Abstract:
:The activity of an (8-hydroxymethylen)-trieicosanyl acetate compound obtained from chloroform extracts of Senna villosa (Mill.) H.S. Irwin & Barneby (Leguminosae) against Trypanosoma cruzi was evaluated in vivo. Oral doses of 2.1, 8.4, and 33.6 microg/g were tested for 28 days in BALB/c mice infected with T. cruzi. Reduced parasitemia levels of 70.5%, 73.8%, and 80.9%, respectively, were observed. A significant reduction in amastigote nests was detected in the cardiac tissue of treated animals at doses of 8.4 and 33.6 microg/g. The LD50 of (8-hydroxymethylen)-trieicosanyl acetate was impossible to determine because none of the animals died, even at oral doses of 5000 microg/g; consequently, it was impossible to determine the acute oral toxicity in vivo.
journal_name
Pharm Bioljournal_title
Pharmaceutical biologyauthors
Jimenez-Coello M,Acosta-Viana KY,Guzman-Marin E,Perez Gonzalez C,Salud Perez Gutierrez Mdoi
10.3109/13880200903241853subject
Has Abstractpub_date
2010-06-01 00:00:00pages
666-71issue
6eissn
1388-0209issn
1744-5116journal_volume
48pub_type
杂志文章abstract:CONTEXT:Brassicaceae plants are associated with protection against cancers due to their glucosinolate contents. OBJECTIVES:We investigate fresh leaves, roots and ripe seeds of Lobularia libyca (Viv.) C.F.W. Meissn. (Brassicaceae) to identify their glucosinolate constituents, antimicrobial and cytotoxic activities Mate...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2016.1223146
更新日期:2016-12-01 00:00:00
abstract::The approach to new drugs through natural products has proved to be the single most successful strategy for the discovery of new drugs, but in recent years its use has been deemphasized by many pharmaceutical companies in favor of approaches based on combinatorial chemistry and genomics, among others.Drug discovery fr...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880200902988629
更新日期:2009-08-01 00:00:00
abstract:CONTEXT:The fruits of Aronia melanocarpa Elliot (Rosaceae), (black chokeberry), and Sambucus nigra L. (Caprifoliaceae), elderberries are rich in anthocyanins. Many studies have reported that anthocyanins are beneficial in diabetes due to their capacity to stimulate insulin secretion and reduce oxidative stress. OBJECT...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.931441
更新日期:2015-04-01 00:00:00
abstract:CONTEXT:Biotransformation systems are profitable tools for structural modification of bioactive natural compounds into valuable biologically active terpenoids. OBJECTIVE:This study determines the biological effect of (R)-(+)-limonene and (-)-α-pinene, and their oxygenated derivatives, (a) perillyl alcohol and (S)-(+)-...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2015.1103753
更新日期:2016-01-01 00:00:00
abstract:CONTEXT:Obesity is the main risk factor for type 2 diabetes mellitus. Secondary metabolites with biological activities and pharmacological potential have been identified in species of the Baccharis genus that are specifically distributed in the Americas. OBJECTIVE:This study evaluated the effects of methanol extracts ...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2015.1067232
更新日期:2016-07-01 00:00:00
abstract::Context 3,4-Oxo-isopropylidene-shikimic acid (ISA) is an analog of shikimic acid (SA). SA is extracted from the dry fruit of Illicium verum Hook. f. (Magnoliaceae), which has been used for treating stomachaches, skin inflammation and rheumatic pain. Objective To investigate the anti-inflammatory, analgesic and antioxi...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2016.1153663
更新日期:2016-10-01 00:00:00
abstract:CONTEXT:Amla [Emblica officinalis Gaertn. (Euphorbiaceae)], a major constituent of several herbal formulations, is a well-known hepatoprotectant. Despite its extensive use, mechanistic understanding of its antioxidant action is rather limited. OBJECTIVE:In the current study, we investigated the effects of E. officinal...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2011.618501
更新日期:2012-04-01 00:00:00
abstract:CONTEXT:Hyperlipidemia is known to be a major risk factor for the development of cardiovascular diseases (CVDs) which include atherosclerosis, coronary heart disease, and stroke. Although there are a large number of anti-hyperlipidemic drugs available, unfortunately, they all have side effects. OBJECTIVE:Terminalia ch...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.962058
更新日期:2015-08-01 00:00:00
abstract:CONTEXT:Indian mustard [Brassica juncea (L.) Czern. & Coss. (Brassicaceae)] is reported to possess diverse pharmacological properties. However, limited information is available concerning its hepatoprotective activity and mechanism of action. OBJECTIVE:To study the protective mechanism of mustard seed extract against ...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.950675
更新日期:2015-07-01 00:00:00
abstract:CONTEXT:Light microscopy is in most cases a quick method for the identification and discrimination of medicinally used plant drugs; moreover, this technique is very inexpensive. Reliable descriptions of the anatomy of plants and their adulterations are prerequisites for necessary purity controls. OBJECTIVE:The anatomy...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2010.548390
更新日期:2011-08-01 00:00:00
abstract:CONTEXT:The bacterium Pseudomonas syringae pv. syringae (Pss) is a pathogen of many plant species and causes, for example, brown spot disease in bean plants (Phaseolus vulgaris). Pss excretes the syringolins, natural product molecules that act as a virulence factors and inhibit the proteasome of the host plants. OBJEC...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2011.626784
更新日期:2012-01-01 00:00:00
abstract:CONTEXT:Glutathione reductase (GR, NADPH:oxidized glutathione oxidoreductase, E.C 1.6.4.2) is a flavoprotein that catalyzes the NADPH-dependent reduction of oxidized glutathione (GSSG). GR is a crucial enzyme in the antioxidant system by maintaining reduced glutathione (GSH). Glucose 6-phosphate dehydrogenase (G6PD, gl...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2010.533187
更新日期:2011-06-01 00:00:00
abstract:CONTEXT:MOTILIPERM was prepared as a mixture of extracts of three medicinal herbs [roots of Morinda officinalis How (Rubiaceae), outer scales of Allium cepa L. (Liliaceae) and seeds of Cuscuta chinensis Lamark (Convolvulaceae)]. OBJECTIVE:To investigate the role of reactive oxygen species (ROS)-based endoplasmic retic...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2017.1421672
更新日期:2018-12-01 00:00:00
abstract:CONTEXT:Panax ginseng C. A. Mey (Araliaceae) has been widely used in clinic for treatment of cardiovascular diseases in China. Ginsenoside Rb3 is the main chemical component of Panax ginseng. OBJECTIVE:The aim of this study was to evaluate the effect of ginsenoside Rb3 on myocardial ischemia-reperfusion injury in rats...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2011.554845
更新日期:2011-09-01 00:00:00
abstract:CONTEXT:Salsola imbricata Forssk. (Chenopodiaceae) has folkloric repute for the treatment of various gastrointestinal and respiratory ailments. OBJECTIVE:The present study investigates spasmolytic and bronchorelaxant effects of S. imbricata. MATERIALS AND METHODS:The crude aqueous-ethanol extract of the aerial parts ...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2017.1291691
更新日期:2017-12-01 00:00:00
abstract:CONTEXT:Tagetes patula L. is one of the French marigold group of the Asteraceae family. It is recognized in folklore for its medicinal and pesticidal properties. OBJECTIVE:In search of more effective, but non-toxic compounds with antioxidative potential led to the bioassay guided isolation studies on the extracts of T...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2010.523006
更新日期:2011-05-01 00:00:00
abstract:CONTEXT:Withania somnifera (Linn.) Dunal (Solanaceae) has long been used as an herb in Ayurvedic and indigenous medicine and has received intense attention in recent years for its chemopreventive properties. OBJECTIVE:The present study focuses on the effect of W. somnifera root powder on the behavioral and radiologica...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.835325
更新日期:2014-03-01 00:00:00
abstract:CONTEXT:The genus Hypericum (Guttiferae) has received considerable scientific interest as a source of biologically active compounds. OBJECTIVE:The study determined the morphogenetic and ontogenetic variation in the main bioactive compounds of two Hypericum species, namely, Hypericum aviculariifolium subsp. depilatum v...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2012.733012
更新日期:2013-03-01 00:00:00
abstract::Escin, a group of chemically related triterpenic glycosides, is widely used in commercial preparations for the treatment of venous insufficiency. Since the zygotic embryo cotyledons accumulate the highest amount of escin, it is currently extracted from the seeds of horse chestnut, Aesculus hippocastanum L. (Hippocasta...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880200903204000
更新日期:2010-05-01 00:00:00
abstract:CONTEXT:Medical therapies for alcohol-induced liver disease are often difficult to handle and limited in efficacy. OBJECTIVE:In an attempt to find natural therapeutics, here, we investigate the preventive effect of persimmon vinegar (PV) and its fractions against alcohol-induced hepatic injury, in addition to the unde...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2016.1158842
更新日期:2016-11-01 00:00:00
abstract:CONTEXT:There have been no reports of the extraction of essential oil (EO) from white cabbage [Brassica oleracea L. var. capitata (L.) Alef. f. alba DC. (Brassicaceae)] (Bocfal) or its chemical composition, antioxidant activity, or hepatoprotective effects. OBJECTIVE:To extract Bocfal EO, to identify and quantify its ...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2016.1258424
更新日期:2017-12-01 00:00:00
abstract:CONTEXT:Cyclophosphamide (CP) causes lung injury in rats through its ability to generate free radicals with subsequent epithelial and endothelial cell damage. OBJECTIVE:This study was conducted to assess whether allicin can ameliorate CP-induced early lung injury in rats. MATERIALS AND METHODS:Male Sprague Dawely rat...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.766895
更新日期:2013-06-01 00:00:00
abstract::Context Shengmai injection (SMI) is a patented Chinese medicine originated from the ancient Chinese herbal compound Shengmai san, which is used extensively for the treatment of cardiovascular and cerebrovascular disease in the clinic. Objective To determine the neuroprotective effect of SMI, we investigated the effect...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2016.1155625
更新日期:2016-10-01 00:00:00
abstract:CONTEXT:Plants and most of the plant-derived compounds have long been known for their potential pharmaceutical effects. They are well known to play an important role in the treatment of several diseases from diabetes to various types of cancers. Today most of the clinically effective pharmaceuticals are developed from ...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.942788
更新日期:2015-05-01 00:00:00
abstract:CONTEXT:Hypertrophic scarring, a common proliferative disorder of dermal fibroblasts, results from an overproduction of collagen and excessive deposition of extracellular matrix. Although the treatment with surgical excisions or steroid hormones can modify the symptoms, numerous treatment-related complications have als...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2010.542761
更新日期:2011-07-01 00:00:00
abstract:CONTEXT:Herbal therapies are used worldwide to treat health conditions. In Mexico, generations have used them to treat gingivitis, periodontitis, mouth infections, and discoloured teeth. However, few studies have collected scientific evidence on their effects. OBJECTIVE:This study aimed at searching and compiling scie...
journal_title:Pharmaceutical biology
pub_type: 杂志文章,评审
doi:10.1080/13880209.2017.1347188
更新日期:2017-12-01 00:00:00
abstract:CONTEXT:Several studies have demonstrated that essential oils and their major components have antioxidant activity. p-Cymene is a monoterpene and a major constituent of essential oils of various species of plants. OBJECTIVE:This paper evaluated the antioxidant potential of p-cymene in the hippocampus of mice by determ...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.923003
更新日期:2015-03-01 00:00:00
abstract:CONTEXT:The roots of Alafia barteri Oliver (Apocynaceae), Combretum mucronatum Schumach (Combretaceae) and Capparis thonningii Schum (Capparaceae) are used in Traditional African Medicine to alleviate painful and inflammatory conditions. OBJECTIVE:This study investigated the analgesic and anti-inflammatory effects of ...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.880487
更新日期:2014-09-01 00:00:00
abstract:CONTEXT:Naringin is a bioflavonoid derivative and is predominantly found in Citrus paradisi Macf., Citrus sinensis (Linn.) Osbeck, Citrus unshiu Marc., Citrus reticulata Blanco cv. Nobilis, Citrus tachibana (Makino) Tanaka, Citrus junos Sieb. ex Tanaka (Rutaceae), and related citrus species. It has anti-inflammatory ef...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2010.550054
更新日期:2011-08-01 00:00:00
abstract:CONTEXT:High-mobility group box 1 (HMGB1) protein is a highly abundant protein that can promote the pathogenesis of inflammatory. Some experiments have demonstrated a vital role for HMGB1 to modulate the immune function of regulatory T-cells (Tregs). Astragaloside IV (AST IV), an extract from Astragalus membranaceus Mo...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2016.1216133
更新日期:2016-12-01 00:00:00