Abstract:
PURPOSE:To determine the effects of a subconjunctival injection of mitomycin-C (MMC) on iridial circulation in rabbits. METHODS:Dutch rabbits anesthetized with pentobarbital received a 0.2-ml subconjunctival injection of 0.4 mg/ml or 0.1 mg/ml MMC; the contralateral eye received 0.2 ml physiological saline. Intraocular pressure (IOP) and NB( iris), a quantitative index of iridial tissue blood velocity, were measured up to 24 hours after treatment. RESULTS:At a dosage of 0.4 mg/ml MMC, NB iris obtained from the iridial area adjacent to the injection site decreased significantly by 13.6% and 18.6% at 1 and 2 hours (P = 0.03, 0.01, respectively) after treatment; NB iris obtained on the contralateral side of the injection showed no significant change. In eyes treated with 0.1 mg/ml MMC, NB iris did not change significantly. The mean IOP was significantly lower by 3.1, 3.0, and 1.8 mm Hg at 6, 12, and 24 hours after the 0.4 mg/ml injection of MMC compared with the fellow eyes (P = 0.03, 0.01, and 0.03, respectively), the IOP decreased by 1.7 mm Hg at 4 hours in the eyes treated with 0.1 mg/ml MMC (P = 0. 04). CONCLUSIONS:Subconjunctival injections of 0.2 ml of 0.4 mg/ ml MMC caused not only a significant decrease of IOP but also a transient but significant effect on iridial circulation.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Tomidokoro A,Araie M,Tamaki Y,Muta Kdoi
10.1076/ceyr.19.2.197.5327subject
Has Abstractpub_date
1999-08-01 00:00:00pages
197-200issue
2eissn
0271-3683issn
1460-2202journal_volume
19pub_type
杂志文章abstract:PURPOSE:Androgens are thought to play a role in the regulation of the human lacrimal gland. Androgen receptor mRNA has been isolated from human lacrimal tissue; however, it is not known which cell(s) in human lacrimal tissue may contain androgen receptors. This study is an immunohistochemical investigation of the locat...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.18.4.300.5362
更新日期:1999-04-01 00:00:00
abstract:PURPOSE:Klotho genes are expressed in limited tissues and have been found to be a pathogenic factor of age-related diseases in mammals, but their expressions and functions in human eyes are yet to be defined. This study was performed to investigate the expression of Klotho family genes in human ocular tissues and anter...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1259421
更新日期:2017-06-01 00:00:00
abstract:PURPOSE:To examine whether transforming growth factor-beta 2 (TGF-beta 2) induces the expression of alpha-smooth muscle actin (SMA), a biochemical marker of myofibroblasts, in cultured bovine retinal pigment epithelial (RPE) cells. METHODS:Bovine RPE cells were cultured in F-12 nutrient mixture supplemented with 5% fe...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689608995147
更新日期:1996-11-01 00:00:00
abstract:PURPOSE:To evaluate the feasibility of retinal vein bypass surgery for induced branch retinal-vein occlusion (BRVO) in the living porcine eye. METHODS:Fifteen minipigs were used in the study. Seven days before vascular surgery, hyaluronidase and plasmin were intravitreally injected for induction of posterior vitreous ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2014.997887
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:Hypercarbia has been suggested as a risk factor for retinopathy of prematurity (ROP). We investigated the effect of hypercarbia on the retinal vasculature of the neonatal rat to determine whether hypercarbia alone could induce preretinal neovascularization analogous to ROP. METHODS:In a preliminary blood gas s...
journal_title:Current eye research
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract:PURPOSE:To investigate the effects of pyrrolidine dithiocarbamate (PDTC), a nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) inhibitor, on the expression of matrix metalloproteinases (MMP) and MMP-mediated apoptosis in retinal ganglion cells (RGCs) following the transection of the optic nerve (ON) in ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2011.606591
更新日期:2011-11-01 00:00:00
abstract::The ocular penetration pathways of three alpha 2-adrenergic agents (p-aminoclonidine, AGN 190342, and clonidine) were investigated in rabbits both in vitro and in vivo. The corneal permeabilities of the compounds correlated positively with their octanol/water distribution coefficients. The ocular drug absorption via c...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689008997579
更新日期:1990-11-01 00:00:00
abstract:PURPOSE:To develop a standardized method for measuring from iris photographs, light and dark segments of areas and densities of iris color. METHODS:Computerized image analysis was used to measure the iris photographs. The reproducibility of this method was studied in 30 normal eyes with three different colored irides,...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.22.6.412.5490
更新日期:2001-06-01 00:00:00
abstract::As it is known that chlorpromazine (CPZ) can bind to melanins as well as cause ocular phototoxicity, we investigated the cytotoxic effects of UV-visible irradiation of melanotic and amelanotic retinal pigment epithelial (RPE) cells in the presence of CPZ. At low concentrations (5 micrograms/ml) of CPZ a photosensitiza...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688809047014
更新日期:1988-01-01 00:00:00
abstract::Posterior vitreous detachment (PVD) and epiretinal membranes occur in a number of vitreoretinal diseases. We have developed an experimental model in which we can provide the morphologic correlation of these dynamic processes. The method provides the opportunity to study epiretinal membrane formation with the scanning ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688609020055
更新日期:1986-04-01 00:00:00
abstract:PURPOSE:A pilot study was conducted to evaluate human corneal epithelial cell shedding in response to wearing a silicone hydrogel contact lens/solution combination inducing corneal staining. The nature of ex vivo collected cells staining with fluorescein was also examined. METHODS:A contralateral eye study was conduct...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.3109/02713683.2013.841255
更新日期:2014-03-01 00:00:00
abstract:PURPOSE:This study identifies the prevalence and risk factors of sensorineural hearing loss and primary open-angle glaucoma (POAG). MATERIALS AND METHODS:Patients aged 19 years or older who had undergone both ophthalmologic examination and audiometry as part of the Korea National Health and Nutrition Examination Surve...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1712424
更新日期:2020-08-01 00:00:00
abstract:SIGNIFICANCE:Adopting a risk stratification system and appropriate listing of cases reduces the rates of intraoperative complications during phacoemulsification. Such listing would allow both safe surgery and enhance training, by ensuring an appropriately experienced surgeon is available to operate on a case or supervi...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1801759
更新日期:2020-07-30 00:00:00
abstract:PURPOSE:Alternative splicing of the last exon (exon 8) of vascular endothelial growth factor (VEGF) pre-mRNA is a key element in the balance of pro- and anti-angiogenic VEGF isoforms in exudative age-related macular degeneration (exAMD) and proliferative diabetic retinopathy (PDR). Three splicing factors, SRp40, ASF/SF...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2010.548892
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:To evaluate the intraocular distribution and metabolism of the lipid prodrug of foscarnet, 1-O-octadecyl-sn-glycerol-3- phosphonoformate (ODG-PFA), following intravitreal administration. METHODS:Twenty rabbits received ODG-[14C]PFA intravitreal injection, yielding 0.632 mM resultant intravitreal concentration....
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.18.3.161.5366
更新日期:1999-03-01 00:00:00
abstract:PURPOSE:To investigate retinal imaging and ablation using femtosecond laser pulses. MATERIALS AND METHODS:Two non-amplified near-infrared femtosecond lasers were used to irradiate porcine retinal specimens in vitro. The lasers were used for tissue removal as well as multiphoton laser scanning microscopy. RESULTS:Abla...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680801956452
更新日期:2008-04-01 00:00:00
abstract:PURPOSE:Investigated the effect of N-3-aminomethylbenzylacetamidine (1400 W), a highly selective inhibitor of inducible nitric oxide synthase (iNOS), on the effector phase of EAU. METHODS:Sixteen Lewis rats were sensitized with bovine retinal S-antigen; ten of them injected subcutaneously with 1400 W (20 mg/kg) three ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.26.1.1.14250
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:To compare the abilities of balanced salt solution, BSS Plus and Hartmann's lactated Ringer's (HLR) solution to maintain the viability of retinal vascular endothelial cells (RVEC) in vitro. METHODS:Cultured retinal vascular endothelial cells were suspended in each irrigating solution for four hours. Viability ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.3.239.15414
更新日期:1997-03-01 00:00:00
abstract::We studied the effects of a forskolin suspension on intraocular pressure (IOP) in normal albino and pigmented rabbits and in alpha-chymotrypsin induced ocular hypertensive rabbits. Experimental-induced ocular hypertensive rabbits were produced by injecting of alpha-chymotrypsin (167 units) into the posterior chamber o...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688809033195
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND:Spectral domain optical coherence tomography (SD-OCT) in patients can deliver retinal cross-sectional images with high resolution. This may allow the evaluation of the extent of damage to the retinal pigment epithelium (RPE) and the neurosensory retina after laser treatment. This article aims to investigate ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680902964892
更新日期:2009-07-01 00:00:00
abstract:PURPOSE:To test if nicotine counteracts the dampening effect of human cytomegalovirus (HCMV) infection of NF-kappaB in retinal pigment epithelial (RPE) cells, thereby increasing the permissiveness of RPE cells for HCMV replication. METHODS:Human ARPE-19 cells were transfected with NF-kappaB luciferase DNA, inoculated ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680500514651
更新日期:2006-02-01 00:00:00
abstract:PURPOSE:Phagocytosis of rod outer segments (ROS) is an important function of retinal pigment epithelial (RPE) cells. Since the details of the process are not fully known, we studied effects of cytokines produced by RPE and photoreceptor cells on phagocytosis of ROS by rat RPE cells. METHODS:RPE cells were isolated and...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689609000760
更新日期:1996-05-01 00:00:00
abstract:PURPOSE:To learn if peripheral nerve pathways are necessary for corneal expansion and anterior segment growth under a 12-hr light:dark cycle or for the inhibition of corneal expansion under constant light rearing. METHODS:Recently hatched White Leghorn chicks under anesthesia received unilateral ciliary ganglionectomy...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680600738127
更新日期:2006-06-01 00:00:00
abstract:PURPOSE:To evaluate central corneal thickness (CCT) and corneal volume (CV) in healthy eyes using swept source anterior segment optical coherence tomography (SS-AS-OCT) and other devices. METHODS:Thirty-three healthy right eyes of 33 subjects were investigated. CCT was measured with SS-AS-OCT, rotating Scheimpflug cam...
journal_title:Current eye research
pub_type: 临床试验,杂志文章
doi:10.3109/02713683.2012.745878
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To investigate the biomechanical effect induced by radial keratotomy on outflow facility in paired, enucleated whole porcine eyes. METHODS:Freshly enucleated porcine eyes were perfused at a constant pressure of 10 mm Hg. Radial keratotomy (RK), with a 3.5 mm central clear zone and eight radial incisions, was p...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.12.1193.5027
更新日期:1997-12-01 00:00:00
abstract::A prototype automated flicker perimeter was used to investigate flicker luminance thresholds in glaucoma patients (n = 11), ocular hypertensives (high risk n = 10, low and intermediate risk n = 21) and normal controls (n = 10). Differential light sensitivity was measured for one eye of each subject using a flickering ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689409047005
更新日期:1994-10-01 00:00:00
abstract::Antifibrosis agents have improved the success of glaucoma filtration surgery, although undesired side effects are not readily reversible and may present a major limitation in the use of these agents. Our purpose was to study the efficacy of cytosine arabinoside (Ara-C) as an adjunctive antimetabolite in glaucoma surge...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689409025140
更新日期:1994-11-01 00:00:00
abstract::A model system for retinal adhesion, consisting of interacting bovine pigment, epithelium (PE) cells and photoreceptor outer segments, was utilized to examine any adhesive role of the interphotoreceptor matrix. PE cells were dissociated by trypsin treatment of the eyecup, and were allowed to replenish their surface pr...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688109001859
更新日期:1981-01-01 00:00:00
abstract:PURPOSE:Psychiatric conditions and not just the treatments themselves might be involved in the pathophysiology of dry eye disease (DED). The aim of our study was to evaluate the association between depression and DED using objective and subjective tests in patients with newly diagnosed depressive disorder who were not ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1236966
更新日期:2017-05-01 00:00:00
abstract:PURPOSE:Considerable evidence suggests that both axial and peripheral refraction play important roles in eye growth control. The large variability in peripheral refraction seen in adults and children indicates that the peripheral retina is exposed to a wide range of refractive errors. The current lack of appropriate me...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.27.2.61.15454
更新日期:2003-07-01 00:00:00