Low molecular-weight gel fraction of Aloe vera exhibits gastroprotection by inducing matrix metalloproteinase-9 inhibitory activity in alcohol-induced acute gastric lesion tissues.

abstract：CONTEXT:Stachys guyoniana Noë ex. Batt. and Mentha aquatica L. are two Algerian Lamiaceae used in folk medicine. OBJECTIVE:To investigate their antioxidant, anticholinesterase and antibacterial activities. MATERIAL AND METHODS:n-Butanol (BESG), ethyl acetate (EESG) and chloroform (CESG) extracts of S. guyoniana and m...

journal_title：Pharmaceutical biology

authors： Ferhat M,Erol E,Beladjila KA,Çetintaş Y,Duru ME,Öztürk M,Kabouche A,Kabouche Z

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:Cancer dramatically impacts human life expectancy and quality of life. Natural substances from vegetables, herbs and spices could be beneficial in the prevention or treatment of a variety of cancers. Crocus sativus (Iridaceae), which has been used as a folk medicine for treating diseases for ages, showed obviou...

journal_title：Pharmaceutical biology

authors： Zhang Z,Wang CZ,Wen XD,Shoyama Y,Yuan CS

更新日期：2013-07-01 00:00:00

abstract：CONTEXT:Hydroxysafflor yellow A (HSYA) has been shown to have neuroprotective effects in cerebral infarction. However, its underlying roles in apoptosis and inflammation in Parkinson's disease (PD) are unknown. OBJECTIVE:The present study investigates the effects and underlying mechanisms of HSYA on dopaminergic (DA) ...

journal_title：Pharmaceutical biology

authors： Yang X,Li Y,Chen L,Xu M,Wu J,Zhang P,Nel D,Sun B

更新日期：2020-12-01 00:00:00

abstract：:Clitoria ternatea , commonly known as Shankpushpi, is widely used in the traditional Indian system of medicine as a brain tonic and is believed to promote memory and intelligence. We examined the effectiveness of alcoholic extracts of aerial and root parts of C. ternatea at 300 and 500 mg/kg doses orally in rats in at...

journal_title：Pharmaceutical biology

authors： Taranalli AD,Cheeramkuzhy TC

更新日期：2000-01-01 00:00:00

abstract：CONTEXT:The pharmaceutical alkaloid huperzine A (HupA), currently used in herbal supplements and medicines worldwide, is predominantly sourced from the Chinese lycopod Huperzia serrata (Thunb. ex Murray) Trev. (Lycopodiaceae), which on average contains only 0.08 mg HupA g(-1) dry weight, and is experiencing a rapid dec...

journal_title：Pharmaceutical biology

authors： Lim WH,Goodger JQ,Field AR,Holtum JA,Woodrow IE

更新日期：2010-09-01 00:00:00

abstract：CONTEXT:Hypertrophic scarring, a common proliferative disorder of dermal fibroblasts, results from an overproduction of collagen and excessive deposition of extracellular matrix. Although the treatment with surgical excisions or steroid hormones can modify the symptoms, numerous treatment-related complications have als...

journal_title：Pharmaceutical biology

authors： Wu JG,Wei YJ,Ran X,Zhang H,Nian H,Qin LP

更新日期：2011-07-01 00:00:00

abstract：:Context: Curcumin, a polyphenolic compound extracted from the rhizome of the tropical plant Curcuma longa L. (Zingiberaceae), has been considered as a cancer chemopreventive drug by American National Cancer Institute.Objective: To examine the effect of curcumin on acute monocytic leukaemia SHI-1 cells in vivo.Material...

journal_title：Pharmaceutical biology

authors： Zhu G,Shen Q,Jiang H,Ji O,Zhu L,Zhang L

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:Brassicaceae plants are associated with protection against cancers due to their glucosinolate contents. OBJECTIVES:We investigate fresh leaves, roots and ripe seeds of Lobularia libyca (Viv.) C.F.W. Meissn. (Brassicaceae) to identify their glucosinolate constituents, antimicrobial and cytotoxic activities Mate...

journal_title：Pharmaceutical biology

authors： Al-Gendy AA,Nematallah KA,Zaghloul SS,Ayoub NA

更新日期：2016-12-01 00:00:00

abstract：CONTEXT:Despite phytochemical studies of Agrimonia pilosa Ledeb. (Rosaceae), the antidiabetic effects of this plant are unknown. OBJECTIVE:This study characterizes the isolated compounds from the aerial parts of A. pilosa and evaluates their PTP1B and α-glucosidase inhibitory properties. MATERIALS AND METHODS:Ethanol...

journal_title：Pharmaceutical biology

authors： Na B,Nguyen PH,Zhao BT,Vo QH,Min BS,Woo MH

更新日期：2016-01-01 00:00:00

abstract：:The activity of an (8-hydroxymethylen)-trieicosanyl acetate compound obtained from chloroform extracts of Senna villosa (Mill.) H.S. Irwin & Barneby (Leguminosae) against Trypanosoma cruzi was evaluated in vivo. Oral doses of 2.1, 8.4, and 33.6 microg/g were tested for 28 days in BALB/c mice infected with T. cruzi. Re...

journal_title：Pharmaceutical biology

authors： Jimenez-Coello M,Acosta-Viana KY,Guzman-Marin E,Perez Gonzalez C,Salud Perez Gutierrez M

更新日期：2010-06-01 00:00:00

abstract：CONTEXT:Amaranth and canola oils have been used traditionally. Amaranth has been identified as being of interest because of its outstanding nutritive value. Amaranth oil is a rich source of highly unsaturated fats and so could be a valuable dietary alternative for individuals affected with obesity. Reactive oxygen spec...

journal_title：Pharmaceutical biology

authors： Kanikowska D,Kanikowska A,Rutkowski R,Włochal M,Orzechowska Z,Juchacz A,Zawada A,Grzymisławski M,Roszak M,Sato M,Bręborowicz A,Witowski J

更新日期：2019-12-01 00:00:00

abstract：CONTEXT:Agastache mexicana (Kunth) Lint & Epling (Lamiaceae) is a plant used in Mexican traditional medicine for the treatment of hypertension, anxiety and so on. OBJECTIVE:To determine the vasorelaxant effect and functional mode of action of dichloromethane-soluble extract from A. mexicana (DEAm) and isolate the cons...

journal_title：Pharmaceutical biology

authors： Flores-Flores A,Hernández-Abreu O,Rios MY,León-Rivera I,Aguilar-Guadarrama B,Castillo-España P,Perea-Arango I,Estrada-Soto S

更新日期：2016-12-01 00:00:00

abstract：CONTEXT:Psoralen and anastrozole are always used together for breast cancer patients in Chinese clinics. OBJECTIVE:This study investigates the effects of psoralen on the pharmacokinetics of anastrozole in rats and its potential mechanism. MATERIALS AND METHODS:The pharmacokinetics of orally administered anastrozole (...

journal_title：Pharmaceutical biology

authors： Zhang Y,Wu J,Zhou Y,Yin Y,Chen H

更新日期：2018-12-01 00:00:00

abstract：:Context:Caragana pruinosa Kom. (Fabaceae), a commonly used folk medicine, has been found to possess antitumor effects. However, the antiproliferative effect of 2,4-dihydroxy-3'-methoxy-4'-ethoxychalcone (DMEC) derived from C. pruinosa against multiple myeloma (MM) has never been investigated. Objective: This study sys...

journal_title：Pharmaceutical biology

authors： Zhu F,Jiang D,Zhang M,Zhao B

更新日期：2019-12-01 00:00:00

abstract：:Context 3,4-Oxo-isopropylidene-shikimic acid (ISA) is an analog of shikimic acid (SA). SA is extracted from the dry fruit of Illicium verum Hook. f. (Magnoliaceae), which has been used for treating stomachaches, skin inflammation and rheumatic pain. Objective To investigate the anti-inflammatory, analgesic and antioxi...

journal_title：Pharmaceutical biology

authors： Sun JY,You CY,Dong K,You HS,Xing JF

更新日期：2016-10-01 00:00:00

abstract：:Context Gelidiella acerosa (Forsskål) Feldmann & G. Hamel (Rhodophyta-Gelidiales) is a marine red macroalga. Our previous work found that a benzene extract of G. acerosa possesses noticeable neuroprotective activity, when evaluated through in vitro and in vivo systems. Objective Bioactive-guided fractionation and iden...

journal_title：Pharmaceutical biology

authors： Syad AN,Rajamohamed BS,Shunmugaiah KP,Kasi PD

更新日期：2016-10-01 00:00:00

abstract：CONTEXT:Glycyrrhiza glabra L. (Febaceae) has been widely used in traditional medicine and scientifically explored for its anticonvulsant and memory improving potential. OBJECTIVE:The objective of this study is to investigate the effect of flavonoid rich fraction of G. glabra root extract against phenytoin-induced cogn...

journal_title：Pharmaceutical biology

authors： Singh P,Singh D,Goel RK

更新日期：2016-07-01 00:00:00

abstract：CONTEXT:Salvia semiatrata Zucc. (Lamiaceae) is a species used as a tranquilizer and to relieve pain in folk medicine in Santiago Huauclilla, Oaxaca, Mexico. OBJECTIVE:To evaluate the antinociceptive and anxiolytic-like effects of S. semiatrata extracts and identify a bioactive metabolite. MATERIALS AND METHODS:The ex...

journal_title：Pharmaceutical biology

authors： Ortiz-Mendoza N,Zavala-Ocampo LM,Martínez-Gordillo MJ,González-Trujano ME,Peña FAB,Rodríguez IJB,Chávez JAR,Dorazco-González A,Aguirre-Hernández E

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:Melatonin, a pineal hormone and a potent antioxidant, has important roles in metabolic regulation. OBJECTIVE:This study investigated serum asymmetric dimethylarginine (ADMA), homocysteine (Hcy), nitric oxide (NO) levels, known to be reliable markers of cardiovascular diseases, and determined possible protectiv...

journal_title：Pharmaceutical biology

authors： Kantar Ş,Türközkan N,Bircan FS,Paşaoğlu ÖT

更新日期：2015-07-01 00:00:00

abstract：:Proteins from Parkia speciosa Hassk. (Fabaceae) seeds were extracted and stepwise precipitated using ammonium sulfate. Proteins precipitated with 25% ammonium sulfate were separated by affinity chromatography on Affi-Gel Blue gel followed by protein liquid chromatography on Superdex 200. The protein Gj, which was iden...

journal_title：Pharmaceutical biology

authors： Chankhamjon K,Petsom A,Sawasdipuksa N,Sangvanich P

更新日期：2010-01-01 00:00:00

abstract：CONTEXT:Alpinia oxyphylla Miquel (Zingiberaceae) is a traditional Chinese herbal medicine widely used for the treatment of intestinal disorders, urosis and diuresis. However, information about antioxidant and cytotoxic properties of its fruits remains to be elucidated. OBJECTIVE:The ethanol crude extract (CE) and its ...

journal_title：Pharmaceutical biology

authors： Wang CZ,Yuan HH,Bao XL,Lan MB

更新日期：2013-11-01 00:00:00

abstract：CONTEXT:Safranal (SAF) is verified to have potential effects in promoting nerve growth. OBJECTIVES:This study verifies the role of SAF in promoting dopaminergic neurons growth in vitro and in vivo. MATERIAL AND METHODS:Rat neural stem cells (NSC) were treated with 1, 20, or 100 ng/mL of SAF, and the expression levels...

journal_title：Pharmaceutical biology

authors： Zhao Y,Xi G

更新日期：2018-12-01 00:00:00

abstract：CONTEXT:The genus Premna (Lamiaceae), distributed throughout tropical and subtropical Asia, Africa, Australia and the Pacific Islands, is used in folk medicine primarily to treat inflammation, immune-related diseases, stomach disorders, wound healing, and skin diseases. OBJECTIVES:This review exhaustively gathers avai...

journal_title：Pharmaceutical biology

authors： Dianita R,Jantan I

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:Ginger has been used commonly in the traditional system of medicine for the treatment of respiratory disorders. OBJECTIVE:The present study investigates the immunosuppressive activity of ginger by using the mouse model of ovalbumin-induced allergic asthma. MATERIALS AND METHODS:Treatment with ethanol extract ...

journal_title：Pharmaceutical biology

authors： Khan AM,Shahzad M,Raza Asim MB,Imran M,Shabbir A

更新日期：2015-03-01 00:00:00

abstract：:The approach to new drugs through natural products has proved to be the single most successful strategy for the discovery of new drugs, but in recent years its use has been deemphasized by many pharmaceutical companies in favor of approaches based on combinatorial chemistry and genomics, among others.Drug discovery fr...

journal_title：Pharmaceutical biology

authors： Cao S,Kingston DG

更新日期：2009-08-01 00:00:00

abstract：CONTEXT:Granulocyte colony stimulating factor (G-CSF) has been commonly used to treat neutropenia caused by chemotherapy, radiotherapy, and organ transplants. Improved in vitro efficacy of G-CSF has already been observed by conjugating it to polyethylene glycol (PEG). OBJECTIVE:The in vivo bioassay using tetrazolium d...

journal_title：Pharmaceutical biology

authors： Tiwari K,Wavdhane M,Haque S,Govender T,Kruger HG,Mishra MK,Chandra R,Tiwari D

更新日期：2015-06-01 00:00:00

abstract：:Tuberculosis remains a serious public health problem, with nine million cases being reported annually. Treatment with antibiotics is the most effective mechanism to control this disease, although the increase in cases with resistant strains, co-infection with HIV, and the long duration of treatment has established the...

journal_title：Pharmaceutical biology

authors： Ramos DF,Almeida da Silva PE

更新日期：2010-03-01 00:00:00

abstract：CONTEXT:Recent studies have shown compound Danshen dripping pills (CDDP) could improve microcirculation in ischemic/reperfusion injury and other microvascular disorders. The mechanism for CDDP's role in microcirculation is not clear. OBJECTIVE:To explore the protective effects of CDDP on microvascular dysfunction. MA...

journal_title：Pharmaceutical biology

authors： Zhang Y,Zhao J,Ding R,Niu W,He Z,Liang C

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the aqueous extract from aerial parts of Artemisia copa Phil. (Asteraceae) administered orallyfor its psychopharmacological activities in several experimental models. METHODS:The extract was administered p.o. in Swiss albino mice and tested on pentobarbital-induced hypnosis, locomotor activity, e...

journal_title：Pharmaceutical biology

authors： Miño JH,Moscatelli V,Acevedo C,Ferraro G

更新日期：2010-12-01 00:00:00

abstract：CONTEXT:Plants and most of the plant-derived compounds have long been known for their potential pharmaceutical effects. They are well known to play an important role in the treatment of several diseases from diabetes to various types of cancers. Today most of the clinically effective pharmaceuticals are developed from ...

journal_title：Pharmaceutical biology

authors： Koc S,Isgor BS,Isgor YG,Shomali Moghaddam N,Yildirim O

更新日期：2015-05-01 00:00:00