Abstract:
PURPOSE:There is a substantial literature showing that the selective estrogen receptor modulator tamoxifen can block swelling-activated chloride channels, such as those in astrocytes. This study aimed to test the hypothesis that anatomic characteristics consistent with swelling may be measured within the optic nerve head (ONH) of tamoxifen users whose ONH appearance is considered within normal limits.
METHODS:Indices of ONH topography were measured using the Heidelberg Retina Tomograph II (HRT) for two populations of women ages 40-69 years: (1) subjects using tamoxifen (20 mg/day) as adjuvant therapy after successful primary treatment for breast cancer and (2) control subjects not using any hormonal medication. All subjects had excellent visual acuity (with 20/20 or better in the test eye), and all appeared to be free of eye disease, as based on conventional photographic assessment. The study design was cross-sectional. The various ONH indices were assessed as functions of the duration of tamoxifen use.
RESULTS:The optic cups of short-term tamoxifen users ( journal_name journal_title authors doi subject pub_date pages issue eissn issn pii journal_volume pub_type
abstract::Purpose/Aim: To assess the changes in anterior eye segment biometrics and intraocular pressure during and after wearing swimming goggles.Materials and methods: Anterior segment biometry and intraocular pressure were assessed in 20 healthy young adults (22.2 ± 4.7 years) during the wearing of a drilled swimming goggle....
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1662056
更新日期:2020-05-01 00:00:00
abstract::Purpose: The goal of this work was to determine whether the retinal tissue perfusion (RTP) is impaired in patients with multiple sclerosis (MS). Methods: Seventy-four patients [66 relapsing-remitting MS (RRMS) and 8 clinically isolated syndrome (CIS)] and 74 age- and gender-matched healthy controls were recruited. RTP...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1612444
更新日期:2019-10-01 00:00:00
abstract:PURPOSE:This study was designed to investigate the presence of the secretory phospholipase A2 receptor in RPE, a protein closely related to the phagocytic mannose receptor. METHODS:Proteins from cultured rat, pig, and human RPE were separated by SDS-PAGE and immunoblotted with a polyclonal guinea pig sPLA2 receptor an...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.19.1.1.5345
更新日期:1999-07-01 00:00:00
abstract::Purpose: To evaluate the correlation between pain during cataract surgery and preoperative anxiety.Methods: This prospective observational masked study included 103 eyes of 103 consecutive patients who underwent routine clear corneal incision phacoemulsification surgery at the Department of Ophthalmology, Rambam Healt...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1666996
更新日期:2020-04-01 00:00:00
abstract::Birefringence variations, seen as regularly spaced altering light and dark rings (bands), have been observed along the length of unfixed, freshly isolated rod outer segments (ROS) of both Rana pipiens and Xenopus laevis. In our hands, the spatial frequency of the banding pattern is from 1.3-1.6u/band in Rana pipiens a...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409007412
更新日期:1984-11-01 00:00:00
abstract::A bovine lens "native" plasma membrane fraction containing its full compliment of extrinsic proteins was prepared by sucrose density centrifugation of the water insoluble fraction. The major membrane fraction was found at the 25/45% sucrose interface. This fraction contained 73% of the total water insoluble phospholip...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689209000748
更新日期:1992-08-01 00:00:00
abstract:PURPOSE:To compare the differences in higher-order aberrations (HOAs) after laser subepithelial keratomileusis (LASEK) between two different laser platforms. METHODS:One hundred and seven eyes of 107 patients were included in this study. Fifty-six eyes underwent LASEK with the Triple-A profile (an ablation profile of ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1726404
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:After corneal injury, persistent epithelial defects (PED's) may occur due to the chronic failure of the regenerating epithelium to adhere to the underlying stroma. The aim of this study was to examine the potential of epsilonaminocaproic acid (EACA) as a topical treatment for PED's. EACA inhibits the activation...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.18.2.150.5382
更新日期:1999-02-01 00:00:00
abstract::With Golgi impregnation, a simple amacrine cell type is described in the chick retina. The most relevant morphological feature of these retinal neurons is a single straight, radial trunk which dichotomizes tangentially in a rectilinear expansion in the 5th stratum of the inner plexiform layer (IPL). ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688908995187
更新日期:1989-02-01 00:00:00
abstract::The effect of cyclosporine (CsA) treatment in both primary and secondary Chlamydia trachomatis ocular infection in cynomolgus monkeys was studied. Following primary infection, CsA-treated animals developed severe clinical symptoms which persisted for up to 12 weeks compared to control animals which developed less seve...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688709034831
更新日期:1987-05-01 00:00:00
abstract::Purpose: To provide a normative data set of swept-source optical coherence tomography angiography (SS-OCTA) peripapillary vessel density (VD) measurements and assess correlations with age, gender, disc area and axial length (AL). Material and Methods: This was an observational cross-sectional study conducted on 346 ri...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1744164
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:To review the microbiological spectrum and antibiotic sensitivities of the pathogens that cause culture-proven endophthalmitis and to understand the status and trends of antibiotic susceptibility at a public hospital over a 10-year period. METHODS:The data of 577 culture-proven endophthalmitis isolates collect...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1188118
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:To evaluate the suitablity of commercially available moisture retention eyewear for treating evaporative dry eye. METHODS:Eleven patients with evaporative dry eyes were prescibed moisture retention eyewear for 3 months in addition to regular lubricant eye drops. Frequency and severity of dry eye symptoms, c...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2014.932389
更新日期:2015-05-01 00:00:00
abstract::Using phosphorus-31 nuclear magnetic resonance (P-31 NMR) spectroscopy the rat crystalline lens was evaluated as a potential animal model for the study of lens metabolic processes relevant to the human. The P-31 NMR spectra of intact rat lenses and rat lens PCA extracts provided comparable qualitative and quantitative...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688109019974
更新日期:1981-01-01 00:00:00
abstract::EDGF, a growth factor purified from bovine retina is able to increase the rate of wound healing of rabbit corneal epithelium in a dose dependent way. Two applications a day are enough to obtain the maximum rate. The most purified preparation of EDGF is as effective as EGF or pFGF in promoting this phenomenon and allow...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409003059
更新日期:1984-04-01 00:00:00
abstract:PURPOSE:To evaluate the clinical outcomes of laser in situ keratomileusis (LASIK) using a new approach for the calculation of the ablation profile based on wavefront vertexing from pupil plane to corneal. METHODS:One hundred eyes of 50 patients (age, 21-41 years) with low and moderate myopia were enrolled in this pros...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1822418
更新日期:2020-09-16 00:00:00
abstract::Papavarine, cholera toxin, and isoproterenol each elevated cyclic AMP in cultured rat retinal pigment epithelium and reduced the phagocytosis of isolated rod outer segments (38-66% of controls) during a 4 hour incubation. In addition, cultured pigment epithelium was preincubated with 25 mM exogenous cyclic AMP for two...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688608995161
更新日期:1986-01-01 00:00:00
abstract:PURPOSE:Most studies of cell growth of the RPE employ cultures which have been previously passaged, but here we investigated freshly-explanted RPE cells, which may have been growth-quiescent for years, within the eye to determine whether co-culture affects initial outgrowth in primary culture. METHODS:Bovine or human ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.9.891.5051
更新日期:1997-09-01 00:00:00
abstract:PURPOSE:To determine the effectiveness of topically applied fluoroquinolones for experimental Pseudomonas or Serratia keratitis. METHODS:Bacteria were injected intrastromally (10(3) colony forming units [CFU]). From 16 to 22 hours post-infection (PI), a single topical drop of moxifloxacin (Vigamox, 0.545%), levofloxac...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.28.5.337.28676
更新日期:2004-05-01 00:00:00
abstract:PURPOSE:Both HSV-1 and HSV-2 express LAT during viral latency. Previous studies indicated that deletion of either LAT impairs viral reactivation from latency, but that the HSV-1 LAT confers the ability to reactivate efficiently from trigeminal ganglia onto HSV-2. We sought to determine whether the HSV-2 LAT could funct...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.26.3.219.14896
更新日期:2003-03-01 00:00:00
abstract:PURPOSE:To examine the effects of external modulation of epithelial-mesenchymal interaction on conjunctival epithelial cell differentiation characteristics. METHODS:Keratin K4 and laminin beta2 chain protein localization was examined in an organotypic model which facilitates the comparison of differentiation character...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.18.1.28.5394
更新日期:1999-01-01 00:00:00
abstract:AIMS:To elucidate the intramuscular distribution and branching patterns of the abducens nerve in the lateral rectus (LR) muscle so as to provide anatomical confirmation of the presence of compartmentalization, including for use in clinical applications such as botulinum toxin injections. METHODS:Thirty whole-mount hum...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1438631
更新日期:2018-06-01 00:00:00
abstract::The mechanism of oxidative damage to the lens through intraocular photochemical generation of superoxide and its derivatization to other oxidants such as singlet oxygen, hydroxyl radical and hydrogen peroxide has been studied. Rat lenses when organ cultured aerobically in TC 199 containing additional amounts of ribofl...
journal_title:Current eye research
pub_type: 杂志文章,评审
doi:10.3109/02713688408997186
更新日期:1984-01-01 00:00:00
abstract:PURPOSE:Raman spectroscopy could potentially be used as a diagnostic tool for the detection of meibomian gland dysfunction by measuring the composition, conformation, and amount of meibum lipid on the lid margin. Toward this goal and to test our studies of meibum lipid using infrared spectroscopy, we measured the Raman...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713680903122029
更新日期:2009-10-01 00:00:00
abstract:PURPOSE:To study the efficacy and outcomes of short-term postoperative vitreoretinal tamponade with perfluorocarbon heavy liquid in patients with giant retinal tear. MATERIALS AND METHODS:The study group consisted of 13 consecutive patients (13 eyes) who presented with giant retinal tear at a tertiary medical center i...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1266664
更新日期:2017-07-01 00:00:00
abstract::Phosphatidic acid (PA) is an obligate intermediate in the phosphatidylinositol (PI) cycle and may serve as a sensitive marker for this pathway of reactions. Previously, we have shown that acetylcholine (ACh) stimulates formation of labeled PA in whole rat corneas whose phospholipids were prelabeled with [14C]arachidon...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688709034832
更新日期:1987-05-01 00:00:00
abstract:PURPOSE:To compare serum levels of chemerin in type 2 diabetes mellitus (T2DM) with or without retinopathy, and to investigate the relationship between serum chemerin levels and diabetes retinopathy. MATERIALS AND METHODS:A total of 60 T2DM patients and 20 healthy subjects (control group) were enrolled in this study. ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1004718
更新日期:2016-01-01 00:00:00
abstract::Two different measures of response to therapy were evaluated in a model of keratitis caused by Aspergillus fumigatus in Dutch-belted rabbits. Combined pre and post-inoculation treatment with oral fluconazole 37.5 mg/kg bid or itraconazole 40 mg/kg bid was compared to post-inoculation treatment only and untreated contr...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689209069165
更新日期:1992-01-01 00:00:00
abstract::The maximal velocity (Vmax) and the apparent dissociation constant (K0.5) of Na+K+-ATPase have each been estimated with respect to sodium and potassium ion activation. These estimations were made from the enzymatic activity of plasma membrane preparations derived from bovine corneal endothelial cells. The determinatio...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688709034834
更新日期:1987-05-01 00:00:00
abstract:PURPOSE:To learn if peripheral nerve pathways are necessary for corneal expansion and anterior segment growth under a 12-hr light:dark cycle or for the inhibition of corneal expansion under constant light rearing. METHODS:Recently hatched White Leghorn chicks under anesthesia received unilateral ciliary ganglionectomy...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680600738127
更新日期:2006-06-01 00:00:00