Protective effect of hydroxysafflor yellow A on dopaminergic neurons against 6-hydroxydopamine, activating anti-apoptotic and anti-neuroinflammatory pathways.

abstract：CONTEXT:The plant Hygrophila auriculata (K. Schum) Heine. (Acanthaceae) is widely used in the Indian System of Medicine as "Rasayana" for treating brain and liver diseases. OBJECTIVES:The present study evaluated the in vivo antioxidant and neuroprotective effect of aterpenoid rich fraction (TF) from Hygrophila auricul...

journal_title：Pharmaceutical biology

authors： Kanhere R,Anjana A,Anbu J,Sumithra M,K F H NA

更新日期：2013-02-01 00:00:00

abstract：CONTEXT:Silymarin, a flavonolignan from Silybum marianum (L.) Gaertn. (Asteraceae), has been reported to have antioxidant and anti-inflammatory properties. Therefore, it may be worthwhile to study the effect of silymarin on wound healing. OBJECTIVE:To evaluate the effect of silymarin on human fibroblast cells in an in...

journal_title：Pharmaceutical biology

authors： Sharifi R,Pasalar P,Kamalinejad M,Dehpour AR,Tavangar SM,Paknejad M,Mehrabani Natanzi M,Nourbakhsh M,Ahmadi Ashtiani HR,Akbari M,Rastegar H

更新日期：2013-03-01 00:00:00

abstract：CONTEXT:Zhi-Zi-Hou-Pu decoction (ZZHPD) is a traditional prescription which has been used to treat "Yu-syndrome" (depression and melancholia) in Chinese herbal medication. OBJECTIVE:To evaluate antidepressant activities of ZZHPD, its fractions and possible mechanism(s) of action. MATERIALS AND METHODS:ZZHPD (1241, 24...

journal_title：Pharmaceutical biology

authors： Yao AM,Ma FF,Zhang LL,Feng F

更新日期：2013-02-01 00:00:00

abstract：CONTEXT:Calotropis procera (Ait.) R. Br. (Asclepiadaceae), Ficus elastica Roxb. (Moraceae) and Zingiber officinale Roscoe (Zingiberaceae) have been traditionally used to treat many diseases. OBJECTIVE:The antischistosomal activity of these plant extracts was evaluated against Schistosoma mansoni. MATERIALS AND METHOD...

journal_title：Pharmaceutical biology

authors： Seif el-Din SH,El-Lakkany NM,Mohamed MA,Hamed MM,Sterner O,Botros SS

更新日期：2014-02-01 00:00:00

abstract：CONTEXT:Tournefortia sarmentosa Lam. (Boraginaceae), a Chinese herbal medicine, is commonly used as a detoxicant or anti-inflammatory agent. OBJECTIVE:As acetaminophen (APAP) is a well-known hepatotoxin, we investigated the effect of the aqueous extract of the T. sarmentosa on APAP-induced hepatotoxicity in vivo and i...

journal_title：Pharmaceutical biology

authors： Teng CY,Lai YL,Huang HI,Hsu WH,Yang CC,Kuo WH

更新日期：2012-03-01 00:00:00

abstract：CONTEXT:Agastache mexicana (Kunth) Lint & Epling (Lamiaceae) is a plant used in Mexican traditional medicine for the treatment of hypertension, anxiety and so on. OBJECTIVE:To determine the vasorelaxant effect and functional mode of action of dichloromethane-soluble extract from A. mexicana (DEAm) and isolate the cons...

journal_title：Pharmaceutical biology

authors： Flores-Flores A,Hernández-Abreu O,Rios MY,León-Rivera I,Aguilar-Guadarrama B,Castillo-España P,Perea-Arango I,Estrada-Soto S

更新日期：2016-12-01 00:00:00

abstract：:Breast cancer (BCa) is the most commonly occurring cancer in women, comprising almost one third of all malignancies. Previously we reported that the n-hexane fraction (hSL) of the Siddha herbal medicine, Semecarpus Lehyam, relatively sensitized estrogen receptor-negative (ER(-)) BCa when compared to estrogen receptor-...

journal_title：Pharmaceutical biology

authors： Zhao W,Zhu L,Srinivasan S,Damodaran C,Rohr J

更新日期：2009-09-01 00:00:00

abstract：CONTEXT:Millettia barteri (Benth.) Dunn (Fabaceae) is an African medicinal plant used in folk medicine to treat many diseases. This species, as well as other Mellettia species, has been of interest to researchers because of their wide range of traditional uses. OBJECTIVE:Phytochemical, antimicrobial and 2,2-diphenyl-1...

journal_title：Pharmaceutical biology

authors： Havyarimana L,Ndendoung ST,Tamokou Jde D,Atchadé Ade T,Tanyi JM

更新日期：2012-02-01 00:00:00

abstract：CONTEXT:Eryngium maritimum L. and the endemic Eryngium kotschyi Boiss. of the Apiaceae family are used for antiinflammatory, antivenom, antinociceptive and diuretic purposes in folk medicine in Turkey. OBJECTIVE:This study investigated the cytotoxic effects of the plant extracts belonging to Eryngium L. genus on vario...

journal_title：Pharmaceutical biology

authors： Yurdakök B,Baydan E

更新日期：2013-12-01 00:00:00

abstract：CONTEXT:Stachys guyoniana Noë ex. Batt. and Mentha aquatica L. are two Algerian Lamiaceae used in folk medicine. OBJECTIVE:To investigate their antioxidant, anticholinesterase and antibacterial activities. MATERIAL AND METHODS:n-Butanol (BESG), ethyl acetate (EESG) and chloroform (CESG) extracts of S. guyoniana and m...

journal_title：Pharmaceutical biology

authors： Ferhat M,Erol E,Beladjila KA,Çetintaş Y,Duru ME,Öztürk M,Kabouche A,Kabouche Z

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:Virgin coconut oil (VCO) has been reported to possess antioxidative, anti-inflammatory and anti-stress properties. OBJECTIVE:Capitalizing on these therapeutic effects, this study investigated for the first time the potential of VCO on memory improvement in vivo. MATERIALS AND METHODS:Thirty male Wistar rats (...

journal_title：Pharmaceutical biology

authors： Rahim NS,Lim SM,Mani V,Abdul Majeed AB,Ramasamy K

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:The resistance of bacteria to antibiotics is raising serious concern globally. Asian medicinal plants could improve the current treatment strategies for bacterial infections. The antibacterial properties of medicinal plants used by the Khyang tribe in Bangladesh have not been investigated. OBJECTIVE:The presen...

journal_title：Pharmaceutical biology

authors： Hossan MS,Jindal H,Maisha S,Samudi Raju C,Devi Sekaran S,Nissapatorn V,Kaharudin F,Su Yi L,Khoo TJ,Rahmatullah M,Wiart C

更新日期：2018-12-01 00:00:00

abstract：CONTEXT:Vicenin-1, a flavonol glycoside, has potent platelet aggregation inhibition, antioxidant, radioprotectants and anti-inflammatory activities. OBJECTIVE:To establish a rapid, simple, precise and sensitive high-performance liquid chromatography (HPLC) method for determination of vicenin-1 in rat plasma, and to in...

journal_title：Pharmaceutical biology

authors： Kandhare AD,Bodhankar SL,Mohan V,Thakurdesai PA

更新日期：2016-11-01 00:00:00

abstract：CONTEXT:Hypertrophic scarring, a common proliferative disorder of dermal fibroblasts, results from an overproduction of collagen and excessive deposition of extracellular matrix. Although the treatment with surgical excisions or steroid hormones can modify the symptoms, numerous treatment-related complications have als...

journal_title：Pharmaceutical biology

authors： Wu JG,Wei YJ,Ran X,Zhang H,Nian H,Qin LP

更新日期：2011-07-01 00:00:00

abstract：CONTEXT:Commiphora myrrha (Burseraceae), a shrub resembling a small tree, has been used for several centuries for the treatment of various diseases. OBJECTIVE:This study investigates the hepatoprotective activity of C. myrrha ethanol extract against d-galactosamine/lipopolysaccharide (d-GalN/LPS)-induced acute hepatic...

journal_title：Pharmaceutical biology

authors： Ahmad A,Raish M,Ganaie MA,Ahmad SR,Mohsin K,Al-Jenoobi FI,Al-Mohizea AM,Alkharfy KM

更新日期：2015-01-01 00:00:00

abstract：CONTEXT:The poor prognostic outcome of breast cancer is largely due to its resistance to cancer therapies. Development of therapeutic agents that can inhibit growth and induce apoptosis in breast cancer cells can help solve the problem. Emodin is an active anthraquinone that has been reported to have diverse biological...

journal_title：Pharmaceutical biology

authors： Li WY,Chan RY,Yu PH,Chan SW

更新日期：2013-09-01 00:00:00

abstract：CONTEXT:1 D is a novel derivative of curcumin and shows very promising antitumor activities in various cancer cell lines. OBJECTIVE:To characterize its preclinical pharmacokinetic profiles, a novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantification of 1 ...

journal_title：Pharmaceutical biology

authors： Sun J,Jiang T,Xu W,Feng Z,Quan X,Leng P,Sun W,Zhao J,Jing F,Li J

更新日期：2019-12-01 00:00:00

abstract：:Physalis alkekengi L. (Solanaceae) is a popular plant in traditional European and Chinese folk medicine, and it has been reported to have many ethnopharmacological properties including antifungal, anti-cough, anti-inflammatory, analgesic, and febricide activities. Some active components from Physalis species have been...

journal_title：Pharmaceutical biology

authors： Helvaci S,Kökdil G,Kawai M,Duran N,Duran G,Güvenç A

更新日期：2010-02-01 00:00:00

abstract：:Chemical constituents as well as cytotoxic and insecticidal activity of the crude methanol extract from the leaves of Phyllanthus reticulatus Poir. (Euphorbiaceae) were investigated. (5R*,6R*)-4,6-Dimethoxycarbonyl-5-[2',3',4'-trihydroxy-6'-(methoxycarbonyl) phenyl]-5,6-dihydro-2H-pyran-2-one (1) along with 3,4,3'-tri...

journal_title：Pharmaceutical biology

authors： Pojchaijongdee N,Sotanaphun U,Limsirichaikul S,Poobrasert O

更新日期：2010-07-01 00:00:00

abstract：CONTEXT:Glycosmis pentaphylla (Retz.) DC (Rutaceae) is a shrub, traditionally used to treat anemia, rheumatism, as an anthelmintic, febrifuge and vermifuge, for jaundice, and liver complaints. OBJECTIVE:This study evaluated the hepatoprotective activity of G. pentaphylla against paracetamol-induced hepatotoxicity in S...

journal_title：Pharmaceutical biology

authors： Nayak SS,Jain R,Sahoo AK

更新日期：2011-02-01 00:00:00

abstract：CONTEXT:Anemarsaponin BII is one of the most active saponins isolated from Anemarrhena asphodeloides Bunge (Asparagaceae), a commonly used Chinese traditional paediatric medicine. OBJECTIVE:This study investigates the effects of anemarsaponin BII on the activity of CYP450s to provide more guidance for the clinical use...

journal_title：Pharmaceutical biology

authors： Wang M,Jiang W,Zhou J,Xue X,Yin C

更新日期：2020-12-01 00:00:00

abstract：:The novel compound 1'''-hydroxy-2''',3'''-epoxylupinifolin ( 1 ), together with three known prenylated flavanones were identified from the stem of Derris reticulata during our reinvestigation of the plant. The structures were determined by spectroscopic methods including detailed study of NMR spectral data (DEPT, 2D-C...

journal_title：Pharmaceutical biology

authors： Prawat H,Mahidol C,Ruchirawat S

更新日期：2000-01-01 00:00:00

abstract：CONTEXT:Salvicine is a pharmacologically active derivative from Chinese medicinal plant Salvia prionitis Hance (Labiatae). It has been reported that salvicine inactivates β1 integrin and inhibits integrin-mediated cell adhesion to fibronectin. Given the emerging correlation between integrins and angiogenesis, we propos...

journal_title：Pharmaceutical biology

authors： Zhang Y,Wang L,Chen Y,Qing C

更新日期：2013-08-01 00:00:00

abstract：CONTEXT:Investigating potential central nervous system (CNS) activities of Crataegus monogyna Jacq. (Rosaceae), hawthorn, fruit extracts. OBJECTIVE:Evaluating CNS effects and analgesic activities of hawthorn fruit extracts based on the traditional uses of the plant for neurosedative and pain killer actions. MATERIALS...

journal_title：Pharmaceutical biology

authors： Can OD,Ozkay UD,Oztürk N,Oztürk Y

更新日期：2010-08-01 00:00:00

abstract：CONTEXT:Baohuoside-I was reported to induce apoptosis in non-small-cell lung cancer and inhibit the growth of multiple myeloma cells. The antitumour potential of baohuoside-I has not been demonstrated in melanoma yet. OBJECTIVE:To investigate the potential antitumour activity of baohuoside-I against melanoma and eluci...

journal_title：Pharmaceutical biology

authors： Peng YG,Zhang L

更新日期：2018-12-01 00:00:00

abstract：:Proteins from Parkia speciosa Hassk. (Fabaceae) seeds were extracted and stepwise precipitated using ammonium sulfate. Proteins precipitated with 25% ammonium sulfate were separated by affinity chromatography on Affi-Gel Blue gel followed by protein liquid chromatography on Superdex 200. The protein Gj, which was iden...

journal_title：Pharmaceutical biology

authors： Chankhamjon K,Petsom A,Sawasdipuksa N,Sangvanich P

更新日期：2010-01-01 00:00:00

abstract：:Context 3,4-Oxo-isopropylidene-shikimic acid (ISA) is an analog of shikimic acid (SA). SA is extracted from the dry fruit of Illicium verum Hook. f. (Magnoliaceae), which has been used for treating stomachaches, skin inflammation and rheumatic pain. Objective To investigate the anti-inflammatory, analgesic and antioxi...

journal_title：Pharmaceutical biology

authors： Sun JY,You CY,Dong K,You HS,Xing JF

更新日期：2016-10-01 00:00:00

abstract：:The effect of Celastrus paniculatus Willd. (Celastraceae) seed aqueous extract on learning and memory was studied using elevated plus maze and passive avoidance test (sodium nitrite induced amnesia rodent model). The aqueous seed extract was administered orally in two different doses to rats (350 and 1050 mg/kg) and t...

journal_title：Pharmaceutical biology

authors： Bhanumathy M,Harish MS,Shivaprasad HN,Sushma G

更新日期：2010-03-01 00:00:00

abstract：:Context Yellow tea containing the same catechins as other types of tea but in different proportions has been suggested to possess potent anticancer activities. Objective This study investigates the chemopreventive effect of yellow tea aqueous extract against N-nitrosodiethylamine (NDEA)-induced liver carcinogenesis in...

journal_title：Pharmaceutical biology

authors： Kujawska M,Ewertowska M,Adamska T,Ignatowicz E,Gramza-Michałowska A,Jodynis-Liebert J

更新日期：2016-09-01 00:00:00

abstract：CONTEXT:Light microscopy is in most cases a quick method for the identification and discrimination of medicinally used plant drugs; moreover, this technique is very inexpensive. Reliable descriptions of the anatomy of plants and their adulterations are prerequisites for necessary purity controls. OBJECTIVE:The anatomy...

journal_title：Pharmaceutical biology

authors： Fritz E,Saukel J

更新日期：2011-08-01 00:00:00