Bilaminar Structure of the Human Optic Nerve Sheath.

Abstract:

PURPOSE/AIM:We aimed to characterize the connective tissue microanatomy, elastin abundance, and fiber orientation in the human optic nerve sheath, also known as the optic nerve dura mater, for correlation with its biomechanical properties. MATERIALS AND METHODS:Seven whole human orbits aged 4-93 years, and five isolated human optic nerve sheaths aged 26-75 years were formalin fixed, paraffin embedded, coronally sectioned, stained by Masson trichrome and van Gieson's elastin methods, and analyzed quantitatively for elastin fiber abundance and orientation. Elastin area fraction was defined as area stained for elastin divided by total area. RESULTS:While unilaminar in children, the adult ON sheath exhibited distinct inner and outer layers. Collagen was denser and more compact in the inner layer. Elastin area fraction was significantly greater at 6.0 ± 0.4% (standard error of mean) in the inner than outer layer at 3.6 ± 0.4% (P < 10-5). Elastin fibers had three predominant orientations: longitudinal, diagonal, and circumferential. Of circumferential fibers, 63 ± 4.7% were in the inner and 37 ± 4.7% in the outer layer (P < 10-4). Longitudinal and diagonal fibers were uniformly distributed in both layers. Elastin density and sheath thickness increased significantly with age (P < .01). CONCLUSIONS:The adult human optic nerve sheath is bilaminar, with each layer containing elastin fibers oriented in multiple directions consistent with isotropic properties. Differences in laminar elastin density and orientation may reflect greater tensile loading in the inner than in the outer layer.

journal_name

Curr Eye Res

journal_title

Current eye research

authors

Le A,Shin A,Park J,Poukens V,Demer JL

doi

10.1080/02713683.2020.1739314

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

864-872

issue

7

eissn

0271-3683

issn

1460-2202

journal_volume

45

pub_type

杂志文章
  • Effect of intraocular irrigating solutions on the viability of cultured retinal vascular endothelial cells.

    abstract:PURPOSE:To compare the abilities of balanced salt solution, BSS Plus and Hartmann's lactated Ringer's (HLR) solution to maintain the viability of retinal vascular endothelial cells (RVEC) in vitro. METHODS:Cultured retinal vascular endothelial cells were suspended in each irrigating solution for four hours. Viability ...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.1076/ceyr.16.3.239.15414

    authors: Mourad KM,Edelhauser HF,Capone A Jr,Lynn MJ,Geroski DH

    更新日期:1997-03-01 00:00:00

  • Altered Functional Connectivity of the Primary Visual Cortex in Adult Comitant Strabismus: A Resting-State Functional MRI Study.

    abstract:PURPOSE:The aim of this study was to examine the functional connectivity between the primary visual cortex and other cortical areas during rest in normal subjects and patients with comitant strabismus using functional magnetic resonance imaging (fMRI). METHODS:A prospective, observational study was conducted. Ten pati...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.1080/02713683.2018.1540642

    authors: Yan X,Wang Y,Xu L,Liu Y,Song S,Ding K,Zhou Y,Jiang T,Lin X

    更新日期:2019-03-01 00:00:00

  • Distribution of a steroid antagonist in the eye following topical administration.

    abstract::The distribution of a steroid antagonist, RU486, that is known to reduce rabbit intraocular pressure has been examined in the eye. On an equal tissue weight basis, the corneal epithelium is the site of maximal absorption followed by conjunctival tissues (bulbar and palpebral) and the rest of the cornea. Aqueous humor ...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.3109/02713688609015138

    authors: Cheeks L,Green K

    更新日期:1986-09-01 00:00:00

  • Calcium Dobesilate Prevents Neurodegeneration and Vascular Leakage in Experimental Diabetes.

    abstract:PURPOSE:The mechanisms involved in the reported beneficial effects of Calcium dobesilate monohydrate (CaD) for the treatment of diabetic retinopathy (DR) remain to be elucidated. The main aim of the present study is to examine whether CaD prevents early events in the pathogenesis of DR such as neurodegeneration and vas...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.1080/02713683.2017.1302591

    authors: Solà-Adell C,Bogdanov P,Hernández C,Sampedro J,Valeri M,Garcia-Ramirez M,Pasquali C,Simó R

    更新日期:2017-09-01 00:00:00

  • Corneal epithelial VEGF and cytochrome P450 4B1 expression in a rabbit model of closed eye contact lens wear.

    abstract:PURPOSE:The similar and overlapping activity of VEGF and the potent corneal-derived angiogenic eicosanoid 12(R)-HETrE calls for a study of the temporal relationship in the expression of these two autocoids. Since recent evidence suggests that hypoxia induces the expression of a CYP4B1 mRNA which might be involved in th...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.1076/ceyr.23.1.1.5422

    authors: Mastyugin V,Mosaed S,Bonazzi A,Dunn MW,Schwartzman ML

    更新日期:2001-07-01 00:00:00

  • Retinal Tissue Perfusion in Patients with Multiple Sclerosis.

    abstract::Purpose: The goal of this work was to determine whether the retinal tissue perfusion (RTP) is impaired in patients with multiple sclerosis (MS). Methods: Seventy-four patients [66 relapsing-remitting MS (RRMS) and 8 clinically isolated syndrome (CIS)] and 74 age- and gender-matched healthy controls were recruited. RTP...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.1080/02713683.2019.1612444

    authors: Liu Y,Delgado S,Jiang H,Lin Y,Hernandez J,Deng Y,Gameiro GR,Wang J

    更新日期:2019-10-01 00:00:00

  • Phototoxicity of chlorpromazine on retinal pigment epithelial cells.

    abstract::As it is known that chlorpromazine (CPZ) can bind to melanins as well as cause ocular phototoxicity, we investigated the cytotoxic effects of UV-visible irradiation of melanotic and amelanotic retinal pigment epithelial (RPE) cells in the presence of CPZ. At low concentrations (5 micrograms/ml) of CPZ a photosensitiza...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.3109/02713688809047014

    authors: Persad S,Menon IA,Basu PK,Carre F

    更新日期:1988-01-01 00:00:00

  • Serum zinc levels in retinitis pigmentosa.

    abstract::Serum zinc and copper levels were analyzed in 26 retinitis pigmentosa patients and compared with serum zinc levels of a control group. Serum zinc levels were documented to be decreased with a mean concentration of 0.735 +/- 0.167 micrograms/ml (p less than 0.001). Serum copper levels, on the other hand, were found to ...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.3109/02713688409011750

    authors: Karcioglu ZA,Stout R,Hahn HJ

    更新日期:1984-08-01 00:00:00

  • Modulation of postoperative scarring with tacrolimus and octreotide in experimental glaucoma filtration surgery.

    abstract:PURPOSE:The purposes of this study were to investigate the effects of topically administrated Tacrolimus and Octreotide on modulation of postoperative scarring in experimental glaucoma filtration surgery and to compare the antifibrotic properties of these agents with mitomycin-C (MMC). MATERIAL AND METHODS:A total of ...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.3109/02713683.2011.635404

    authors: Arslan S,Aydemir O,Güler M,Dağlı AF

    更新日期:2012-03-01 00:00:00

  • Effect of repeated applanation tonometry on the accuracy of intraocular pressure measurements.

    abstract:PURPOSE:To evaluate the stability of successive applanation tonometry measurements in glaucomatous eyes. METHODS:A prospective, comparative, randomized, and evaluator-masked study was conducted in a tertiary medical center. Sixty-seven patients with glaucoma attending our glaucoma clinic underwent four successive intr...

    journal_title:Current eye research

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/02713681003678824

    authors: Gaton DD,Ehrenberg M,Lusky M,Wussuki-Lior O,Dotan G,Weinberger D,Snir M

    更新日期:2010-06-01 00:00:00

  • Modification of amniotic membrane as a depot carrier for bevacizumab - an in-vitro model for a slow release mechanism.

    abstract:PURPOSE:Corneal ulceration may be treated with human amniotic membrane (HAM) while neovascularization remains a common complication of corneal ulceration. As several factors contained within HAM may contribute to reduced corneal scarring, we investigated if HAM may be additionally loaded with bevacizumab and potentiall...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.3109/02713683.2012.757326

    authors: Mayer WJ,Grüterich M,Kook D,Sigg W,Kernt M,Messmer EM,Haritoglou C,Kampik A,Wolf A

    更新日期:2013-04-01 00:00:00

  • Calmodulin antagonists induce changes in lens permeability and transparency.

    abstract::Calmodulin has been shown to perform several important functions in the lens including regulation of the plasma membrane Ca(2+)-ATPase. This study investigated the effects of a variety of different CaM antagonists on rat lens membrane potential, membrane resistance, intracellular Na+ and Ca2+ content and transparency,...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.3109/02713689408995780

    authors: Sanderson J,Gandolfi SA,Duncan G

    更新日期:1994-03-01 00:00:00

  • Changes in diabetic retinal matrix protein mRNA levels in a common transgenic mouse strain.

    abstract::Recently, all the structural features of non-proliferative diabetic retinopathy have been demonstrated in mice fed 30% galactose for 21-26 months. To determine whether changes in retinal matrix protein mRNA levels occur early in the course of murine diabetes we used a competitive RT-PCR method to quantitate retinal mR...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:

    authors: Nishikawa T,Giardino I,Edelstein D,Brownlee M

    更新日期:2000-07-01 00:00:00

  • Point-wise relationships between visual field sensitivity and macular thickness determined by spectral-domain optical coherence tomography.

    abstract:PURPOSE:To evaluate the point-wise relationships between visual field sensitivity (VFS), as measured by standard automated perimetry (SAP), and macular thickness, as determined by spectral-domain optical coherence tomography (SD-OCT), in patients with glaucoma. MATERIALS AND METHODS:One hundred and six glaucoma subjec...

    journal_title:Current eye research

    pub_type: 临床试验,杂志文章

    doi:10.3109/02713683.2013.787433

    authors: Kim JM,Sung KR,Yoo YC,Kim CY

    更新日期:2013-08-01 00:00:00

  • Identification of heat shock proteins binding to an immunodominant uveitopathogenic peptide of IRBP.

    abstract::Intracellular binding proteins have been identified and isolated from B cells by their ability to bind to the synthetic peptide (1169-1191), the major immunodominant epitope of bovine interphotoreceptor retinoid-binding protein (IRBP) coupled to cyanogen bromide activated Sepharose 4B. After SDS-PAGE, two discrete pro...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.3109/02713689408995790

    authors: Rengarajan K,de Smet MD,Chader GJ,Wiggert B

    更新日期:1994-04-01 00:00:00

  • Alterations of energetic metabolite levels by free radicals during optic nerve ischemia.

    abstract::An experimental model of optic nerve ischemia was designed in the rabbit to determine early biochemical alterations, i.e.--changes of high energy phosphate metabolites (ATP and phosphocreatine)--in occlusive and peri-occlusive areas. Vascular occlusion provoked a rapid fall of ATP and phosphocreatine in the optic nerv...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.3109/02713689209001779

    authors: Vériac S,Tissié G,Bonne C

    更新日期:1992-03-01 00:00:00

  • HLA DQA tissue typing of cadaveric eye bank donor material with polymerase chain reaction.

    abstract::It has been suggested that the provision of HLA matched tissue for corneal transplantation would be beneficial for graft survival especially in high risk patients. In this study we report the application of a polymerase chain reaction (PCR) based tissue typing procedure to type cadaveric donor material. Using beta-glo...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.3109/02713689209001798

    authors: Rakoczy P,Garlepp M,Constable I

    更新日期:1992-05-01 00:00:00

  • Protection of cone photoreceptor M-opsin degradation with 9-cis-β-carotene-rich alga Dunaliella bardawil in Rpe65(-/-) mouse retinal explant culture.

    abstract:PURPOSE:RPE65, a retinal pigment epithelium-specific 65-kDa protein, plays a critical role in the visual cycle of the eye. Rpe65(-/-) mice develop vision loss due to a lack of 11-cis-retinal, degradation of M-opsin and mislocalization of S-opsin. Several studies have suggested that 9-cis-β-carotene, a precursor of 9-ci...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.3109/02713683.2014.907430

    authors: Ozaki T,Nakazawa M,Kudo T,Hirano S,Suzuki K,Ishiguro S

    更新日期:2014-12-01 00:00:00

  • The evaluation of therapeutic responses in experimental keratomycosis.

    abstract::Two different measures of response to therapy were evaluated in a model of keratitis caused by Aspergillus fumigatus in Dutch-belted rabbits. Combined pre and post-inoculation treatment with oral fluconazole 37.5 mg/kg bid or itraconazole 40 mg/kg bid was compared to post-inoculation treatment only and untreated contr...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.3109/02713689209069165

    authors: O'Day DM,Head WS,Robinson RD,Williams TE,Gedde S

    更新日期:1992-01-01 00:00:00

  • Chronic electrical stimulation of sympathetic nerves: effects on blood-aqueous barrier.

    abstract::The effect of electrical stimulation of the sympathetic nerves on the blood-aqueous barrier was investigated in rabbits. The permeability of the barrier was assessed during either acute, chronic or following chronic nerve stimulation. During acute and chronic stimulation of the sympathetic nerves, fluorescein entered ...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.3109/02713689009069929

    authors: Bartels SP,Pawlowski AM

    更新日期:1990-10-01 00:00:00

  • Chloroquine keratopathy of rheumatoid arthritis patients detected by in vivo confocal microscopy.

    abstract:AIM:To investigate microscopic changes in corneal morphology in chloroquine (CQ)-treated patients without corneal abnormalities being diagnosable by slit lamp microscopy. METHODS:Thirty-six eyes of 36 patients with rheumatoid arthritis (RA) were divided into two groups: group 1 included 26 patients receiving chloroqui...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.3109/02713683.2011.631719

    authors: Ma X,He L,He D,Xu J

    更新日期:2012-04-01 00:00:00

  • Quantifying retinal irradiance levels in light damage experiments.

    abstract::From knowledge of the optical parameters of experimental animal eyes and radiometric parameters of the light source, it is possible to provide accurate retinal irradiances (dose rates). Examples are given for the rat, cat, monkey and other animals of interest. Fluorescent lamps and incandescent lamp radiances are prov...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.3109/02713688408997199

    authors: Sliney DH

    更新日期:1984-01-01 00:00:00

  • Effects of hypoxia and post-hypoxic recovery on chick retinal pigment epithelium potentials and light-evoked responses in vitro.

    abstract:PURPOSE:To determine the cellular mechanisms involved in the hypoxia-induced alteration of the retinal pigment epithelium (RPE) potentials and the light-evoked responses of the RPE in chicks. In addition, to determine the mechanisms involved in the recovery of the RPE during the post-hypoxic period. METHODS:In vitro p...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.1080/02713689808951219

    authors: Nakazaki S,Nao-i N,Sawada A

    更新日期:1998-04-01 00:00:00

  • Preoperative Anxiety Levels and Pain during Cataract Surgery.

    abstract::Purpose: To evaluate the correlation between pain during cataract surgery and preoperative anxiety.Methods: This prospective observational masked study included 103 eyes of 103 consecutive patients who underwent routine clear corneal incision phacoemulsification surgery at the Department of Ophthalmology, Rambam Healt...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.1080/02713683.2019.1666996

    authors: Socea SD,Abualhasan H,Magen O,Zayit-Soudry S,Blumenthal EZ,Duvdevan N,Mimouni M

    更新日期:2020-04-01 00:00:00

  • The lack of extracellular laminin beta2 chain deposition correlates to the loss of conjunctival epithelial keratin K4 localization in culture.

    abstract:PURPOSE:To examine the effects of external modulation of epithelial-mesenchymal interaction on conjunctival epithelial cell differentiation characteristics. METHODS:Keratin K4 and laminin beta2 chain protein localization was examined in an organotypic model which facilitates the comparison of differentiation character...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.1076/ceyr.18.1.28.5394

    authors: Kurpakus MA,Lin L

    更新日期:1999-01-01 00:00:00

  • Characterization of alpha 2-adrenergic receptors, negatively coupled to adenylate cyclase, in rabbit ciliary processes.

    abstract::Inhibition of ciliary process adenylate cyclase was studied on rabbit membrane preparations. When considered individually, epinephrine, GTP and NaCl did not inhibit adenylate cyclase activity. On the other hand, when present together, epinephrine, GTP (10(-5) M) and NaCl (200 mM) acted synergistically to cause a 27% i...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.3109/02713688809047034

    authors: Kintz P,Himber J,de Burlet G,Andermann G

    更新日期:1988-03-01 00:00:00

  • Efficacy of 9-(2-phosphonylmethoxyethyl)adenine in the therapy of TK+ and TK- herpes simplex virus experimental keratitis.

    abstract::The acyclic nucleoside phosphonate analogue PMEA [9-(2-phosphonylmethoxyethyl)adenine] is a broad spectrum antiviral agent effective against DNA viruses and retroviruses. It is particularly active against the human immunodeficiency virus and, like other phosphonylmethoxyalkyl derivatives, it also inhibits HSV-1, TK- H...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.3109/02713689109020370

    authors: Maudgal PC,De Clercq E

    更新日期:1991-01-01 00:00:00

  • The effect of collagen cross-linking procedure on the material of intracorneal ring segments.

    abstract:PURPOSE:To assess the potential impact of corneal crosslinking treatment (365 nm ultraviolet (UV)A irradiation with riboflavin) on the material properties of Intracorneal Rings Segments (ICRS). MATERIALS AND METHODS:Material properties were studied using FT-IR spectroscopy and UV-Vis spectroscopy. Rings were examined:...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.3109/02713683.2014.941071

    authors: Sideroudi H,Labiris G,Soto-Beobide A,Voyiatzis G,Chrissanthopoulos A,Kozobolis V

    更新日期:2015-05-01 00:00:00

  • Diffuse luminance flicker increases retinal vessel diameter in humans.

    abstract:PURPOSE:To determine retinal vessel diameter variations in response to neuronal activity induced by diffuse luminance flicker. METHODS:The diameter of retinal arteries and veins was measured in 9 normal subjects by computer analysis of fundus pictures taken in monochromatic light under normal conditions of illuminatio...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.1076/ceyr.16.12.1252.5021

    authors: Formaz F,Riva CE,Geiser M

    更新日期:1997-12-01 00:00:00

  • Natural course of posterior subcapsular cataract over a short time period.

    abstract::Purpose/aim of the study: To observe and analyze the weekly changes in morphology and size of vacuoles, so called Wedl cells, in eyes with posterior subcapsular cataract (PSC). MATERIALS AND METHODS:Thirty-six eyes of 36 patients with pronounced PSC were included in this prospective study. High-resolution retroillumi...

    journal_title:Current eye research

    pub_type: 杂志文章

    doi:10.1080/02713683.2017.1343852

    authors: Neumayer T,Hirnschall N,Georgopoulos M,Findl O

    更新日期:2017-12-01 00:00:00