Abstract:
CONTEXT:Neuroprotective therapy to rescue dopaminergic neurons is an important trait in the management of Parkinson's disease (PD). OBJECTIVE:The present study identified and evaluated SFSE-T, a standardized hydroalcoholic extract of Trigonella foenum-graecum L. seeds (Fabaceae), in animal models of PD. MATERIALS AND METHODS:The identification of SFSE-T was carried out by high-performance liquid chromatography for the marker compound trigonelline (TGN). The effects of single dose oral treatment of SFSE-T (10, 30 or 100 mg/kg) were studied using animal models of PD, namely, 6-hydroxydopamine (6-OHDA)-induced unilateral lesions in rats, and 4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurodegeneration in C57BL/6 mice. The effects of SFSE-T on monoamino oxidase (MAO) enzyme in vitro as well as possible side effects of SFSE-T in vivo were also evaluated. RESULTS:The concentration of TGN in a test sample of SFSE-T was found to be 82%. SFSE-T (30 mg/kg, oral) showed a significant increase in the number of ipsilateral rotations (45.67 rotations in 30-min period) as compared with vehicle control group (no rotations) when tested in 6-OHDA-induced unilateral lesioned rats. SFSE-T (30 mg/kg, oral) showed significant reversal of motor dysfunction (spontaneous motor activity scores, speed, distance traveled and number of square crossed) caused by MPTP induced lesions in C57BL/6 mice in pretreatment (1 h) schedule but not in post-treatment (1 h) schedule. SFSE-T neither showed anticholinergic effects nor showed selective MAO-B enzyme inhibition in vitro. DISCUSSION AND CONCLUSION:SFSE-T showed reversal of motor symptoms in an animal model of PD probably through neuroprotective properties.
journal_name
Pharm Bioljournal_title
Pharmaceutical biologyauthors
Gaur V,Bodhankar SL,Mohan V,Thakurdesai PAdoi
10.3109/13880209.2012.747547subject
Has Abstractpub_date
2013-05-01 00:00:00pages
550-7issue
5eissn
1388-0209issn
1744-5116journal_volume
51pub_type
杂志文章abstract::Context 3,4-Oxo-isopropylidene-shikimic acid (ISA) is an analog of shikimic acid (SA). SA is extracted from the dry fruit of Illicium verum Hook. f. (Magnoliaceae), which has been used for treating stomachaches, skin inflammation and rheumatic pain. Objective To investigate the anti-inflammatory, analgesic and antioxi...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2016.1153663
更新日期:2016-10-01 00:00:00
abstract:CONTEXT:In traditional medicine propolis is widely used for the treatment of various ailments including ulcer and wound healing. The phytochemical screening of Indian propolis indicates the presence of biologically active ingredients in appreciable amounts. In the absence of systematic evaluation of wound healing prope...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880200903578754
更新日期:2010-11-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2017.1285944
更新日期:2017-12-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880200903373664
更新日期:2010-09-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.910535
更新日期:2015-01-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1076/1388-0209(200009)3841-AFT298
更新日期:2000-01-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2016.1158287
更新日期:2016-11-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2015.1089294
更新日期:2016-01-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2015.1129545
更新日期:2016-09-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.942787
更新日期:2015-05-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章,评审
doi:10.3109/13880209.2013.832776
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the aqueous extract from aerial parts of Artemisia copa Phil. (Asteraceae) administered orallyfor its psychopharmacological activities in several experimental models. METHODS:The extract was administered p.o. in Swiss albino mice and tested on pentobarbital-induced hypnosis, locomotor activity, e...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2010.486407
更新日期:2010-12-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.864685
更新日期:2014-06-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880200903241853
更新日期:2010-06-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章,评审
doi:10.3109/13880209.2012.698286
更新日期:2013-01-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2011.626784
更新日期:2012-01-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.914957
更新日期:2015-02-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章,评审
doi:10.3109/13880209.2016.1150302
更新日期:2016-10-01 00:00:00
abstract::Viscum angulatum Heyne ex DC (Viscaceae) is a leafless hemiparasitic shrub traditionally used in Asian countries for the treatment of hypertension. In the present study, the methanol extract of the whole plant was examined for diuretic activity in rats. The activity was evaluated using parameters such as urine volume ...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880200903150427
更新日期:2010-04-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880200903204000
更新日期:2010-05-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.931439
更新日期:2015-04-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2015.1016181
更新日期:2016-01-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章,评审
doi:10.3109/13880209.2015.1027778
更新日期:2016-01-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.866966
更新日期:2014-06-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2010.501084
更新日期:2011-02-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2016.1158842
更新日期:2016-11-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.924149
更新日期:2015-04-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章,评审
doi:10.3109/13880209.2013.837492
更新日期:2014-03-01 00:00:00