Abstract:
PURPOSE:To evaluate the effect of short-term hypobaric hypoxic conditions (STHC) on intraocular pressure (IOP) in healthy subjects. METHODS:The study group was comprised of 30 healthy participants (60 eyes) with a mean age of 24.8 years. IOP was measured with a Tono-Pen XL tonometer at ground level (792 m above sea level, prehypoxic) during hypobaric hypoxic exposure (equivalent to 9144 m) and at ground level again after this exposure (post-hypoxic). For each condition, the mean of 3 consecutive measurements of IOP was calculated. In each condition, central corneal thickness was also measured. RESULTS:IOP in the hypobaric hypoxic condition (18.23 +/- 2.84 mmHg) was significantly greater than IOP in both the prehypoxic condition (16.52 +/- 2.84 mmHg) (p < 0.001) and the post-hypoxic condition (17.02 +/- 2.52 mmHg) (p < 0.01). When corrected for hypoxia-related changes in CCT, IOP under hypobaric hypoxic conditions was still greater than IOP in both the prehypoxic and post-hypoxic conditions. There was no significant difference between IOP levels in the prehypoxic and post-hypoxic conditions (p > 0.05). CONCLUSION:STHC caused a significant increase in IOP in healthy participants. But this significant increase in IOP cannot be solely explained by a CCT-related overestimation error due to the increase in CCT. Individuals with IOP-related disorders such as glaucoma should be cautious when facing potential exposure to hypobaric hypoxic conditions.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Karadag R,Sen A,Golemez H,Basmak H,Yildirim N,Karadurmus N,Koseoglu E,Akin Adoi
10.1080/02713680802416696subject
Has Abstractpub_date
2008-10-01 00:00:00pages
864-7issue
10eissn
0271-3683issn
1460-2202pii
904014340journal_volume
33pub_type
杂志文章abstract:PURPOSE:Matrix metalloproteinases (MMPs) play an important role in the degradation of extracellular matrix (ECM) proteins in the retina. Breakdown of ECM proteins results in neovascularization and tractional retinal detachment, which eventually lead to the symptoms of proliferative diabetic retinopathy. Müller cells ar...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.682635
更新日期:2012-09-01 00:00:00
abstract::Inhibition of ciliary process adenylate cyclase was studied on rabbit membrane preparations. When considered individually, epinephrine, GTP and NaCl did not inhibit adenylate cyclase activity. On the other hand, when present together, epinephrine, GTP (10(-5) M) and NaCl (200 mM) acted synergistically to cause a 27% i...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688809047034
更新日期:1988-03-01 00:00:00
abstract:PURPOSE:To investigate orbital biomechanical properties in patients with thyroid orbitopathy and in age- and gender-matched healthy subjects using the Corvis-ST (CST, Oculus Wetzlar, Germany). METHODS:The CST allows a non-contact tonometry with an ultra-high-speed Scheimpflug device to record the deformation of the co...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2017.1405044
更新日期:2018-03-01 00:00:00
abstract::Activity of RNA polymerases I, II and III (distinguished using alpha-amanitin) and activity of DNA polymerases alpha and beta (distinguished using N-ethylmaleimide) were assayed for varying intervals and at varying substrate (UTP or dTTP) concentrations in the purified nuclear fraction from corneal epithelium of carba...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688709025204
更新日期:1987-03-01 00:00:00
abstract:AIM:To compare patient satisfaction and experience after external dacryocystorhinostomy (EX-DCR) versus transcanalicular DCR (TC-DCR) with a diode laser and to evaluate the change in quality of life following simultaneous bilateral DCR. METHODS:Prospective evaluation of 38 eyes of 19 patients with bilateral nasolacrim...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.658488
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:Acyclovir has been shown to be effective in preventing recurrent herpes simplex virus lesions of the genitalia and oral labia. The purpose of the current study was to determine the effect of acyclovir on the appearance of infectious virus in the peripheral nervous system and in an end organ, the eye. MATERIALS...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680490504560
更新日期:2004-08-01 00:00:00
abstract:PURPOSE:The present study was aimed to investigate the expression of purinergic P2 receptors in oxygen-induced retinal neovascularization. METHODS:Immunohistochemistry was used to study the expression of purinergic P2Y2 and P2X2 receptors in the neonatal mouse retina during normal vascular development and after oxygen...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680701885470
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:To evaluate the stability of successive applanation tonometry measurements in glaucomatous eyes. METHODS:A prospective, comparative, randomized, and evaluator-masked study was conducted in a tertiary medical center. Sixty-seven patients with glaucoma attending our glaucoma clinic underwent four successive intr...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.3109/02713681003678824
更新日期:2010-06-01 00:00:00
abstract::Two anti-fibrotic agents were evaluated in vitro for potential application in trabeculectomy. The rate of collagen formation by cultured rabbit corneal fibroblasts was determined by [3H]proline uptake and hydroxylation assay. Incubation of fibroblasts, for 96 hours, with 16 mM 2,4-pyridine dicarboxylic acid (2,4-PDCA)...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689309001833
更新日期:1993-06-01 00:00:00
abstract::Purpose: To investigate the cytotoxic effects of fresh black carbon (FBC) particles and ozone-oxidized BC (OBC) particles on human corneal epithelial cells (HCECs), and the role of the NLRP3 inflammasome signal pathway in the process.Methods: HCECs were treated with different doses of FBC and OBC particles, the cell i...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1698051
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:To compare the intensity of posterior capsule opacification (PCO) between two intraocular lenses (IOLs) of the same optic material, but with different haptic design (1-piece vs. 3-piece). METHODS:This prospective intraindividual controlled cohort study comprised eighty eyes of 40 patients with bilateral age...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.3109/02713683.2012.717242
更新日期:2013-01-01 00:00:00
abstract::We measured the relative solubility of collagen in acetic acid after pepsin digestion and tentatively identified the types of collagen present in corneas of rabbits of various ages and in corneal scar tissue, using hydroxyproline assays and polyacrylamide gel electrophoretic analyses. More than 80% of the collagen in ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688109019966
更新日期:1981-01-01 00:00:00
abstract:PURPOSE:Unstable tear film characterized by shorting of tear break-up time (BUT) is associated with discomfort and dryness in contact lens wearers. The glycocalyx is thought to be crucial in maintaining the wettability and lubrication of the ocular surface. We evaluated the ocular surface glycocalyx in soft contact len...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2014.999948
更新日期:2016-01-01 00:00:00
abstract::The selective DA2 agonist, N-0437, produced an acute reduction in intraocular pressure (IOP) and pupil diameter (PD) when applied topically to the eyes of normal monkeys. Ocular hypotension and miosis were primarily unilateral in nature, dose-related and lasted 3 to 5 hours following drug instillation. In normal monke...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688708997557
更新日期:1987-11-01 00:00:00
abstract:PURPOSE:To determine whether environmental factors or bacterial viability affect the binding of two strains of P. aeruginosa to mouse cornea. METHODS:Scarified corneas were placed in organ culture and inoculated with P. aeruginosa cell suspensions containing either ATCC 19660 or PAO1 bacterial strains classed as cytot...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.17.3.231.5226
更新日期:1998-03-01 00:00:00
abstract:PURPOSE:To establish autologous iris pigment epithelial (IPE) cell transplantation in monkey eyes. METHODS:Autologous IPE cells from three monkeys were obtained by peripheral iridectomy, and cell culture was performed with autologous serum. The cultured cells were labeled with DiI, and transplantation was performed by...
journal_title:Current eye research
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
abstract::Systemically administered fluorescein is converted to fluorescein glucuronide. The conjugate is fluorescent and interferes with the measurement of fluorescein in the anterior chamber. Carboxyfluorescein is a hydrophilic derivative of fluorescein. In the rabbit, carboxyfluorescein is not converted as readily to a fluor...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688609025171
更新日期:1986-05-01 00:00:00
abstract:PURPOSE:The prospective study evaluated the effects of optical defocus on kinetic sensitivity using automated kinetic perimetry. MATERIALS AND METHODS:The 17 eyes of 17 healthy young participants were evaluated. All of the participants had myopia (≥ -5.00 D) and mild to no astigmatism (<1.00 D). Automated kinetic peri...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2014.961614
更新日期:2015-01-01 00:00:00
abstract::Purpose: To determine the refractive astigmatism following toric intraocular lens (tIOL) implantation without consideration of posterior keratometric astigmatism with a conventional tIOL calculator for eyes with low keratometric astigmatism (0.75D to 2.5D) and to theoretically compare the outcomes with predicted refra...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1638418
更新日期:2019-12-01 00:00:00
abstract::Steroids are widely used in the prevention of corneal neovascularization in a wide range of natural and experimental situations. However, no information is available on their effect on the growth of the individual limbal blood vascular cells or of lymphatic cells involved in corneal neovascularization. In addition, tr...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689508999908
更新日期:1995-01-01 00:00:00
abstract::Inoculation of herpes simplex virus Type 1 into the anterior chamber of BALB/c mice induces a characteristic ocular infection involving primarily the anterior segment of virus-injected eyes and the retina of contralateral uninjected eyes. In the BALB/c strain, which is susceptible to herpetic retinitis, anti-HSV delay...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688808995741
更新日期:1988-02-01 00:00:00
abstract::The basement membrane of the crystalline lens of the diabetic rat was found to have a similar elasticity modulus at high stress to that of normal membrane. However, at low stress and extension Young's modulus of elasticity was 0.36 (Mean) +/- 0.15 (SD) X 10(6) Nm-2 and about 30 per cent lower than that of normal membr...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688108998358
更新日期:1981-01-01 00:00:00
abstract::Purpose: To provide a normative data set of swept-source optical coherence tomography angiography (SS-OCTA) peripapillary vessel density (VD) measurements and assess correlations with age, gender, disc area and axial length (AL). Material and Methods: This was an observational cross-sectional study conducted on 346 ri...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1744164
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:Unoprostone isopropyl is an ocular hypotensive that was originally produced as a prostaglandin F2alpha analogue and is eventually recognized as a synthetic docosanoid. The compound is recently suggested to have potent neuroprotective ability in the retina. The purpose of this study is to test whether and how th...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680490889465
更新日期:2004-12-01 00:00:00
abstract::From knowledge of the optical parameters of experimental animal eyes and radiometric parameters of the light source, it is possible to provide accurate retinal irradiances (dose rates). Examples are given for the rat, cat, monkey and other animals of interest. Fluorescent lamps and incandescent lamp radiances are prov...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688408997199
更新日期:1984-01-01 00:00:00
abstract::This study asks whether retinal adhesiveness is affected by cytochalasin D, a drug that is known to alter the apical morphology of the retinal pigment epithelium (RPE). Cytochalasin D was injected intravitreally in Dutch rabbits and retinal adhesiveness measured 0.5 to 72 h later by two methods: in vitro peeling of th...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689508995817
更新日期:1995-12-01 00:00:00
abstract::Recently, all the structural features of non-proliferative diabetic retinopathy have been demonstrated in mice fed 30% galactose for 21-26 months. To determine whether changes in retinal matrix protein mRNA levels occur early in the course of murine diabetes we used a competitive RT-PCR method to quantitate retinal mR...
journal_title:Current eye research
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
abstract:PURPOSE:Pigmentation of the iris is caused by varying amounts of melanin pigment granula in a constant number of melanocytes in the superficial stroma. Melanin has been shown to act as antioxidant. We have now investigated lipid peroxidation in dependence on stromal pigmentation in isolated porcine irises. METHODS:The...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.22.3.229.5511
更新日期:2001-03-01 00:00:00
abstract::Importance: To analyze the characteristics and risk factors for pupillary capture (PC) of the intraocular lens (IOL) in congenital ectopia lentis (CEL) patients.Methods: Data of CEL patients who underwent lens extraction and intraocular implantation from 2013 to 2016 at Zhongshan Ophthalmic Center in China were collec...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1668418
更新日期:2020-04-01 00:00:00
abstract:PURPOSE:To investigate the morphological or functional differences of retina in amblyopia. MATERIALS AND METHODS:Forty-one patients with unilateral strabismic, anisometropic or combined amblyopia were included in the study. A control group was composed of 16 normal children. All participants were tested with optical c...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2013.779721
更新日期:2013-07-01 00:00:00