Abstract:
PURPOSE:To investigate the expression in the mouse retina and the function in a retinal cell of cullin5 that is known as a protein that is associated with ubiquitilation. METHODS:The retinal sites of expressing cullin5 were determined by immunohistochemistry with a specific antibody for cullin5. Retinal cells were transfected with HA-tagged cullin5 using an adenovirus system, and retinal cells were exposed to L-glutamate with or without an over-expression of cullin5. RESULTS:Cullin5 was expressed in the retina of C57BL/6N mice and the retinal ganglion cell layer (RGL) of retina was strongly immunostained. Further, cullin5 was localized in the retinal ganglion cell (RGC). An over-expression of cullin5 reduced the percentage of retinal cell deaths induced by L-glutamate. CONCLUSIONS:The expression of cullin5 on retinal cells and reduction in the percentage of dead retinal cells induced by L-glutamate suggest that cullin5 has neuroprotective properties in retinal cells.
journal_name
Curr Eye Resjournal_title
Current eye researchauthors
Kanamoto T,Okumichi H,Rimayanti U,Kiuchi Ydoi
10.3109/02713683.2010.514658subject
Has Abstractpub_date
2011-01-01 00:00:00pages
66-70issue
1eissn
0271-3683issn
1460-2202journal_volume
36pub_type
杂志文章abstract:PURPOSE:Current standard of care for neovascular eye diseases require repeated intravitreal bolus injections of anti-vascular endothelial growth factors (anti-VEGFs). The purpose of this study was to validate a degradable microsphere-thermoresponsive hydrogel drug delivery system (DDS) capable of releasing bioactive af...
journal_title:Current eye research
pub_type: 杂志文章
doi:10.1080/02713683.2018.1533983
更新日期:2019-03-01 00:00:00
abstract::Approximately 90% of all ophthalmic drug formulations are now applied as eyedrops. Although eyedrops are convenient and well accepted by patients, about 95% of the drug contained in the drops is lost due to absorption through the conjunctiva or through the tear drainage. A major fraction of the drug eventually enters ...
journal_title:Current eye research
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journal_title:Current eye research
pub_type: 杂志文章
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713688409000791
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journal_title:Current eye research
pub_type: 杂志文章
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journal_title:Current eye research
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journal_title:Current eye research
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713689608995151
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journal_title:Current eye research
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journal_title:Current eye research
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journal_title:Current eye research
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更新日期:2012-02-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
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journal_title:Current eye research
pub_type: 杂志文章
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更新日期:1998-05-01 00:00:00
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journal_title:Current eye research
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更新日期:2017-08-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
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更新日期:1996-09-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
doi:10.3109/02713683.2010.542867
更新日期:2011-03-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
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更新日期:1984-04-01 00:00:00
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更新日期:1986-01-01 00:00:00
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journal_title:Current eye research
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更新日期:1990-08-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章,多中心研究
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更新日期:2012-07-01 00:00:00
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journal_title:Current eye research
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doi:
更新日期:2000-07-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
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更新日期:2004-10-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
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更新日期:2008-05-01 00:00:00
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journal_title:Current eye research
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更新日期:2020-10-04 00:00:00
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journal_title:Current eye research
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更新日期:2019-09-01 00:00:00
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journal_title:Current eye research
pub_type: 杂志文章
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更新日期:2009-03-01 00:00:00