Hydrogen peroxide localization in ocular tissue: an electron microscopic cytochemical study.

abstract：PURPOSE:To investigate the multifocal electroretinogram (mfERG) and subjective function in early age-related maculopathy (ARM). METHODS:Seventeen subjects with early ARM with visual acuity (VA) of 6/12 or better and 20 age-matched control subjects were examined. We assessed mfERGs, high and low contrast distance VA, n...

journal_title：Current eye research

authors： Feigl B,Brown B,Lovie-Kitchin J,Swann P

更新日期：2004-10-01 00:00:00

abstract：AIM:To compare patient satisfaction and experience after external dacryocystorhinostomy (EX-DCR) versus transcanalicular DCR (TC-DCR) with a diode laser and to evaluate the change in quality of life following simultaneous bilateral DCR. METHODS:Prospective evaluation of 38 eyes of 19 patients with bilateral nasolacrim...

journal_title：Current eye research

authors： Yeniad B,Uludag G,Kozer-Bilgin L

更新日期：2012-04-01 00:00:00

abstract：PURPOSE:Frequent steroid drops represent a challenge in patient compliance. This study evaluated the safety and efficacy of 5 minute topical dexamethasone sodium phosphate-Visulex (DSP-Visulex) treatment regimen (two applications on the first week then weekly after) compared to daily prednisolone acetate 1% (PA) for no...

journal_title：Current eye research

authors： Papangkorn K,Truett KR,Vitale AT,Jhaveri C,Scales DK,Foster CS,Montieth A,Higuchi JW,Brar B,Higuchi WI

更新日期：2019-02-01 00:00:00

abstract：:We assessed the role of platelet-activating factor (PAF) in corneal allograft rejection and evaluated the effects of a PAF antagonist on corneal inflammation, cellular infiltration, vascularization, and edema. Rabbits with vascularized corneas served as recipients of allogeneic cornea grafts. Rabbits with normal corne...

journal_title：Current eye research

authors： Cohen RA,Gebhardt BM,Bazan NG

更新日期：1994-02-01 00:00:00

abstract：PURPOSE:To assess the effect of aging on optical quality in a normal population. METHODS:We prospectively examined 100 normal eyes of 100 healthy volunteers (50 men, 50 women; ages, 20-69 years; mean age ± standard deviation, 44.6 ± 15.5 years). We quantitatively assessed the values of MTF cutoff frequency, Strehl rat...

journal_title：Current eye research

authors： Kamiya K,Umeda K,Kobashi H,Shimizu K,Kawamorita T,Uozato H

更新日期：2012-10-01 00:00:00

abstract：:Lipid synthesis was investigated in bovine lens in organ culture for 9 hours using 14C acetate as a precursor. The greatest incorporation occurred in phospholipid fraction with phosphatidyl choline being the major phospholipid labeled. Considerable activity was incorporated in the free fatty acid fraction, cholesterol...

journal_title：Current eye research

authors： Albers-Jackson B,Nga Do A

更新日期：1987-09-01 00:00:00

abstract：:Na/K ATPase activity has been determined in normal and cataractous human lenses using labeled ATP as a substrate. The enzyme is distributed throughout the lens with approximately 1/3 of the total activity in the capsule-epithelium and 1/2 of the activity in the cortex. Furthermore, the activity of Na/K ATPase decrease...

journal_title：Current eye research

authors： Kobatashi S,Roy D,Spector A

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:The purpose of the current study is to assess changes in the expression of Acid-Sensing Ion Channel (ASIC)1a and ASIC2 in retinal ganglion cells (RGCs) after retinal ischemia and reperfusion (I/R) injury and to test if inhibition of ASIC1a provides RGC neuroprotection. METHODS:Transient ischemia was induced in...

journal_title：Current eye research

authors： Dibas A,Millar C,Al-Farra A,Yorio T

更新日期：2018-07-01 00:00:00

abstract：PURPOSE:This study sought to evaluate the efficacy of bevacizumab (Avastin), an anti-VEGF agent, in the reduction of corneal neovascularization in a rodent model, and compare between the effect of intraocular and subconjunctival injection. METHODS:Corneal neovascularization was induced by application of a mixture of 7...

journal_title：Current eye research

authors： Avisar I,Weinberger D,Kremer I

更新日期：2010-02-01 00:00:00

abstract：:Four groups of BALB/c mice were treated locally with different concentrations (0.1-1.0%) of retinoic acid (Etretinate) ointment for a period of one to four weeks. A fifth group was treated with the ointment base only. Ia-positive dendritic cells were identified by an indirect immunofluorescence technique which was con...

journal_title：Current eye research

authors： Kremer I,Gabai U,Arbizo M,Arbizo V,Laibson PR

更新日期：1995-03-01 00:00:00

abstract：:Human endothelial morphologic changes were quantitated by specular microscopy and computer-assisted morphometry to establish normal baselines of various morphologic parameters. Cellular polymegethism and cellular pleomorphism increases with age, and normal baseline parameters are detailed. Furthermore, no significant ...

journal_title：Current eye research

authors： Yee RW,Matsuda M,Schultz RO,Edelhauser HF

更新日期：1985-06-01 00:00:00

abstract：PURPOSE:The purposes of this study were to investigate the effects of topically administrated Tacrolimus and Octreotide on modulation of postoperative scarring in experimental glaucoma filtration surgery and to compare the antifibrotic properties of these agents with mitomycin-C (MMC). MATERIAL AND METHODS:A total of ...

journal_title：Current eye research

authors： Arslan S,Aydemir O,Güler M,Dağlı AF

更新日期：2012-03-01 00:00:00

abstract：:Purpose: To evaluate the effect of isolated oblique muscle weakening on horizontal deviation in patients with A- and V-pattern exotropia.Methods: The medical records of patients who underwent bilateral oblique muscle weakening for A- and V-pattern exotropia associated oblique muscle overaction between 2011 and 2018 we...

journal_title：Current eye research

authors： Wang X,Zhang W,Liu L

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:Pseudoexfoliation (PXF) is a microfibrillopathy involving disordered elastogenesis. Abnormal extracellular matrix (ECM) production underlies the pathophysiology of PXF. The enzyme Lysyl oxidase (LOX) and its isoforms are known to cross-link the elastin and collagen. Though the etiopathogensis of PXF is not well...

journal_title：Current eye research

authors： Gayathri R,Coral K,Sharmila F,Sripriya S,Sripriya K,Manish P,Shantha B,Ronnie G,Vijaya L,Narayanasamy A

更新日期：2016-10-01 00:00:00

abstract：:The effect of cyclosporine (CsA) treatment in both primary and secondary Chlamydia trachomatis ocular infection in cynomolgus monkeys was studied. Following primary infection, CsA-treated animals developed severe clinical symptoms which persisted for up to 12 weeks compared to control animals which developed less seve...

journal_title：Current eye research

authors： Young E,Schachter J,Prendergast RA,Taylor HR

更新日期：1987-05-01 00:00:00

abstract：PURPOSE:To evaluate the feasibility of retinal vein bypass surgery for induced branch retinal-vein occlusion (BRVO) in the living porcine eye. METHODS:Fifteen minipigs were used in the study. Seven days before vascular surgery, hyaluronidase and plasmin were intravitreally injected for induction of posterior vitreous ...

journal_title：Current eye research

authors： Shen LJ,Chen YQ,Cheng D,Zhang C,Jiang L,Hong M,Kang QY

更新日期：2016-01-01 00:00:00

abstract：:To investigate the role of lymphocytes in the pathogenesis of uveitis, we analyzed the expression of memory markers, CD29 and CD45RO antigens, and apoptosis-related Fas antigen on T lymphocytes in the aqueous humor (AH) and peripheral blood (PB) from patients with uveitis. Using three-color flow cytometry, we assessed...

journal_title：Current eye research

authors： Ohta K,Norose K,Wang XC,Ito S,Yano A,Segawa K

更新日期：1996-03-01 00:00:00

abstract：PURPOSE:To investigate the antiproliferative effects of the subconjunctival injection of human RAD50 (hRAD50) on fibroblasts after glaucoma filtering surgery. METHODS:After glaucoma filtering surgery in normal rabbit eye, the subconjunctival injection of hRAD50 was performed. Morphologic changes in the subconjunctival...

journal_title：Current eye research

authors： Yoon KC,Yang KJ,Seo JS,Lee SE,Heo T,Chun BJ,Jung S,Kim KK,Ahn KY

更新日期：2004-03-01 00:00:00

abstract：:Components of the Renin Angiotensin System (RAS) have been detected in ocular tissues and fluids. The source of the ocular RAS proteins is unknown but possibilities include diffusion or leakage from the systemic circulation, specific uptake from the blood, or local synthesis. We have used RT-PCR and in situ hybridizat...

journal_title：Current eye research

authors： Brandt CR,Pumfery AM,Micales B,Bindley CD,Lyons GE,Sramek SJ,Wallow IH

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Diabetes has been associated with decline in accommodative function in some ethnic groups. This outcome, however, could differ since ethnic variations in accommodation have been noted. This study investigated the relationship between plasma sugar level on subjective accommodative amplitude and accommodative ...

journal_title：Current eye research

authors： Abokyi S,Ilechie A,Asaam KA,Ntodie M

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:Histidine is an indispensable amino acid with an imidazole ring and it is a precursor of histamine, carnosine, and anserine. Histidine has been proposed to act as a neurotransmitter or neuromodulator in mammalian central nervous system (CNS), including retina. In this study, we report histidine-like immunoreact...

journal_title：Current eye research

authors： Kusakari Y,Nishikawa S,Ishiguro S,Tamai M

更新日期：1997-06-01 00:00:00

abstract：PURPOSE/AIM:To quantitatively analyse the evolution of TUNEL-labeling, after in vivo exposure to UVB. METHODS:Altogether, 16 Sprague Dawley rats were unilaterally exposed in vivo for 15 min to close to threshold dose, 5 kJ/m(2), of ultraviolet radiation in the 300 nm wavelength region. Animals were sacrificed in group...

journal_title：Current eye research

authors： Kronschläger M,Yu Z,Talebizadeh N,Meyer LM,Hallböök F,Söderberg PG

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:We report on the use of subconjunctival bevacizumab on corneal vessel density in recurrent pterygia. METHODS:The charts of 5 patients with recurrent pterygium, who received subconjunctival injections of bevacizumab (2.5 mg/0.1 ml) were retrospectively reviewed. Ophthalmic evaluation included Snellen visual acu...

journal_title：Current eye research

authors： Bahar I,Kaiserman I,McAllum P,Rootman D,Slomovic A

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:We identified a novel mutation in Paired Box gene 6 (PAX6) and characterized its associated clinical features of severe ocular malformation in a Chinese family with congenital aniridia. METHODS:We studied two patients with aniridia from a Chinese family. All patients and noncarriers in this family underwent fu...

journal_title：Current eye research

authors： He Y,Pan Z,Luo F

更新日期：2012-10-01 00:00:00

abstract：:The present study examined the anti-herpetic effect of the glycoprotein inhibitors, hydroxynorvaline and 2-deoxyglucose, alone and in combination with trifluridine on murine ocular herpes. Following ocular inoculation with a large dose of HSV-1 RE strain (10(6) pfu), ICR mice were treated during the acute infection wi...

journal_title：Current eye research

authors： Gordon YJ,Cheng KP,Araullo-Cruz T,Romanowski E,Johnson BJ,Blough HA

更新日期：1986-02-01 00:00:00

abstract：:The administration of 0.1-0.5% of ethanol produces a slow increase in the transepithelial potential (TEP) of about 2 mV in the bovine pigment epithelium (RPE) under ordinary room lighting. However, virtually no response could be observed when ethanol was administered in the dark. Because of this apparent light sensiti...

journal_title：Current eye research

authors： Pautler EL

更新日期：1994-09-01 00:00:00

abstract：AIM OF THE STUDY:The similarity of many benign intrabulbar lesions to a malignant tumor requires detailed differential diagnostics. However, none of the known methods can be used as the only one to determine the type of lesions. The aim of this study was to determine color Doppler imaging (CDI) markers characteristic o...

journal_title：Current eye research

authors： Modrzejewska M,Wiącek MP

更新日期：2017-11-01 00:00:00

abstract：:Previous studies have reported the expression of acidic fibroblast growth factor (aFGF) by rat, bovine, and human retinal pigment epithelium (RPE) in vivo. To critically examine the expression of aFGF by RPE cells, we studied the density dependence of steady-state levels of mRNA and protein expression in vitro. Northe...

journal_title：Current eye research

authors： Kitaoka T,Bost LM,Ishigooka H,Aotaki-Keen AE,Hjelmeland LM

更新日期：1993-11-01 00:00:00

abstract：PURPOSE:The expression of human leukocyte antigen (HLA) class II molecules on the cell surface is necessary for the presentation of peptide antigens to helper CD4 T lymphocytes of the immune system. We studied the immunoexpression of HLA class II antigen in conjunctival precursor lesions and conjunctival squamous cell ...

journal_title：Current eye research

authors： Abhyankar D,Lakshmi SA,Pushparaj V,Biswas J,Krishnakumar S

更新日期：2003-09-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine the retinal expression of angiogenic chemokines/cytokines in a mouse model of oxygen-induced retinopathy. METHODS:C57BL/6 (B6) mice were exposed to 75% oxygen from postnatal day 7 (P7) to P12 and then recovered in room air. Reverse transcription-polymerase chain react...

journal_title：Current eye research

authors： Powers MR,Davies MH,Eubanks JP

更新日期：2005-04-01 00:00:00