Compare the efficacy of treatment of pneumococcal keratitis with cholesterol, moxifloxacin, or a mixture of the two (moxifloxacin/cholesterol). MATERIALS AND METHODS:New Zealand white rabbits were injected intrastromally with 10(6) colony-forming units (CFU) of a clinical keratitis strain of Streptococcus pneu...

journal_title：Current eye research

authors： Sanders ME,Tullos NA,Taylor SD,Norcross EW,King LB,Tolo I,Marquart ME

更新日期：2010-12-01 00:00:00

abstract：:Posterior subcapsular cataracts (PSC) are associated with hereditary retinal dystrophy in the Royal College of Surgeons (RCS) rat model and with human retinitis pigmentosa. The relationship of lens and retinal pathology has never been explained. Previous studies of pink-eyed RCS rats aged 2.5 to 11 months had shown an...

journal_title：Current eye research

authors： Hess HH,Newsome DA,Knapka JJ,Westney GE

更新日期：1982-01-01 00:00:00

abstract：:Steroids are widely used in the prevention of corneal neovascularization in a wide range of natural and experimental situations. However, no information is available on their effect on the growth of the individual limbal blood vascular cells or of lymphatic cells involved in corneal neovascularization. In addition, tr...

journal_title：Current eye research

authors： Boneham GC,Collin HB

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:The aim of the present study was to calculate the diameter of the central retinal artery from results as obtained with non-invasive techniques in healthy young subjects. METHODS:Twenty-four healthy male subjects participated in this study. Total retinal blood flow was calculated from combined bi-directional la...

journal_title：Current eye research

authors： Dorner GT,Polska E,Garhöfer G,Zawinka C,Frank B,Schmetterer L

更新日期：2002-12-01 00:00:00

abstract：:Calf gamma-crystallins were separated by preparative flat-bed isoelectric focusing and characterized according to their immunological properties, molecular weights and isoelectric points. Immunologically 4 different groups of gamma-crystallins (gamma 1a-1d-crystallin) could be detected. The main immunological componen...

journal_title：Current eye research

authors： Bours J,Vornhagen R,Herlt M,Rink H

更新日期：1981-01-01 00:00:00

abstract：:The possible roles of monocytes and lymphocytes in vitreous fibrosis were examined by injecting various numbers of the peripheral cell types into the rabbit vitreous. Our results indicated that the degree of vitreous fibrosis and the presence of traction retinal detachment corresponded to the number of cells injected....

journal_title：Current eye research

authors： Raymond LA,Katakami C,Lipman MJ,Alexander DW,Spaulding AG,Choromokos E,Kao WW

更新日期：1988-12-01 00:00:00

abstract：:The administration of 0.1-0.5% of ethanol produces a slow increase in the transepithelial potential (TEP) of about 2 mV in the bovine pigment epithelium (RPE) under ordinary room lighting. However, virtually no response could be observed when ethanol was administered in the dark. Because of this apparent light sensiti...

journal_title：Current eye research

authors： Pautler EL

更新日期：1994-09-01 00:00:00

abstract：:Previous studies have reported the expression of acidic fibroblast growth factor (aFGF) by rat, bovine, and human retinal pigment epithelium (RPE) in vivo. To critically examine the expression of aFGF by RPE cells, we studied the density dependence of steady-state levels of mRNA and protein expression in vitro. Northe...

journal_title：Current eye research

authors： Kitaoka T,Bost LM,Ishigooka H,Aotaki-Keen AE,Hjelmeland LM

更新日期：1993-11-01 00:00:00

abstract：:Introduction: Metabolic syndrome is a disorder characterized by a constellation of findings including truncal obesity, elevated blood pressure, abnormal cholesterol levels, and high blood glucose. Recent evidence suggests that metabolic syndrome may be associated with increased risk of age-related macular degeneration...

journal_title：Current eye research

authors： Roddy GW,Rosa RH,Viker KB,Holman BH,Hann CR,Krishnan A,Gores GJ,Bakri SJ,Fautsch MP

更新日期：2020-06-01 00:00:00

abstract：:Recently, growth factors are known to phosphorylate tyrosine residues of proteins to regulate cellular functions. We investigated growth factor-dependent phosphorylation of membrane proteins in cultured human retinal pigment epithelial (RPE) cells. The phosphorylation experiments were done in membrane preparations of ...

journal_title：Current eye research

authors： Yoshimura N,Kuriyama S,Iwaki M,Honda Y

更新日期：1992-10-01 00:00:00

abstract：:We previously reported that Ia+ monolayers of LEW rat corneal endothelial (CE) cells were unable to stimulate proliferation of MHC compatible T cell lines or IL-2 release from hybridomas, and inhibited [3H]-thymidine incorporation when added to conventional lymphocyte proliferation assays. Our purpose was to further a...

journal_title：Current eye research

authors： Kawashima H,Gregerson DS

更新日期：1994-08-01 00:00:00

abstract：PURPOSE:To determine the roles of the murine interleukin-8 receptor homolog (mIL-8Rh, neutrophil chemokine CXC receptor 2) and macrophage inflammatory protein-1alpha (MIP-1alpha, a CC chemokine) in two eye inflammation models: endotoxin-induced uveitis (EIU) and immune complex-induced uveitis (reverse passive Arthus re...

journal_title：Current eye research

authors： Brito BE,O'Rourke LM,Pan Y,Huang X,Park JM,Zamora D,Cook DN,Planck SR,Rosenbaum JT

更新日期：1999-07-01 00:00:00

abstract：:Retinal pigment epithelia (RPE) and retinal neurons (RN) arise from the same underlying precursor cell population. It is worthwhile to explore the transdifferentiation potential of RPE cells, given the benefits that could accrue from turning RPE into neural retina containing all its normal cellular subpopulations. Fac...

journal_title：Current eye research

authors： Khera S,Tiwari A,Srinivasan R,Gupta A,Luthra-Guptasarma M

更新日期：2012-07-01 00:00:00

abstract：PURPOSE:NiCl(2) (15 microM) enhances the ERG b-wave amplitude of vertebrate retina, up to 1.5-fold by blocking E/R-type voltage-gated Ca(2+) channels, which is mediated by blocking the release of GABA onto ionotropic GABA-A and GABA-C receptors. In vivo, it is likely that zinc, rather than nickel ions, may be involved ...

journal_title：Current eye research

authors： Siapich SA,Wrubel H,Albanna W,Alnawaiseh M,Hescheler J,Weiergräber M,Lüke M,Schneider T

更新日期：2010-04-01 00:00:00

abstract：:Purpose: To compare four visual acuity (VA) scoring termination rules. Methods: A computer simulation generated 30,000 virtual patients who underwent 10 repetitions for each of four termination rules, on both the Snellen and ETDRS charts (2.4 million tests performed in total). Three termination rules focused on the sm...

journal_title：Current eye research

authors： Mimouni M,Shamir RR,Cohen AD,El-Yaniv R,Cohen MJ,Joskowicz L,Blumenthal EZ

更新日期：2019-07-01 00:00:00

abstract：:Two proteins, with molecular weights of 49 (CP49) and 115 kDa (CP115) as judged by SDS PAGE, have been shown by immunocytochemistry to be components of the beaded filament, a cytoskeletal structure thus far demonstrated only in the lens fiber cell. We have used antibodies reactive with CP49 to screen a mouse lens cDNA...

journal_title：Current eye research

authors： Hess JF,Casselman JT,FitzGerald PG

更新日期：1993-01-01 00:00:00

abstract：:Glucocorticoid-induced ocular hypertension has been demonstrated in both animals and humans. It is possible that glucocorticoid-induced changes in trabecular meshwork (TM) cells are responsible for this hypertension. In order to elaborate further the effect of glucocorticoids on the trabecular meshwork, the ultrastruc...

journal_title：Current eye research

authors： Wilson K,McCartney MD,Miggans ST,Clark AF

更新日期：1993-09-01 00:00:00