Abstract:
:Calcium permeability was significantly increased in lenses from rats 36 h following a single injection of a cataractogenic dose of sodium selenite (30 nmol/g body weight) and this permeability returned to control values by 72 h post-injection (PI). The greater Ca2+ permeability could be partially reversed by incubating lenses in medium containing 2 mM dithiothreitol (DTT). Estimations of Ca-ATPase activity revealed the greatest level occurred in the epithelial layer and that the nucleus had no detectable activity. By 48 h PI both Ca(2+)-pump activity and the Ca(2+)-dependent ATP hydrolytic activity were less compared to controls in membrane preparations from rat lenses. Only the hydrolytic activity could be partially restored by treatment with 5 mM DTT. Both permeability and active Ca2+ transport were affected by selenite in a manner that would lead to increased Ca2+ accumulation in lenses from rats treated with selenite. It is suggested that the oxidative damage that accompanies in vivo exposure to selenite could affect Ca2+ homeostasis in the lens by directly altering permeability and Ca-ATPase.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Wang Z,Bunce GE,Hess JLdoi
10.3109/02713689308999466subject
Has Abstractpub_date
1993-03-01 00:00:00pages
213-8issue
3eissn
0271-3683issn
1460-2202journal_volume
12pub_type
杂志文章abstract::The basement membrane of the crystalline lens of the diabetic rat was found to have a similar elasticity modulus at high stress to that of normal membrane. However, at low stress and extension Young's modulus of elasticity was 0.36 (Mean) +/- 0.15 (SD) X 10(6) Nm-2 and about 30 per cent lower than that of normal membr...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688108998358
更新日期:1981-01-01 00:00:00
abstract:PURPOSE:Due to a possible link in humans between atherosclerosis, a high-fat diet, and the development of age-related retinal degenerations, we investigated retinal changes with age and diet in high-fat-fed C57BL/6 mice, a mouse model of human atherosclerosis. METHODS:We fed C57BL/6J mice either a normal chow diet or ...
journal_title:Current eye research
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract:PURPOSE:Acyclovir has been shown to be effective in preventing recurrent herpes simplex virus lesions of the genitalia and oral labia. The purpose of the current study was to determine the effect of acyclovir on the appearance of infectious virus in the peripheral nervous system and in an end organ, the eye. MATERIALS...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680490504560
更新日期:2004-08-01 00:00:00
abstract::Retinal pigment epithelia (RPE) and retinal neurons (RN) arise from the same underlying precursor cell population. It is worthwhile to explore the transdifferentiation potential of RPE cells, given the benefits that could accrue from turning RPE into neural retina containing all its normal cellular subpopulations. Fac...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.664673
更新日期:2012-07-01 00:00:00
abstract::We studied the protective effects of passive immunization with virus specific antibody in newborn rabbits inoculated subcutaneously with type 2 herpes simplex virus (HSV-2). Newborn rabbits given anti-HSV-2 antibody intraperitoneally (IP) on days 0, 2 and 4 post infection had smaller herpetic skin lesions and reduced ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688709020084
更新日期:1987-01-01 00:00:00
abstract::Lens epithelial cells were isolated from samples of C57BL/6 and CD-1 mice at different ages between 1 and 5 months, and assayed for the level of N-acetyl-beta-glucosaminidase and their ability to replicate in-vitro. The lens epithelial cells from C57BL/6 mice had a reduced replicative potential compared to other norma...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688208996354
更新日期:1982-01-01 00:00:00
abstract:PURPOSE:To investigate the association of nailfold capillaroscopy, heart rate variability (HRV), and clinical characteristics of glaucoma with the plasma matrix metalloproteinase-9 (MMP-9) level in normal-tension glaucoma (NTG). MATERIALS AND METHODS:We conducted a prospective, cross-sectional study on 25 patients wit...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2014.971937
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:To compare the quality of corneal endothelium of precut Descemet-stripping automated endothelial keratoplasty (DSAEK) tissue when transported with and without the anterior lamellar corneal tissue (ALCT) when organ-culture corneal storage methods are used. METHODS:After microkeratome-assisted excision of anteri...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2011.648045
更新日期:2012-02-01 00:00:00
abstract::Purpose: To map the time course of changes in intraocular straylight of the human eye 1 year after initial lens wearing for orthokeratology treatment using the objective double-pass technique. Materials and Methods: A total of 35 subjects (19 males and 16 females) completed the study. The mean age was 11.46 ± 2.33 yea...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1514056
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:The repair of the corneal epithelium is modulated by matrix metalloproteinases. The present study examined the effects of recombinant (r-) tissue inhibitors of metalloproteinases-1 and -2 (TIMP-1 and -2) on the proliferation of cultured epithelial cells from rabbit cornea, and on the spreading of a sheet of squ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.17.1.47.5247
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:To study the association of cell proliferation in uveal melanoma with the mean of the 10 largest nucleoli (MLN), microvascular prognostic factors, and survival. METHODS:Population-based, retrospective cohort study of 167 choroidal and ciliary body melanomas enucleated from 1972 to 1981. Mouse monoclonal antibo...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680500478535
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:Nona-D-arginine amide (D9R) affected a cure of Pseudomonas aeruginosa corneal disease when combined with ciprofloxacin. In this study, we show that D9R alone and prophylactic treatment with D9R significantly reduced corneal pathology and bacterial burden associated with P. aeruginosa infection. MATERIALS AND M...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713680903487609
更新日期:2010-03-01 00:00:00
abstract:PURPOSE:To evaluate choroidal thickness (CT) and retinal morphological changes in eyes with neovascular age-related macular degeneration (nAMD) following ranibizumab or aflibercept intravitreal treatment. MATERIALS AND METHODS:This was a prospective, observational, comparative study where 76 eyes of 76 consecutive pat...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2017.1405045
更新日期:2018-03-01 00:00:00
abstract::Introduction: Metabolic syndrome is a disorder characterized by a constellation of findings including truncal obesity, elevated blood pressure, abnormal cholesterol levels, and high blood glucose. Recent evidence suggests that metabolic syndrome may be associated with increased risk of age-related macular degeneration...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1694156
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:Maintaining mature and viable retinal pigment epithelial cells (RPE) in vitro has proven challenging. Investigating compounds that can promote RPE-viability and maturation is motivated by RPE transplantation research, the quest to understand RPE physiology, and a desire to modulate RPE in pathological states. W...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1809001
更新日期:2020-09-01 00:00:00
abstract::Purpose: To determine the refractive astigmatism following toric intraocular lens (tIOL) implantation without consideration of posterior keratometric astigmatism with a conventional tIOL calculator for eyes with low keratometric astigmatism (0.75D to 2.5D) and to theoretically compare the outcomes with predicted refra...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1638418
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:This study was performed to compare the positive predictive value of peripapillary retinal nerve fiber layer (RNFL) thickness measurements obtained using Cirrus high-definition optical coherence tomography (Cirrus HD-OCT; Carl Zeiss Meditec, Dublin, CA) and spectral OCT/scanning laser ophthalmoscopy (SLO) (OPKO...
journal_title:Current eye research
pub_type: 临床试验,杂志文章
doi:10.3109/02713683.2013.824989
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To evaluate the point-wise relationships between visual field sensitivity (VFS), as measured by standard automated perimetry (SAP), and macular thickness, as determined by spectral-domain optical coherence tomography (SD-OCT), in patients with glaucoma. MATERIALS AND METHODS:One hundred and six glaucoma subjec...
journal_title:Current eye research
pub_type: 临床试验,杂志文章
doi:10.3109/02713683.2013.787433
更新日期:2013-08-01 00:00:00
abstract::Purpose/Aim of the study: A recently proposed technique enables the generation of continuously increasing mosaic images of the corneal sub-basal nerve plexus (SNP) using in vivo corneal confocal microscopy (CCM). The aim of the present study was to investigate the progression of the corneal nerve fiber length (CNFL) m...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1221977
更新日期:2017-04-01 00:00:00
abstract::Components of the Renin Angiotensin System (RAS) have been detected in ocular tissues and fluids. The source of the ocular RAS proteins is unknown but possibilities include diffusion or leakage from the systemic circulation, specific uptake from the blood, or local synthesis. We have used RT-PCR and in situ hybridizat...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689409047011
更新日期:1994-10-01 00:00:00
abstract::We adapted a previously described procedure to quantitate collagen in corneal tissue sections prepared from paraffin-embedded samples. The method entailed staining the deparaffinized tissue sections with Sirius red, eluting the bound dye with NaOH-methanol, and estimating the color in a spectrophotometer as an indicat...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688609015119
更新日期:1986-08-01 00:00:00
abstract:PURPOSE:To evaluate the length of the trabecular meshwork (TM) from the scleral spur (SS) to Schwalbe's line (SL) and assess the detectability of the SS in histopathology specimens. METHODS:This study included 158 angle images from 79 cross-sectional slides derived from eyes enucleated for melanoma. The slides were st...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.700757
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:A quick, simple, and efficient extraction technique was developed for the removal of protein from soft hydrophilic contact lenses. METHODS:An extraction solvent consisting of a 50:50 mix of 0.2% trifluoroacetic acid and acetonitrile was used to remove protein from in vitro laboratory-deposited and human-worn c...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.5.503.7049
更新日期:1997-05-01 00:00:00
abstract:PURPOSE:To assess the upper eyelid kinematics during spontaneous blinking in unilateral paralytic lagophthalmos before and after upper eyelid load with gold weight (GW) or autogenous temporalis fascia (TF) sling. DESIGN:Comparative case series. SUBJECTS:Patients with long-standing unresolved unilateral facial palsy w...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.3109/02713683.2015.1031252
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:Corneal scarring is a common poor outcome of corneal trauma. Transforming growth factor β-1 plays a vital role in corneal fibrosis, inducing keratocyte transformation to myofibroblasts. Other than corneal transplantation, no other curative treatment methods for corneal scarring are currently available. Hypercap...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1820526
更新日期:2020-09-11 00:00:00
abstract::The lacrimal gland stores retinyl esters which are synthesized by the enzyme acyl CoA:retinyl acyl transferase. Retinol is released from retinyl ester reserves by retinyl ester hydrolase (REH). Since the lacrimal gland secretes retinol, this gland should also contain this enzyme. To identify bile salt-dependent REH ac...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689209033486
更新日期:1992-09-01 00:00:00
abstract::It has been hypothesized that an activator of Ca-ATPase co-exists with Ca-ATPase in the mouse lens. Though the Ca-ATPase activity could be measured from mouse lens homogenate, its activity could not be determined in individual soluble and insoluble fractions. The Ca-ATPase activity, however, could be detected when an ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409065593
更新日期:1984-05-01 00:00:00
abstract:PURPOSE:To investigate the biomechanical effect induced by radial keratotomy on outflow facility in paired, enucleated whole porcine eyes. METHODS:Freshly enucleated porcine eyes were perfused at a constant pressure of 10 mm Hg. Radial keratotomy (RK), with a 3.5 mm central clear zone and eight radial incisions, was p...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.12.1193.5027
更新日期:1997-12-01 00:00:00
abstract:PURPOSE:To review the microbiological spectrum and antibiotic sensitivities of the pathogens that cause culture-proven endophthalmitis and to understand the status and trends of antibiotic susceptibility at a public hospital over a 10-year period. METHODS:The data of 577 culture-proven endophthalmitis isolates collect...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1188118
更新日期:2017-03-01 00:00:00
abstract::Phosphorylated proteins of the chick lens were identified following incubation of lenses in a medium containing 32P and subsequent analysis by gel electrophoresis. The acidic variant of the vimentin and both subunits of fodrin were phosphorylated, as were the 95 Kd and 49 Kd proteins associated with the beaded-chain f...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409167214
更新日期:1984-07-01 00:00:00