Abstract:
PURPOSE:This study aims to evaluate and correlate the levels of interleukin-6 (IL-6) and thrombin-antithrombin III complex (TAT) in the vitreous of patients with different vitreoretinal pathologies. METHODS:Vitreous samples were collected from 78 patients scheduled for pars plana vitrectomy at a tertiary medical center. Patients were divided by the underlying vitreoretinal pathophysiology, as follows: macular hole (MH)/epiretinal membrane (ERM) (n = 26); rhegmatogenous retinal detachment (RRD) (n = 32); and proliferative diabetic retinopathy (PDR) (n = 20). Levels of IL-6 and TAT were measured by enzyme-linked immunosorbent assay and compared among the groups. RESULTS:A significant difference was found in the vitreal IL-6 and TAT levels between the MH/ERM group and both the PDR and RRD groups (P < 0.001 for all). Diabetes was associated with higher IL-6 levels in the RRD group. Different relationships between the IL-6 and TAT levels were revealed in patients with different ocular pathologies. CONCLUSION:Our results imply that variations in vitreal TAT level may be attributable not only to an inflammatory reaction or blood-retinal barrier breakdown, but also to intraocular tissue-dependent regulation of thrombin.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Ehrlich R,Zahavi A,Axer-Siegel R,Budnik I,Dreznik A,Dahbash M,Nisgav Y,Megiddo E,Kenet G,Weinberger D,Livnat Tdoi
10.1080/02713683.2017.1313432subject
Has Abstractpub_date
2017-09-01 00:00:00pages
1269-1272issue
9eissn
0271-3683issn
1460-2202journal_volume
42pub_type
杂志文章abstract:PURPOSE:Several previous studies have shown that glycoconjugates of extracellular matrix, cell membrane and nucleus play an important role in the mediation of cell proliferation, migration and differentiation. Lens epithelial cells and lens fiber cells show regional differences with regard to these parameters. If glyco...
journal_title:Current eye research
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doi:10.1076/ceyr.16.6.527.5083
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journal_title:Current eye research
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journal_title:Current eye research
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journal_title:Current eye research
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journal_title:Current eye research
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journal_title:Current eye research
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journal_title:Current eye research
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journal_title:Current eye research
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doi:10.3109/02713689508995817
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journal_title:Current eye research
pub_type: 杂志文章,meta分析,评审
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更新日期:2005-07-01 00:00:00
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更新日期:2014-12-01 00:00:00
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journal_title:Current eye research
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journal_title:Current eye research
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更新日期:2008-03-01 00:00:00
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journal_title:Current eye research
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journal_title:Current eye research
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doi:10.3109/02713689409047005
更新日期:1994-10-01 00:00:00
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journal_title:Current eye research
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更新日期:2016-01-01 00:00:00
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journal_title:Current eye research
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更新日期:2016-01-01 00:00:00
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journal_title:Current eye research
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更新日期:2018-02-01 00:00:00
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journal_title:Current eye research
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更新日期:2021-01-11 00:00:00
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