Changes in connexin43 in early ocular surface development.

abstract：PURPOSE:To investigate the biomechanical effect induced by radial keratotomy on outflow facility in paired, enucleated whole porcine eyes. METHODS:Freshly enucleated porcine eyes were perfused at a constant pressure of 10 mm Hg. Radial keratotomy (RK), with a 3.5 mm central clear zone and eight radial incisions, was p...

journal_title：Current eye research

authors： Becker HH,Eisenberg DL,Wang N,Steinert RF,Schuman JS

更新日期：1997-12-01 00:00:00

abstract：PURPOSE:Human beta-defensins 1 and 2 (hBD-1, -2) are antimicrobial peptides found in several epithelia including corneal epithelium. Breach of the epithelium leaves the cornea vulnerable to infection so we sought to determine if there is an increase in defensin expression after injury. METHODS:The epithelium from huma...

journal_title：Current eye research

authors： McDermott AM,Redfern RL,Zhang B

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:Corneal wound healing after excimer laser photorefractive keratectomy (PRK) passes through a series of characteristic stages which have earlier been defined by means of histological, histochemical, and biochemical approaches. We investigated the potential of confocal microscopy to verify morphological changes i...

journal_title：Current eye research

authors： Linna T,Tervo T

更新日期：1997-07-01 00:00:00

abstract：:Lens epithelial cells were isolated from samples of C57BL/6 and CD-1 mice at different ages between 1 and 5 months, and assayed for the level of N-acetyl-beta-glucosaminidase and their ability to replicate in-vitro. The lens epithelial cells from C57BL/6 mice had a reduced replicative potential compared to other norma...

journal_title：Current eye research

authors： Lipman RD,Muggleton-Harris AL

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:The high prevalence of positive family history of keratoconus (KC) in KC patients is well-known. However, the results regarding the association between family history of KC and disease severity are controversial. The aim of this study was to evaluate the possible association between family history and severity ...

journal_title：Current eye research

authors： Naderan M,Rajabi MT,Zarrinbakhsh P,Naderan M,Bakhshi A

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:We identified a novel mutation in Paired Box gene 6 (PAX6) and characterized its associated clinical features of severe ocular malformation in a Chinese family with congenital aniridia. METHODS:We studied two patients with aniridia from a Chinese family. All patients and noncarriers in this family underwent fu...

journal_title：Current eye research

authors： He Y,Pan Z,Luo F

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:Dry eye is a common condition known to have many systemic co-morbidities. We aim to report the frequency of depression and anxiety suspects in eye clinic patients and explore the association between dry eye signs and symptoms with depression and anxiety. MATERIALS AND METHODS:Adult outpatients were recruited f...

journal_title：Current eye research

authors： Liyue H,Chiang PP,Sung SC,Tong L

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:Accumulation of lipoprotein-derived lipids including esterified and unesterified cholesterol in Bruch's membrane of human eyes is a major age-related change involved in initiating and sustaining soft drusen in age-related macular degeneration (AMD). The apolipoprotein (apo) A-I mimetic peptide 4F is a small ant...

journal_title：Current eye research

authors： Rudolf M,Mir Mohi Sefat A,Miura Y,Tura A,Raasch W,Ranjbar M,Grisanti S,Aherrahrou Z,Wagner A,Messinger JD,Garber DW,Anantharamaiah GM,Curcio CA

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:To investigate the characteristics of anterior chamber inflammatory reaction induced by intravitreal injection of endothelin-1 (ET-1). METHODS:The time course of changes in aqueous protein concentration (APC) after intravitreal injection of 10(-4), 10(-5), 10(-6) and 10(-7) M ET-1 into rabbit eyes was measured...

journal_title：Current eye research

authors： Shoji N,Oshika T,Masuda K

更新日期：1998-02-01 00:00:00

abstract：PURPOSE:To investigate the antiproliferative effects of the subconjunctival injection of human RAD50 (hRAD50) on fibroblasts after glaucoma filtering surgery. METHODS:After glaucoma filtering surgery in normal rabbit eye, the subconjunctival injection of hRAD50 was performed. Morphologic changes in the subconjunctival...

journal_title：Current eye research

authors： Yoon KC,Yang KJ,Seo JS,Lee SE,Heo T,Chun BJ,Jung S,Kim KK,Ahn KY

更新日期：2004-03-01 00:00:00

abstract：PURPOSE:We investigated the impact of target properties on vertical fusion amplitude (VFA) using a 3D display platform; the performance of the subjects allowed us to assess how central and peripheral retina regions interact during the fusion process. MATERIAL AND METHODS:Fourteen subjects were involved in the test. VF...

journal_title：Current eye research

authors： Zhang D,Neveu P,Fattakhova Y,Ferragut S,Lamard M,Cochener B,de Bougrenet de la Tocnaye JL

更新日期：2017-03-01 00:00:00

abstract：:VIP markedly stimulates intracellular cAMP accumulation in the human retinoblastoma Y-79 cell line. cAMP increased about 5-fold above the basal level with 10(-8)M VIP and reached a maximum level (about 70-fold increase) with 2 X 10(-6)M VIP. Glucagon at 6 X 10(-8)M significantly increased cAMP accumulation with a maxi...

journal_title：Current eye research

authors： Kyritsis A,Koh SW,Chader GJ

更新日期：1984-02-01 00:00:00

abstract：:5-Fluorouracil (5-FU) and Mitomycin C (MMC) are used as adjunct chemotherapy during glaucoma filtering surgery to suppress conjunctival fibroblast proliferation. Since part of these agents may gain access to the anterior chamber and cause cytotoxicity to the corneal endothelium we set up an in vitro system to establis...

journal_title：Current eye research

authors： Nuyts RM,Pels E,Greve EL

更新日期：1992-06-01 00:00:00

abstract：:The effects of transforming growth factor-beta (TGF beta) and epidermal growth factor (EGF) on the synthesis of collagen and fibronectin, and on the proliferation of human corneal stromal fibroblasts in vitro, were evaluated. Human corneal stromal fibroblasts in culture were incubated for 48 hours with TGF beta or EGF...

journal_title：Current eye research

authors： Ohji M,SundarRaj N,Thoft RA

更新日期：1993-08-01 00:00:00

abstract：PURPOSE:This study sought to evaluate the efficacy of bevacizumab (Avastin), an anti-VEGF agent, in the reduction of corneal neovascularization in a rodent model, and compare between the effect of intraocular and subconjunctival injection. METHODS:Corneal neovascularization was induced by application of a mixture of 7...

journal_title：Current eye research

authors： Avisar I,Weinberger D,Kremer I

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:The aim of this pilot study was to determine the presence of complement activation products in tears from pre- and postkeratoplasty eyes and the fellow eyes in order to investigate the activation of the classical and alternative pathways of the complement system in the early postkeratoplasty period. METHODS:Te...

journal_title：Current eye research

authors： Kerényi A,Nagy G,Veres A,Varga L,Füst A,Nagymihány A,Czumbel N,Süveges I,Füst G

更新日期：2002-02-01 00:00:00

abstract：:Purpose: The optical coherence tomography (OCT) has been used to evaluate the changes of retinal degeneration in patients with diabetic peripheral neuropathy (DPN) in recent years, but the results of previous studies were controversial. Therefore, systematic review and meta-analysis were performed to evaluate the degr...

journal_title：Current eye research

authors： Liu B,Wang W,Zhou R,Zeng X,Zhu Z

更新日期：2021-01-11 00:00:00

abstract：:Endothelin-1 (ET-1) affects intraocular pressure (IOP) in rabbits. First, we studied IOP responses to the intravitreal injection of various doses of ET-1 ranging from 5 ng to 5 micrograms in unanesthetized rabbits, and observed a transient rise in IOP, from 0.5 to 2 h in duration, invariably followed by a prolonged IO...

journal_title：Current eye research

authors： Sugiyama K,Haque MS,Okada K,Taniguchi T,Kitazawa Y

更新日期：1995-06-01 00:00:00

abstract：AIM:To investigate microscopic changes in corneal morphology in chloroquine (CQ)-treated patients without corneal abnormalities being diagnosable by slit lamp microscopy. METHODS:Thirty-six eyes of 36 patients with rheumatoid arthritis (RA) were divided into two groups: group 1 included 26 patients receiving chloroqui...

journal_title：Current eye research

authors： Ma X,He L,He D,Xu J

更新日期：2012-04-01 00:00:00

abstract：PURPOSE:To investigate the spectral content of intraocular pressure (IOP) pulse wave by advanced spectral signal processing of continuous IOP readings obtained by dynamic contour tonometry. PATIENTS AND METHODS:A non-interventional case-control study included 20 healthy subjects, 20 previously untreated primary open a...

journal_title：Current eye research

authors： Božić M,Dukić ML,Stojković M

更新日期：2012-11-01 00:00:00

abstract：:Previous attempts to prepare monoclonal antibodies (MAbs) against S-antigen, a photoreceptor cell protein involved in the visual process and a potent autoantigen for the induction of experimental autoimmune uveitis (EAU), have yielded MAbs which define only carboxyl terminal epitopes. In this study we devised alternat...

journal_title：Current eye research

authors： Donoso LA,Gregerson DS,Smith L,Robertson S,Knospe V,Vrabec T,Kalsow CM

更新日期：1990-04-01 00:00:00

abstract：:Purpose: To provide a normative data set of swept-source optical coherence tomography angiography (SS-OCTA) peripapillary vessel density (VD) measurements and assess correlations with age, gender, disc area and axial length (AL). Material and Methods: This was an observational cross-sectional study conducted on 346 ri...

journal_title：Current eye research

authors： Fernández-Vigo JI,Kudsieh B,Shi H,De-Pablo-Gómez-de-Liaño L,Serrano-Garcia I,Ruiz-Moreno JM,Martínez-de-la-Casa JM,García-Feijóo J,Fernández-Vigo JÁ

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:To evaluate the effect of short-term hypobaric hypoxic conditions (STHC) on intraocular pressure (IOP) in healthy subjects. METHODS:The study group was comprised of 30 healthy participants (60 eyes) with a mean age of 24.8 years. IOP was measured with a Tono-Pen XL tonometer at ground level (792 m above sea le...

journal_title：Current eye research

authors： Karadag R,Sen A,Golemez H,Basmak H,Yildirim N,Karadurmus N,Koseoglu E,Akin A

更新日期：2008-10-01 00:00:00

abstract：:A reduced nicotinamide adenine dinucleotide phosphate (NAD(P)H)-dependent hydrogen peroxide-generating activity of rat ocular tissue was investigated cytochemically utilizing the cerium method. NADPH or NADH oxidation resulted in electron-dense fine granular deposits on the corneal epithelial and endothelial plasma me...

journal_title：Current eye research

authors： Atalla LR,Sevanian A,Rao NA

更新日期：1988-09-01 00:00:00

abstract：PURPOSE:Nitric oxide production can cause either apoptotic or necrotic cell death through oxidative stress. We aimed to investigate the nitrite oxide metabolites (NOx) and nitrite levels in the aqueous humor of rabbit eyes after different methods of corneal collagen cross-linking (CXL). MATERIALS AND METHODS:Twenty-fo...

journal_title：Current eye research

authors： Yuksel N,Ozel-Turkcu U,Yalinbas D,Novruzlu S,Bilgihan A,Bilgihan K

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:Increases in matrix proteins, such as type I collagen and fibronectin, are observed with aging in the retinal pigment epithelium (RPE) basement membrane. However, little is known about altered gene expression profiles of RPE associated with increases in matrix proteins. We investigated changes in gene expressio...

journal_title：Current eye research

authors： Imai H,Honda S,Kondo N,Ishibashi K,Tsukahara Y,Negi A

更新日期：2007-10-01 00:00:00

abstract：PURPOSE:Compare the efficacy of treatment of pneumococcal keratitis with cholesterol, moxifloxacin, or a mixture of the two (moxifloxacin/cholesterol). MATERIALS AND METHODS:New Zealand white rabbits were injected intrastromally with 10(6) colony-forming units (CFU) of a clinical keratitis strain of Streptococcus pneu...

journal_title：Current eye research

authors： Sanders ME,Tullos NA,Taylor SD,Norcross EW,King LB,Tolo I,Marquart ME

更新日期：2010-12-01 00:00:00

abstract：:Purpose: Notch signaling plays a vital role in the differentiation and proliferation of corneal epithelial cells from limbal stem cells. The temporal regulation of Notch signaling during this differentiation remains unknown. Hence, we investigated the importance of temporal activation/blockage of Notch signaling durin...

journal_title：Current eye research

authors： Dhamodaran K,Subramani M,Krishna L,Matalia H,Jayadev C,Chinnappaiah N,Shetty R,Das D

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:To learn if peripheral nerve pathways are necessary for corneal expansion and anterior segment growth under a 12-hr light:dark cycle or for the inhibition of corneal expansion under constant light rearing. METHODS:Recently hatched White Leghorn chicks under anesthesia received unilateral ciliary ganglionectomy...

journal_title：Current eye research

authors： Stone RA,Sugimoto R,Capehart C,Pendrak K,Lin T

更新日期：2006-06-01 00:00:00

abstract：:The goal of this study was to determine the effect of extracellular matrix components on the phagocytic function of the retinal pigment epithelial (RPE) cell. Cultured human fetal RPE cells were established in culture and plated on three commercially-prepared substrates: collagen IV, fibronectin and laminin and on thr...

journal_title：Current eye research

authors： Miceli MV,Newsome DA

更新日期：1996-01-01 00:00:00