Abstract:
:Retinal degeneration is a leading cause of untreatable blindness in the industrialised world. It is typically irreversible and there are few curative treatments available. The use of stem cells to generate new retinal neurons for transplantation purposes has received significant interest in recent years and is beginning to move towards clinical trials. However, such approaches are likely to be most effective for relatively focal areas of repair. An intriguing complementary approach is endogenous self-repair. Retinal cells from the ciliary marginal zone (CMZ), retinal pigment epithelium (RPE) and Müller glial cells (MG) have all been shown to play a role in retinal repair, typically in lower vertebrates. Among them, MG have received renewed interest, due to their distribution throughout (centre to periphery) the neural retina and their potential to re-acquire a progenitor-like state following retinal injury with the ability to proliferate and generate new neurons. Triggering these innate self-repair mechanisms represents an exciting therapeutic option in treating retinal degeneration. However, these cells behave differently in mammalian and non-mammalian species, with a considerably restricted potential in mammals. In this short review, we look at some of the recent progress made in our understanding of the signalling pathways that underlie MG-mediated regeneration in lower vertebrates, and some of the challenges that have been revealed in our attempts to reactivate this process in the mammalian retina.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Langhe R,Pearson RAdoi
10.1080/02713683.2019.1669665subject
Has Abstractpub_date
2020-03-01 00:00:00pages
349-360issue
3eissn
0271-3683issn
1460-2202journal_volume
45pub_type
杂志文章abstract::Phosphorylated proteins of the chick lens were identified following incubation of lenses in a medium containing 32P and subsequent analysis by gel electrophoresis. The acidic variant of the vimentin and both subunits of fodrin were phosphorylated, as were the 95 Kd and 49 Kd proteins associated with the beaded-chain f...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409167214
更新日期:1984-07-01 00:00:00
abstract::Thyroxine-treated human lens epithelial cells, HLE B-3, were grown in either a normoxic or hyperoxic atmosphere as a first step in identifying factors related to their increased viability. Reactive oxygen species, ROS, and the apparent mitochondrial membrane potential, Delta Psi(m), were measured using fluorescent pro...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680802167554
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Aqueous extract of Pleurotus tuberregium (PT) has been shown to reduce intraocular pressure (IOP) but the underlying mechanism has not been explained. PURPOSE:To investigate the effect of PT on the bovine iris in vitro in comparison with acetylcholine (ACh). METHOD:Strips of the iris were mounted in 10 ml ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.747615
更新日期:2013-03-01 00:00:00
abstract:PURPOSE:Intravitreal injection of ciliary neurotrophic factor (CNTF) is known to induce glial intermediate filament protein (GFAP) expression in retinal Müller cells. Because CNTF binding can activate multiple signaling kinases, we have examined the involvement of JAK/STAT pathway in GFAP induction in Müller cells. ME...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.24.4.305.8408
更新日期:2002-04-01 00:00:00
abstract:PURPOSE:To study the effect of cataract surgery with intraocular lens (IOL) on frequency doubling perimetry (FDP). METHODS:Patients aged 40 years or above seen at our outpatient clinic with no ocular pathology except for visually significant cataract and visual acuity 6/24 or better were eligible. They underwent FDP b...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680490904278
更新日期:2005-02-01 00:00:00
abstract::The cytoskeletal proteins of the human lens were studied by SDS-PAGE, 2-D electrophoresis and immunologically. Spectrin, vimentin and actin were identified in the superficial fiber cells of human lenses even to age 87 years. These proteins are lost from the deeper cortical and nuclear fiber cells, where a broad zone o...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688408997222
更新日期:1984-02-01 00:00:00
abstract::Purpose: To map the time course of changes in intraocular straylight of the human eye 1 year after initial lens wearing for orthokeratology treatment using the objective double-pass technique. Materials and Methods: A total of 35 subjects (19 males and 16 females) completed the study. The mean age was 11.46 ± 2.33 yea...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1514056
更新日期:2019-01-01 00:00:00
abstract::Rainbow trout (Oncorhynchus mykiss) were used to model the solar radiation-induced cataract that occurs in hatchery-reared lake trout (Salvelinus namaycush). Rainbow trout eyes were exposed to wideband predominantly UVB radiant energy from a filtered 1000W xenon source. Lenticular damage was assessed and classified an...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689308999477
更新日期:1993-02-01 00:00:00
abstract:PURPOSE:Acanthamoeba keratitis is a sight-threatening corneal infection. It is known that: (i) more amoebae bind to the surface of injured corneas than to the normal corneal surface and (ii) mannose-containing glycoproteins (GPs) possess binding sites for Acanthamoeba. The present study was undertaken to determine whet...
journal_title:Current eye research
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract::Four groups of BALB/c mice were treated locally with different concentrations (0.1-1.0%) of retinoic acid (Etretinate) ointment for a period of one to four weeks. A fifth group was treated with the ointment base only. Ia-positive dendritic cells were identified by an indirect immunofluorescence technique which was con...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689509033511
更新日期:1995-03-01 00:00:00
abstract::Importance: To analyze the characteristics and risk factors for pupillary capture (PC) of the intraocular lens (IOL) in congenital ectopia lentis (CEL) patients.Methods: Data of CEL patients who underwent lens extraction and intraocular implantation from 2013 to 2016 at Zhongshan Ophthalmic Center in China were collec...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1668418
更新日期:2020-04-01 00:00:00
abstract::Serum zinc and copper levels were analyzed in 26 retinitis pigmentosa patients and compared with serum zinc levels of a control group. Serum zinc levels were documented to be decreased with a mean concentration of 0.735 +/- 0.167 micrograms/ml (p less than 0.001). Serum copper levels, on the other hand, were found to ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409011750
更新日期:1984-08-01 00:00:00
abstract:OBJECTIVES:To evaluate the suitablity of commercially available moisture retention eyewear for treating evaporative dry eye. METHODS:Eleven patients with evaporative dry eyes were prescibed moisture retention eyewear for 3 months in addition to regular lubricant eye drops. Frequency and severity of dry eye symptoms, c...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2014.932389
更新日期:2015-05-01 00:00:00
abstract:PURPOSE:Compare the efficacy of treatment of pneumococcal keratitis with cholesterol, moxifloxacin, or a mixture of the two (moxifloxacin/cholesterol). MATERIALS AND METHODS:New Zealand white rabbits were injected intrastromally with 10(6) colony-forming units (CFU) of a clinical keratitis strain of Streptococcus pneu...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2010.512114
更新日期:2010-12-01 00:00:00
abstract::The 'fast PIII' rod mediated photoreceptor response to flashes of monochromatic light has been investigated in isolated retinae of the RCS rat at age 30 days. A loss of both sensitivity and maximum response amplitude were found, with a concurrent slowing of the response kinetics. These observations indicate a rod abno...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409000805
更新日期:1984-09-01 00:00:00
abstract::Purpose: To evaluate the microvascular density of the peripapillary and parafoveal areas of the eyes with primary angle closure disease (PACD) using optical coherence tomography angiography (OCTA). Materials and methods: An observational study was conducted with 76 PACD patients (29 eyes with primary angle closure sus...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1849728
更新日期:2020-11-26 00:00:00
abstract:PURPOSE:Recent advances in technology now provide tools capable of tracking genome-wide expression changes occurring in progressive pathological processes. The present experiments were carried out to determine if acetylcholine receptor α 6 subunit (Chrna6) is a reliable retinal ganglion cell (RGC) marker in adult mouse...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.724512
更新日期:2013-01-01 00:00:00
abstract::The management of opportunistic infections is a significant problem in acquired immunodeficiency syndrome (AIDS) and the development of more effective chemotherapeutic agents is needed. We present the ocular manifestations of an AIDS-like disease in rhesus monkeys experimentally infected with simian immunodeficiency v...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689008999571
更新日期:1990-08-01 00:00:00
abstract:PURPOSE/AIM OF THE STUDY:Polarization-sensitive anterior-segmental optical coherence tomography (PS-OCT) is useful to evaluate the filtering blebs after trabeculectomy. However, the attenuation phenomenon of OCT signal disturbs the visibility of intra-bleb's structure and distribution of birefringence; a specific param...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1825749
更新日期:2020-10-04 00:00:00
abstract::Lenses from normal Wistar rats and those from a Wistar strain with X-ray-induced cataract mutation were examined electron microscopically for morphological characterization and acid phosphatase (AcPase) localization. Ocular anlages of 11 through 18 days of gestation were included in the study. A late-separating or per...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409003064
更新日期:1984-04-01 00:00:00
abstract:PURPOSE:Retinal pigment epithelial (RPE) cell proliferation is an important step in the pathogenesis of ocular diseases such as proliferative retinopathy. Growth factors play a major role in modulating the development and progression of these diseases. The aim of this study was to examine the effects of single growth f...
journal_title:Current eye research
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
abstract:PURPOSE:A pilot study was conducted to evaluate human corneal epithelial cell shedding in response to wearing a silicone hydrogel contact lens/solution combination inducing corneal staining. The nature of ex vivo collected cells staining with fluorescein was also examined. METHODS:A contralateral eye study was conduct...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.3109/02713683.2013.841255
更新日期:2014-03-01 00:00:00
abstract:PURPOSE:To identify vitreous proteins that were differentially expressed in patients suffering from proliferative diabetic retinopathy with active neovascularization. METHODS:The vitreous samples of 15 active proliferative diabetic retinopathy patients were analyzed by two-dimensional gel electrophoresis and mass spec...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680600557030
更新日期:2006-03-01 00:00:00
abstract:PURPOSE:The present study was aimed to investigate the expression of purinergic P2 receptors in oxygen-induced retinal neovascularization. METHODS:Immunohistochemistry was used to study the expression of purinergic P2Y2 and P2X2 receptors in the neonatal mouse retina during normal vascular development and after oxygen...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680701885470
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:So far tear substitutes have demonstrated a limited role in restoring ocular surface damage in dry eye syndrome (DES). The aim of this study was to assess the efficacy of a new ocular surface modulator in an in vitro model of human corneal epithelium (HCE) damaged by severe osmotic stress mirroring the features...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1184282
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:Age-related macular degeneration (AMD) is the most common cause of visual loss. The dry AMD is characterized by retinal pigment epithelium (RPE) death and changes in AMD lead to severe loss of vision. Coumarin-derived esculetin has a number of therapeutic and pharmacological effects such as anti-inflammatory an...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1481517
更新日期:2018-09-01 00:00:00
abstract::The effect of electrical stimulation of the sympathetic nerves on the blood-aqueous barrier was investigated in rabbits. The permeability of the barrier was assessed during either acute, chronic or following chronic nerve stimulation. During acute and chronic stimulation of the sympathetic nerves, fluorescein entered ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689009069929
更新日期:1990-10-01 00:00:00
abstract::Levels of rhodopsin in the photoreceptors of Long-Evans rats were reduced by approximately 55% through dietary deprivation of vitamin A. The interaction of visual pigment with G-protein was examined in receptor outer segment (ROS) membranes obtained from these animals. A binding assay was used to quantitate affinity o...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688908996390
更新日期:1989-04-01 00:00:00
abstract:PURPOSE:The purpose of these studies is to develop an in vitro model of corneal endothelial aging and to investigate age-related changes in morphology, mitosis, prostaglandin synthesis and prostaglandin response pathways. METHODS:First-passage rabbit corneal endothelial cells were grown in vitro for up to 30 days afte...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.5.428.7048
更新日期:1997-05-01 00:00:00
abstract:PURPOSE:To assess changes in retinal vascular caliber in response to short-term use of nepafenac eye drops in patients with mild diabetic macular edema. MATERIALS AND METHODS:Thirty-four patients with previously untreated bilateral mild diabetic macular edema were included in this prospective study. For each participa...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.1080/02713683.2017.1399425
更新日期:2018-03-01 00:00:00