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Voxel-based morphometry of the visual-related cortex in primary open angle glaucoma.

Abstract：

PURPOSE:To study changes in the morphometric characteristics of the whole brain visual-related cortex in various stages of primary open angle glaucoma (POAG) in vivo. MATERIALS AND METHODS:Thirty POAG patients (nine early stage cases and 21 advanced-late stage cases) and 30 gender-, education-, and age-matched healthy controls were enrolled in the study. Image data were obtained with a T1 weighted three-dimensional magnetization prepared rapid acquisition gradient echo sequence (T1WI 3D MP RAGE). Voxel-based morphometry (VBM) analysis was used to assess regional differences in gray matter (GM) densities on T1WI 3D MP RAGE scans of patients versus controls. RESULTS:Compared with controls, brain regions with GM density changes were not found in the early stage of POAG patients but were found in the advanced-late stage of POAG patients. These changes with GM density reduction were mainly located in the bilateral primary visual cortex (BA17 and BA18), bilateral paracentral lobule (BA5), right precentral gyrus (BA6), right middle frontal gyrus (BA9), right inferior temporal gyrus (BA20), right angular gyrus (BA39), left praecuneus (BA7), left middle temporal gyrus (BA21), and superior temporal gyrus (BA22). Conversely, patients showed increased GM density in BA39 near the most damaged regions. In addition, in the advanced-late stage of POAG, some reduced GM density areas were related to binocular mean defect (MD) and disease duration (ranging from r = -0.761 to r = -0.458). CONCLUSIONS:Our results suggest that there are different types of pathogenesis at different stages of POAG. Atrophy and degeneration of the visual-related cortex existed in the dorsal and ventral visual pathways in the advanced-late stage of POAG but were not found in the early stage of POAG using VBM. Such GM density changes are likely associated with the pathogenesis of POAG.

journal_name

Curr Eye Res

journal_title

Current eye research

authors

Li C,Cai P,Shi L,Lin Y,Zhang J,Liu S,Xie B,Shi Y,Yang H,Li S,Du H,Wang J

doi

10.3109/02713683.2012.683506

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

794-802

issue

eissn

0271-3683

issn

1460-2202

journal_volume

pub_type

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Voxel-based morphometry of the visual-related cortex in primary open angle glaucoma.