Abstract:
:Macrophages are invariably present in the intraocular membranes of patients with traumatic proliferative vitreoretinopathy (PVR). There are two sources from which these macrophages could be recruited: adjacent tissues and the systemic circulation. In the study described herein, the role of circulating white blood cells and monocytes in experimental, traumatic PVR was studied. The circulating white blood cells of 20 rabbits were depleted by intravenous injection of strontium-89. Posterior perforating eye injury with subsequent intravitreal injection of autologous whole blood or autologous activated macrophages was then performed on these leukopenic animals. The experiments demonstrated that severe bone marrow depression reduced significantly the incidence of retinal detachments in eyes receiving whole blood, and reduced the severity of retinal detachments in eyes injected with activated macrophages. An association between the degree of leukopenia, monocytopenia, and protection from retinal detachment was demonstrated. These results support the hypothesis that macrophage infiltration is an important component of intraocular cellular proliferation, but does not exclude the role of other types of white blood cells in the pathogenesis of PVR.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Gabrielian K,Wang HM,Lee M,Ogden TE,Ryan SJdoi
10.3109/02713689409042392subject
Has Abstractpub_date
1994-01-01 00:00:00pages
1-9issue
1eissn
0271-3683issn
1460-2202journal_volume
13pub_type
杂志文章abstract::The effects of 4% epinephrine bitartrate and 0.5% timolol on ocular and optic nerve blood flow were studied in phakic and aphakic rabbit eyes using a radioactive microsphere (85Sr) technique. Either epinephrine or timolol was given topically as eight drops in the hour immediately preceding blood flow measurements (one...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409000822
更新日期:1984-10-01 00:00:00
abstract::Lipid synthesis was investigated in bovine lens in organ culture for 9 hours using 14C acetate as a precursor. The greatest incorporation occurred in phospholipid fraction with phosphatidyl choline being the major phospholipid labeled. Considerable activity was incorporated in the free fatty acid fraction, cholesterol...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688709034889
更新日期:1987-09-01 00:00:00
abstract:PURPOSE:Post-surgical macular edema is an important clinical problem resulting from breakdown of the blood-retinal barrier (BRB) after surgery. This study was designed to develop a mouse model of post-surgical BRB breakdown. METHODS:Two 25-gauge needles, one for infusion and one for aspiration, were inserted through t...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680490503769
更新日期:2004-06-01 00:00:00
abstract::Cultured retinal glial cells from the rat are responsive to modulation by vasoactive intestinal peptide (VIP). VIP (1 X 10(-6) M) elevated the intracellular cyclic AMP concentration from the basal level of (4.4-11.1) p mole/mg protein to (354-440) p mole/mg protein in three minutes at 25 degrees C. The half-maximal co...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688909000045
更新日期:1989-11-01 00:00:00
abstract:PURPOSE:Recent advances in technology now provide tools capable of tracking genome-wide expression changes occurring in progressive pathological processes. The present experiments were carried out to determine if acetylcholine receptor α 6 subunit (Chrna6) is a reliable retinal ganglion cell (RGC) marker in adult mouse...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.724512
更新日期:2013-01-01 00:00:00
abstract:AIM:To test the feasibility of implanting human anterior lens capsules (HALCs) with porcine corneal endothelial cells (pCEC) in vivo in Göttingen minipigs and at the same time test the suitability of Göttingen minipig as model for endothelial keratoplasty. MATERIALS AND METHODS:Cell-carrier constructs of decellularize...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1706747
更新日期:2020-08-01 00:00:00
abstract::Prorenin (PR) was localized by electron microscopic (EM) immunostaining of cryo-ultramicrotomy sections of human ciliary body and correlated with light microscopic immunostaining. Both layers of the ciliary epithelium contained the prohormone. However, density was much higher in the adjacent extracellular spaces, part...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689309020401
更新日期:1993-10-01 00:00:00
abstract::In uveal vessels of isolated arterially perfused rabbit eyes there is direct evidence for the presence of post-junctional alpha 1-receptors and indirect evidence for alpha 2-receptors. Since vasoconstriction by epinephrine could not be blocked by an alpha 1-antagonist, only 30% by an alpha 2-antagonist and almost full...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688508999963
更新日期:1985-01-01 00:00:00
abstract:PURPOSE:Deficiency in Cystathionine β-synthase (CBS) leads to an abnormal accumulation of homocysteine and results in classical homocystinuria, a multi-systemic disorder that affects connective tissue, muscles, the central nervous system, and the eyes. However, the genetic players and mechanisms underlying vision alter...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2020.1818262
更新日期:2020-09-07 00:00:00
abstract:PURPOSE:To compare the quality of corneal endothelium of precut Descemet-stripping automated endothelial keratoplasty (DSAEK) tissue when transported with and without the anterior lamellar corneal tissue (ALCT) when organ-culture corneal storage methods are used. METHODS:After microkeratome-assisted excision of anteri...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2011.648045
更新日期:2012-02-01 00:00:00
abstract::With Golgi impregnation, a simple amacrine cell type is described in the chick retina. The most relevant morphological feature of these retinal neurons is a single straight, radial trunk which dichotomizes tangentially in a rectilinear expansion in the 5th stratum of the inner plexiform layer (IPL). ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688908995187
更新日期:1989-02-01 00:00:00
abstract:PURPOSE:C5a anaphylatoxin is a potent inflammatory mediator that acts on polymorphonuclear cells (PMN) and monocytes via C5a receptors (C5aR). It mediates chemotaxis of both cell types and stimulates cytokine release from the latter. To investigate whether C5a can act on retinal pigment epithelial (RPE) cells, we exami...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.23.5.320.5437
更新日期:2001-11-01 00:00:00
abstract::We measured the relative solubility of collagen in acetic acid after pepsin digestion and tentatively identified the types of collagen present in corneas of rabbits of various ages and in corneal scar tissue, using hydroxyproline assays and polyacrylamide gel electrophoretic analyses. More than 80% of the collagen in ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688109019966
更新日期:1981-01-01 00:00:00
abstract:PURPOSE:We performed nailfold capillary microscopy to explore microvasculature abnormalities in uveitis overall and uveitis stratified in various ways. METHODS:This was a cross-sectional, case-control, observational study. One hundred and seven uveitis patients and 130 control subjects were included. We used a JH-1004...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1496265
更新日期:2018-11-01 00:00:00
abstract:PURPOSE:To investigate the association of nailfold capillaroscopy, heart rate variability (HRV), and clinical characteristics of glaucoma with the plasma matrix metalloproteinase-9 (MMP-9) level in normal-tension glaucoma (NTG). MATERIALS AND METHODS:We conducted a prospective, cross-sectional study on 25 patients wit...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2014.971937
更新日期:2015-01-01 00:00:00
abstract::Papavarine, cholera toxin, and isoproterenol each elevated cyclic AMP in cultured rat retinal pigment epithelium and reduced the phagocytosis of isolated rod outer segments (38-66% of controls) during a 4 hour incubation. In addition, cultured pigment epithelium was preincubated with 25 mM exogenous cyclic AMP for two...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688608995161
更新日期:1986-01-01 00:00:00
abstract:PURPOSE:To characterize the pupil light reflex (PLR), electroretinographic (ERG) and tonometric parameters in healthy rat eyes. METHODS:Brown Norway rats were used for experiments. The PLR was evaluated with a computerized pupillometer (n = 27), ERGs were recorded simultaneously from both eyes (n = 27) and IOP was mea...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.25.2.69.10156
更新日期:2002-08-01 00:00:00
abstract::Intravitreal injection of purified human chorionic gonadotropin (hCG) in rabbits decreased intraocular pressure (IOP). A dose-dependent decrease in IOP was observed with intravitreal hCG concentrations at 30 nM and 100 nM. The onset of this effect was later than 10 hr following the injection and it lasted for more tha...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688809015151
更新日期:1988-10-01 00:00:00
abstract:PURPOSE:To investigate the expression in the mouse retina and the function in a retinal cell of cullin5 that is known as a protein that is associated with ubiquitilation. METHODS:The retinal sites of expressing cullin5 were determined by immunohistochemistry with a specific antibody for cullin5. Retinal cells were tra...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2010.514658
更新日期:2011-01-01 00:00:00
abstract::Components of the Renin Angiotensin System (RAS) have been detected in ocular tissues and fluids. The source of the ocular RAS proteins is unknown but possibilities include diffusion or leakage from the systemic circulation, specific uptake from the blood, or local synthesis. We have used RT-PCR and in situ hybridizat...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689409047011
更新日期:1994-10-01 00:00:00
abstract:PURPOSE:Intravitreal injection of ciliary neurotrophic factor (CNTF) is known to induce glial intermediate filament protein (GFAP) expression in retinal Müller cells. Because CNTF binding can activate multiple signaling kinases, we have examined the involvement of JAK/STAT pathway in GFAP induction in Müller cells. ME...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.24.4.305.8408
更新日期:2002-04-01 00:00:00
abstract:PURPOSE:The aim of this study was to establish the antioxidant status and oxidative stress in patients with primary open-angle glaucoma (POAG) and pseudoexfoliative glaucoma (PEG). METHODS:Serum levels of total antioxidant capacity (TAC) and superoxide dismutase (SOD) as indicators of antioxidant status; and total oxi...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2011.584370
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:Previous studies revealed an association of tumor necrosis factor super family-15 (TNFSF15) gene polymorphisms with several autoimmune diseases, but their roles in the development of Graves' disease (GD) and Graves' ophthalmopathy (GO) remain unclear. The aim of this study was to explore the correlation between...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2019.1705494
更新日期:2020-07-01 00:00:00
abstract:PURPOSE:To investigate the effects of rapamycin on the TNF-α-induced secretion of interleukin-6 (IL-6) and IL-8 in orbital fibroblasts and its possible mechanism. MATERIALS AND METHODS:Orbital fibroblasts were obtained from patients with thyroid-associated ophthalmopathy. IL-6 and IL-8 levels were measured by enzyme-l...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2012.750368
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:The purpose of these studies is to develop an in vitro model of corneal endothelial aging and to investigate age-related changes in morphology, mitosis, prostaglandin synthesis and prostaglandin response pathways. METHODS:First-passage rabbit corneal endothelial cells were grown in vitro for up to 30 days afte...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.16.5.428.7048
更新日期:1997-05-01 00:00:00
abstract:BACKGROUND:Spectral domain optical coherence tomography (SD-OCT) in patients can deliver retinal cross-sectional images with high resolution. This may allow the evaluation of the extent of damage to the retinal pigment epithelium (RPE) and the neurosensory retina after laser treatment. This article aims to investigate ...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713680902964892
更新日期:2009-07-01 00:00:00
abstract:PURPOSE:Folic acid (FA) is an essential nutrient for normal embryonic development. FA deficiency (FAD) in maternal diet increases the risk of several defects among the progeny, especially, neural tube defects. The eye begins its development from the neural tube; however, the relationship between FAD and ocular developm...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1545911
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:To examine the effect of elevated extracellular glucose, thus simulating diabetes, on migration, adhesion and proliferation of SV40 transformed human corneal epithelial (HCE) cells. METHODS:HCE cells were maintained in serum supplemented media containing 5 mM, 17.5 mM or 38 mM D-glucose. Cell migration was det...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.17.9.924.5133
更新日期:1998-09-01 00:00:00
abstract::Activity of RNA polymerases I, II and III (distinguished using alpha-amanitin) and activity of DNA polymerases alpha and beta (distinguished using N-ethylmaleimide) were assayed for varying intervals and at varying substrate (UTP or dTTP) concentrations in the purified nuclear fraction from corneal epithelium of carba...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688709025204
更新日期:1987-03-01 00:00:00
abstract:PURPOSE:To evaluate the intraocular distribution and metabolism of the lipid prodrug of foscarnet, 1-O-octadecyl-sn-glycerol-3- phosphonoformate (ODG-PFA), following intravitreal administration. METHODS:Twenty rabbits received ODG-[14C]PFA intravitreal injection, yielding 0.632 mM resultant intravitreal concentration....
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1076/ceyr.18.3.161.5366
更新日期:1999-03-01 00:00:00