Abstract:
CONTEXT:Hypertrophic scarring, a common proliferative disorder of dermal fibroblasts, results from an overproduction of collagen and excessive deposition of extracellular matrix. Although the treatment with surgical excisions or steroid hormones can modify the symptoms, numerous treatment-related complications have also been established. OBJECTIVE:To investigate the effects of essential oil (EO) from rhizomes of Ligusticum chuanxiong Hort. (Umbelliferae) on hypertrophic scarring in a rabbit ear model. MATERIALS AND METHODS:A rabbit ear model of hypertrophic scarring was established. EO (5, 10, and 20%) was applied once daily to the scars for 22 days. After 28 days of post-wounding, excision of scars was respectively performed for both histological examination and assays of the levels of collagen I, collagen III, matrix metalloproteinase-1 (MMP-1), and transforming growth factor beta 1 (TGF-β₁). The scar elevation index (SEI) was also determined. RESULTS:After 22 days of treatment with indicated concentrations of EO, hypertrophic scarring was significantly inhibited in the rabbit ears. The levels of TGF-β₁, collagen I, and collagen III evidently decreased and MMP-1 level markedly increased in the scar tissue. SEI was also significantly reduced. Immunohistochemical findings exhibited significant amelioration of the scar tissue. DISCUSSION AND CONCLUSION:EO suppresses hypertrophic scarring in the rabbit ear model and is a probably effective cure for human hypertrophic scarring.
journal_name
Pharm Bioljournal_title
Pharmaceutical biologyauthors
Wu JG,Wei YJ,Ran X,Zhang H,Nian H,Qin LPdoi
10.3109/13880209.2010.542761subject
Has Abstractpub_date
2011-07-01 00:00:00pages
764-9issue
7eissn
1388-0209issn
1744-5116journal_volume
49pub_type
杂志文章abstract:CONTEXT:The extraction method and the crude wound healing effects of sacchachitin from Ganoderma tsugae Murr. (Ganodermataceae) has been cited. However, its purity is still largely limited. OBJECTIVE:An improvement of the fractionation protocol to purify the sacchachitin from Ganoderma lucidum L. (Ganodermataceae) (SG...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2012.711840
更新日期:2013-01-01 00:00:00
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journal_title:Pharmaceutical biology
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doi:10.3109/13880209.2012.684691
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journal_title:Pharmaceutical biology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.3109/13880209.2015.1016182
更新日期:2016-01-01 00:00:00
abstract::Context The bark of Ailanthus altissima (Mill.) Swingle (Simaroubaceae) is traditionally used to treat ascariasis, diarrhoea, spermatorrhoea, bleeding and gastrointestinal diseases. Objective The objective of this study is to investigate the antitumour activity and mechanism of 2-dihydroailanthone isolated from A. alt...
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更新日期:2016-09-01 00:00:00
abstract::Viscum angulatum Heyne ex DC (Viscaceae) is a leafless hemiparasitic shrub traditionally used in Asian countries for the treatment of hypertension. In the present study, the methanol extract of the whole plant was examined for diuretic activity in rats. The activity was evaluated using parameters such as urine volume ...
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更新日期:2010-04-01 00:00:00
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journal_title:Pharmaceutical biology
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更新日期:2010-09-01 00:00:00
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journal_title:Pharmaceutical biology
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doi:10.3109/13880209.2013.784342
更新日期:2013-09-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2000-01-01 00:00:00
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更新日期:2000-01-01 00:00:00
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journal_title:Pharmaceutical biology
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更新日期:2014-08-01 00:00:00
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更新日期:2013-12-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
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journal_title:Pharmaceutical biology
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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更新日期:2015-01-01 00:00:00
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更新日期:2014-10-01 00:00:00