Abstract:
CONTEXT:Many plant extracts and compounds are being investigated for their cytotoxicity and hence their medicinal or therapeutic properties. Reports of toxicity studies with limonoid analogs have been sparse and have involved mainly crude extracts. In this study, individual natural limonoids have been isolated and their toxicity manipulated via semisynthesis. OBJECTIVE:The lethality of limonoid analogs from Swietenia macrophylla King and Swietenia aubrevilleana Stehlé & Cusin (Meliaceae) against Artemia salina Leach was determined. MATERIALS AND METHODS:Four known natural limonoids were isolated from the dry ground seeds of S. macrophylla and S. aubrevilleana, modified using acylation and hydrolysis reactions and tested in A. salina lethality assays at 1-400 ppm. A 50% lethal concentration (LC(50)) was determined by probit analysis. RESULTS:Higher levels of toxicity were achieved in most of the prepared analogs compared with the parent natural limonoids. The compound showing the highest toxicity with LC(50) 3.9 ppm was 3-O-benzoyl-3-detigloylisoswietenine (20). Other analogs with high toxicity were 6-O-benzoylswietenolide (7), 6-O-benzoylswietenine (17), and 3,6-O,O-dipropionylswietenolide (9), which showed LC(50) values of 4.3, 7.5, and 28.5 ppm, respectively. DISCUSSION AND CONCLUSIONS:Toxicity can be improved via semisynthesis. The compounds exhibiting high toxicity (low LC(50)) may be good candidates for cytotoxicity studies.
journal_name
Pharm Bioljournal_title
Pharmaceutical biologyauthors
Fowles RG,Mootoo BS,Ramsewak RS,Khan Adoi
10.3109/13880209.2011.581670subject
Has Abstractpub_date
2012-02-01 00:00:00pages
264-7issue
2eissn
1388-0209issn
1744-5116journal_volume
50pub_type
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2016.1183684
更新日期:2016-12-01 00:00:00
abstract::Rhinacanthus nasutus (L.) Kurz (Acanthaceae) has long been used in Thai traditional medicine for treatment of tinea versicolor, ringworm, pruritic rash, and abscess. The active constituents are known as a group of naphthoquinone esters, rhinacanthins. This work focused on establishment of R. nasutus root cultures and ...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880200903578747
更新日期:2010-11-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880200903241853
更新日期:2010-06-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1080/13880209.2019.1693605
更新日期:2019-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1080/13880209.2016.1190764
更新日期:2016-12-01 00:00:00
abstract::Physalis alkekengi L. (Solanaceae) is a popular plant in traditional European and Chinese folk medicine, and it has been reported to have many ethnopharmacological properties including antifungal, anti-cough, anti-inflammatory, analgesic, and febricide activities. Some active components from Physalis species have been...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
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journal_title:Pharmaceutical biology
pub_type: 杂志文章,评审
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更新日期:2013-02-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2015.1091480
更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
doi:10.3109/13880209.2010.533187
更新日期:2011-06-01 00:00:00
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更新日期:2016-07-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-12-01 00:00:00
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journal_title:Pharmaceutical biology
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更新日期:2015-05-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2010.501084
更新日期:2011-02-01 00:00:00
abstract::Nine species belonging to the genus Lippia - Verbenaceae - are used in Argentine folk medicine. Four of them are known under the trivial name "poleo": L. turbinata Griseb., L. fissicalyx Troncoso, L. integrifolia (Griseb.) Hieron. and L. grisebachiana Mold. Mainly, their leaves are employed as digestive, stomaquique, ...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1076/1388-0209(200004)3821-1FT120
更新日期:2000-01-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2014-06-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2013-02-01 00:00:00
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更新日期:2018-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-07-01 00:00:00
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更新日期:2017-12-01 00:00:00
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pub_type: 杂志文章
doi:10.3109/13880209.2014.950386
更新日期:2015-06-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2012-07-01 00:00:00
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更新日期:2016-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2016-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00