Correlation between Interleukin-6 and Thrombin-Antithrombin III Complex Levels in Retinal Diseases.

Abstract:

PURPOSE:This study aims to evaluate and correlate the levels of interleukin-6 (IL-6) and thrombin-antithrombin III complex (TAT) in the vitreous of patients with different vitreoretinal pathologies. METHODS:Vitreous samples were collected from 78 patients scheduled for pars plana vitrectomy at a tertiary medical center. Patients were divided by the underlying vitreoretinal pathophysiology, as follows: macular hole (MH)/epiretinal membrane (ERM) (n = 26); rhegmatogenous retinal detachment (RRD) (n = 32); and proliferative diabetic retinopathy (PDR) (n = 20). Levels of IL-6 and TAT were measured by enzyme-linked immunosorbent assay and compared among the groups. RESULTS:A significant difference was found in the vitreal IL-6 and TAT levels between the MH/ERM group and both the PDR and RRD groups (P < 0.001 for all). Diabetes was associated with higher IL-6 levels in the RRD group. Different relationships between the IL-6 and TAT levels were revealed in patients with different ocular pathologies. CONCLUSION:Our results imply that variations in vitreal TAT level may be attributable not only to an inflammatory reaction or blood-retinal barrier breakdown, but also to intraocular tissue-dependent regulation of thrombin.

journal_name

Curr Eye Res

journal_title

Current eye research

authors

Ehrlich R,Zahavi A,Axer-Siegel R,Budnik I,Dreznik A,Dahbash M,Nisgav Y,Megiddo E,Kenet G,Weinberger D,Livnat T

doi

10.1080/02713683.2017.1313432

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

1269-1272

issue

9

eissn

0271-3683

issn

1460-2202

journal_volume

42

pub_type

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