Pre-treatment with compound Danshen dripping pills prevents lipid infusion-induced microvascular dysfunction in mice.

abstract：CONTEXT:Cucurbitacins are a group of triterpenoids that have a cucurbitane skeleton with a wide range of biological activities. OBJECTIVES:This study evaluated the anticancer properties of one cucurbitacin isolated from Cayaponia racemosa Cong. (Cucurbitaceae), 2β,3β,16α,20(R),25-pentahydroxy-22-oxocucurbita-5-en (1),...

journal_title：Pharmaceutical biology

authors： Militão GC,Dantas IN,Ferreira PM,Alves AP,Chaves DC,Monte FJ,Pessoa C,Odorico de Moraes M,Costa-Lotufo LV

更新日期：2012-12-01 00:00:00

abstract：CONTEXT:Dicranopteris linearis (Burm.f.) Underw. (Gleicheniaceae) has been scientifically proven to exert various pharmacological activities. Nevertheless, its anti-proliferative potential has not been extensively investigated. OBJECTIVE:To investigate the anti-proliferative potential of D. linearis leaves and determi...

journal_title：Pharmaceutical biology

authors： Baharuddin AA,Roosli RAJ,Zakaria ZA,Md Tohid SF

更新日期：2018-12-01 00:00:00

abstract：CONTEXT:The pharmaceutical alkaloid huperzine A (HupA), currently used in herbal supplements and medicines worldwide, is predominantly sourced from the Chinese lycopod Huperzia serrata (Thunb. ex Murray) Trev. (Lycopodiaceae), which on average contains only 0.08 mg HupA g(-1) dry weight, and is experiencing a rapid dec...

journal_title：Pharmaceutical biology

authors： Lim WH,Goodger JQ,Field AR,Holtum JA,Woodrow IE

更新日期：2010-09-01 00:00:00

abstract：CONTEXT:Cotinus coggygria Scop. (Anacardiaceae) leaves that were used as wound healing in traditional Balkan and Anatolian folk medicine, could be potentially effective in treating diabetic wounds. OBJECTIVE:This study investigates biochemical and histological effects of ethanol extract of C. coggygria (CCE) on excisi...

journal_title：Pharmaceutical biology

authors： Aksoy H,Sen A,Sancar M,Sekerler T,Akakin D,Bitis L,Uras F,Kultur S,Izzettin FV

更新日期：2016-11-01 00:00:00

abstract：CONTEXT:Many plant extracts and compounds are being investigated for their cytotoxicity and hence their medicinal or therapeutic properties. Reports of toxicity studies with limonoid analogs have been sparse and have involved mainly crude extracts. In this study, individual natural limonoids have been isolated and thei...

journal_title：Pharmaceutical biology

authors： Fowles RG,Mootoo BS,Ramsewak RS,Khan A

更新日期：2012-02-01 00:00:00

abstract：CONTEXT:Aloe has been used for the prevention and cure of various diseases and symptoms including burns, injuries, oedema and pain. OBJECTIVE:This study determines the specific inhibitory activity of matrix metalloproteinase (MMP)-9 induced by the low molecular-weight gel fraction of Aloe vera (L.) Burm.f. (lgfAv) on ...

journal_title：Pharmaceutical biology

authors： Park CH,Son HU,Yoo CY,Lee SH

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:Peripheral axon injury and degeneration are often mediated by oxidative stress and inflammation. The hydroalcoholic extract of the red propolis (HERP) has attracted great attention because of its antioxidant and anti-inflammatory activities. OBJECTIVE:The objective of this work is to study the effect of HERP o...

journal_title：Pharmaceutical biology

authors： Barbosa RA,Nunes TL,Nunes TL,da Paixão AO,Belo Neto R,Moura S,Albuquerque Junior RL,Cândido EA,Padilha FF,Quintans-Júnior LJ,Gomes MZ,Cardoso JC

更新日期：2016-01-01 00:00:00

abstract：CONTEXT:Brassicaceae plants are associated with protection against cancers due to their glucosinolate contents. OBJECTIVES:We investigate fresh leaves, roots and ripe seeds of Lobularia libyca (Viv.) C.F.W. Meissn. (Brassicaceae) to identify their glucosinolate constituents, antimicrobial and cytotoxic activities Mate...

journal_title：Pharmaceutical biology

authors： Al-Gendy AA,Nematallah KA,Zaghloul SS,Ayoub NA

更新日期：2016-12-01 00:00:00

abstract：CONTEXT:Phytochemical and pharmacological data on Ducrosia anethifolia (DC.) Boiss. (Apiaceae), an Iranian medicinal plant, are scarce; however, furocoumarins are characteristic compounds of D. anethifolia. OBJECTIVE:Our experiments identify the secondary metabolites of D. anethifolia and assess their antitumor and an...

journal_title：Pharmaceutical biology

authors： Mottaghipisheh J,Nové M,Spengler G,Kúsz N,Hohmann J,Csupor D

更新日期：2018-12-01 00:00:00

abstract：:Escin, a group of chemically related triterpenic glycosides, is widely used in commercial preparations for the treatment of venous insufficiency. Since the zygotic embryo cotyledons accumulate the highest amount of escin, it is currently extracted from the seeds of horse chestnut, Aesculus hippocastanum L. (Hippocasta...

journal_title：Pharmaceutical biology

authors： Calić-Dragosavac D,Zdravković-Korać S,Savikin-Fodulović K,Radojević L,Vinterhalter B

更新日期：2010-05-01 00:00:00

abstract：CONTEXT:Pomegranate [Punica granatum L. (Lythraceae)] is rich in antioxidants. OBJECTIVE:The present work was undertaken to evaluate the protective effects of methanol extract of pomegranate peel extract (PPE) against a rat model of oxidative stress generated by treatment with mercuric chloride (HgCl(2)). MATERIALS A...

journal_title：Pharmaceutical biology

authors： Kumar D,Singh S,Singh AK,Rizvi SI

更新日期：2013-04-01 00:00:00

abstract：:Context: Curcumin, a polyphenolic compound extracted from the rhizome of the tropical plant Curcuma longa L. (Zingiberaceae), has been considered as a cancer chemopreventive drug by American National Cancer Institute.Objective: To examine the effect of curcumin on acute monocytic leukaemia SHI-1 cells in vivo.Material...

journal_title：Pharmaceutical biology

authors： Zhu G,Shen Q,Jiang H,Ji O,Zhu L,Zhang L

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:Portulacerebroside A (PCA) is a novel cerebroside compound isolated from Portulaca oleracea L. (Portulacaceae), an edible and medicinal plant distributed in the temperate and tropical zones worldwide. OBJECTIVE:This study investigates the effects of PCA in human liver cancer HCCLM3 cells on metastasis and inva...

journal_title：Pharmaceutical biology

authors： Ji Q,Zheng GY,Xia W,Chen JY,Meng XY,Zhang H,Rahman K,Xin HL

更新日期：2015-05-01 00:00:00

abstract：CONTEXT:Millettia barteri (Benth.) Dunn (Fabaceae) is an African medicinal plant used in folk medicine to treat many diseases. This species, as well as other Mellettia species, has been of interest to researchers because of their wide range of traditional uses. OBJECTIVE:Phytochemical, antimicrobial and 2,2-diphenyl-1...

journal_title：Pharmaceutical biology

authors： Havyarimana L,Ndendoung ST,Tamokou Jde D,Atchadé Ade T,Tanyi JM

更新日期：2012-02-01 00:00:00

abstract：CONTEXT: Despite the myriad uses of Annona senegalensis Pers. (Annonaceae) leaves in folklore medicine of Nigeria, the basis is yet to be substantiated by scientific investigations. OBJECTIVES: To investigate the antioxidant (in vitro and in vivo) and drug detoxification potential of aqueous extract of A. senegalensis...

journal_title：Pharmaceutical biology

authors： Ajboye TO,Yakubu MT,Salau AK,Oladiji AT,Akanji MA,Okogun JI

更新日期：2010-12-01 00:00:00

abstract：CONTEXT:MOTILIPERM was prepared as a mixture of extracts of three medicinal herbs [roots of Morinda officinalis How (Rubiaceae), outer scales of Allium cepa L. (Liliaceae) and seeds of Cuscuta chinensis Lamark (Convolvulaceae)]. OBJECTIVE:To investigate the role of reactive oxygen species (ROS)-based endoplasmic retic...

journal_title：Pharmaceutical biology

authors： Soni KK,Zhang LT,Choi BR,Karna KK,You JH,Shin YS,Lee SW,Kim CY,Zhao C,Chae HJ,Kim HK,Park JK

更新日期：2018-12-01 00:00:00

abstract：:Context Ginseng is a widely used herbal medicine in China but its mechanism of action remains unclear. Objective The objectives of this work were to study the protective effect of ginsenoside Rg1 on subacute murine renal damage induced by d-galactose and its mechanism. Materials and methods C57BL/6J mice were injected...

journal_title：Pharmaceutical biology

authors： Fan Y,Xia J,Jia D,Zhang M,Zhang Y,Huang G,Wang Y

更新日期：2016-09-01 00:00:00

abstract：CONTEXT:Several plant-derived natural products have been used in clinical phase for applications in neurological, cardiovascular, and inflammatory diseases. Arbutus andrachne L. (Ericacea) is an evergreen shrub native to the Mediterranean region. Traditionally, the fruits and leaves of Arbutus tree are well known and u...

journal_title：Pharmaceutical biology

authors： Abidi E,Habib J,Yassine A,Chahine N,Mahjoub T,Elkak A

更新日期：2016-01-01 00:00:00

abstract：CONTEXT:Eryngium maritimum L. and the endemic Eryngium kotschyi Boiss. of the Apiaceae family are used for antiinflammatory, antivenom, antinociceptive and diuretic purposes in folk medicine in Turkey. OBJECTIVE:This study investigated the cytotoxic effects of the plant extracts belonging to Eryngium L. genus on vario...

journal_title：Pharmaceutical biology

authors： Yurdakök B,Baydan E

更新日期：2013-12-01 00:00:00

abstract：:Context The underground edible tuber of Dioscorea alata L. (Dioscoreaceae) is a functional food with high nutritive value and therapeutic potential. The tuber is known to possess anti-inflammatory properties in traditional medicine. Objective The present study explores the anti-inflammatory activity and standardisatio...

journal_title：Pharmaceutical biology

authors： Dey P,Roy Chowdhuri S,Sarkar MP,Chaudhuri TK

更新日期：2016-08-01 00:00:00

abstract：CONTEXT:Granulocyte colony stimulating factor (G-CSF) has been commonly used to treat neutropenia caused by chemotherapy, radiotherapy, and organ transplants. Improved in vitro efficacy of G-CSF has already been observed by conjugating it to polyethylene glycol (PEG). OBJECTIVE:The in vivo bioassay using tetrazolium d...

journal_title：Pharmaceutical biology

authors： Tiwari K,Wavdhane M,Haque S,Govender T,Kruger HG,Mishra MK,Chandra R,Tiwari D

更新日期：2015-06-01 00:00:00

abstract：CONTEXT:Liver disease is a serious ailment and the scenario is worsened by the lack of precise therapeutic regimens. Currently available therapies for liver ailments are not apposite and systemic toxicity inhibits their long term use. Medicinal plants have been traditionally used for treating liver diseases since centu...

journal_title：Pharmaceutical biology

authors： Ghosh N,Ghosh R,Mandal V,Mandal SC

更新日期：2011-09-01 00:00:00

abstract：CONTEXT:Augmented renal clearance (ARC) refers to enhanced renal elimination of circulating solute, and has attracted wide attention in recent years. OBJECTIVE:This study evaluates the effects of ARC on serum vancomycin concentration in patients administered vancomycin. MATERIALS AND METHODS:This was a retrospective ...

journal_title：Pharmaceutical biology

authors： Chu Y,Luo Y,Qu L,Zhao C,Jiang M

更新日期：2016-12-01 00:00:00

abstract：CONTEXT:Salvicine is a pharmacologically active derivative from Chinese medicinal plant Salvia prionitis Hance (Labiatae). It has been reported that salvicine inactivates β1 integrin and inhibits integrin-mediated cell adhesion to fibronectin. Given the emerging correlation between integrins and angiogenesis, we propos...

journal_title：Pharmaceutical biology

authors： Zhang Y,Wang L,Chen Y,Qing C

更新日期：2013-08-01 00:00:00

abstract：UNLABELLED:Abstract Context: Solute carrier transporters (SLCs) are membrane proteins responsible for cellular influx of various substances including many pharmaceutical agents; therefore, they largely impact on drug disposition and elimination in body. Punica granatum Linnaeus (Lythraceae), pomegranate, is a fruit wit...

journal_title：Pharmaceutical biology

authors： Li Z,Wang K,Zheng J,Cheung FS,Chan T,Zhu L,Zhou F

更新日期：2014-12-01 00:00:00

abstract：CONTEXT:Plants and most of the plant-derived compounds have long been known for their potential pharmaceutical effects. They are well known to play an important role in the treatment of several diseases from diabetes to various types of cancers. Today most of the clinically effective pharmaceuticals are developed from ...

journal_title：Pharmaceutical biology

authors： Koc S,Isgor BS,Isgor YG,Shomali Moghaddam N,Yildirim O

更新日期：2015-05-01 00:00:00

abstract：CONTEXT:Ginger [Zingiber officinale Roscoe. (Zingiberaceae)] has been universally used as a spice as well as for its health benefits. OBJECTIVE:The present study evaluates the protective effect of the standardized extract of ginger against isoproterenol (ISO)-induced myocardial infarction (MI) in rats. MATERIALS AND ...

journal_title：Pharmaceutical biology

authors： Amran AZ,Jantan I,Dianita R,Buang F

更新日期：2015-01-01 00:00:00

abstract：:The activity of an (8-hydroxymethylen)-trieicosanyl acetate compound obtained from chloroform extracts of Senna villosa (Mill.) H.S. Irwin & Barneby (Leguminosae) against Trypanosoma cruzi was evaluated in vivo. Oral doses of 2.1, 8.4, and 33.6 microg/g were tested for 28 days in BALB/c mice infected with T. cruzi. Re...

journal_title：Pharmaceutical biology

authors： Jimenez-Coello M,Acosta-Viana KY,Guzman-Marin E,Perez Gonzalez C,Salud Perez Gutierrez M

更新日期：2010-06-01 00:00:00

abstract：:The effect of Celastrus paniculatus Willd. (Celastraceae) seed aqueous extract on learning and memory was studied using elevated plus maze and passive avoidance test (sodium nitrite induced amnesia rodent model). The aqueous seed extract was administered orally in two different doses to rats (350 and 1050 mg/kg) and t...

journal_title：Pharmaceutical biology

authors： Bhanumathy M,Harish MS,Shivaprasad HN,Sushma G

更新日期：2010-03-01 00:00:00

abstract：CONTEXT:Polygonum multiflorum is known as a medicinal plant. It has been used as a folk medicine which showed antioxidative property. OBJECTIVE:Protective effects of the water extracts (w/v:1/10) from fresh P. multiflorum (WEP) on carbon tetrachloride (CCl(4))-induced liver damage in rats were investigated. MATERIALS...

journal_title：Pharmaceutical biology

authors： Lee BH,Huang YY,Duh PD,Wu SC

更新日期：2012-03-01 00:00:00