Vehicle used for triamcinolone acetonide is toxic to ocular tissues of the pigmented rabbit.

abstract：PURPOSE:Matrix metalloproteinases (MMPs) are involved in posterior capsule opacification (PCO), but the mechanisms that promote MMP expression are yet to be determined. In this study, we investigated whether type I collagen, which is only detected in aged or cataractous lens capsules, affects the expression and activat...

journal_title：Current eye research

authors： Shimada A,Miyata Y,Kosano H

更新日期：2014-05-01 00:00:00

abstract：PURPOSE:Increases in matrix proteins, such as type I collagen and fibronectin, are observed with aging in the retinal pigment epithelium (RPE) basement membrane. However, little is known about altered gene expression profiles of RPE associated with increases in matrix proteins. We investigated changes in gene expressio...

journal_title：Current eye research

authors： Imai H,Honda S,Kondo N,Ishibashi K,Tsukahara Y,Negi A

更新日期：2007-10-01 00:00:00

abstract：PURPOSE:To evaluate macular ganglion cell complex (GCC) thickness and peripapillary retinal nerve fiber layer (RNFL) thickness in patients treated with SSRIs. METHODS:The present study included 62 eyes of 31 patients who were using SSRIs and 60 eyes of 30 healthy, age- and gender-matched control subjects. All patients...

journal_title：Current eye research

authors： Guclu H,Gorgulu Y,Gurlu VP,Kose Cinar R,Ozal SA,Çaliyurt O

更新日期：2018-04-01 00:00:00

abstract：:Due to the multiple barriers imposed by the eye against the penetration of drugs, the ocular delivery and targeting are considered difficult to achieve. A major challenge in ocular drug therapy is to improve the poor bioavailability of topically applied ophthalmic drugs by overcoming the severe constraints imposed by ...

journal_title：Current eye research

authors： Souto EB,Doktorovova S,Gonzalez-Mira E,Egea MA,Garcia ML

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:To determine the roles of the murine interleukin-8 receptor homolog (mIL-8Rh, neutrophil chemokine CXC receptor 2) and macrophage inflammatory protein-1alpha (MIP-1alpha, a CC chemokine) in two eye inflammation models: endotoxin-induced uveitis (EIU) and immune complex-induced uveitis (reverse passive Arthus re...

journal_title：Current eye research

authors： Brito BE,O'Rourke LM,Pan Y,Huang X,Park JM,Zamora D,Cook DN,Planck SR,Rosenbaum JT

更新日期：1999-07-01 00:00:00

abstract：:Experiments were conducted to test the influence of thapsigargin on the NaK-ATPase activity of cultured cells (ODM2) derived from human nonpigmented ciliary epithelium. The rate of ouabain-sensitive ATP hydrolysis (Na,K-ATPase activity) was diminished in cells that had been pretreated with thapsigargin then permeabili...

journal_title：Current eye research

authors： Mito T,Kuwahara S,Delamere NA

更新日期：1995-08-01 00:00:00

abstract：PURPOSE/AIM:To quantitatively analyse the evolution of TUNEL-labeling, after in vivo exposure to UVB. METHODS:Altogether, 16 Sprague Dawley rats were unilaterally exposed in vivo for 15 min to close to threshold dose, 5 kJ/m(2), of ultraviolet radiation in the 300 nm wavelength region. Animals were sacrificed in group...

journal_title：Current eye research

authors： Kronschläger M,Yu Z,Talebizadeh N,Meyer LM,Hallböök F,Söderberg PG

更新日期：2013-08-01 00:00:00

abstract：:Previous studies have reported the expression of acidic fibroblast growth factor (aFGF) by rat, bovine, and human retinal pigment epithelium (RPE) in vivo. To critically examine the expression of aFGF by RPE cells, we studied the density dependence of steady-state levels of mRNA and protein expression in vitro. Northe...

journal_title：Current eye research

authors： Kitaoka T,Bost LM,Ishigooka H,Aotaki-Keen AE,Hjelmeland LM

更新日期：1993-11-01 00:00:00

abstract：:Retinal degeneration is a leading cause of untreatable blindness in the industrialised world. It is typically irreversible and there are few curative treatments available. The use of stem cells to generate new retinal neurons for transplantation purposes has received significant interest in recent years and is beginni...

journal_title：Current eye research

authors： Langhe R,Pearson RA

更新日期：2020-03-01 00:00:00

abstract：:Fresh isolates of neonatal human corneal endothelial cells were maintained in tissue culture using a technique employing collagen-coated, dextran-based microcarrier beads. This method provides large yields of endothelial cells suitable for biochemical and/or transplant studies without exposing the cells to enzymatic p...

journal_title：Current eye research

authors： Insler MS,Lopez JG

更新日期：1990-01-01 00:00:00

abstract：:Calpains are calcium-activated proteinases which have been implicated in tissue differentiation and degeneration. The aims of the present study were: (1) to determine the relationship between postnatal age and calpain activity in the rat retina; (2) to test if calpain activity was aberrant in the RCS retina at differe...

journal_title：Current eye research

authors： Azarian SM,Williams DS

更新日期：1995-08-01 00:00:00

abstract：:To enhance efforts directed at unraveling the role and mechanisms of leukocytes in mediating injury to corneal epithelium, an isolated bovine corneal cup was developed and evaluated. Bovine peripheral leukocytes and lysates were added to the corneal epithelial surface of isolated cornea for various periods after which...

journal_title：Current eye research

authors： Elgebaly SA,Gillies C,Forouhar F,Hashem M,Baddour M,O'Rourke J,Kreutzer DL

更新日期：1985-01-01 00:00:00

abstract：:Steroids are widely used in the prevention of corneal neovascularization in a wide range of natural and experimental situations. However, no information is available on their effect on the growth of the individual limbal blood vascular cells or of lymphatic cells involved in corneal neovascularization. In addition, tr...

journal_title：Current eye research

authors： Boneham GC,Collin HB

更新日期：1995-01-01 00:00:00

abstract：:Although experimental models of autoimmune uveitis predict pinealitis coincident with uveitis, there is no direct evidence of pineal pathology accompanying a human uveitis. Horses with naturally occurring uveitis are a potential source of eye and pineal tissues that are not available from human patients with active uv...

journal_title：Current eye research

authors： Kalsow CM,Dwyer AE,Smith AW,Nifong TP

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:To investigate retinal imaging and ablation using femtosecond laser pulses. MATERIALS AND METHODS:Two non-amplified near-infrared femtosecond lasers were used to irradiate porcine retinal specimens in vitro. The lasers were used for tissue removal as well as multiphoton laser scanning microscopy. RESULTS:Abla...

journal_title：Current eye research

authors： Hild M,Krause M,Riemann I,Mestres P,Toropygin S,Löw U,Brückner K,Seitz B,Jonescu-Cuypers C,König K

更新日期：2008-04-01 00:00:00

abstract：:In primates, ciliary muscle contraction causes accommodation and facilitates aqueous outflow. In living rhesus monkeys, accommodative, outflow facility, and ciliary muscle movement responses to cholinergic agonists all decline with age. We developed an apparatus to determine in vitro whether the latter is related to i...

journal_title：Current eye research

authors： Poyer JF,Kaufman PL,Flügel C

更新日期：1993-05-01 00:00:00

abstract：:Purpose: To investigate to what extent the OSDI can be utilized as a discriminative test for clinical findings. Methods: One thousand and ninety patients with dry eye disease (DED) were consecutively included and examined for osmolarity, tear film break-up time (TFBUT), ocular protection index (OPI), ocular surface st...

journal_title：Current eye research

authors： Yazdani M,Chen X,Tashbayev B,Utheim ØA,Ræder S,Hua Y,Eidet JR,Stojanovic A,Dartt DA,Utheim TP

更新日期：2019-09-01 00:00:00

abstract：:Prorenin (PR) was localized by electron microscopic (EM) immunostaining of cryo-ultramicrotomy sections of human ciliary body and correlated with light microscopic immunostaining. Both layers of the ciliary epithelium contained the prohormone. However, density was much higher in the adjacent extracellular spaces, part...

journal_title：Current eye research

authors： Wallow IH,Sramek SJ,Bindley CD,Darjatmoko SR,Gange SJ

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy of intravitreal (IV) triamcinolone acetonide (IVTA) versus subtenon (ST) triamcinolone acetonide (STTA) injection for the treatment of diabetic macular edema (DME). METHODS:Searches for randomized clinical trials published between 1 January 1950 and 15 March 2011 were conducted using ...

journal_title：Current eye research

authors： Qi HP,Bi S,Wei SQ,Cui H,Zhao JB

更新日期：2012-12-01 00:00:00

abstract：PURPOSE:Alternative splicing of the last exon (exon 8) of vascular endothelial growth factor (VEGF) pre-mRNA is a key element in the balance of pro- and anti-angiogenic VEGF isoforms in exudative age-related macular degeneration (exAMD) and proliferative diabetic retinopathy (PDR). Three splicing factors, SRp40, ASF/SF...

journal_title：Current eye research

authors： Carter JG,Cherry J,Williams K,Turner S,Bates DO,Churchill AJ

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:To explore the roles of interleukin (IL)-17A in alkali-induced corneal neovascularization (CRNV). METHODS:Induction of CRNV by alkali injury was performed and compared in recombinant mouse IL-17A protein or anti-mouse IL-17A neutralizing antibody (Ab)-treated mice. The expression of IL-17A, IL-17A receptor (IL...

journal_title：Current eye research

authors： Liu G,Wu H,Lu P,Zhang X

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a member of the TIMP family of proteins, playing a significant role in the control of extracellular matrix remodelling. TIMP-3 might play a role in the regulation of retinal neovascularization during progression of diabetic retinopathy. Recently, three novel p...

journal_title：Current eye research

authors： Beránek M,Kanková K,Tschöplová S,Kolár P,Vácha J

更新日期：2003-08-01 00:00:00

abstract：:Recently, growth factors are known to phosphorylate tyrosine residues of proteins to regulate cellular functions. We investigated growth factor-dependent phosphorylation of membrane proteins in cultured human retinal pigment epithelial (RPE) cells. The phosphorylation experiments were done in membrane preparations of ...

journal_title：Current eye research

authors： Yoshimura N,Kuriyama S,Iwaki M,Honda Y

更新日期：1992-10-01 00:00:00

abstract：PURPOSE:The present study was conducted to develop and characterize a functional primary culture of pigmented rabbit conjunctival epithelial cells on permeable support exhibiting tight barrier properties. METHODS:Conjunctival epithelial cells were isolated by 0.2% protease treatment, cultured at 0.5-1.8 x 10(6) cells/...

journal_title：Current eye research

authors： Saha P,Kim KJ,Lee VH

更新日期：1996-12-01 00:00:00

abstract：PURPOSE:To determine the role of apoptosis in the pathogenesis of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome. METHODS:Forty-three eyes from patients with cytomegalovirus retinitis treated before the introduction of highly active anti-retroviral therapy were examined by routine hi...

journal_title：Current eye research

authors： Buggage RR,Chan CC,Matteson DM,Reed GF,Whitcup SM

更新日期：2000-09-01 00:00:00

abstract：:Recent reports from this laboratory indicate that dopamine (DA2) agonists can lower intraocular pressure (IOP) in rabbits, monkeys and rats. This communication suggests that the cat nictitating membrane (CNM) preparation is a useful model for localizing the site(s) and mechanism(s) of action of dopamine (DA2) agonists...

journal_title：Current eye research

authors： Potter DE,Burke JA

更新日期：1984-11-01 00:00:00

abstract：:Purpose: To compare four visual acuity (VA) scoring termination rules. Methods: A computer simulation generated 30,000 virtual patients who underwent 10 repetitions for each of four termination rules, on both the Snellen and ETDRS charts (2.4 million tests performed in total). Three termination rules focused on the sm...

journal_title：Current eye research

authors： Mimouni M,Shamir RR,Cohen AD,El-Yaniv R,Cohen MJ,Joskowicz L,Blumenthal EZ

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:Age-related macular degeneration (AMD) is the most common cause of visual loss. The dry AMD is characterized by retinal pigment epithelium (RPE) death and changes in AMD lead to severe loss of vision. Coumarin-derived esculetin has a number of therapeutic and pharmacological effects such as anti-inflammatory an...

journal_title：Current eye research

authors： Ozal SA,Turkekul K,Gurlu V,Guclu H,Erdogan S

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:Post-surgical macular edema is an important clinical problem resulting from breakdown of the blood-retinal barrier (BRB) after surgery. This study was designed to develop a mouse model of post-surgical BRB breakdown. METHODS:Two 25-gauge needles, one for infusion and one for aspiration, were inserted through t...

journal_title：Current eye research

authors： Liu H,Demetriades AM,Xiao WH,Campochiaro PA,Vinores SA

更新日期：2004-06-01 00:00:00

abstract：PURPOSE:To assess changes in retinal vascular caliber in response to short-term use of nepafenac eye drops in patients with mild diabetic macular edema. MATERIALS AND METHODS:Thirty-four patients with previously untreated bilateral mild diabetic macular edema were included in this prospective study. For each participa...

journal_title：Current eye research

authors： Evliyaoğlu F,Akpolat Ç,Kurt MM,Çekiç O,Nuri Elçioğlu M

更新日期：2018-03-01 00:00:00