Pathologic changes in the retinal pigment epithelium and Bruch's membrane of fat-fed atherogenic mice.

abstract：:Birefringence variations, seen as regularly spaced altering light and dark rings (bands), have been observed along the length of unfixed, freshly isolated rod outer segments (ROS) of both Rana pipiens and Xenopus laevis. In our hands, the spatial frequency of the banding pattern is from 1.3-1.6u/band in Rana pipiens a...

journal_title：Current eye research

authors： Andrews LD,Mackenzie JM Jr,Basinger SF

更新日期：1984-11-01 00:00:00

abstract：:The cytoskeletal proteins of the human lens were studied by SDS-PAGE, 2-D electrophoresis and immunologically. Spectrin, vimentin and actin were identified in the superficial fiber cells of human lenses even to age 87 years. These proteins are lost from the deeper cortical and nuclear fiber cells, where a broad zone o...

journal_title：Current eye research

authors： Maisel H,Ellis M

更新日期：1984-02-01 00:00:00

abstract：PURPOSE:To investigate whether retinal impairment was affected by age of rats in acute glaucoma model. METHODS:Young adult and aged rats were randomly divided into normal control, 45 mmHg, 60 mmHg and 90 mmHg groups. Intraocular pressures (IOP) of rats were acutely elevated to 45 mmHg, 60 mmHg and 90 mmHg, respectivel...

journal_title：Current eye research

authors： Tan C,Hu T,Peng MC,Liu SL,Tong JB,Ouyang W,Le Y

更新日期：2015-03-01 00:00:00

abstract：:Purpose: To determine the refractive astigmatism following toric intraocular lens (tIOL) implantation without consideration of posterior keratometric astigmatism with a conventional tIOL calculator for eyes with low keratometric astigmatism (0.75D to 2.5D) and to theoretically compare the outcomes with predicted refra...

journal_title：Current eye research

authors： Nanavaty MA,Teeluck K,Bardan AS,Bedi KK,Ali S

更新日期：2019-12-01 00:00:00

abstract：:Purpose/aim of the study: To observe and analyze the weekly changes in morphology and size of vacuoles, so called Wedl cells, in eyes with posterior subcapsular cataract (PSC). MATERIALS AND METHODS:Thirty-six eyes of 36 patients with pronounced PSC were included in this prospective study. High-resolution retroillumi...

journal_title：Current eye research

authors： Neumayer T,Hirnschall N,Georgopoulos M,Findl O

更新日期：2017-12-01 00:00:00

abstract：:Purpose: The optical coherence tomography (OCT) has been used to evaluate the changes of retinal degeneration in patients with diabetic peripheral neuropathy (DPN) in recent years, but the results of previous studies were controversial. Therefore, systematic review and meta-analysis were performed to evaluate the degr...

journal_title：Current eye research

authors： Liu B,Wang W,Zhou R,Zeng X,Zhu Z

更新日期：2021-01-11 00:00:00

abstract：PURPOSE:To explore the roles of interleukin (IL)-17A in alkali-induced corneal neovascularization (CRNV). METHODS:Induction of CRNV by alkali injury was performed and compared in recombinant mouse IL-17A protein or anti-mouse IL-17A neutralizing antibody (Ab)-treated mice. The expression of IL-17A, IL-17A receptor (IL...

journal_title：Current eye research

authors： Liu G,Wu H,Lu P,Zhang X

更新日期：2017-03-01 00:00:00

abstract：:Vernier and grating acuity were measured in infants up to 6 months of age using a two-alternative forced-choice preferential looking technique. Vernier resolution was measured using a horizontal vernier grating. The grating was presented on half of the screen while the other half contained horizontal lines which were ...

journal_title：Current eye research

authors： Manny RE,Klein SA

更新日期：1984-03-01 00:00:00

abstract：OBJECTIVES:To evaluate the suitablity of commercially available moisture retention eyewear for treating evaporative dry eye. METHODS:Eleven patients with evaporative dry eyes were prescibed moisture retention eyewear for 3 months in addition to regular lubricant eye drops. Frequency and severity of dry eye symptoms, c...

journal_title：Current eye research

authors： Waduthantri S,Tan CH,Fong YW,Tong L

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:To evaluate the ultrastructure of the cut edge and associated endothelial cell loss following donor cornea trephination with a standard punch, vacuum punch, and vacuum trephine and artificial anterior chamber system. MATERIALS AND METHODS:This laboratory investigation compared trephinations (8.0 mm) performed ...

journal_title：Current eye research

authors： Moshirfar M,Meyer JJ,Kang PC

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:Membrane-associated mucins are important components of the ocular tear film. Our objective was to characterize the expression of membrane-associated mucins MUC1, MUC4, and MUC16 in healthy cornea, healthy conjunctiva, fibrovascular tissue (pannus) covering the corneal surface in limbal stem cell deficiency (LSC...

journal_title：Current eye research

authors： Pauklin M,Kakkassery V,Steuhl KP,Meller D

更新日期：2009-03-01 00:00:00

abstract：:Glaucoma is increasingly recognized as a neurodegenerative disorder, characterized by the accelerated loss of retinal ganglion cells (RGCs) and their axons. Impaired axonal transport has been implicated as a pathogenic mechanism in a number of neurodegenerative diseases, including glaucoma. The long RGC axon, with its...

journal_title：Current eye research

authors： Fahy ET,Chrysostomou V,Crowston JG

更新日期：2016-01-01 00:00:00

abstract：:From knowledge of the optical parameters of experimental animal eyes and radiometric parameters of the light source, it is possible to provide accurate retinal irradiances (dose rates). Examples are given for the rat, cat, monkey and other animals of interest. Fluorescent lamps and incandescent lamp radiances are prov...

journal_title：Current eye research

authors： Sliney DH

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:The repair of the corneal epithelium is modulated by matrix metalloproteinases. The present study examined the effects of recombinant (r-) tissue inhibitors of metalloproteinases-1 and -2 (TIMP-1 and -2) on the proliferation of cultured epithelial cells from rabbit cornea, and on the spreading of a sheet of squ...

journal_title：Current eye research

authors： Saika S,Kawashima Y,Okada Y,Tanaka SI,Yamanaka O,Ohnishi Y,Ooshima A

更新日期：1998-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to examine the functional connectivity between the primary visual cortex and other cortical areas during rest in normal subjects and patients with comitant strabismus using functional magnetic resonance imaging (fMRI). METHODS:A prospective, observational study was conducted. Ten pati...

journal_title：Current eye research

authors： Yan X,Wang Y,Xu L,Liu Y,Song S,Ding K,Zhou Y,Jiang T,Lin X

更新日期：2019-03-01 00:00:00

abstract：:The present study examined the anti-herpetic effect of the glycoprotein inhibitors, hydroxynorvaline and 2-deoxyglucose, alone and in combination with trifluridine on murine ocular herpes. Following ocular inoculation with a large dose of HSV-1 RE strain (10(6) pfu), ICR mice were treated during the acute infection wi...

journal_title：Current eye research

authors： Gordon YJ,Cheng KP,Araullo-Cruz T,Romanowski E,Johnson BJ,Blough HA

更新日期：1986-02-01 00:00:00

abstract：PURPOSE:To validate the more easily applicable "flush" tear collection technique as a viable alternative to basal and reflex tear collection. MATERIALS AND METHODS:Total protein content (TPC) and immunoglobulin A (IgA) concentrations were determined in the basal, reflex, and flush tears of 16 healthy non-contact lens ...

journal_title：Current eye research

authors： Markoulli M,Papas E,Petznick A,Holden B

更新日期：2011-03-01 00:00:00

abstract：:The corneal endothelium of alloxan diabetic dogs was examined by wide-field specular microscopy and compared to that of age-matched non-diabetic dogs. Computer-assisted morphometry of individual cells showed that the diabetic dog endothelium had marked polymegethism and pleomorphism similar to that previously describe...

journal_title：Current eye research

authors： Yee RW,Matsuda M,Kern TS,Engerman RL,Edelhauser HF

更新日期：1985-07-01 00:00:00

abstract：PURPOSE:To investigate the effect of topical iganidipine, a new dihydropyridine derivative calcium channel blocker, on impairment of the ocular circulation caused by endothelin-1 (ET-1), we examined modification of the effect of ET-1 on visual-evoked potential (VEP) in albino rabbits. METHODS:To clarify whether VEP co...

journal_title：Current eye research

authors： Oku H,Sugiyama T,Kojima S,Watanabe T,Ikeda T

更新日期：2000-02-01 00:00:00

abstract：PURPOSE:The pneumococcal capsule is required for pathogenesis in systemic infections, yet reports show most conjunctivitis outbreaks are caused by nonencapsulated pneumococci, while keratitis infections are caused by encapsulated strains. This study aims to determine the effect of capsule in pneumococcal keratitis and ...

journal_title：Current eye research

authors： Norcross EW,Tullos NA,Taylor SD,Sanders ME,Marquart ME

更新日期：2010-09-01 00:00:00

abstract：:Cornea endothelial cells sensitized with rose bengal and exposed to light demonstrated a wavelength dependent alteration in physiological response. Corneas exposed to 549 millimicron swelled at rates similar to controls exposed to identical energy levels of incandescent light. Corneas exposed to 451, 500, 612, and 651...

journal_title：Current eye research

authors： Hull DS,Csukas S,Green K

更新日期：1981-01-01 00:00:00

abstract：:The water soluble (WS), urea soluble (US) and urea insoluble (UI) fractions from individual human lenses 1.8 to 65 years of age were isolated from concentric fiber layers. In lenses younger than 19 years, a uniform distribution in the amount of WS, US and UI fractions was found throughout the entire lens. These fracti...

journal_title：Current eye research

authors： Li LK,Roy D,Spector A

更新日期：1986-02-01 00:00:00

abstract：:It has been hypothesized that an activator of Ca-ATPase co-exists with Ca-ATPase in the mouse lens. Though the Ca-ATPase activity could be measured from mouse lens homogenate, its activity could not be determined in individual soluble and insoluble fractions. The Ca-ATPase activity, however, could be detected when an ...

journal_title：Current eye research

authors： Iwata S,Shirasawa E,Takehana M

更新日期：1984-05-01 00:00:00

abstract：PURPOSE:A quick, simple, and efficient extraction technique was developed for the removal of protein from soft hydrophilic contact lenses. METHODS:An extraction solvent consisting of a 50:50 mix of 0.2% trifluoroacetic acid and acetonitrile was used to remove protein from in vitro laboratory-deposited and human-worn c...

journal_title：Current eye research

authors： Keith D,Hong B,Christensen M

更新日期：1997-05-01 00:00:00

abstract：:To investigate the role of lymphocytes in the pathogenesis of uveitis, we analyzed the expression of memory markers, CD29 and CD45RO antigens, and apoptosis-related Fas antigen on T lymphocytes in the aqueous humor (AH) and peripheral blood (PB) from patients with uveitis. Using three-color flow cytometry, we assessed...

journal_title：Current eye research

authors： Ohta K,Norose K,Wang XC,Ito S,Yano A,Segawa K

更新日期：1996-03-01 00:00:00

abstract：PURPOSE:This study aims to evaluate and correlate the levels of interleukin-6 (IL-6) and thrombin-antithrombin III complex (TAT) in the vitreous of patients with different vitreoretinal pathologies. METHODS:Vitreous samples were collected from 78 patients scheduled for pars plana vitrectomy at a tertiary medical cente...

journal_title：Current eye research

authors： Ehrlich R,Zahavi A,Axer-Siegel R,Budnik I,Dreznik A,Dahbash M,Nisgav Y,Megiddo E,Kenet G,Weinberger D,Livnat T

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:Oxidative stress is considered a major factor in the deterioration of retinal pigment epithelium (RPE) cells in dry age-related macular degeneration (AMD). The MAPK ERK1/2 can be activated by oxidative stress, may exert both pro- and anti-apoptotic functions, and has recently been proposed as a major factor in ...

journal_title：Current eye research

authors： Koinzer S,Reinecke K,Herdegen T,Roider J,Klettner A

更新日期：2015-01-01 00:00:00

abstract：:Achieving the long-term goal of successful engraftment of retinal tissues into eyes blinded by endogenous retinal failure will depend, at least in part, on controlling the immune response to antigens expressed on retinal grafts. Since histoincompatible tissues will have to be used for such transplants, methods to cont...

journal_title：Current eye research

authors： Jiang LQ,Streilein JW

更新日期：1992-07-01 00:00:00

abstract：PURPOSE:Phagocytosis of rod outer segments (ROS) is an important function of retinal pigment epithelial (RPE) cells. Since the details of the process are not fully known, we studied effects of cytokines produced by RPE and photoreceptor cells on phagocytosis of ROS by rat RPE cells. METHODS:RPE cells were isolated and...

journal_title：Current eye research

authors： Hayashi A,Nakae K,Naka H,Ohji M,Tano Y

更新日期：1996-05-01 00:00:00

abstract：:Intravitreal injection of purified human chorionic gonadotropin (hCG) in rabbits decreased intraocular pressure (IOP). A dose-dependent decrease in IOP was observed with intravitreal hCG concentrations at 30 nM and 100 nM. The onset of this effect was later than 10 hr following the injection and it lasted for more tha...

journal_title：Current eye research

authors： Liu JH,Dacus AC

更新日期：1988-10-01 00:00:00