Analgesic and anti-inflammatory effects of the methanol root extracts of some selected Nigerian medicinal plants.

Abstract:

CONTEXT:The roots of Alafia barteri Oliver (Apocynaceae), Combretum mucronatum Schumach (Combretaceae) and Capparis thonningii Schum (Capparaceae) are used in Traditional African Medicine to alleviate painful and inflammatory conditions. OBJECTIVE:This study investigated the analgesic and anti-inflammatory effects of the methanol root extracts of Alafia barteri (MeAB), C. mucronatum (MeCM), and Capparis thonningii (MeCT). MATERIALS AND METHODS:Analgesic activity of the extracts (50, 100, and 200 mg/kg, p.o. 1 h) was evaluated using acetic acid-, formalin- and hot plate-induced pain while anti-inflammatory actions (100 or 200 mg/kg) were investigated using the carrageenan- and xylene-induced edema tests. RESULTS:MeAB, MeCM, and MeCT (200 mg/kg) inhibited acetic acid-induced abdominal constriction by 55.07, 46.67, and 47.25%, respectively. In the formalin test, the index of pain inhibition of early and late phases was, respectively, 47.83 and 81.98% for MeAB, 56.10 and 63.81% for MeCM, and 42.84 and 63.29% for MeCT (200 mg/kg). MeAB and MeCT pretreatments significantly increased the reaction time by 46.67 and 25.53%, respectively, 120 min post-treatment in the hot-plate test. Naloxone (5 mg/kg, s.c.) pretreatment 15 min before extract administration, significantly (p < 0.05) reversed the analgesic effect of MeAB and MeCT in the formalin test. MeAB, MeCM, and MeCT showed significant anti-inflammatory activity with 60.44 and 30.39%, 63.74 and 58.08%, and 50.55 and 77.84% (200 mg/kg, 4 h), respectively, inhibition of paw and ear edema. DISCUSSION AND CONCLUSION:The analgesic and anti-inflammatory effects of MeAB and MeCT involve an interaction with opioid pathway and/or inhibition of chemical mediators of pain and inflammation.

journal_name

Pharm Biol

journal_title

Pharmaceutical biology

authors

Ishola IO,Agbaje EO,Adeyemi OO,Shukla R

doi

10.3109/13880209.2014.880487

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

1208-16

issue

9

eissn

1388-0209

issn

1744-5116

journal_volume

52

pub_type

杂志文章
  • Antispasmodic and bronchorelaxant activities of Salsola imbricata are mediated through dual Ca+2 antagonistic and β-adrenergic agonistic effects.

    abstract:CONTEXT:Salsola imbricata Forssk. (Chenopodiaceae) has folkloric repute for the treatment of various gastrointestinal and respiratory ailments. OBJECTIVE:The present study investigates spasmolytic and bronchorelaxant effects of S. imbricata. MATERIALS AND METHODS:The crude aqueous-ethanol extract of the aerial parts ...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.1080/13880209.2017.1291691

    authors: Aslam N,Janbaz KH

    更新日期:2017-12-01 00:00:00

  • Immunomodulatory effect of Aegle marmelos leaf extract on freshwater fish Cyprinus carpio infected by bacterial pathogen Aeromonas hydrophila.

    abstract:CONTEXT:Aquatic organisms (especially fish) require potent defense mechanisms to protect themselves against pathogen invasion and disease formation. The use of immunostimulants in fish culture can prevent the diseases through augmentation of both specific and non-specific immunity. OBJECTIVE:A study was conducted to i...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.3109/13880201003713598

    authors: Pratheepa V,Ramesh S,Sukumaran N

    更新日期:2010-11-01 00:00:00

  • Antioxidant, anti-collagenase and anti-elastase activities of Phyllanthus emblica, Manilkara zapota and silymarin: an in vitro comparative study for anti-aging applications.

    abstract::Context Phyllanthus emblica L. (Euphorbiaceae) (amla), Manilkara zapota L.P. Royen (Sapotaceae) (sapota) and silymarin are reported to contain antioxidant effects. However, information on other biological activities relating to the anti-aging properties is limited. Objective To compare in vitro antioxidants, anti-coll...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.3109/13880209.2015.1133658

    authors: Pientaweeratch S,Panapisal V,Tansirikongkol A

    更新日期:2016-09-01 00:00:00

  • Antimicrobial activity of the extracts and physalin D from Physalis alkekengi and evaluation of antioxidant potential of physalin D.

    abstract::Physalis alkekengi L. (Solanaceae) is a popular plant in traditional European and Chinese folk medicine, and it has been reported to have many ethnopharmacological properties including antifungal, anti-cough, anti-inflammatory, analgesic, and febricide activities. Some active components from Physalis species have been...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.3109/13880200903062606

    authors: Helvaci S,Kökdil G,Kawai M,Duran N,Duran G,Güvenç A

    更新日期:2010-02-01 00:00:00

  • Antiproliferative and cytotoxic activities of furocoumarins of Ducrosia anethifolia.

    abstract:CONTEXT:Phytochemical and pharmacological data on Ducrosia anethifolia (DC.) Boiss. (Apiaceae), an Iranian medicinal plant, are scarce; however, furocoumarins are characteristic compounds of D. anethifolia. OBJECTIVE:Our experiments identify the secondary metabolites of D. anethifolia and assess their antitumor and an...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.1080/13880209.2018.1548625

    authors: Mottaghipisheh J,Nové M,Spengler G,Kúsz N,Hohmann J,Csupor D

    更新日期:2018-12-01 00:00:00

  • Effects of intragastric administration of five oyster components on endurance exercise performance in mice.

    abstract:CONTEXT:Oysters [Crassostrea plicatula Gmelin (Ostreidae)] are widely used for food in coastal areas. It is reported to have several qualities such as improving sexual and immune function. They has been approved by Chinese Ministry of Health as a functional food. OBJECTIVE:The effects of five types of oyster component...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.3109/13880209.2013.866966

    authors: Hao G,Zhang C,Cao W,Hao J

    更新日期:2014-06-01 00:00:00

  • Phytoextract of Indian mustard seeds acts by suppressing the generation of ROS against acetaminophen-induced hepatotoxicity in HepG2 cells.

    abstract:CONTEXT:Indian mustard [Brassica juncea (L.) Czern. & Coss. (Brassicaceae)] is reported to possess diverse pharmacological properties. However, limited information is available concerning its hepatoprotective activity and mechanism of action. OBJECTIVE:To study the protective mechanism of mustard seed extract against ...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.3109/13880209.2014.950675

    authors: Parikh H,Pandita N,Khanna A

    更新日期:2015-07-01 00:00:00

  • Silymarin alleviates bleomycin-induced pulmonary toxicity and lipid peroxidation in mice.

    abstract:CONTEXT:The application of bleomycin is limited due to its side effects including lung toxicity. Silymarin is a flavonoid complex isolated from milk thistle [Silybum marianum L. (Asteraceae)] which has been identified as an antioxidant and anti-inflammatory compound. OBJECTIVE:This study evaluates the effect of silyma...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.3109/13880209.2014.889176

    authors: Razavi-Azarkhiavi K,Ali-Omrani M,Solgi R,Bagheri P,Haji-Noormohammadi M,Amani N,Sepand MR

    更新日期:2014-10-01 00:00:00

  • Protein tyrosine phosphatase 1B (PTP1B) inhibitory activity and glucosidase inhibitory activity of compounds isolated from Agrimonia pilosa.

    abstract:CONTEXT:Despite phytochemical studies of Agrimonia pilosa Ledeb. (Rosaceae), the antidiabetic effects of this plant are unknown. OBJECTIVE:This study characterizes the isolated compounds from the aerial parts of A. pilosa and evaluates their PTP1B and α-glucosidase inhibitory properties. MATERIALS AND METHODS:Ethanol...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.3109/13880209.2015.1048372

    authors: Na B,Nguyen PH,Zhao BT,Vo QH,Min BS,Woo MH

    更新日期:2016-01-01 00:00:00

  • Essential oil compositions and antioxidant properties of the roots of twelve Anatolian Paeonia taxa with special reference to chromosome counts.

    abstract::Essential oil compositions and antioxidant potentials of fourteen ethanol (75%) root extracts prepared from twelve taxa of the genus Paeonia (Paeoniaceae), including P. arietina Anders., P. daurica Andrews, P. xkayae N. Ozhatay, P. kesrouanensis Thiéb., P. mascula (L.) Miller subsp. arasicola G. Kaynak, ö. Yilmaz & R....

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.3109/13880200903029332

    authors: Orhan I,Demirci B,Omar I,Siddiqui H,Kaya E,Choudhary MI,Ecevit-Genç G,Ozhatay N,Sener B,Başer KH

    更新日期:2010-01-01 00:00:00

  • The genus Scrophularia: a source of iridoids and terpenoids with a diverse biological activity.

    abstract:CONTEXT:Scrophularia genus (Scrophulariaceae) includes about 350 species commonly known as figwort. Many species of this genus grow wild in nature and have not been cultivated yet. However, some species are in danger of extinction. OBJECTIVE:This paper reviews the chemical compounds, biological activities and the ethn...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章,评审

    doi:10.1080/13880209.2017.1397178

    authors: Pasdaran A,Hamedi A

    更新日期:2017-12-01 00:00:00

  • Antipyretic and antimalarial activities of Solenostemon monostachyus.

    abstract:CONTEXT:Solenostemon monostachyus P. Beauv (Lamiaceae) is an important herb used traditionally in the treatment of malaria, fever, and other diseases. OBJECTIVES:Antiplasmodial and antipyretic activities of S. monostachyus aerial extract were evaluated to ascertain the folkloric claim of its antimalarial and antipyret...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.3109/13880209.2015.1070880

    authors: Okokon J,Davis KA,Azare BA

    更新日期:2016-01-01 00:00:00

  • Comparison of some secondary metabolite content in the seventeen species of the Boraginaceae family.

    abstract:CONTEXT:The Boraginaceae family comprises plants that have important therapeutic and cosmetic applications. Their pharmacological effect is related to the presence of naphthaquinones, flavonoids, terpenoids, phenols, or purine derivative - allantoin. OBJECTIVE:In the present study, comparison of some secondary metabol...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.1080/13880209.2016.1265986

    authors: Dresler S,Szymczak G,Wójcik M

    更新日期:2017-12-01 00:00:00

  • Therapeutic potential of gossypol: an overview.

    abstract:CONTEXT:Polyphenols are naturally occurring compounds found in fruits, vegetables, cereals, and beverages. Polyphenols occupy a unique place in biological science for their pharmacological properties. Gossypol is a polyphenolic compound that has attracted attention because of its biological effects. OBJECTIVE:Gossypol...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章,评审

    doi:10.3109/13880209.2013.832776

    authors: Keshmiri-Neghab H,Goliaei B

    更新日期:2014-01-01 00:00:00

  • Assessment of in vitro. Antifungal Activities of Various Extracts of Indigenous Bahraini Medicinal Plants.

    abstract::The in vitro. antifungal activity of the aqueous, ethanol, chloroform, petroleum ether, and residue extracts from 10 indigenous Bahraini plants used in folk medicine for the treatment of various diseases is reported. Extract efficacy was evaluated using the agar well diffusion assay against four filamentous fungi and ...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.1080/13880200590951766

    authors: Mandeel Q,Taha A

    更新日期:2005-01-01 00:00:00

  • Antioxidant, anticholinesterase and antibacterial activities of Stachys guyoniana and Mentha aquatica.

    abstract:CONTEXT:Stachys guyoniana Noë ex. Batt. and Mentha aquatica L. are two Algerian Lamiaceae used in folk medicine. OBJECTIVE:To investigate their antioxidant, anticholinesterase and antibacterial activities. MATERIAL AND METHODS:n-Butanol (BESG), ethyl acetate (EESG) and chloroform (CESG) extracts of S. guyoniana and m...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.1080/13880209.2016.1238488

    authors: Ferhat M,Erol E,Beladjila KA,Çetintaş Y,Duru ME,Öztürk M,Kabouche A,Kabouche Z

    更新日期:2017-12-01 00:00:00

  • Identification of urushiols as the major active principle of the Siddha herbal medicine Semecarpus Lehyam: Anti-tumor agents for the treatment of breast cancer.

    abstract::Breast cancer (BCa) is the most commonly occurring cancer in women, comprising almost one third of all malignancies. Previously we reported that the n-hexane fraction (hSL) of the Siddha herbal medicine, Semecarpus Lehyam, relatively sensitized estrogen receptor-negative (ER(-)) BCa when compared to estrogen receptor-...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.1080/13880200902942410

    authors: Zhao W,Zhu L,Srinivasan S,Damodaran C,Rohr J

    更新日期:2009-09-01 00:00:00

  • beta-Adrenoreceptor antagonists reduce cancer cell proliferation, invasion, and migration.

    abstract:CONTEXT:Propranolol, atenolol, and ICI118,551 are non-selective β-adrenergic receptor (AR), β1-AR, and β2-AR antagonists, respectively. OBJECTIVE:We investigated the efficacy of propranolol, atenolol, and ICI118,551 on proliferation, migration, and invasion of non-stimulated breast (MCF7), colon (HT-29), and hepatocel...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.3109/13880209.2014.892513

    authors: Işeri OD,Sahin FI,Terzi YK,Yurtcu E,Erdem SR,Sarialioglu F

    更新日期:2014-11-01 00:00:00

  • Ethno medicinal survey of plants used by the indigenes of Rivers State of Nigeria.

    abstract:CONTEXT:The medicinal plants used in the traditional medicine of Rivers State of Nigeria were surveyed. OBJECTIVE:The survey aims to identify and document the plants used amongst the indigenes of Rivers State. MATERIALS AND METHODS:Semi-structured interviews were conducted during a field trip to gather information fr...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.3109/13880209.2012.661740

    authors: Ajibesin KK,Bala DN,Umoh UF

    更新日期:2012-09-01 00:00:00

  • Brown seaweeds protect against azoxymethane-induced hepatic repercussions through up-regulation of peroxisome proliferator-activated receptor gamma and attenuation of oxidative stress.

    abstract:CONTEXT:Seaweeds of the genera Turbinaria and Padina have long been used as food and in traditional medicine for treating several diseases. OBJECTIVE:The current study determines the protective efficacy of the brown seaweeds Turbinaria ornata (Turner) J. Agardh (Sargassaceae) and Padina pavonia (Linnaeus) J.V. Lamouro...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.3109/13880209.2016.1160938

    authors: Abdella EM,Mahmoud AM,El-Derby AM

    更新日期:2016-11-01 00:00:00

  • Bombacaceae: a phytochemical review.

    abstract:CONTEXT:Bombacaceae is a small family of the order Malvales and contains about 28 genera and 200 species. Members of this family are not only showy ornamentals but they possess significant economical and commercial reputation as well. In addition, various plant parts of several species are widely used as foods and trad...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章,评审

    doi:10.3109/13880209.2012.698286

    authors: Refaat J,Desoky SY,Ramadan MA,Kamel MS

    更新日期:2013-01-01 00:00:00

  • Effects of hawthorn seed and pulp extracts on the central nervous system.

    abstract:CONTEXT:Investigating potential central nervous system (CNS) activities of Crataegus monogyna Jacq. (Rosaceae), hawthorn, fruit extracts. OBJECTIVE:Evaluating CNS effects and analgesic activities of hawthorn fruit extracts based on the traditional uses of the plant for neurosedative and pain killer actions. MATERIALS...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.3109/13880200903305500

    authors: Can OD,Ozkay UD,Oztürk N,Oztürk Y

    更新日期:2010-08-01 00:00:00

  • Citronellal, a monoterpene present in Java citronella oil, attenuates mechanical nociception response in mice.

    abstract:CONTEXT:Citronellal is a monoterpene present in the oil of many species, including Cymbopogon winterianus Jowitt (Poaceae). OBJECTIVE:The present study investigated the effect of citronellal on inflammatory nociception induced by different stimuli and examined the involvement of the NO-cGMP-ATP-sensitive K⁺ channel pa...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.3109/13880209.2013.781656

    authors: de Santana MT,de Oliveira MG,Santana MF,De Sousa DP,Santana DG,Camargo EA,de Oliveira AP,Almeida JR,Quintans-Júnior LJ Jr

    更新日期:2013-09-01 00:00:00

  • Photoprotective effects of cranberry juice and its various fractions against blue light-induced impairment in human retinal pigment epithelial cells.

    abstract:CONTEXT:Cranberry has numerous biological activities, including antioxidation, anticancer, cardioprotection, as well as treatment of urinary tract infection (UTI), attributed to abundant phenolic contents. OBJECTIVE:The current study focused on the effect of cranberry juice (CJ) on blue light exposed human retinal pig...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.1080/13880209.2016.1263344

    authors: Chang CH,Chiu HF,Han YC,Chen IH,Shen YC,Venkatakrishnan K,Wang CK

    更新日期:2017-12-01 00:00:00

  • Role of saffron and its constituents on cancer chemoprevention.

    abstract:CONTEXT:Cancer dramatically impacts human life expectancy and quality of life. Natural substances from vegetables, herbs and spices could be beneficial in the prevention or treatment of a variety of cancers. Crocus sativus (Iridaceae), which has been used as a folk medicine for treating diseases for ages, showed obviou...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章,评审

    doi:10.3109/13880209.2013.771190

    authors: Zhang Z,Wang CZ,Wen XD,Shoyama Y,Yuan CS

    更新日期:2013-07-01 00:00:00

  • Possible effects of Phillyrea latifolia on weight loss in rats fed a high-energy diet.

    abstract::Context Phillyrea latifolia L. (Oleaceae), commonly found in the Mediterranean region in Turkey, is used as medicinal teas for weight loss and hyperglycaemia in folk medicine. Objective The study investigated the possible effects of P. latifolia leaves aqueous extract's on weight loss and biochemical-histological chan...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.3109/13880209.2015.1137952

    authors: Yazici-Tutunis S,Gurel-Gurevin E,Ustunova S,Demirci-Tansel C,Mericli F

    更新日期:2016-10-01 00:00:00

  • Protective effect of centipedegrass against Aβ oligomerization and Aβ-mediated cell death in PC12 cells.

    abstract:CONTEXT:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the abnormal accumulation of β-amyloid (Aβ). Multiple Aβ-aggregated species have been identified, and neurotoxicity appears to be correlated with the amount of non-fibrillar oligomers. Potent inhibitors of Aβ oligomer formation or Aβ-indu...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.3109/13880209.2014.974062

    authors: Song Y,Kim HD,Lee MK,Kim MK,Kang SN,Ko YG,Won CK,Kim GS,Lee SS,Bai HW,Chung BY,Cho JH

    更新日期:2015-01-01 00:00:00

  • Flavonol glycosides and other phenolic compounds from Viola tianshanica and their anti-complement activities.

    abstract:CONTEXT:Viola tianshanica Maxim. (Violaceae) is a perennial herb distributed in Central Asia, especially in the Xinjiang Uygur Autonomous Region (XUAR) of China. Preliminary study showed that the ethanol extract of the herb exhibited the anti-complement activity against the classical pathway, but the active components ...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.3109/13880209.2015.1055635

    authors: Qin Y,Wen Q,Cao J,Yin C,Chen D,Cheng Z

    更新日期:2016-07-01 00:00:00

  • Protective effect of MOTILIPERM in varicocele-induced oxidative injury in rat testis by activating phosphorylated inositol requiring kinase 1α (p-IRE1α) and phosphorylated c-Jun N-terminal kinase (p-JNK) pathways.

    abstract:CONTEXT:MOTILIPERM was prepared as a mixture of extracts of three medicinal herbs [roots of Morinda officinalis How (Rubiaceae), outer scales of Allium cepa L. (Liliaceae) and seeds of Cuscuta chinensis Lamark (Convolvulaceae)]. OBJECTIVE:To investigate the role of reactive oxygen species (ROS)-based endoplasmic retic...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.1080/13880209.2017.1421672

    authors: Soni KK,Zhang LT,Choi BR,Karna KK,You JH,Shin YS,Lee SW,Kim CY,Zhao C,Chae HJ,Kim HK,Park JK

    更新日期:2018-12-01 00:00:00

  • Anti-inflammatory activity of standardized dichloromethane extract of Salvia connivens on macrophages stimulated by LPS.

    abstract:CONTEXT:A previous study demonstrated that the chloroform extract of Salvia connivens Epling (Lamiaceae) has anti-inflammatory activity. OBJECTIVE:Identification of the active components in the dicholorometane extract (DESC), and, standardization of the extract based in ursolic acid. MATERIAL AND METHODS:DESC was pre...

    journal_title:Pharmaceutical biology

    pub_type: 杂志文章

    doi:10.1080/13880209.2017.1305423

    authors: González-Chávez MM,Ramos-Velázquez CS,Serrano-Vega R,Pérez-González C,Sánchez-Mendoza E,Pérez-Gutiérrez S

    更新日期:2017-12-01 00:00:00