Localization of vasoactive intestinal polypeptide and neurotensin immunoreactivities in the avian retina.

abstract：AIM:To test the feasibility of implanting human anterior lens capsules (HALCs) with porcine corneal endothelial cells (pCEC) in vivo in Göttingen minipigs and at the same time test the suitability of Göttingen minipig as model for endothelial keratoplasty. MATERIALS AND METHODS:Cell-carrier constructs of decellularize...

journal_title：Current eye research

authors： Telinius N,Spinozzi D,Rasic D,Dapena I,Baandrup U,Miron A,Oellerich S,Hjortdal J

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:To determine, by a plaque reduction assay, the in vitro efficacy of novel antiviral agents in the treatment of feline herpes virus 1 (FHV-1) keratitis in the domestic cat (Felis felis). MATERIALS AND METHODS:A standard plaque reduction assay was performed using a laboratory strain of FHV-1 and embryo-derived f...

journal_title：Current eye research

authors： Williams DL,Fitzmaurice T,Lay L,Forster K,Hefford J,Budge C,Blackmore K,Robinson JC,Field HF

更新日期：2004-08-01 00:00:00

abstract：:Processing of visual information within the retina depends in large measure upon a complement of chemical neurotransmitters which are released at synaptic contacts between individual neurons. Numerous investigators have participated in the identification of many of these transmitters and their assignment to specific n...

journal_title：Current eye research

authors： Pourcho RG

更新日期：1996-07-01 00:00:00

abstract：PURPOSE:Oxidative stress is considered a major factor in the deterioration of retinal pigment epithelium (RPE) cells in dry age-related macular degeneration (AMD). The MAPK ERK1/2 can be activated by oxidative stress, may exert both pro- and anti-apoptotic functions, and has recently been proposed as a major factor in ...

journal_title：Current eye research

authors： Koinzer S,Reinecke K,Herdegen T,Roider J,Klettner A

更新日期：2015-01-01 00:00:00

abstract：:With Golgi impregnation, a simple amacrine cell type is described in the chick retina. The most relevant morphological feature of these retinal neurons is a single straight, radial trunk which dichotomizes tangentially in a rectilinear expansion in the 5th stratum of the inner plexiform layer (IPL). ...

journal_title：Current eye research

authors： Genis-Galvez JM,Chmielewski CE,Prada FA

更新日期：1989-02-01 00:00:00

abstract：PURPOSE:Increases in matrix proteins, such as type I collagen and fibronectin, are observed with aging in the retinal pigment epithelium (RPE) basement membrane. However, little is known about altered gene expression profiles of RPE associated with increases in matrix proteins. We investigated changes in gene expressio...

journal_title：Current eye research

authors： Imai H,Honda S,Kondo N,Ishibashi K,Tsukahara Y,Negi A

更新日期：2007-10-01 00:00:00

abstract：:The effects of light damage were studied in four inbred strains of albino rats, Fischer (F344), Lewis (L), Wistar (W), and Buffalo (BUF). Thirty-five-day-old rats (3 from each strain) were kept in cyclic light for two weeks, after which they were exposed to constant fluorescent light (180-190 foot-candles, 490-580 nm)...

journal_title：Current eye research

authors： Borges JM,Edward DP,Tso MO

更新日期：1990-08-01 00:00:00

abstract：PURPOSE:To determine if the Schirmer I test (without anesthesia) cut-off value is a predictor of dry eye severity in a large Norwegian cohort of dry eye disease (DED) patients, which are grouped into six levels of tear production. METHODS:Patients (n = 1090) with DED of different etiologies received an extensive dry e...

journal_title：Current eye research

authors： Yazdani M,Chen X,Tashbayev B,Utheim ØA,Ræder S,Lagali N,Stojanovic A,Dartt DA,Utheim TP

更新日期：2018-12-01 00:00:00

abstract：:Calpains are calcium-activated proteinases which have been implicated in tissue differentiation and degeneration. The aims of the present study were: (1) to determine the relationship between postnatal age and calpain activity in the rat retina; (2) to test if calpain activity was aberrant in the RCS retina at differe...

journal_title：Current eye research

authors： Azarian SM,Williams DS

更新日期：1995-08-01 00:00:00

abstract：PURPOSE/AIM:We aimed to characterize the connective tissue microanatomy, elastin abundance, and fiber orientation in the human optic nerve sheath, also known as the optic nerve dura mater, for correlation with its biomechanical properties. MATERIALS AND METHODS:Seven whole human orbits aged 4-93 years, and five isolat...

journal_title：Current eye research

authors： Le A,Shin A,Park J,Poukens V,Demer JL

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:To develop an improved diagnostic test for rod-cone dysplasia type 1 (rcd1). The rcd1 phenotype is an early onset, autosomal recessive disease caused by a mutation in the canine rod cyclic GMP phosphodiesterase beta-subunit (PDE6B) gene. A G to A transition in codon 807 at nucleotide position 2420 results in a ...

journal_title：Current eye research

authors： Ray K,Tejero MD,Baldwin VJ,Aguirre GD

更新日期：1996-05-01 00:00:00

abstract：PURPOSE:We wished to establish which matrix metalloproteinases (MMPs) and metalloproteinase inhibitors (TIMPs) were present in human interphotoreceptor matrix (IPM) and vitreous. METHODS:IPM and vitreous were obtained from postmortem human eyebank eyes. Western immunoblots were probed with antibodies against human MMP...

journal_title：Current eye research

authors： Plantner JJ,Smine A,Quinn TA

更新日期：1998-02-01 00:00:00

abstract：:The corneal endothelium is known to contain gap junctions on its lateral borders. Here we show that the endothelial cells of the rabbit cornea are highly dye coupled. Lucifer Yellow CH introduced into a single cell through either an intracellular glass microelectrode or a patch electrode rapidly spreads into its neigh...

journal_title：Current eye research

authors： Rae JL,Lewno AW,Cooper K,Gates P

更新日期：1989-08-01 00:00:00

abstract：PURPOSE:To examine the morphological changes in the meibomian glands of eyes of patients with dry eye disease using the non-contact infrared meibography system and to assess their relationship with meibomian dropout, signs, and tear-film function. METHODS:Subjects included 264 randomly selected patients (528 eyes) suf...

journal_title：Current eye research

authors： Feng Y,Gao Z,Feng K,Qu H,Hong J

更新日期：2014-10-01 00:00:00

abstract：:Glaucoma is increasingly recognized as a neurodegenerative disorder, characterized by the accelerated loss of retinal ganglion cells (RGCs) and their axons. Impaired axonal transport has been implicated as a pathogenic mechanism in a number of neurodegenerative diseases, including glaucoma. The long RGC axon, with its...

journal_title：Current eye research

authors： Fahy ET,Chrysostomou V,Crowston JG

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:To compare serum levels of chemerin in type 2 diabetes mellitus (T2DM) with or without retinopathy, and to investigate the relationship between serum chemerin levels and diabetes retinopathy. MATERIALS AND METHODS:A total of 60 T2DM patients and 20 healthy subjects (control group) were enrolled in this study. ...

journal_title：Current eye research

authors： Du J,Li R,Xu L,Ma R,Liu J,Cheng J,Zhang Z,Sun H

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:To compare the antiviral effect of a peptide derived from human apolipoprotein E (1% apoEdp) with 1% trifluorothymidine against HSV-1 thymidine kinase (TK)-positive (HSV-1 McKrae) and with 3% foscarnet against HSV-1 TK-negative (KOS background) in the rabbit eye model of acute HSV-1 epithelial keratitis. MATER...

journal_title：Current eye research

authors： Bhattacharjee PS,Neumann DM,Hill JM

更新日期：2009-02-01 00:00:00

abstract：PURPOSE:Acyclovir has been shown to be effective in preventing recurrent herpes simplex virus lesions of the genitalia and oral labia. The purpose of the current study was to determine the effect of acyclovir on the appearance of infectious virus in the peripheral nervous system and in an end organ, the eye. MATERIALS...

journal_title：Current eye research

authors： Gebhardt BM,Kaufman HE,Hill JM

更新日期：2004-08-01 00:00:00

abstract：:The effect of electrical stimulation of the sympathetic nerves on the blood-aqueous barrier was investigated in rabbits. The permeability of the barrier was assessed during either acute, chronic or following chronic nerve stimulation. During acute and chronic stimulation of the sympathetic nerves, fluorescein entered ...

journal_title：Current eye research

authors： Bartels SP,Pawlowski AM

更新日期：1990-10-01 00:00:00

abstract：PURPOSE:To validate the more easily applicable "flush" tear collection technique as a viable alternative to basal and reflex tear collection. MATERIALS AND METHODS:Total protein content (TPC) and immunoglobulin A (IgA) concentrations were determined in the basal, reflex, and flush tears of 16 healthy non-contact lens ...

journal_title：Current eye research

authors： Markoulli M,Papas E,Petznick A,Holden B

更新日期：2011-03-01 00:00:00

abstract：PURPOSE:NiCl(2) (15 microM) enhances the ERG b-wave amplitude of vertebrate retina, up to 1.5-fold by blocking E/R-type voltage-gated Ca(2+) channels, which is mediated by blocking the release of GABA onto ionotropic GABA-A and GABA-C receptors. In vivo, it is likely that zinc, rather than nickel ions, may be involved ...

journal_title：Current eye research

authors： Siapich SA,Wrubel H,Albanna W,Alnawaiseh M,Hescheler J,Weiergräber M,Lüke M,Schneider T

更新日期：2010-04-01 00:00:00

abstract：:The efficiency of protein immobilization to provide a hydrogel surface with a high affinity for corneal epithelial cells was investigated. The cell adhesive proteins collagen and fibronectin, and the cell adhesive oligopeptide RGDS (arginine-glycine-aspartic acid-serine) were successfully covalently immobilized on pol...

journal_title：Current eye research

authors： Kobayashi H,Ikada Y

更新日期：1991-10-01 00:00:00

abstract：PURPOSE:Robo1, a member of the roundabout (Robo) family, serves as neuronal guidance receptors and has been reported to mediate tumor angiogenesis. In this study, we investigated the function of Robo1 and its possible role in retinal angiogenesis in vitro and in vivo. METHODS:Expression of Robo1 in relation to retinal...

journal_title：Current eye research

authors： Huang L,Xu Y,Yu W,Li X,Liqun C,He X,Peiying H

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:Proliferative vitreoretinopathy is a serious complication of retinal detachment surgery in which retinal pigment epithelial cells abnormally proliferate within the vitreous cavity and under the retinal surface. Octreotide acetate, a somatostatin analog, has been shown to inhibit the cellular proliferation of a ...

journal_title：Current eye research

authors： Luo Q,Peyman GA,Conway MD,Woltering EA

更新日期：1996-09-01 00:00:00

abstract：PURPOSE:To evaluate the point-wise relationships between visual field sensitivity (VFS), as measured by standard automated perimetry (SAP), and macular thickness, as determined by spectral-domain optical coherence tomography (SD-OCT), in patients with glaucoma. MATERIALS AND METHODS:One hundred and six glaucoma subjec...

journal_title：Current eye research

authors： Kim JM,Sung KR,Yoo YC,Kim CY

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:Endothelial cells of different vascular systems may express site-specific adhesion molecules to attract leukocyte subsets. This study describes a method to visualize and compare leukocyte-endothelial interactions in three vascular beds within the same eye in mice. METHODS:Digital in vivo fluorescence microscop...

journal_title：Current eye research

authors： Rosenbaum JT,Brischetto M,Crespo S,Bierwirth M,Oveson K,Planck SR,Becker MD

更新日期：2002-03-01 00:00:00

abstract：PURPOSE:The fibroblast growth factors (FGFs) are a family of 9 heparin binding proteins which have been proposed to play key roles in angiogenesis. Basic FGF (bFGF), acidic FGF (aFGF) and FGF5 have previously been demonstrated to be expressed in the normal retina and RPE. In this study, the expression of FGF5 was explo...

journal_title：Current eye research

authors： Kitaoka T,Morse LS,Schneeberger S,Ishigooka H,Hjelmeland LM

更新日期：1997-04-01 00:00:00

abstract：PURPOSE:To study the effect of cataract surgery with intraocular lens (IOL) on frequency doubling perimetry (FDP). METHODS:Patients aged 40 years or above seen at our outpatient clinic with no ocular pathology except for visually significant cataract and visual acuity 6/24 or better were eligible. They underwent FDP b...

journal_title：Current eye research

authors： Arvind H,George R,Baskaran M,Raju P,Ramesh SV,Paul PG,Vijaya L

更新日期：2005-02-01 00:00:00

abstract：:The content of rhodopsin in the eyes of 15 donors (30 eyes) was determined. Both retinal and pigment epithelial fractions were collected from each globe, extracted using 1% CTAB, and the rhodopsin difference spectrum of each fraction was obtained separately. The total amount of rhodopsin, obtained by summing the amoun...

journal_title：Current eye research

authors： Fulton AB,Dodge J,Schremser JL,Armstrong A,Lanier F,Dawson WW,Williams TP

更新日期：1990-12-01 00:00:00

abstract：PURPOSE:Retinal pigment epithelial (RPE) cell proliferation is an important step in the pathogenesis of ocular diseases such as proliferative retinopathy. Growth factors play a major role in modulating the development and progression of these diseases. The aim of this study was to examine the effects of single growth f...

journal_title：Current eye research

authors： Kaven CW,Spraul CW,Zavazava NK,Lang GK,Lang GE

更新日期：2000-06-01 00:00:00