Abstract:
:DNA sequence analysis of overlapping shotgun and restriction fragments have revealed the entire sequence of the human lens fiber cell intrinsic membrane protein MP19 gene (also termed MP17, MP18, and MP20). The 8,056 bp MP19 gene contains 5 exons encoding a mature protein of 173 amino acids, which displayed a very high degree of identity (91%) with that of bovine MP19, deduced from a bovine cDNA sequence. The exon range in size from 52 bases (exon 1) to about 340 bases (exon 5). The introns consist of two large segments (introns B and C) of about 4,700 bases and 1,800 bases, respectively, and two small segments (intron A and D) of about 450 and 250 bases each. Seven Alu family DNA repeats are found within the human MP19 gene. The sequenced gene includes 100 bases of 5' flanking sequence.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Church RL,Wang JHdoi
10.3109/02713689309033503subject
Has Abstractpub_date
1993-12-01 00:00:00pages
1057-65issue
12eissn
0271-3683issn
1460-2202journal_volume
12pub_type
杂志文章abstract:PURPOSE:Corneal autofluorescence is related to advanced glycation end products formed by glucose that reaches the cornea via the aqueous humour. The aim of the study was to examine the influence on autofluorescence of changes in permeability of the blood aqueous barrier. METHODS:Corneal autofluorescence was measured i...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.26.4.307.15433
更新日期:2003-05-01 00:00:00
abstract:PURPOSE:The pneumococcal capsule is required for pathogenesis in systemic infections, yet reports show most conjunctivitis outbreaks are caused by nonencapsulated pneumococci, while keratitis infections are caused by encapsulated strains. This study aims to determine the effect of capsule in pneumococcal keratitis and ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2010.492462
更新日期:2010-09-01 00:00:00
abstract::The short and long term response of the trabecular meshwork to a phagocytic challenge and the response of the meshwork to different types of foreign particles was studied by injecting one eye of 25 adult cats with a phagocytic agent (zymosan, blood, or latex microspheres) while the fellow eye received a control soluti...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688909000037
更新日期:1989-11-01 00:00:00
abstract:PURPOSE:To investigate epithelial cell adhesion and proliferation on a newly developed elastin-like polymer (ELP) that mimics the functional characteristics of extracellular matrices. MATERIALS AND METHODS:A genetically engineered ELP with cell attachment sequences was adsorbed onto glass coverslips as 1, 2, or 3 mole...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680802542053
更新日期:2009-01-01 00:00:00
abstract::Lacrimal gland fluid is an important component of the precorneal tear film. The rate of lacrimal gland fluid secretion is controlled primarily by parasympathetic innervation, and it is, apparently, modulated by sympathetic innervation. Lacrimal gland fluid is produced in two stages, secretion of a primary fluid which ...
journal_title:Current eye research
pub_type: 杂志文章,评审
doi:10.3109/02713688908995761
更新日期:1989-06-01 00:00:00
abstract:PURPOSE:To optimize cultured human corneal endothelial cell (cHCEC) sheet transplantation technique for maintenance of cHCEC viability. MATERIALS AND METHODS:cHCEC sheets cultured on a collagen scaffold were covered with or without Viscoat® and exposed to humidified air in the incubator. cHCEC sheets with or without V...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2015.1101774
更新日期:2016-09-01 00:00:00
abstract:PURPOSE:To investigate the therapeutic role of topical and oral fluconazole treatment using a rabbit model of Aspergillus fumigatus keratitis. METHODS:Aspergillus fumigatus spores were injected into the corneal stroma of the right eye of 20 rabbits. Forty-eight hours later the rabbits were randomly divided into three ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.26.2.113.14514
更新日期:2003-02-01 00:00:00
abstract:PURPOSE:To quantitatively measure the flow, nonflow, density, and foveal avascular zone (FAZ) assessment tool parameters of optical coherence tomography angiography (OCTA) in patients with nonocular Behcet's Disease (BD), and to compare the results with those obtained in healthy controls. METHODS:FAZ parameters, flow ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1530361
更新日期:2019-02-01 00:00:00
abstract::Purpose: To investigate to what extent the OSDI can be utilized as a discriminative test for clinical findings. Methods: One thousand and ninety patients with dry eye disease (DED) were consecutively included and examined for osmolarity, tear film break-up time (TFBUT), ocular protection index (OPI), ocular surface st...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1604972
更新日期:2019-09-01 00:00:00
abstract::Purpose: The purpose of this study is to present the study design and one month's preliminary results of a 2-year randomized trial, Combined Atropine with Orthokeratology (AOK), for myopia control study. Methods: Children aged 6 to <11 years and with 1.00-4.00 D myopia were randomly assigned to AOK group or ortho-k al...
journal_title:Current eye research
pub_type: 杂志文章,随机对照试验
doi:10.1080/02713683.2019.1568501
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:The mechanism by which prostaglandin(PG)F2 alpha increases uveoscleral outflow and lowers intraocular pressure in primates is not known. In cultured human ciliary muscle cells, PGF2 alpha induces the expression of the protooncogene c-fos which is known to induce the transcription of genes such as matrix metallo...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689609017628
更新日期:1996-08-01 00:00:00
abstract::Water-soluble (WS) and water-insoluble (WI) crystallins were prepared from calf and bovine lenses. The WS-crystallins were analyzed by capillary isotachophoresis and by immunoelectrophoresis with polyvalent and alpha-, beta-, gamma-crystallin specific antisera. The WI-crystallins were first solubilized in formamide an...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409065590
更新日期:1984-05-01 00:00:00
abstract:PURPOSE:To study the efficacy and outcomes of short-term postoperative vitreoretinal tamponade with perfluorocarbon heavy liquid in patients with giant retinal tear. MATERIALS AND METHODS:The study group consisted of 13 consecutive patients (13 eyes) who presented with giant retinal tear at a tertiary medical center i...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2016.1266664
更新日期:2017-07-01 00:00:00
abstract:PURPOSE:To determine by immunohistochemistry the distribution of different nitric oxide synthases (NOS) isoforms in the porcine eye. METHODS:By light microscopy (immunofluorescence), porcine ocular tissues were investigated using monoclonal antibodies against neuronal NOS (nNOS; NOS I), endothelial NOS (ecNOS; NOS III...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.18.5.375.5355
更新日期:1999-05-01 00:00:00
abstract::Corneal acidosis has been shown to reduce corneal hydration control (CHC) as measured by the rate, expressed as the percent recovery per hour (PRPH), at which the thickness of the cornea decreases exponentially after an increased hydration load. Since the effect of pH on corneal function is of scientific interest and ...
journal_title:Current eye research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/02713689508999932
更新日期:1995-05-01 00:00:00
abstract:PURPOSE:To explore the in vitro proliferative potential of human limbal epithelial cells after 31 degrees C organ-culture storage and to investigate putative factors influencing it. METHODS:185 cultures of limbal explants were carried-out either from full-thickness explants (n = 102) or from enzymatically dissociated ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680600681228
更新日期:2006-05-01 00:00:00
abstract::Using phosphorus-31 nuclear magnetic resonance (P-31 NMR) spectroscopy the rat crystalline lens was evaluated as a potential animal model for the study of lens metabolic processes relevant to the human. The P-31 NMR spectra of intact rat lenses and rat lens PCA extracts provided comparable qualitative and quantitative...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688109019974
更新日期:1981-01-01 00:00:00
abstract::The selective DA2 agonist, N-0437, produced an acute reduction in intraocular pressure (IOP) and pupil diameter (PD) when applied topically to the eyes of normal monkeys. Ocular hypotension and miosis were primarily unilateral in nature, dose-related and lasted 3 to 5 hours following drug instillation. In normal monke...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688708997557
更新日期:1987-11-01 00:00:00
abstract:PURPOSE:The aim of this study was to characterize a standardized porcine ex-vivo testing system for intraocular pressure (IOP) monitoring after vitrectomy with different endotamponades. METHODS:Twenty-four pig eyes, six per endotamponade group were obtained immediately postmortem. After pars plana vitrectomy, vitreous...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2017.1297461
更新日期:2017-08-01 00:00:00
abstract:PURPOSE:To investigate the tissue blood flow in the neuroretinal rim of the optic disk and macula after rhegmatogenous retinal detachment (RRD) surgery. METHODS:Tissue blood flow in the neuroretinal rim of the optic disk and macula was measured with the Heidelberg retina flowmeter in 53 eyes of 53 patients who had und...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680701531108
更新日期:2007-09-01 00:00:00
abstract::Purpose: To determine the refractive astigmatism following toric intraocular lens (tIOL) implantation without consideration of posterior keratometric astigmatism with a conventional tIOL calculator for eyes with low keratometric astigmatism (0.75D to 2.5D) and to theoretically compare the outcomes with predicted refra...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1638418
更新日期:2019-12-01 00:00:00
abstract::We assessed the role of platelet-activating factor (PAF) in corneal allograft rejection and evaluated the effects of a PAF antagonist on corneal inflammation, cellular infiltration, vascularization, and edema. Rabbits with vascularized corneas served as recipients of allogeneic cornea grafts. Rabbits with normal corne...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689409042408
更新日期:1994-02-01 00:00:00
abstract::The ocular penetration pathways of three alpha 2-adrenergic agents (p-aminoclonidine, AGN 190342, and clonidine) were investigated in rabbits both in vitro and in vivo. The corneal permeabilities of the compounds correlated positively with their octanol/water distribution coefficients. The ocular drug absorption via c...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689008997579
更新日期:1990-11-01 00:00:00
abstract:PURPOSE:To evaluate the effect of the birth weight and the postconceptional age on the tear production of preterm and term newborn infants and to evaluate the changes in tear production during the first two months of life. SUBJECTS--METHODS: Both eyes of medically stable term and preterm infants were included in the st...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.28.2.145.26235
更新日期:2004-02-01 00:00:00
abstract::We have examined the T cell specificity of a Lewis rat T cell line (R208) specific for a pathogenic, 123 residue cyanogen bromide produced peptide of bovine S-antigen by using two independent sets of overlapping synthetic peptides representing the entire length of the 123 residue fragment. S-antigen, a 48 kDa immunopa...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689008999429
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:Experiments were performed to evaluate the effect of various pro- and anti-inflammatory cytokines on the human fetal retinal pigment epithelium's (HFRPE) expression of major histocompatibility complex (MHC) and costimulatory molecules. METHODS:Pure cultures of HFRPE cells were isolated. HFRPE cells were incuba...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.23.4.285.5456
更新日期:2001-10-01 00:00:00
abstract::The goal of this study was to determine the effect of extracellular matrix components on the phagocytic function of the retinal pigment epithelial (RPE) cell. Cultured human fetal RPE cells were established in culture and plated on three commercially-prepared substrates: collagen IV, fibronectin and laminin and on thr...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689609017607
更新日期:1996-01-01 00:00:00
abstract::Purpose: To determine the prevalence of posterior segment manifestations among consecutive patients with pathological myopia attending our University Hospital general ophthalmology clinic and their association with age, refractive error, axial length and each other. Methods: Patients diagnosed with pathological myopia...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1606252
更新日期:2019-09-01 00:00:00
abstract::In experimental work on retinal ischemia and its medical management, we have been disturbed by the large variations in the electroetinogram (ERG) recovery of rabbit eyes subjected to similar degrees of ischemia. We investigated whether body temperature might be one of the critical factors. We studied pigmented Dutch r...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689508999918
更新日期:1995-02-01 00:00:00
abstract::Purpose: To evaluate the microvascular density of the peripapillary and parafoveal areas of the eyes with primary angle closure disease (PACD) using optical coherence tomography angiography (OCTA). Materials and methods: An observational study was conducted with 76 PACD patients (29 eyes with primary angle closure sus...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1849728
更新日期:2020-11-26 00:00:00