Protective effect on phenytoin-induced cognition deficit in pentylenetetrazol kindled mice: A repertoire of Glycyrrhiza glabra flavonoid antioxidants.

abstract：CONTEXT:Cucurbitacins are a group of triterpenoids that have a cucurbitane skeleton with a wide range of biological activities. OBJECTIVES:This study evaluated the anticancer properties of one cucurbitacin isolated from Cayaponia racemosa Cong. (Cucurbitaceae), 2β,3β,16α,20(R),25-pentahydroxy-22-oxocucurbita-5-en (1),...

journal_title：Pharmaceutical biology

authors： Militão GC,Dantas IN,Ferreira PM,Alves AP,Chaves DC,Monte FJ,Pessoa C,Odorico de Moraes M,Costa-Lotufo LV

更新日期：2012-12-01 00:00:00

abstract：CONTEXT:The plant Hygrophila auriculata (K. Schum) Heine. (Acanthaceae) is widely used in the Indian System of Medicine as "Rasayana" for treating brain and liver diseases. OBJECTIVES:The present study evaluated the in vivo antioxidant and neuroprotective effect of aterpenoid rich fraction (TF) from Hygrophila auricul...

journal_title：Pharmaceutical biology

authors： Kanhere R,Anjana A,Anbu J,Sumithra M,K F H NA

更新日期：2013-02-01 00:00:00

abstract：CONTEXT:Propranolol, atenolol, and ICI118,551 are non-selective β-adrenergic receptor (AR), β1-AR, and β2-AR antagonists, respectively. OBJECTIVE:We investigated the efficacy of propranolol, atenolol, and ICI118,551 on proliferation, migration, and invasion of non-stimulated breast (MCF7), colon (HT-29), and hepatocel...

journal_title：Pharmaceutical biology

authors： Işeri OD,Sahin FI,Terzi YK,Yurtcu E,Erdem SR,Sarialioglu F

更新日期：2014-11-01 00:00:00

abstract：:Context:Melastoma dodecandrum Lour. (Melastomataceae) is a traditional Chinese medicine. This is the first study to report a protective effect of the ethanol extract from M. dodecandrum (MDE) in type 2 diabetic (T2DM) rats.Objective: To investigate the therapeutic mechanism of MDE in T2DM rats.Materials and methods: S...

journal_title：Pharmaceutical biology

authors： Weng J,Zhou J,Liang L,Li L

更新日期：2019-12-01 00:00:00

abstract：CONTEXT:Augmented renal clearance (ARC) refers to enhanced renal elimination of circulating solute, and has attracted wide attention in recent years. OBJECTIVE:This study evaluates the effects of ARC on serum vancomycin concentration in patients administered vancomycin. MATERIALS AND METHODS:This was a retrospective ...

journal_title：Pharmaceutical biology

authors： Chu Y,Luo Y,Qu L,Zhao C,Jiang M

更新日期：2016-12-01 00:00:00

abstract：:Heliopsis longipes S.F. Blake (Asteraceae: Heliantheae) (chilcuague) is used in Mexican traditional medicine against parasites and to alleviate tooth and muscle pains. Its biocide effect has already been experimentally demonstrated; however, its analgesic action and its action on the nervous system (NS) have not been ...

journal_title：Pharmaceutical biology

authors： Cilia-López VG,Juárez-Flores BI,Aguirre-Rivera JR,Reyes-Agüero JA

更新日期：2010-02-01 00:00:00

abstract：CONTEXT:Liver disease is a serious ailment and the scenario is worsened by the lack of precise therapeutic regimens. Currently available therapies for liver ailments are not apposite and systemic toxicity inhibits their long term use. Medicinal plants have been traditionally used for treating liver diseases since centu...

journal_title：Pharmaceutical biology

authors： Ghosh N,Ghosh R,Mandal V,Mandal SC

更新日期：2011-09-01 00:00:00

abstract：CONTEXT:Despite phytochemical studies of Agrimonia pilosa Ledeb. (Rosaceae), the antidiabetic effects of this plant are unknown. OBJECTIVE:This study characterizes the isolated compounds from the aerial parts of A. pilosa and evaluates their PTP1B and α-glucosidase inhibitory properties. MATERIALS AND METHODS:Ethanol...

journal_title：Pharmaceutical biology

authors： Na B,Nguyen PH,Zhao BT,Vo QH,Min BS,Woo MH

更新日期：2016-01-01 00:00:00

abstract：UNLABELLED:CONTEXT. Huperzia saururus (Lam.) Trevis. (Lycopodiaceae), an autochthonous plant species in Argentina, is used as a memory improver in traditional medicine. It was studied for this reason and the purified alkaloid extract did show significant activity on learning and memory. The species is mostly consumed i...

journal_title：Pharmaceutical biology

authors： Vallejo MG,Dimmer JA,Ortega MG,Cabrera JL,Agnese AM

更新日期：2013-10-01 00:00:00

abstract：CONTEXT:Ethnobotanical claims of medicinal plants used in northern Maputaland are limited. Objectives To establish scientific validity for a selection of the plants used in Maputaland to treat skin diseases. MATERIALS AND METHODS:Aqueous and dichloromethane-methanol extracts were prepared from 37 plant species which w...

journal_title：Pharmaceutical biology

authors： Nciki S,Vuuren S,van Eyk A,de Wet H

更新日期：2016-11-01 00:00:00

abstract：CONTEXT:Light microscopy is in most cases a quick method for the identification and discrimination of medicinally used plant drugs; moreover, this technique is very inexpensive. Reliable descriptions of the anatomy of plants and their adulterations are prerequisites for necessary purity controls. OBJECTIVE:The anatomy...

journal_title：Pharmaceutical biology

authors： Fritz E,Saukel J

更新日期：2011-08-01 00:00:00

abstract：CONTEXT:Cancer, being a cause of death for major fraction of population worldwide, is one of the most studied diseases and is being investigated for the development of new technologies and more accurate therapies. Still the currently available therapies for cancer have many lacunae which affect the patient's health sev...

journal_title：Pharmaceutical biology

authors： Rai M,Jogee PS,Agarkar G,dos Santos CA

更新日期：2016-01-01 00:00:00

abstract：CONTEXT:Dyslipidemia is one of the major risk factors for cardiovascular disease in diabetes mellitus (DM). The availability of multiple lipid-lowering drugs and supplements provides new opportunities for patients to regulate lipid levels. OBJECTIVE:The present study was designed to evaluate the effect of Butea monosp...

journal_title：Pharmaceutical biology

authors： Divya BT,Mini S

更新日期：2014-08-01 00:00:00

abstract：CONTEXT:The content of withanolides in the roots of Withania somnifera (L.) Dunal (Solanaceae) is important for therapeutic application. Earlier studies have shown that the deficiency of macro- and micronutrients affects the growth of W. somnifera. Therefore, we examined the effect of these deficiencies on the withanol...

journal_title：Pharmaceutical biology

authors： Devkar ST,Suryapujary SM,Jagtap SD,Katyare SS,Hegde MV

更新日期：2015-04-01 00:00:00

abstract：CONTEXT:Uncaria tomentosa D.C. (Rubiaceae) has several biological activities, including activity against resistant Candida strains. The synergistic interaction with terbinafine or fluconazole can be an important alternative to overcome this resistance. OBJECTIVES:The potential synergy between a water insoluble fractio...

journal_title：Pharmaceutical biology

authors： Moraes RC,Carvalho AR,Lana AJ,Kaiser S,Pippi B,Fuentefria AM,Ortega GG

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:Sepsis continues to be a significant problem for critical care patients. OBJECTIVE:To evaluate the protective effects of IgM-enriched immunoglobulin and erythropoietin on pulmonary and small intestine tissues in a rat model of intra-abdominal sepsis induced via the cecal ligation and puncture (CLP) method. MA...

journal_title：Pharmaceutical biology

authors： Ates I,Dogan N,Aksoy M,Halıcı Z,Gündogdu C,Keles MS

更新日期：2015-01-01 00:00:00

abstract：CONTEXT:Glycosmis pentaphylla (Retz.) DC (Rutaceae) is a shrub, traditionally used to treat anemia, rheumatism, as an anthelmintic, febrifuge and vermifuge, for jaundice, and liver complaints. OBJECTIVE:This study evaluated the hepatoprotective activity of G. pentaphylla against paracetamol-induced hepatotoxicity in S...

journal_title：Pharmaceutical biology

authors： Nayak SS,Jain R,Sahoo AK

更新日期：2011-02-01 00:00:00

abstract：CONTEXT:Diabetic nephropathy is one of the important microvascular complications of diabetes; however, the main problem remains is the control of progression of nephropathy in diabetes. Chebulic acid was selected, as tannins from Terminalia chebula are used as antidiabetic, renoprotective, antioxidant, hypotensive and ...

journal_title：Pharmaceutical biology

authors： Silawat N,Gupta VB

更新日期：2013-01-01 00:00:00

abstract：CONTEXT:Silymarin (SM) is extracted from milk thistle Silybum marianum L. [Asteraceae (Compositae)] and known for antioxidative and anti-inflammatory effects. OBJECTIVE:The potential antidepressant-like effect of acute SM and possible involvement of nitric oxide (NO) were determined in male mice. MATERIAL AND METHODS...

journal_title：Pharmaceutical biology

authors： Khoshnoodi M,Fakhraei N,Dehpour AR

更新日期：2015-05-01 00:00:00

abstract：:Context: Fuzheng Huayu recipe (FZHY) combined with entecavir (ETV) is used to treat the cirrhosis caused by chronic hepatitis B (CHB) infection.Objective: To investigate the effect of FZHY on ETV pharmacokinetics under different conditions.Materials and methods: A model of liver fibrosis was created by intraperitoneal...

journal_title：Pharmaceutical biology

authors： Yang T,Zheng TH,Zhao Q,Liu W,Li SP,Tao YY,Wang CH,Liu CH

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:Medical therapies for alcohol-induced liver disease are often difficult to handle and limited in efficacy. OBJECTIVE:In an attempt to find natural therapeutics, here, we investigate the preventive effect of persimmon vinegar (PV) and its fractions against alcohol-induced hepatic injury, in addition to the unde...

journal_title：Pharmaceutical biology

authors： Lee HM,Park MY,Kim J,Shin JH,Park KS,Kwon O

更新日期：2016-11-01 00:00:00

abstract：CONTEXT:Curcumol has recently attracted special attention due to its potential activities in many chronic disorders. Moreover, the traditional role of turmeric [Curcuma longa L. (Zingiberaceae)] in suppression of hyperglycemia is of great interest. OBJECTIVES:The present work explores the potential acute and subchroni...

journal_title：Pharmaceutical biology

authors： Raafat KM,Omar AG

更新日期：2016-08-01 00:00:00

abstract：CONTEXT:Naringin is a bioflavonoid derivative and is predominantly found in Citrus paradisi Macf., Citrus sinensis (Linn.) Osbeck, Citrus unshiu Marc., Citrus reticulata Blanco cv. Nobilis, Citrus tachibana (Makino) Tanaka, Citrus junos Sieb. ex Tanaka (Rutaceae), and related citrus species. It has anti-inflammatory ef...

journal_title：Pharmaceutical biology

authors： Si-Si W,Liao L,Ling Z,Yun-Xia Y

更新日期：2011-08-01 00:00:00

abstract：CONTEXT:Brassicaceae plants are associated with protection against cancers due to their glucosinolate contents. OBJECTIVES:We investigate fresh leaves, roots and ripe seeds of Lobularia libyca (Viv.) C.F.W. Meissn. (Brassicaceae) to identify their glucosinolate constituents, antimicrobial and cytotoxic activities Mate...

journal_title：Pharmaceutical biology

authors： Al-Gendy AA,Nematallah KA,Zaghloul SS,Ayoub NA

更新日期：2016-12-01 00:00:00

abstract：:Context 3,4-Oxo-isopropylidene-shikimic acid (ISA) is an analog of shikimic acid (SA). SA is extracted from the dry fruit of Illicium verum Hook. f. (Magnoliaceae), which has been used for treating stomachaches, skin inflammation and rheumatic pain. Objective To investigate the anti-inflammatory, analgesic and antioxi...

journal_title：Pharmaceutical biology

authors： Sun JY,You CY,Dong K,You HS,Xing JF

更新日期：2016-10-01 00:00:00

abstract：CONTEXT:2,7-Dihydroxy-3-methylanthraquinone (DDMN) is reported to have a remarkable anticancer activity against gastric cancer SGC-7901 cells. OBJECTIVE:The objective of this study is to study the anticancer effect and mechanism of DDMN on SGC-7901 cells. MATERIALS AND METHODS:The MTT assay was used to determine the ...

journal_title：Pharmaceutical biology

authors： Zhu H,Zheng Z,Zhang J,Liu X,Liu Y,Yang W,Liu Y,Zhang T,Zhao Y,Liu Y,Su X,Gu X

更新日期：2016-01-01 00:00:00

abstract：CONTEXT:Ginger [Zingiber officinale Roscoe. (Zingiberaceae)] has been universally used as a spice as well as for its health benefits. OBJECTIVE:The present study evaluates the protective effect of the standardized extract of ginger against isoproterenol (ISO)-induced myocardial infarction (MI) in rats. MATERIALS AND ...

journal_title：Pharmaceutical biology

authors： Amran AZ,Jantan I,Dianita R,Buang F

更新日期：2015-01-01 00:00:00

abstract：CONTEXT:Solenostemon monostachyus P. Beauv (Lamiaceae) is an important herb used traditionally in the treatment of malaria, fever, and other diseases. OBJECTIVES:Antiplasmodial and antipyretic activities of S. monostachyus aerial extract were evaluated to ascertain the folkloric claim of its antimalarial and antipyret...

journal_title：Pharmaceutical biology

authors： Okokon J,Davis KA,Azare BA

更新日期：2016-01-01 00:00:00

abstract：:The approach to new drugs through natural products has proved to be the single most successful strategy for the discovery of new drugs, but in recent years its use has been deemphasized by many pharmaceutical companies in favor of approaches based on combinatorial chemistry and genomics, among others.Drug discovery fr...

journal_title：Pharmaceutical biology

authors： Cao S,Kingston DG

更新日期：2009-08-01 00:00:00

abstract：:Context Previous studies have shown that Scutellariae Radix, the dried root of Scutellaria baicalensis Georgi (Labiatae), has a certain inhibitory effect on P-glycoprotein (P-gp), but the effects of its main active constituents on P-gp are still ambiguous. Objectives In vitro studies were performed to investigate the ...

journal_title：Pharmaceutical biology

authors： Miao Q,Wang Z,Zhang Y,Miao P,Zhao Y,Zhang Y,Ma S

更新日期：2016-09-01 00:00:00