Abstract:
PURPOSE:Acyclovir has been shown to be effective in preventing recurrent herpes simplex virus lesions of the genitalia and oral labia. The purpose of the current study was to determine the effect of acyclovir on the appearance of infectious virus in the peripheral nervous system and in an end organ, the eye. MATERIALS AND METHODS:Mice latent for the McKrae strain of herpes simplex virus type 1 were given 3.5 mg/ml acyclovir in their drinking water. Control animals received water without drug. Acyclovir treatment was continued for 4 successive days. On the third day, the mice were subjected to a brief period of hyperthermic stress to induce viral reactivation. Twenty-four hours after stress induction, swabs of the ocular surface and homogenates of the cornea and trigeminal ganglia were analyzed for the presence of infectious herpes simplex virus type 1 and viral DNA. RESULTS:Acyclovir treatment significantly decreased the frequency of infectious virus in the ocular tear film and the cornea but not in the trigeminal ganglion. The corneal homogenates of acyclovir-treated animals contained smaller amounts of viral DNA compared with untreated controls, whereas the amounts of viral DNA in the trigeminal ganglia of acyclovir-treated and untreated animals were similar. CONCLUSIONS:These results suggest that oral administration of acyclovir, at least at the dose used in this study, is effective in modestly reducing viral replication in peripheral tissues such as the eye but is not effective in inhibiting viral reactivation and viral DNA synthesis in the peripheral nervous system in mice subjected to induction of reactivation by hyperthermic stress.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Gebhardt BM,Kaufman HE,Hill JMdoi
10.1080/02713680490504560subject
Has Abstractpub_date
2004-08-01 00:00:00pages
137-44issue
2-3eissn
0271-3683issn
1460-2202pii
9PX1MK7T1B5N5JNDjournal_volume
29pub_type
杂志文章abstract::A model for endothelial transport is updated to include recent evidence. We discuss electrolyte movements based on a Na+-K+ ATPase, a Na+-H+ exchanger, a Na+-HCO3 coupler, a Cl- -HCO-3 exchanger, a K+-Cl-coupler, and K+ and anion channels. We discuss near-isotonic transport of fluid on the basis of recent findings of ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688509025148
更新日期:1985-04-01 00:00:00
abstract:PURPOSE:To evaluate macular ganglion cell complex (GCC) thickness and peripapillary retinal nerve fiber layer (RNFL) thickness in patients treated with SSRIs. METHODS:The present study included 62 eyes of 31 patients who were using SSRIs and 60 eyes of 30 healthy, age- and gender-matched control subjects. All patients...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2017.1420198
更新日期:2018-04-01 00:00:00
abstract::Components of the Renin Angiotensin System (RAS) have been detected in ocular tissues and fluids. The source of the ocular RAS proteins is unknown but possibilities include diffusion or leakage from the systemic circulation, specific uptake from the blood, or local synthesis. We have used RT-PCR and in situ hybridizat...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689409047011
更新日期:1994-10-01 00:00:00
abstract:PURPOSE:Predicting the toxic potential of compounds to the ocular surface has depended on the Draize test for the past half century. Alternatives to Draize testing have recently been sought for a number of reasons. Stress gene expression has emerged as a means of quantifying cellular reaction and, thus, the toxic poten...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.19.2.115.5325
更新日期:1999-08-01 00:00:00
abstract:PURPOSE:To assess the distribution of dark-light changes in iris features and associated factors amongst American Caucasians, American Chinese and mainland Chinese aged 40 years and over. METHODS:Four gender- and age-matched cohorts: Caucasians, American Chinese, Southern Chinese and Northern Chinese comprised the stu...
journal_title:Current eye research
pub_type: 杂志文章,多中心研究
doi:10.3109/02713683.2012.660593
更新日期:2012-07-01 00:00:00
abstract::Purpose: To compare four visual acuity (VA) scoring termination rules. Methods: A computer simulation generated 30,000 virtual patients who underwent 10 repetitions for each of four termination rules, on both the Snellen and ETDRS charts (2.4 million tests performed in total). Three termination rules focused on the sm...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1589524
更新日期:2019-07-01 00:00:00
abstract::An experimental model of optic nerve ischemia was designed in the rabbit to determine early biochemical alterations, i.e.--changes of high energy phosphate metabolites (ATP and phosphocreatine)--in occlusive and peri-occlusive areas. Vascular occlusion provoked a rapid fall of ATP and phosphocreatine in the optic nerv...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689209001779
更新日期:1992-03-01 00:00:00
abstract::The variation of central corneal thickness with age was measured weekly at 10am by ultrasound pachometry in 10 normal (5 to 19 weeks of age) and 10 alloxan-induced diabetic (9 to 19 weeks of age) rabbits. The diurnal variation of corneal thickness was also measured at 2 hour intervals for a period of 24 hours on both ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689008999611
更新日期:1990-05-01 00:00:00
abstract::This study asks whether retinal adhesiveness is affected by cytochalasin D, a drug that is known to alter the apical morphology of the retinal pigment epithelium (RPE). Cytochalasin D was injected intravitreally in Dutch rabbits and retinal adhesiveness measured 0.5 to 72 h later by two methods: in vitro peeling of th...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689508995817
更新日期:1995-12-01 00:00:00
abstract:PURPOSE:After corneal injury, persistent epithelial defects (PED's) may occur due to the chronic failure of the regenerating epithelium to adhere to the underlying stroma. The aim of this study was to examine the potential of epsilonaminocaproic acid (EACA) as a topical treatment for PED's. EACA inhibits the activation...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.18.2.150.5382
更新日期:1999-02-01 00:00:00
abstract::Severe retinopathy of prematurity (ROP) occurs in the smallest and sickest of premature infants. We hypothesized that, in a rat model of oxygen induced retinopathy, abnormal neovascularization would occur more frequently in larger litters where the pups are subject to postnatal growth retardation. Four litters of newb...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689608995831
更新日期:1996-04-01 00:00:00
abstract::Purpose: To determine the refractive astigmatism following toric intraocular lens (tIOL) implantation without consideration of posterior keratometric astigmatism with a conventional tIOL calculator for eyes with low keratometric astigmatism (0.75D to 2.5D) and to theoretically compare the outcomes with predicted refra...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1638418
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:Corneal scarring is a common poor outcome of corneal trauma. Transforming growth factor β-1 plays a vital role in corneal fibrosis, inducing keratocyte transformation to myofibroblasts. Other than corneal transplantation, no other curative treatment methods for corneal scarring are currently available. Hypercap...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1820526
更新日期:2020-09-11 00:00:00
abstract:PURPOSE:Phoria is used in the diagnosis of binocular dysfunctions, such as convergence insufficiency. A common treatment for convergence insufficiency is vision therapy, yet it is controversial whether the phoria changes as a result of rehabilitation. Phoria can vary due to the duration and/or the type of prior visual ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.694551
更新日期:2012-11-01 00:00:00
abstract:PURPOSE:To determine the cellular mechanisms involved in the hypoxia-induced alteration of the retinal pigment epithelium (RPE) potentials and the light-evoked responses of the RPE in chicks. In addition, to determine the mechanisms involved in the recovery of the RPE during the post-hypoxic period. METHODS:In vitro p...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713689808951219
更新日期:1998-04-01 00:00:00
abstract:PURPOSE:To investigate the tissue blood flow in the neuroretinal rim of the optic disk and macula after rhegmatogenous retinal detachment (RRD) surgery. METHODS:Tissue blood flow in the neuroretinal rim of the optic disk and macula was measured with the Heidelberg retina flowmeter in 53 eyes of 53 patients who had und...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680701531108
更新日期:2007-09-01 00:00:00
abstract:PURPOSE:To determine the relative expression of metallothionein isoforms and their differential induction by oxidative stress in cultured RPE cells and to localize the isoforms in the human chorioretinal complex. METHODS:Total RNA was isolated from cultured human retinal pigment epithelial cells using TRI-Reagent. An ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.24.1.12.5426
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:Klotho genes are expressed in limited tissues and have been found to be a pathogenic factor of age-related diseases in mammals, but their expressions and functions in human eyes are yet to be defined. This study was performed to investigate the expression of Klotho family genes in human ocular tissues and anter...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1259421
更新日期:2017-06-01 00:00:00
abstract::Two of the major in vitro phosphorylated polypeptides of the bovine lens have been identified. Analysis by means of two-dimensional gel electrophoresis (IEF) has demonstrated that the lens phosphorylated 57,000 and 43,000 dalton polypeptides correspond in mobility to purified phosphorylated bovine lens vimentin and ch...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409000838
更新日期:1984-12-01 00:00:00
abstract::The aim of this study was to determine whether or not alpha neoprotein formation can occur in the lens in response to a photolytic process. Alpha crystallin from young calf and aged bovine lenses was irradiated for up to 22 hours with UV light. After cortical alpha crystallin had been irradiated, it completely preserv...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688809001882
更新日期:1988-11-01 00:00:00
abstract::EDGF, a growth factor purified from bovine retina is able to increase the rate of wound healing of rabbit corneal epithelium in a dose dependent way. Two applications a day are enough to obtain the maximum rate. The most purified preparation of EDGF is as effective as EGF or pFGF in promoting this phenomenon and allow...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409003059
更新日期:1984-04-01 00:00:00
abstract:PURPOSE:To determine the plasma levels of the sulfur-containing amino-acids homocysteine, cysteine, cysteinylglycine, glutamylcysteine, glutathione, and taurine in patients with central retinal vein occlusion (CRVO) and in healthy subjects and to ascertain whether there are statistically significant differences between...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713681003698863
更新日期:2010-07-01 00:00:00
abstract:PURPOSE:Basal cell carcinoma (BCC) is a locally invasive skin tumor which can be subdivided into a circumscribed nodular and an invasive fibrosing subtype. There is increasing evidence that macrophages play an important role in interacting between tumor cells and their microenvironment, thereby affecting not only the i...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1478980
更新日期:2018-09-01 00:00:00
abstract:PURPOSE:To investigate the proliferative behavior of the corneal and limbal epithelia after debridement on the central region of the rabbit cornea. METHODS:After scraping a circular epithelial area, 5 mm in diameter, in the center of the cornea, ([3]) H-thymidine ( ([3]) H-TdR) was injected intravitreally, and the rab...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680903007121
更新日期:2009-08-01 00:00:00
abstract::Purpose: To investigate the cytotoxic effects of fresh black carbon (FBC) particles and ozone-oxidized BC (OBC) particles on human corneal epithelial cells (HCECs), and the role of the NLRP3 inflammasome signal pathway in the process.Methods: HCECs were treated with different doses of FBC and OBC particles, the cell i...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1698051
更新日期:2020-06-01 00:00:00
abstract::Recently, all the structural features of non-proliferative diabetic retinopathy have been demonstrated in mice fed 30% galactose for 21-26 months. To determine whether changes in retinal matrix protein mRNA levels occur early in the course of murine diabetes we used a competitive RT-PCR method to quantitate retinal mR...
journal_title:Current eye research
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
abstract:AIM:To test the feasibility of implanting human anterior lens capsules (HALCs) with porcine corneal endothelial cells (pCEC) in vivo in Göttingen minipigs and at the same time test the suitability of Göttingen minipig as model for endothelial keratoplasty. MATERIALS AND METHODS:Cell-carrier constructs of decellularize...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1706747
更新日期:2020-08-01 00:00:00
abstract::Endothelin-1 (ET-1) affects intraocular pressure (IOP) in rabbits. First, we studied IOP responses to the intravitreal injection of various doses of ET-1 ranging from 5 ng to 5 micrograms in unanesthetized rabbits, and observed a transient rise in IOP, from 0.5 to 2 h in duration, invariably followed by a prolonged IO...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689509003759
更新日期:1995-06-01 00:00:00
abstract::Purpose: To evaluate the effect of methylphenidate on visual field testing in healthy adults with abnormal visual field results. Methods: This prospective, randomized, controlled interventional clinical trial comprised all patients who had abnormal visual field test results and normal eye examination and ophthalmic hi...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1858430
更新日期:2020-12-21 00:00:00
abstract:PURPOSE/AIM OF THE STUDY:The aim of this study is to investigate the effect of pseudoexfoliation (PEX) and PEX-induced dry eye on central corneal thickness (CCT). MATERIALS AND METHODS:This cross-sectional study consists of total 270 eyes of 135 patients (67 females, 68 males) in total. After excluding the PEX (-) 32 ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1030505
更新日期:2016-01-01 00:00:00