Chronic electrical stimulation of sympathetic nerves: effects on blood-aqueous barrier.

Abstract:

:The effect of electrical stimulation of the sympathetic nerves on the blood-aqueous barrier was investigated in rabbits. The permeability of the barrier was assessed during either acute, chronic or following chronic nerve stimulation. During acute and chronic stimulation of the sympathetic nerves, fluorescein entered the anterior chamber at a rate significantly slower than in control eyes. After chronic stimulation, both the rate of entry of fluorescein and the aqueous humor protein concentration were much greater than in control eyes indicating breakdown of the blood-aqueous barrier. Treatment with the non-steroidal anti-inflammatory drugs, indomethacin and suprofen, completely blocked the breakdown of the blood-aqueous barrier. These results indicate that sympathetic nerve stimulation can cause the local synthesis of prostaglandins and that these can affect the blood-aqueous barrier.

journal_name

Curr Eye Res

journal_title

Current eye research

authors

Bartels SP,Pawlowski AM

doi

10.3109/02713689009069929

subject

Has Abstract

pub_date

1990-10-01 00:00:00

pages

927-34

issue

10

eissn

0271-3683

issn

1460-2202

journal_volume

9

pub_type

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