Nephropathic cystinosis: immunohistochemical and histopathologic studies of cornea, conjunctiva and iris.

Abstract:

:Specimens of a cornea, conjunctiva and iris were removed at the time of penetrating keratoplasty in a case of nephropathic cystinosis. Immunohistochemical studies revealed the presence of class II antigens on the stromal keratocytes of the cornea and the vascular endothelial cells, pericytes and fibroblasts of the conjunctiva. In addition, there were thinning and focal breaks in Bowman's membrane. Both of these findings may have contributed to the severe photophobia and blepharospasm seen in patients with longstanding cystinosis.

journal_name

Curr Eye Res

journal_title

Current eye research

authors

Kaiser-Kupfer MI,Chan CC,Rodrigues M,Datiles MB,Gahl WA

doi

10.3109/02713688709025222

subject

Has Abstract

pub_date

1987-04-01 00:00:00

pages

617-22

issue

4

eissn

0271-3683

issn

1460-2202

journal_volume

6

pub_type

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