Abstract:
:Purpose: To compare four visual acuity (VA) scoring termination rules. Methods: A computer simulation generated 30,000 virtual patients who underwent 10 repetitions for each of four termination rules, on both the Snellen and ETDRS charts (2.4 million tests performed in total). Three termination rules focused on the smallest character row: all characters were correctly identified (100%), one character was incorrectly identified (one miss) and 50% or more of the characters were correctly identified (50%). The forth termination rule used a calculation in which each character, when correctly recognized, contributed a proportional increment (per-letter). Accuracy, test-retest variability (TRV) and test duration were measured. Next, a clinical study was conducted in which 254 subjects underwent three repetitions of the ETDRS VA test from 4 m, and VA scores for each of the four scoring termination rules were calculated. Results: In the Snellen simulation, the mean accuracy of the 100%, one miss, 50% and per-letter termination rules in decimal was 0.23 (-0.16 logMAR), 0.11 (-0.09 logMAR), 0.10 (-0.08 logMAR), and -0.08 (0.08 logMAR) respectively; while with the ETDRS simulation, the mean accuracy in decimal was 0.34 (-0.22 logMAR), 0.14 (-0.11 logMAR), 0.07 (-0.06 logMAR), and 0.07 (-0.05 logMAR), respectively. For the ETDRS simulation, the per-letter had the lowest TRV values and the longest test duration. In the clinical study (n = 254), the reproducibility of the 100%, one miss, 50% and per-letter was 0.50, 0.53, 0.17, 0.14, respectively. Conclusions: Clinical study and simulation data both suggest that the 100% and one-miss termination rules have higher TRVs, while the 50% and per-letter demonstrated much tighter, and rather close, TRV values.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Mimouni M,Shamir RR,Cohen AD,El-Yaniv R,Cohen MJ,Joskowicz L,Blumenthal EZdoi
10.1080/02713683.2019.1589524subject
Has Abstractpub_date
2019-07-01 00:00:00pages
790-795issue
7eissn
0271-3683issn
1460-2202journal_volume
44pub_type
杂志文章abstract::Langerhans cells (LC) appear to have a role in the processing of antigens presented through cutaneous surfaces. In most species LC are found in the conjunctiva and limbal epithelium but are rarely found in the central cornea. A quantitative study of corneal LC was performed in guinea pigs and rabbits with HSV-1 kerati...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688709020087
更新日期:1987-01-01 00:00:00
abstract:PURPOSE:To assess the incidence of cell proliferation and apoptosis in epiretinal membranes from eyes with proliferative vitreoretinopathy (PVR), proliferative diabetic retinopathy (PDR), and macular pucker (MP) and to further investigate the potential involvement of key executors of apoptosis. METHODS:Epiretinal memb...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680590956306
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVE:To investigate the association between corneal temperature on ocular surface and stability of tear film, and define the normal reference range of corneal surface temperature in the population of Pudong New Area, Shanghai, China. METHODS:Temperature of cornea (TOC) and tear film break-up time (BUT) were measu...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2016.1167920
更新日期:2017-05-01 00:00:00
abstract:PURPOSE:To examine the effects of nitric oxide synthase (NOS) inhibitors on intraocular pressure (IOP) and ocular inflammation following laser irradiation of the rabbit iris, and to investigate the involvement of nitric oxide (NO). METHODS:Thirty min after the intravenous administration of a nonselective inhibitor of ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.17.3.308.5225
更新日期:1998-03-01 00:00:00
abstract::The selective DA2 agonist, N-0437, produced an acute reduction in intraocular pressure (IOP) and pupil diameter (PD) when applied topically to the eyes of normal monkeys. Ocular hypotension and miosis were primarily unilateral in nature, dose-related and lasted 3 to 5 hours following drug instillation. In normal monke...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688708997557
更新日期:1987-11-01 00:00:00
abstract:PURPOSE:This study sought to evaluate the efficacy of bevacizumab (Avastin), an anti-VEGF agent, in the reduction of corneal neovascularization in a rodent model, and compare between the effect of intraocular and subconjunctival injection. METHODS:Corneal neovascularization was induced by application of a mixture of 7...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713680903429007
更新日期:2010-02-01 00:00:00
abstract:PURPOSE:NiCl(2) (15 microM) enhances the ERG b-wave amplitude of vertebrate retina, up to 1.5-fold by blocking E/R-type voltage-gated Ca(2+) channels, which is mediated by blocking the release of GABA onto ionotropic GABA-A and GABA-C receptors. In vivo, it is likely that zinc, rather than nickel ions, may be involved ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713680903509410
更新日期:2010-04-01 00:00:00
abstract:PURPOSE:To investigate the therapeutic role of topical and oral fluconazole treatment using a rabbit model of Aspergillus fumigatus keratitis. METHODS:Aspergillus fumigatus spores were injected into the corneal stroma of the right eye of 20 rabbits. Forty-eight hours later the rabbits were randomly divided into three ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.26.2.113.14514
更新日期:2003-02-01 00:00:00
abstract:PURPOSE:To determine the effects of a subconjunctival injection of mitomycin-C (MMC) on iridial circulation in rabbits. METHODS:Dutch rabbits anesthetized with pentobarbital received a 0.2-ml subconjunctival injection of 0.4 mg/ml or 0.1 mg/ml MMC; the contralateral eye received 0.2 ml physiological saline. Intraocula...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.19.2.197.5327
更新日期:1999-08-01 00:00:00
abstract::Sixteen adult New Zealand white rabbits with previously confirmed herpes simplex virus type 1 (HSV-1) infections were stimulated by iontophoresis of 6-hydroxydopamine into the cornea and were followed-up by topical epinephrine treatment to confirm latency. A total of 224 ocular cultures were obtained, of which 73 were...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688709044511
更新日期:1987-12-01 00:00:00
abstract::The normal aqueous humor contains a variety of soluble immunosuppressive factors, including transforming growth factor-beta, alpha-melanocyte stimulating hormone, and vasoactive intestinal peptide. These factors are largely the secretory products of parenchymal cells of the iris and ciliary body. TGF beta has recently...
journal_title:Current eye research
pub_type: 杂志文章,评审
doi:10.3109/02713689208999510
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:The present study was conducted to develop and characterize a functional primary culture of pigmented rabbit conjunctival epithelial cells on permeable support exhibiting tight barrier properties. METHODS:Conjunctival epithelial cells were isolated by 0.2% protease treatment, cultured at 0.5-1.8 x 10(6) cells/...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689608995151
更新日期:1996-12-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the effect of vitreous reflux (VR) on the short-term effect of intravitreal ranibizumab injection. MATERIALS AND METHODS:The study included 181 eyes of 81 age-related macular degeneration (AMD) and 100 diabetic macular edema (DME) patients. Treatment response was evaluated...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1789664
更新日期:2021-02-01 00:00:00
abstract::A model for endothelial transport is updated to include recent evidence. We discuss electrolyte movements based on a Na+-K+ ATPase, a Na+-H+ exchanger, a Na+-HCO3 coupler, a Cl- -HCO-3 exchanger, a K+-Cl-coupler, and K+ and anion channels. We discuss near-isotonic transport of fluid on the basis of recent findings of ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688509025148
更新日期:1985-04-01 00:00:00
abstract:PURPOSE:To investigate the biomechanical effect induced by radial keratotomy on outflow facility in paired, enucleated whole porcine eyes. METHODS:Freshly enucleated porcine eyes were perfused at a constant pressure of 10 mm Hg. Radial keratotomy (RK), with a 3.5 mm central clear zone and eight radial incisions, was p...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.12.1193.5027
更新日期:1997-12-01 00:00:00
abstract::We previously reported that Ia+ monolayers of LEW rat corneal endothelial (CE) cells were unable to stimulate proliferation of MHC compatible T cell lines or IL-2 release from hybridomas, and inhibited [3H]-thymidine incorporation when added to conventional lymphocyte proliferation assays. Our purpose was to further a...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689408999891
更新日期:1994-08-01 00:00:00
abstract:PURPOSE:Phoria is used in the diagnosis of binocular dysfunctions, such as convergence insufficiency. A common treatment for convergence insufficiency is vision therapy, yet it is controversial whether the phoria changes as a result of rehabilitation. Phoria can vary due to the duration and/or the type of prior visual ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.694551
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Spectral domain optical coherence tomography (SD-OCT) in patients can deliver retinal cross-sectional images with high resolution. This may allow the evaluation of the extent of damage to the retinal pigment epithelium (RPE) and the neurosensory retina after laser treatment. This article aims to investigate ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680902964892
更新日期:2009-07-01 00:00:00
abstract:PURPOSE:Most studies of cell growth of the RPE employ cultures which have been previously passaged, but here we investigated freshly-explanted RPE cells, which may have been growth-quiescent for years, within the eye to determine whether co-culture affects initial outgrowth in primary culture. METHODS:Bovine or human ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.9.891.5051
更新日期:1997-09-01 00:00:00
abstract:PURPOSE:To determine the role of matrix metalloproteinase 9 (MMP9) in advanced glycation end-products (AGEs) induced damage to blood-retinal barrier (BRB) and the therapeutic effects of minocycline, an MMP inhibitor, against the BRB damages. METHODS:Forty-eight Sprague Dawley rats were randomly assigned to 3 groups (1...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680802450984
更新日期:2008-11-01 00:00:00
abstract::The intraocular inflammatory reaction in a murine model of herpes simplex keratouveitis was studied using immunohistochemical techniques. 5 x 10(5) PFU of HSV-1 (Stewart strain) was applied to the abraded cornea of BALB/c mice. The subsequent development of keratouveitis was documented by sequential examination, conve...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688909013892
更新日期:1989-01-01 00:00:00
abstract:PURPOSE:To assess the potential impact of corneal crosslinking treatment (365 nm ultraviolet (UV)A irradiation with riboflavin) on the material properties of Intracorneal Rings Segments (ICRS). MATERIALS AND METHODS:Material properties were studied using FT-IR spectroscopy and UV-Vis spectroscopy. Rings were examined:...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2014.941071
更新日期:2015-05-01 00:00:00
abstract::The cell content of the precorneal tears of eight subjects was sampled following overnight wear of a contact lens in one eye. This was compared with morning samples taken from the other eye, and afternoon samples taken several days later from both eyes. In the morning the median number of desquamated epithelial cells ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688908996380
更新日期:1989-04-01 00:00:00
abstract::Cytoskeletal and membrane proteins were isolated from respectively the urea-soluble and urea-insoluble fractions of the squid lens. The main cytoskeletal polypeptide has a molecular weight (63000) and an amino acid composition similar to those of vertebrate intermediate filament proteins, including mammalian lens vime...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688208996358
更新日期:1982-01-01 00:00:00
abstract:PURPOSE:In the limbo-corneal epithelium the stem and early precursor epithelial cell pool is confined to the limbal rim. Among the features associated with this spatial segregation is the general paucity of connexin43 (Cx43) within the limbal basal cell population and its complete absence in resident stem cells. The li...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.24.6.430.8599
更新日期:2002-06-01 00:00:00
abstract:PURPOSE:There is a substantial literature showing that the selective estrogen receptor modulator tamoxifen can block swelling-activated chloride channels, such as those in astrocytes. This study aimed to test the hypothesis that anatomic characteristics consistent with swelling may be measured within the optic nerve he...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680600602547
更新日期:2006-04-01 00:00:00
abstract:PURPOSE:Frequent steroid drops represent a challenge in patient compliance. This study evaluated the safety and efficacy of 5 minute topical dexamethasone sodium phosphate-Visulex (DSP-Visulex) treatment regimen (two applications on the first week then weekly after) compared to daily prednisolone acetate 1% (PA) for no...
journal_title:Current eye research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1080/02713683.2018.1540707
更新日期:2019-02-01 00:00:00
abstract:PURPOSE:There is limited information on region-specific gene expression in the human corneal stroma. In this study, we aimed to investigate the expression profile of the extracellular matrix and adhesion molecules in the normal corneal stroma using laser capture microdissection (LCM) and molecular techniques. METHODS:...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1200099
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:Intrastromal epithelial migration occurs following deep excimer annular keratectomy. Our purpose is to determine the localization of gelatinase B expression and its relationship to migrating intrastromal epithelial cells following deep annular excimer keratectomy. METHODS:Rabbit corneas were treated with deep ...
journal_title:Current eye research
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract:PURPOSE:To evaluate how corneal deturgescence after Descemet membrane endothelial keratoplasty (DMEK) influences the posterior corneal surface area and the endothelial cell density (ECD) measurements. MATERIALS AND METHODS:A mathematical model was formulated to estimate the increase in posterior corneal surface area a...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.753095
更新日期:2013-02-01 00:00:00