Detection of locally produced antibodies to herpes viruses in the aqueous of patients with acquired immune deficiency syndrome (AIDS) or acute retinal necrosis syndrome (ARN).

Abstract:

:Intraocular synthesis of IgG antibodies against HSV (herpes simplex virus), CMV (cytomegalovirus) and VZV (varicella zoster virus) is considered as an indirect proof of uveoretinal infection. Paired serum and aqueous samples obtained from 16 patients with retinitis associated with AIDS, 3 patients with ARN, 8 patients with posterior uveitis not related to AIDS or ARN and 5 patients with senile cataract were tested for total immunoglobulin G levels and antibodies to HSV, CMV and VZV by the fixed cell immunofluorescence technique. Since therapy must often be started before results of cultures are available, rapid detection of locally produced anti-Herpes Virus antibodies can be a precious tool in the diagnosis of ocular viral infection. Using this technique we were able to confirm the clinically suspected diagnosis in more than 50% of AIDS patients with retinitis and in two out of three patients with ARN.

journal_name

Curr Eye Res

journal_title

Current eye research

authors

Luyendijk L,vd Horn GJ,Visser OH,Suttorp-Schulten MS,vd Biesen PR,Rothova A,Kijlstra A

doi

10.3109/02713689008999412

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

7-11

eissn

0271-3683

issn

1460-2202

journal_volume

9 Suppl

pub_type

杂志文章
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  • Zinc causes an apparent increase in rhodopsin phosphorylation.

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  • Ontogeny of the 35K epsilon crystallin during Rana temporaria lens development.

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    doi:10.3109/02713688109019974

    authors: Kopp SJ,Greiner JV,Glonek T

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  • Effect of ZnCl2 and chelation of zinc ions by N,N-diethyldithiocarbamate (DEDTC) on the ERG b-wave amplitude from the isolated superfused vertebrate retina.

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    更新日期:1998-02-01 00:00:00

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    更新日期:1989-02-01 00:00:00

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    更新日期:2020-03-01 00:00:00

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    authors: Fujita H,Morita I,Takase H,Ohno-Matsui K,Mochizuki M

    更新日期:2003-10-01 00:00:00

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    doi:10.3109/02713689508998401

    authors: Sawada K,Agata J,Eguchi G,Quinlan R,Maisel H

    更新日期:1995-07-01 00:00:00

  • Comparison of Short-Term Choroidal Thickness and Retinal Morphological Changes after Intravitreal Anti-VEGF Therapy with Ranibizumab or Aflibercept in Treatment-Naive Eyes.

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    journal_title:Current eye research

    pub_type: 杂志文章

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    authors: Geroski DH,Hadley A

    更新日期:1992-01-01 00:00:00

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  • A Novel Approach to the Differentiation of Intrabulbar Tumors in Color Doppler Imaging.

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  • Association of Tear Film Stability and Corneal Surface Temperature in Pudong Patients.

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    doi:

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