Protein tyrosine phosphatase 1B (PTP1B) inhibitory activity and glucosidase inhibitory activity of compounds isolated from Agrimonia pilosa.

abstract：:Physalis alkekengi L. (Solanaceae) is a popular plant in traditional European and Chinese folk medicine, and it has been reported to have many ethnopharmacological properties including antifungal, anti-cough, anti-inflammatory, analgesic, and febricide activities. Some active components from Physalis species have been...

journal_title：Pharmaceutical biology

authors： Helvaci S,Kökdil G,Kawai M,Duran N,Duran G,Güvenç A

更新日期：2010-02-01 00:00:00

abstract：CONTEXT:Magnesium lithospermate B (MLB), an active polyphenol acid of Danshen [Radix Salviae miltiorrhizae (Labiatae)], showed renoprotective, neuroprotective and myocardial salvage effects. Previous studies demonstrated that MLB could effectively suppress the production of cytokines and their associated signaling path...

journal_title：Pharmaceutical biology

authors： Quan W,Wei G,Zhou D,Zhu Y,Guo C,Wang Y,Weng Y,Xi M,Wen A

更新日期：2013-11-01 00:00:00

abstract：CONTEXT:Many plant extracts and compounds are being investigated for their cytotoxicity and hence their medicinal or therapeutic properties. Reports of toxicity studies with limonoid analogs have been sparse and have involved mainly crude extracts. In this study, individual natural limonoids have been isolated and thei...

journal_title：Pharmaceutical biology

authors： Fowles RG,Mootoo BS,Ramsewak RS,Khan A

更新日期：2012-02-01 00:00:00

abstract：CONTEXT:Buchenavia tetraphylla (Aubl.) RA Howard (Combretaceae: Combretoideae) is an ethnomedicinal plant with reported antifungal action. OBJECTIVE:This study evaluates the antimicrobial activity of B. tetraphylla leaf extracts against clinical isolates of Candida albicans. The morphological alterations, combinatory ...

journal_title：Pharmaceutical biology

authors： Cavalcanti Filho JR,Silva TF,Nobre WQ,Oliveira de Souza LI,Silva E Silva Figueiredo CS,Figueiredo RC,de Gusmão NB,Silva MV,Nascimento da Silva LC,Correia MT

更新日期：2017-12-01 00:00:00

abstract：:Context Shengmai injection (SMI) is a patented Chinese medicine originated from the ancient Chinese herbal compound Shengmai san, which is used extensively for the treatment of cardiovascular and cerebrovascular disease in the clinic. Objective To determine the neuroprotective effect of SMI, we investigated the effect...

journal_title：Pharmaceutical biology

authors： Yang H,Li L,Zhou K,Wang Y,Guan T,Chai C,Kou J,Yu B,Yan Y

更新日期：2016-10-01 00:00:00

abstract：:Context: Er Miao San (EMS) is a traditional Chinese medicine composed of Atractylodis Rhizoma and Phellodendri Cortex in a 1:1 weight ratio. EMS has been used to treat rheumatism in China for many years.Objective: To evaluate the anti-arthritic activity of EMS extract on adjuvant-induced arthritis (AA) in Sprague-Dawl...

journal_title：Pharmaceutical biology

authors： Dai X,Yang D,Bao J,Zhang Q,Ding J,Liu M,Ding M,Liu M,Liang J,Jia X

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:One traditional medicines, Hypericum perforatum L. (Hypericaceae), possesses several beneficial effects against depression, ulcers, dyspepsia, abdominal pains, burns, bacterial infections, migraine headaches, and sciatica. OBJECTIVE:The present study investigates the antimicrobial activity of the ethanol extra...

journal_title：Pharmaceutical biology

authors： Süntar I,Oyardı O,Akkol EK,Ozçelik B

更新日期：2016-01-01 00:00:00

abstract：CONTEXT:Ginger [Zingiber officinale Roscoe. (Zingiberaceae)] has been universally used as a spice as well as for its health benefits. OBJECTIVE:The present study evaluates the protective effect of the standardized extract of ginger against isoproterenol (ISO)-induced myocardial infarction (MI) in rats. MATERIALS AND ...

journal_title：Pharmaceutical biology

authors： Amran AZ,Jantan I,Dianita R,Buang F

更新日期：2015-01-01 00:00:00

abstract：CONTEXT:Panax ginseng C. A. Mey (Araliaceae) has been widely used in clinic for treatment of cardiovascular diseases in China. Ginsenoside Rb3 is the main chemical component of Panax ginseng. OBJECTIVE:The aim of this study was to evaluate the effect of ginsenoside Rb3 on myocardial ischemia-reperfusion injury in rats...

journal_title：Pharmaceutical biology

authors： Shi Y,Han B,Yu X,Qu S,Sui D

更新日期：2011-09-01 00:00:00

abstract：CONTEXT:Aquatic organisms (especially fish) require potent defense mechanisms to protect themselves against pathogen invasion and disease formation. The use of immunostimulants in fish culture can prevent the diseases through augmentation of both specific and non-specific immunity. OBJECTIVE:A study was conducted to i...

journal_title：Pharmaceutical biology

authors： Pratheepa V,Ramesh S,Sukumaran N

更新日期：2010-11-01 00:00:00

abstract：CONTEXT:Cataract is the clouding of eye lens which causes impairment in vision and accounts for the leading factor of global blindness. Functional food-based prevention of cataract finds application in vision research because of its availability and easy access to all classes of the society. Cassia tora Linn. (Caesalpi...

journal_title：Pharmaceutical biology

authors： Sreelakshmi V,Abraham A

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:Polygonum species have been used in the treatment of several types of inflammatory disorders and cancer. Nevertheless, there are no reports related to the anti-inflammatory and anti-proliferative activities of Polygonum bellardii All. (Polygonaceae). OBJECTIVE:This study investigated the chemical composition o...

journal_title：Pharmaceutical biology

authors： Abd El-Kader AM,El-Readi MZ,Ahmed AS,Nafady AM,Wink M,Ibraheim ZZ

更新日期：2013-08-01 00:00:00

abstract：CONTEXT:Chrysanthemum morifolium Ramat. (Asteraceae) extract (CME) possesses a vasodilator effect in vitro. However, the use of polyphenol-rich CME in the treatment of hypertension-induced cardiac hypertrophy has not been reported. OBJECTIVE:We investigated the effect of polyphenol-rich CME on hypertension-induced car...

journal_title：Pharmaceutical biology

authors： Gao T,Zhu ZY,Zhou X,Xie ML

更新日期：2016-12-01 00:00:00

abstract：:Context Worldwide ethnobotanical research has shown the importance of home gardens as sources of medicinal plants. These resources are worthy of further study in the Argentinean Atlantic Forest due to the richness of medicinal flora and their importance for local people. Objective We studied richness, composition, cul...

journal_title：Pharmaceutical biology

authors： Furlan V,Kujawska M,Hilgert NI,Pochettino ML

更新日期：2016-09-01 00:00:00

abstract：:Viscum angulatum Heyne ex DC (Viscaceae) is a leafless hemiparasitic shrub traditionally used in Asian countries for the treatment of hypertension. In the present study, the methanol extract of the whole plant was examined for diuretic activity in rats. The activity was evaluated using parameters such as urine volume ...

journal_title：Pharmaceutical biology

authors： Jadhav RB,Bhatnagar SP,Surana SJ

更新日期：2010-04-01 00:00:00

abstract：:Context Diabetes is a global health challenge. Although large prospective clinical trials have shown that intensive control of blood glucose or blood pressure reduces the risk for development and progression of vascular complications in diabetes, a substantial number of diabetic patients still experience renal failure...

journal_title：Pharmaceutical biology

authors： Yamagishi S,Matsui T

更新日期：2016-10-01 00:00:00

abstract：CONTEXT:Linum usitatissimum L. (Linaceae), commonly known as flaxseed, is a good source of dietary fiber and lignans. Earlier we reported cardioprotective, antihyperlipidemic, and in vitro antioxidant activity of flax lignan concentrate (FLC) obtained from flaxseed. OBJECTIVES:To isolate secoisolariciresinol diglucosi...

journal_title：Pharmaceutical biology

authors： Zanwar AA,Hegde MV,Rojatkar SR,Sonawane KB,Rajamohanan PR,Bodhankar SL

更新日期：2014-09-01 00:00:00

abstract：CONTEXT:Lycopene is a phytonutrient under considerable investigation for its antioxidant benefits in treating diseases like cancer, cardiovascular diseases, osteoporosis and diabetes. OBJECTIVE:This study explores the effect of lycopene against oxidative damage during experimental hepatitis, induced by D-galactosamine...

journal_title：Pharmaceutical biology

authors： Sheik Abdulazeez S,Thiruvengadam D

更新日期：2013-12-01 00:00:00

abstract：CONTEXT:Investigating potential central nervous system (CNS) activities of Crataegus monogyna Jacq. (Rosaceae), hawthorn, fruit extracts. OBJECTIVE:Evaluating CNS effects and analgesic activities of hawthorn fruit extracts based on the traditional uses of the plant for neurosedative and pain killer actions. MATERIALS...

journal_title：Pharmaceutical biology

authors： Can OD,Ozkay UD,Oztürk N,Oztürk Y

更新日期：2010-08-01 00:00:00

abstract：CONTEXT:Ferulago angulata (Schlecht.) Boiss. (Apiaceae) (FASB) is used to treat liver diseases and has been used both as food and therapeutics by many cultures for thousands of years because of the natural antioxidant compounds. OBJECTIVE:This study determines antioxidant properties of FASB flowers, the levels of mine...

journal_title：Pharmaceutical biology

authors： Kiziltas H,Ekin S,Bayramoglu M,Akbas E,Oto G,Yildirim S,Ozgokce F

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:1 D is a novel derivative of curcumin and shows very promising antitumor activities in various cancer cell lines. OBJECTIVE:To characterize its preclinical pharmacokinetic profiles, a novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantification of 1 ...

journal_title：Pharmaceutical biology

authors： Sun J,Jiang T,Xu W,Feng Z,Quan X,Leng P,Sun W,Zhao J,Jing F,Li J

更新日期：2019-12-01 00:00:00

abstract：:Context: Cisplatin-based chemotherapy was widely used in treating human malignancies. However, side effects and chemoresistance remains the major obstacle.Objective: To verify whether natural borneol (NB) can enhance cisplatin-induced glioma cell apoptosis and explore the mechanism.Materials and methods: Cytotoxicity ...

journal_title：Pharmaceutical biology

authors： Cao WQ,Zhai XQ,Ma JW,Fu XQ,Zhao BS,Zhang P,Fu XY

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:Growing adipose tissue is thought to require adipogenesis, angiogenesis, and extracellular matrix (ECM) remodeling. Close examination of developing adipose tissue microvasculature reveals that angiogenesis often precedes adipogenesis. Since our previous study demonstrated that Ob-X, the anti-angiogenic herbal c...

journal_title：Pharmaceutical biology

authors： Hong Y,Kim MY,Yoon M

更新日期：2011-08-01 00:00:00

abstract：CONTEXT:Propranolol, atenolol, and ICI118,551 are non-selective β-adrenergic receptor (AR), β1-AR, and β2-AR antagonists, respectively. OBJECTIVE:We investigated the efficacy of propranolol, atenolol, and ICI118,551 on proliferation, migration, and invasion of non-stimulated breast (MCF7), colon (HT-29), and hepatocel...

journal_title：Pharmaceutical biology

authors： Işeri OD,Sahin FI,Terzi YK,Yurtcu E,Erdem SR,Sarialioglu F

更新日期：2014-11-01 00:00:00

abstract：CONTEXT:Total glucosides of peony (TGP), compounds extracted from the dried roots of Paeonia lactiflora Pall, have been reported to have anti-inflammatory and antioxidative activities. However, the protective effect of TGP on liver injury and the underlying mechanisms remains unknown in diabetic rats. OBJECTIVES:Curre...

journal_title：Pharmaceutical biology

authors： Xia LL,Zhu QJ,Wu YG

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:Tournefortia sarmentosa Lam. (Boraginaceae), a Chinese herbal medicine, is commonly used as a detoxicant or anti-inflammatory agent. OBJECTIVE:As acetaminophen (APAP) is a well-known hepatotoxin, we investigated the effect of the aqueous extract of the T. sarmentosa on APAP-induced hepatotoxicity in vivo and i...

journal_title：Pharmaceutical biology

authors： Teng CY,Lai YL,Huang HI,Hsu WH,Yang CC,Kuo WH

更新日期：2012-03-01 00:00:00

abstract：CONTEXT:Hesperidin is a flavonoid that has various pharmacological activities including anti-inflammatory, antimicrobial and antiviral activities. OBJECTIVE:The aim of the study is the isolation of hesperidin from the peel of Citrus sinensis L. (Rutaceae), and the evaluation of its antioxidant capacity and cytotoxicit...

journal_title：Pharmaceutical biology

authors： Al-Ashaal HA,El-Sheltawy ST

更新日期：2011-03-01 00:00:00

abstract：CONTEXT:Rabdosia rubescens (Hemsl.) Hara (Lamiaceae) is widely used in traditional Chinese medicines for the treatment of antitumor, antimicrobial, anti-inflammatory and antioxidation. It is also used as a supplement in the treatment of many cancers, such as esophagus, mammary gland, liver and prostate cancers. OBJECT...

journal_title：Pharmaceutical biology

authors： Li F,Fan J,Wu Z,Liu RY,Guo L,Dong Z,Wang Z

更新日期：2013-09-01 00:00:00

abstract：:Context: Puerarin and triptolide are sometimes used together for the treatment of disease in Chinese clinics; however, the drug-drug interaction between puerarin and triptolide is still unknown. Objective: This study investigates the effects of puerarin on the pharmacokinetics of triptolide in rats and clarifies its m...

journal_title：Pharmaceutical biology

authors： Wang Q,Wu Y,Xiang F,Feng Y,Li Z,Ding Y

更新日期：2019-12-01 00:00:00

abstract：CONTEXT:(-)-α-Bisabolol (BISA) is a sesquiterpene alcohol widely used as scent in cosmetic preparations, perfumes, shampoos, toilet soaps and other toiletries with potential for use in the pharmaceutical area. OBJECTIVE:To evaluate the corneal antinociceptive efficacy of BISA and to analyze the best solubilizing agent...

journal_title：Pharmaceutical biology

authors： Teixeira GF,Costa FN,Campos AR

更新日期：2017-12-01 00:00:00