Relationship between retinal fractal dimensions and retinal circulation in patients with type 2 diabetes mellitus.

Abstract:

PURPOSE:To investigate the relationship between retinal fractal dimensions (Dfs) and retinal circulation, which is impaired in early-stage diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (DM). METHODS:Using a laser Doppler velocimetry system, we measured the retinal vessel diameter (D) and blood velocity (V) and calculated the retinal blood flow (RBF) in the retinal arterioles and venules in 106 eyes (106 patients, mean age ± standard deviation, 58.7 ± 9.8 years). Patients with type 2 DM had no (n = 86) or mild nonproliferative DR (n = 20). The Dfs were measured on the retinal photographs using a semiautomatic computer-based program. RESULTS:The average D, V, and RBF in the retinal arterioles and venules were, respectively, 107.9 ± 13.3 and 139.4 ± 20.1 µm, 33.2 ± 7.0 and 22.6 ± 6.1 mm/s and 9.3 ± 2.9 and 10.4 ± 3.8 µl/min. The average Df was 1.4276 ± 0.0193. There was no association between the Df and any retinal circulatory parameters of the retinal arterioles. In contrast, we found significant correlations between the Df and the vessel D (r = 0.37, p = 0.0002) and RBF (r = 0.22, p = 0.026) in the retinal venules. CONCLUSION:The Df might be associated with changes in the retinal circulation in patients with type 2 DM.

journal_name

Curr Eye Res

journal_title

Current eye research

authors

Nagaoka T,Yoshida A

doi

10.3109/02713683.2013.805232

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

1148-52

issue

11

eissn

0271-3683

issn

1460-2202

journal_volume

38

pub_type

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