Cytotoxic properties of sunitinib and sorafenib on human corneal epithelial cells.

abstract：PURPOSE:The purpose of this study was to determine the retinal expression of angiogenic chemokines/cytokines in a mouse model of oxygen-induced retinopathy. METHODS:C57BL/6 (B6) mice were exposed to 75% oxygen from postnatal day 7 (P7) to P12 and then recovered in room air. Reverse transcription-polymerase chain react...

journal_title：Current eye research

authors： Powers MR,Davies MH,Eubanks JP

更新日期：2005-04-01 00:00:00

abstract：PURPOSE:To evaluate the immediate effect of 3% diquafosol ophthalmic solution on tear MUC5AC concentration, periodic acid-Schiff (PAS)-positive goblet cells, and tear film stability in normal and keratoconjunctivitis sicca (KCS) rat models. METHODS:Rats were divided into normal and KCS groups. 3% of diquafosol solutio...

journal_title：Current eye research

authors： Choi KE,Song JS,Kang B,Eom Y,Kim HM

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:To investigate the roles of adherence and matrix metalloproteinases (MMPs) in growth patterns of major fungal pathogens in cornea. METHODS:Ninety-six eyes in 96 rabbits were equally divided into four groups receiving inoculation of fungal conidia of Aspergillus fumigatus, Candida albicans, Fusarium solani, and...

journal_title：Current eye research

authors： Dong X,Shi W,Zeng Q,Xie L

更新日期：2005-08-01 00:00:00

abstract：:Purpose/Aim of the study: A recently proposed technique enables the generation of continuously increasing mosaic images of the corneal sub-basal nerve plexus (SNP) using in vivo corneal confocal microscopy (CCM). The aim of the present study was to investigate the progression of the corneal nerve fiber length (CNFL) m...

journal_title：Current eye research

authors： Allgeier S,Winter K,Bretthauer G,Guthoff RF,Peschel S,Reichert KM,Stachs O,Köhler B

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:To examine the effects of external modulation of epithelial-mesenchymal interaction on conjunctival epithelial cell differentiation characteristics. METHODS:Keratin K4 and laminin beta2 chain protein localization was examined in an organotypic model which facilitates the comparison of differentiation character...

journal_title：Current eye research

authors： Kurpakus MA,Lin L

更新日期：1999-01-01 00:00:00

abstract：:The basement membrane of the crystalline lens of the diabetic rat was found to have a similar elasticity modulus at high stress to that of normal membrane. However, at low stress and extension Young's modulus of elasticity was 0.36 (Mean) +/- 0.15 (SD) X 10(6) Nm-2 and about 30 per cent lower than that of normal membr...

journal_title：Current eye research

authors： Hayes BP,Fisher RF

更新日期：1981-01-01 00:00:00

abstract：:Blood and lymphatic vessel proliferation into the cornea occurs after severe trauma. Whilst the events early in blood vessel growth are reasonably understood, little is known of the early events in lymphangiogenesis. In this study, a model for proliferating lymphatic vessels using tritiated-thymidine autoradiography a...

journal_title：Current eye research

authors： Junghans BM,Collin HB

更新日期：1989-01-01 00:00:00

abstract：:Forty-five patients with virologically confirmed dendritic keratitis were treated in a randomized, double-blind controlled study with a basic therapy of trifluorothymidine (TFT) eye drops. In addition they received different human recombinant interferon (rHu IFN) eye drops. The following results were obtained for aver...

journal_title：Current eye research

authors： Sundmacher R,Mattes A,Neumann-Haefelin D,Adolf G,Kruss B

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Interleukin-6 (IL-6) is produced by a variety of cells involved in inflammation and acts as local intensification signals in pathological processes associated with chronic eye inflammation. This meta-analysis was performed to provide a better understanding of the relationship between IL-6 and diabetic retino...

journal_title：Current eye research

authors： Yao Y,Li R,Du J,Long L,Li X,Luo N

更新日期：2019-05-01 00:00:00

abstract：SIGNIFICANCE:Adopting a risk stratification system and appropriate listing of cases reduces the rates of intraoperative complications during phacoemulsification. Such listing would allow both safe surgery and enhance training, by ensuring an appropriately experienced surgeon is available to operate on a case or supervi...

journal_title：Current eye research

authors： Pooprasert P,Hansell J,Young-Zvandasara T,Muhtaseb M

更新日期：2020-07-30 00:00:00

abstract：:Loteprednol etabonate (LE) is a new corticosteroid based on the "soft drug" concept. Contact lens-associated giant papillary conjunctivitis (GPC) was studied as a model for the anti-inflammatory effect of LE. Patients with bilateral GPC were enrolled in a multicenter, randomized, double-masked, placebo-controlled, par...

journal_title：Current eye research

authors： Bartlett JD,Howes JF,Ghormley NR,Amos JF,Laibovitz R,Horwitz B

更新日期：1993-04-01 00:00:00

abstract：:Purpose: The purpose of this study was to investigate the relationship between aquaporin-1 (AQP-1) protein expression in the choroid and choroid thickness (CT) during the recovery of form-deprivation (FD) myopia in guinea pigs.Materials and Methods: Seventy-two guinea pigs were randomly assigned to the normal control ...

journal_title：Current eye research

authors： Chen W,Zhang H,Zhang Y,Wang Q,Wang Y,Li ZW

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:N-acetyl-cysteine (NAC) is a potent antioxidant known to be a precursor of glutathione. The purpose of this study was to investigate the role of NAC in the development of choroidal neovascularization (CNV). METHODS:CNV was induced in C57BL/6 mice by laser photocoagulation of the ocular fundus. Mice were inject...

journal_title：Current eye research

authors： Hara R,Inomata Y,Kawaji T,Sagara N,Inatani M,Fukushima M,Tanihara H

更新日期：2010-11-01 00:00:00

abstract：:Recently, growth factors are known to phosphorylate tyrosine residues of proteins to regulate cellular functions. We investigated growth factor-dependent phosphorylation of membrane proteins in cultured human retinal pigment epithelial (RPE) cells. The phosphorylation experiments were done in membrane preparations of ...

journal_title：Current eye research

authors： Yoshimura N,Kuriyama S,Iwaki M,Honda Y

更新日期：1992-10-01 00:00:00

abstract：:Purpose: To evaluate the microvascular density of the peripapillary and parafoveal areas of the eyes with primary angle closure disease (PACD) using optical coherence tomography angiography (OCTA). Materials and methods: An observational study was conducted with 76 PACD patients (29 eyes with primary angle closure sus...

journal_title：Current eye research

authors： Wang X,Chen J,Kong X,Sun X

更新日期：2020-11-26 00:00:00

abstract：PURPOSE:To quantitatively measure the flow, nonflow, density, and foveal avascular zone (FAZ) assessment tool parameters of optical coherence tomography angiography (OCTA) in patients with nonocular Behcet's Disease (BD), and to compare the results with those obtained in healthy controls. METHODS:FAZ parameters, flow ...

journal_title：Current eye research

authors： Goker YS,Yılmaz S,Kızıltoprak H,Tekin K,Demir G

更新日期：2019-02-01 00:00:00

abstract：:Two alternative methods for the study of the lens cytoskeleton are described which serve to overcome some of the difficulties imparted by the unique biology of the lens. The first technique involves rapid freezing, thick sectioning, and selective extraction and/or fixation of the lens section. This approach offers sev...

journal_title：Current eye research

authors： FitzGerald PG

更新日期：1990-11-01 00:00:00

abstract：:The effect of electrical stimulation of the sympathetic nerves on the blood-aqueous barrier was investigated in rabbits. The permeability of the barrier was assessed during either acute, chronic or following chronic nerve stimulation. During acute and chronic stimulation of the sympathetic nerves, fluorescein entered ...

journal_title：Current eye research

authors： Bartels SP,Pawlowski AM

更新日期：1990-10-01 00:00:00

abstract：:Purpose/Aim: To assess the changes in anterior eye segment biometrics and intraocular pressure during and after wearing swimming goggles.Materials and methods: Anterior segment biometry and intraocular pressure were assessed in 20 healthy young adults (22.2 ± 4.7 years) during the wearing of a drilled swimming goggle....

journal_title：Current eye research

authors： Jiménez R,Molina R,García JA,Redondo B,Vera J

更新日期：2020-05-01 00:00:00

abstract：PURPOSE:To evaluate differences of phagocytic capacities in rat retinal pigment epithelial (RPE) cells, iris pigment epithelial (IPE) cells, and basic fibroblast growth factor (bFGF) cDNA-transfected IPE (bFGF-IPE) cells in vitro. METHODS:The RPE cells and IPE cells were isolated from adult Long Evans rats' eyes. The ...

journal_title：Current eye research

authors： Sakuragi M,Tomita H,Abe T,Tamai M

更新日期：2001-09-01 00:00:00

abstract：:In the Royal College of Surgeons rat, the migration of phagocytic cells into the subretinal space accompanies photoreceptor cell death during the early stages of retinal dystrophy. These are followed closely by cellular alterations in the retinal pigment epithelium, Müller cells, and outer retinal vessels. We have ide...

journal_title：Current eye research

authors： Roque RS,Caldwell RB

更新日期：1993-03-01 00:00:00

abstract：PURPOSE:The aim of this study is to determine age-related morphological changes in the corneal subbasal nerve plexus (SNP) in two inbred mouse strains. MATERIALS AND METHODS:The corneal SNP was investigated by in vivo confocal laser scanning microscopy (CLSM) in 0.5-, 1-, 1.5-, and 2-year-old C57BL/6J mice and in 0.5-...

journal_title：Current eye research

authors： Reichard M,Weiss H,Poletti E,Ruggeri A,Guthoff RF,Stachs O,Baltrusch S

更新日期：2016-08-01 00:00:00

abstract：:Cultured retinal glial cells from the rat are responsive to modulation by vasoactive intestinal peptide (VIP). VIP (1 X 10(-6) M) elevated the intracellular cyclic AMP concentration from the basal level of (4.4-11.1) p mole/mg protein to (354-440) p mole/mg protein in three minutes at 25 degrees C. The half-maximal co...

journal_title：Current eye research

authors： Koh SW,Roberge FG

更新日期：1989-11-01 00:00:00

abstract：:Lipid synthesis was investigated in bovine lens in organ culture for 9 hours using 14C acetate as a precursor. The greatest incorporation occurred in phospholipid fraction with phosphatidyl choline being the major phospholipid labeled. Considerable activity was incorporated in the free fatty acid fraction, cholesterol...

journal_title：Current eye research

authors： Albers-Jackson B,Nga Do A

更新日期：1987-09-01 00:00:00

abstract：:Penetrating keratoplasty was the only therapeutic choice for the treatment of corneal endothelial decompensation until the introduction of evolutional endothelial keratoplasties, namely Descemet's stripping automated endothelial keratoplasty (DSAEK) and Descemet's membrane endothelial keratoplasty (DMEK). Although now...

journal_title：Current eye research

authors： Okumura N,Koizumi N

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:Predicting the toxic potential of compounds to the ocular surface has depended on the Draize test for the past half century. Alternatives to Draize testing have recently been sought for a number of reasons. Stress gene expression has emerged as a means of quantifying cellular reaction and, thus, the toxic poten...

journal_title：Current eye research

authors： Braunstein SG,Deramaudt TG,Rosenblum DG,Dunn MG,Abraham NG

更新日期：1999-08-01 00:00:00

abstract：PURPOSE:The fibroblast growth factors (FGFs) are a family of 9 heparin binding proteins which have been proposed to play key roles in angiogenesis. Basic FGF (bFGF), acidic FGF (aFGF) and FGF5 have previously been demonstrated to be expressed in the normal retina and RPE. In this study, the expression of FGF5 was explo...

journal_title：Current eye research

authors： Kitaoka T,Morse LS,Schneeberger S,Ishigooka H,Hjelmeland LM

更新日期：1997-04-01 00:00:00

abstract：:EDGF, a growth factor purified from bovine retina is able to increase the rate of wound healing of rabbit corneal epithelium in a dose dependent way. Two applications a day are enough to obtain the maximum rate. The most purified preparation of EDGF is as effective as EGF or pFGF in promoting this phenomenon and allow...

journal_title：Current eye research

authors： Petroutsos G,Courty J,Guimaraes R,Pouliquen Y,Barritault D,Plouët J,Courtois Y

更新日期：1984-04-01 00:00:00

abstract：PURPOSE:Whereas many previous studies have identified the association between sustained near work and myopia, few have assessed the influence of concomitant levels of cognitive effort. This study investigates the effect of cognitive effort on near-work induced transient myopia (NITM). METHODS:Subjects comprised of six...

journal_title：Current eye research

authors： Wolffsohn JS,Gilmartin B,Thomas R,Mallen EA

更新日期：2003-12-01 00:00:00

abstract：PURPOSE:Deficiency in Cystathionine β-synthase (CBS) leads to an abnormal accumulation of homocysteine and results in classical homocystinuria, a multi-systemic disorder that affects connective tissue, muscles, the central nervous system, and the eyes. However, the genetic players and mechanisms underlying vision alter...

journal_title：Current eye research

authors： Flores-Flores M,Moreno-García L,Castro-Martínez F,Nahmad M

更新日期：2020-09-07 00:00:00