Abstract:
CONTEXT:Schizophrenia is a chronic disabling psychiatric disorder affecting 1% of the population worldwide. Due to the adverse effects of available antipsychotic medications, recent investigations have focused on the search for well-tolerated, safe molecules from natural resources to control the severity and progression of schizophrenia. OBJECTIVE:To screen the standardized extract of Bacopa monniera Linn. (Scrophulariaceae) (BM) for its antipsychotic potential in the ketamine-induced psychosis model with mice. MATERIALS AND METHODS:Graded dose of BM (40, 80, and 120 mg/kg, p.o.) were given to the mice 1 h prior to ketamine administration and tested for positive symptoms and cognitive deficits. A chronic ketamine treatment regimen was used to study the effect of BM on negative symptoms such as immobility enhancement. Each mouse was used once for the behavioral studies. RESULTS:BM reduced ketamine-induced hyperactivity with an EC50 value of 76.60 mg/kg. The 80 mg/kg dose was used for all other behavior analysis. Pretreatment with BM at 80 mg/kg showed two-fold increases in transfer latency time (TLT) in passive avoidance task. Chronic BM pretreatment (80 mg/kg p.o. daily × 10 d) ameliorated the ketamine-induced enhanced immobility effect by 21% in the forced swim test. BM treatment reversed ketamine-induced increase in monoamine oxidase activity in both cortex and striatum and normalized the acetylcholinesterase activity and the glutamate levels in the hippocampus. DISCUSSION AND CONCLUSION:Overall our findings suggest that BM possesses antipsychotic properties which might be due to its modulatory action on dopamine, serotonin, and glutamate neurotransmission.
journal_name
Pharm Bioljournal_title
Pharmaceutical biologyauthors
Chatterjee M,Verma R,Kumari R,Singh S,Verma AK,Dwivedi AK,Palit Gdoi
10.3109/13880209.2014.976350subject
Has Abstractpub_date
2015-01-01 00:00:00pages
1850-60issue
12eissn
1388-0209issn
1744-5116journal_volume
53pub_type
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2020.1750658
更新日期:2020-12-01 00:00:00
abstract::Context:Caragana pruinosa Kom. (Fabaceae), a commonly used folk medicine, has been found to possess antitumor effects. However, the antiproliferative effect of 2,4-dihydroxy-3'-methoxy-4'-ethoxychalcone (DMEC) derived from C. pruinosa against multiple myeloma (MM) has never been investigated. Objective: This study sys...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Pharmaceutical biology
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2020.1844760
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2016.1263344
更新日期:2017-12-01 00:00:00
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journal_title:Pharmaceutical biology
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doi:10.1080/13880209.2016.1265986
更新日期:2017-12-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2016.1181660
更新日期:2016-11-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.784342
更新日期:2013-09-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2013-12-13 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.948634
更新日期:2015-06-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.821664
更新日期:2014-02-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2016.1238488
更新日期:2017-12-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2010.547208
更新日期:2011-08-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2010.537666
更新日期:2011-06-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880200590951766
更新日期:2005-01-01 00:00:00
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pub_type: 杂志文章
doi:10.3109/13880209.2014.910533
更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.941505
更新日期:2015-05-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.877492
更新日期:2014-09-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2011-02-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.864685
更新日期:2014-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.981280
更新日期:2015-01-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2014-07-01 00:00:00