当前位置： SCI文献检索 > PHARMACEUTICAL BIOLOGY期刊下所有文献 > Flavonol glycosides and other phenolic compounds from Viola tianshanica and their anti-complement activities.

Flavonol glycosides and other phenolic compounds from Viola tianshanica and their anti-complement activities.

Abstract：

CONTEXT:Viola tianshanica Maxim. (Violaceae) is a perennial herb distributed in Central Asia, especially in the Xinjiang Uygur Autonomous Region (XUAR) of China. Preliminary study showed that the ethanol extract of the herb exhibited the anti-complement activity against the classical pathway, but the active components responsible for this capacity remain unknown and are yet to be studied. OBJECTIVE:The objective of this study was the isolation and identification of the anti-complement constituents of V. tianshanica. MATERIALS AND METHODS:The ethyl acetate and n-butanol fractions from the ethanol extract of V. tianshanica were purified. The structures of the isolates were identified by spectroscopic methods, and comparing their spectral data with those reported in the literature. All the isolates (0.02-2.50 mg/mL) were evaluated for their anti-complement activity against the classical and alternative pathways. RESULTS:Twenty-one phenolic compounds including 15 flavonol O-glycosides (1-15), one flavone 6,8-di-C-glycoside (16), one flavone aglycone (17), and four phenolic acid derivatives (18-21) were isolated and identified. Bioassay showed that 11 compounds inhibited the classical pathway and the alternative pathway with CH50 and AP50 values of 0.113-1.210 mM and 0.120-1.579 mM, respectively. Preliminary mechanistic study using complement-depleted sera demonstrated that 1 acted on C1q, C2, C4, and C9 components, 16 on C1q, C4, and C5, and 21 on C1q, C3, C4, and C9. CONCLUSION:All isolated compounds except 1 and 10 were reported for the first time from V. tianshanica. Compound 16 is the first flavone C-glycoside isolated from the herb. Flavonol O-glycosides and phenolic acids contributed the anti-complement activity of the herb.

journal_name

Pharm Biol

journal_title

Pharmaceutical biology

authors

Qin Y,Wen Q,Cao J,Yin C,Chen D,Cheng Z

doi

10.3109/13880209.2015.1055635

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

1140-7

issue

7

eissn

1388-0209

issn

1744-5116

journal_volume

54

pub_type

杂志文章

相关文献

PHARMACEUTICAL BIOLOGY文献大全
  • Phytochemical, antioxidant, enzyme activity and antifungal properties of Satureja khuzistanica in vitro and in vivo explants stimulated by some chemical elicitors.

    abstract：:Context:Satureja khuzistanica Jamzad. (Lamiaceae), is known for its antifungal and antioxidant compounds, especially rosmarinic acid (RA).Objective: The study examines the effect of elicitors on RA production and phytochemical properties of S. khuzistanica.Materials and methods:In vitro plants were treated with methyl...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.1080/13880209.2020.1743324

    authors： Fatemi F,Abdollahi MR,Mirzaie-Asl A,Dastan D,Papadopoulou K

    更新日期：2020-12-01 00:00:00

  • Protective effect on phenytoin-induced cognition deficit in pentylenetetrazol kindled mice: A repertoire of Glycyrrhiza glabra flavonoid antioxidants.

    abstract：CONTEXT:Glycyrrhiza glabra L. (Febaceae) has been widely used in traditional medicine and scientifically explored for its anticonvulsant and memory improving potential. OBJECTIVE:The objective of this study is to investigate the effect of flavonoid rich fraction of G. glabra root extract against phenytoin-induced cogn...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.3109/13880209.2015.1063673

    authors： Singh P,Singh D,Goel RK

    更新日期：2016-07-01 00:00:00

  • Baccharis dracunculifolia methanol extract enhances glucose-stimulated insulin secretion in pancreatic islets of monosodium glutamate induced-obesity model rats.

    abstract：CONTEXT:Obesity is the main risk factor for type 2 diabetes mellitus. Secondary metabolites with biological activities and pharmacological potential have been identified in species of the Baccharis genus that are specifically distributed in the Americas. OBJECTIVE:This study evaluated the effects of methanol extracts ...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.3109/13880209.2015.1067232

    authors： Hocayen Pde A,Grassiolli S,Leite NC,Pochapski MT,Pereira RA,da Silva LA,Snack AL,Michel RG,Kagimura FY,da Cunha MA,Malfatti CR

    更新日期：2016-07-01 00:00:00

  • Interactions of the active components of Punica granatum (pomegranate) with the essential renal and hepatic human Solute Carrier transporters.

    abstract：UNLABELLED:Abstract Context: Solute carrier transporters (SLCs) are membrane proteins responsible for cellular influx of various substances including many pharmaceutical agents; therefore, they largely impact on drug disposition and elimination in body. Punica granatum Linnaeus (Lythraceae), pomegranate, is a fruit wit...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.3109/13880209.2014.900809

    authors： Li Z,Wang K,Zheng J,Cheung FS,Chan T,Zhu L,Zhou F

    更新日期：2014-12-01 00:00:00

  • Beneficial effects of melatonin on serum nitric oxide, homocysteine, and ADMA levels in fructose-fed rats.

    abstract：CONTEXT:Melatonin, a pineal hormone and a potent antioxidant, has important roles in metabolic regulation. OBJECTIVE:This study investigated serum asymmetric dimethylarginine (ADMA), homocysteine (Hcy), nitric oxide (NO) levels, known to be reliable markers of cardiovascular diseases, and determined possible protectiv...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.3109/13880209.2014.957782

    authors： Kantar Ş,Türközkan N,Bircan FS,Paşaoğlu ÖT

    更新日期：2015-07-01 00:00:00

  • Anxiolytic and sedative-hypnotic activities of polygalasaponins from Polygala tenuifolia in mice.

    abstract：:In the present study, the anxiolytic and sedative-hypnotic activities of polygalasaponins extracted from Polygala tenuifolia Willdenow (Polygalaceae) were determined in mice using hole-board, elevated plus maze, open field, and sodium pentobarbital-induced hypnosis tests. Moreover, the acute toxicity of polygalasaponi...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.3109/13880200903280042

    authors： Yao Y,Jia M,Wu JG,Zhang H,Sun LN,Chen WS,Rahman K

    更新日期：2010-07-01 00:00:00

  • Baohuoside-I suppresses cell proliferation and migration by up-regulating miR-144 in melanoma.

    abstract：CONTEXT:Baohuoside-I was reported to induce apoptosis in non-small-cell lung cancer and inhibit the growth of multiple myeloma cells. The antitumour potential of baohuoside-I has not been demonstrated in melanoma yet. OBJECTIVE:To investigate the potential antitumour activity of baohuoside-I against melanoma and eluci...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.1080/13880209.2017.1418391

    authors： Peng YG,Zhang L

    更新日期：2018-12-01 00:00:00

  • In vitro potential modulation of baicalin and baicalein on P-glycoprotein activity and expression in Caco-2 cells and rat gut sacs.

    abstract：:Context Previous studies have shown that Scutellariae Radix, the dried root of Scutellaria baicalensis Georgi (Labiatae), has a certain inhibitory effect on P-glycoprotein (P-gp), but the effects of its main active constituents on P-gp are still ambiguous. Objectives In vitro studies were performed to investigate the ...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.3109/13880209.2015.1107744

    authors： Miao Q,Wang Z,Zhang Y,Miao P,Zhao Y,Zhang Y,Ma S

    更新日期：2016-09-01 00:00:00

  • Effects of hawthorn seed and pulp extracts on the central nervous system.

    abstract：CONTEXT:Investigating potential central nervous system (CNS) activities of Crataegus monogyna Jacq. (Rosaceae), hawthorn, fruit extracts. OBJECTIVE:Evaluating CNS effects and analgesic activities of hawthorn fruit extracts based on the traditional uses of the plant for neurosedative and pain killer actions. MATERIALS...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.3109/13880200903305500

    authors： Can OD,Ozkay UD,Oztürk N,Oztürk Y

    更新日期：2010-08-01 00:00:00

  • Phytoextract of Indian mustard seeds acts by suppressing the generation of ROS against acetaminophen-induced hepatotoxicity in HepG2 cells.

    abstract：CONTEXT:Indian mustard [Brassica juncea (L.) Czern. & Coss. (Brassicaceae)] is reported to possess diverse pharmacological properties. However, limited information is available concerning its hepatoprotective activity and mechanism of action. OBJECTIVE:To study the protective mechanism of mustard seed extract against ...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.3109/13880209.2014.950675

    authors： Parikh H,Pandita N,Khanna A

    更新日期：2015-07-01 00:00:00

  • Screening study of blood-supplementing active components in water decoction of Angelica sinensis processed with yellow rice wine based on response surface methodology.

    abstract：CONTEXT:Angelica sinensis (Oliv.) Diels (Apiaceae) (syn. Angelica polymorpha Maxim var. sinensis Oliver) processed with yellow rice wine (WAS) has a blood-supplementing effect. OBJECTIVE:To establish an optimal technology for preparing water decoction of WAS (WASD), and screen blood-supplementing fractions. MATERIALS...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.1080/13880209.2020.1844760

    authors： Ji P,Li C,Wei Y,Wu F,Liu S,Hua Y,Yao W,Zhang X,Yuan Z,Wen Y

    更新日期：2020-12-01 00:00:00

  • Antimutagenic and antioxidant activity of a protein fraction from aerial parts of Urtica dioica.

    abstract：CONTEXT:Urtica dioica L. (Urticaceae), stinging nettle, has been employed as a folklore remedy for a wide spectrum of ailments, including urinary disorders, prostatic hyperplasia, and liver diseases. It has been also used traditionally for cancer treatment. OBJECT:To evaluate the potential chemopreventive properties o...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.3109/13880209.2014.950386

    authors： Di Sotto A,Mazzanti G,Savickiene N,Staršelskytė R,Baksenskaite V,Di Giacomo S,Vitalone A

    更新日期：2015-06-01 00:00:00

  • Silymarin alleviates bleomycin-induced pulmonary toxicity and lipid peroxidation in mice.

    abstract：CONTEXT:The application of bleomycin is limited due to its side effects including lung toxicity. Silymarin is a flavonoid complex isolated from milk thistle [Silybum marianum L. (Asteraceae)] which has been identified as an antioxidant and anti-inflammatory compound. OBJECTIVE:This study evaluates the effect of silyma...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.3109/13880209.2014.889176

    authors： Razavi-Azarkhiavi K,Ali-Omrani M,Solgi R,Bagheri P,Haji-Noormohammadi M,Amani N,Sepand MR

    更新日期：2014-10-01 00:00:00

  • Evaluation of aqueous extract of Felicia muricata leaves for anti-inflammatory, antinociceptive, and antipyretic activities.

    abstract：CONTEXT:Felicia muricata Thunb. (Nees) (Asteraceae) leaves are used in folklore medicine of South Africa as an oral remedy for pain and inflammation. However, the efficacy of the plant part is yet to be validated with scientific experiments. OBJECTIVE:The current study is an effort to investigate the anti-inflammatory...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.3109/13880200903373664

    authors： Ashafa AO,Yakubu MT,Grierson DS,Afolayan AJ

    更新日期：2010-09-01 00:00:00

  • Alleviating effect of Mallotus roxburghianus in heat-induced testicular dysfunction in Wistar rats.

    abstract：CONTEXT:Hyperthermia causes detrimental effects on the testes leading to fertility problems. Mallotus roxbhurghianus Muell. Arg. (Euphorbiaceae) is used in traditional medicine and possesses antioxidant property. However, the mechanisms remain unknown in the context of alleviative action of M. roxburghianus against hea...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.3109/13880209.2015.1091480

    authors： Kumar Roy V,Marak TR,Gurusubramanian G

    更新日期：2016-01-01 00:00:00

  • Evaluation of anti-inflammatory activity and standardisation of hydro-methanol extract of underground tuber of Dioscorea alata.

    abstract：:Context The underground edible tuber of Dioscorea alata L. (Dioscoreaceae) is a functional food with high nutritive value and therapeutic potential. The tuber is known to possess anti-inflammatory properties in traditional medicine. Objective The present study explores the anti-inflammatory activity and standardisatio...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.3109/13880209.2015.1104702

    authors： Dey P,Roy Chowdhuri S,Sarkar MP,Chaudhuri TK

    更新日期：2016-08-01 00:00:00

  • Antinociceptive and anxiolytic-like effects of a neo-clerodane diterpene from Salvia semiatrata aerial parts.

    abstract：CONTEXT:Salvia semiatrata Zucc. (Lamiaceae) is a species used as a tranquilizer and to relieve pain in folk medicine in Santiago Huauclilla, Oaxaca, Mexico. OBJECTIVE:To evaluate the antinociceptive and anxiolytic-like effects of S. semiatrata extracts and identify a bioactive metabolite. MATERIALS AND METHODS:The ex...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.1080/13880209.2020.1784235

    authors： Ortiz-Mendoza N,Zavala-Ocampo LM,Martínez-Gordillo MJ,González-Trujano ME,Peña FAB,Rodríguez IJB,Chávez JAR,Dorazco-González A,Aguirre-Hernández E

    更新日期：2020-12-01 00:00:00

  • Influence of clitoria ternatea extracts on memory and central cholinergic activity in rats.

    abstract：:Clitoria ternatea , commonly known as Shankpushpi, is widely used in the traditional Indian system of medicine as a brain tonic and is believed to promote memory and intelligence. We examined the effectiveness of alcoholic extracts of aerial and root parts of C. ternatea at 300 and 500 mg/kg doses orally in rats in at...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.1076/1388-0209(200001)3811-BFT051

    authors： Taranalli AD,Cheeramkuzhy TC

    更新日期：2000-01-01 00:00:00

  • Inhibition of invasion and metastasis of human liver cancer HCCLM3 cells by portulacerebroside A.

    abstract：CONTEXT:Portulacerebroside A (PCA) is a novel cerebroside compound isolated from Portulaca oleracea L. (Portulacaceae), an edible and medicinal plant distributed in the temperate and tropical zones worldwide. OBJECTIVE:This study investigates the effects of PCA in human liver cancer HCCLM3 cells on metastasis and inva...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.3109/13880209.2014.941505

    authors： Ji Q,Zheng GY,Xia W,Chen JY,Meng XY,Zhang H,Rahman K,Xin HL

    更新日期：2015-05-01 00:00:00

  • Antioxidant and drug detoxification potential of aqueous extract of Annona senegalensis leaves in carbon tetrachloride-induced hepatocellular damage.

    abstract：CONTEXT: Despite the myriad uses of Annona senegalensis Pers. (Annonaceae) leaves in folklore medicine of Nigeria, the basis is yet to be substantiated by scientific investigations. OBJECTIVES: To investigate the antioxidant (in vitro and in vivo) and drug detoxification potential of aqueous extract of A. senegalensis...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.3109/13880209.2010.483247

    authors： Ajboye TO,Yakubu MT,Salau AK,Oladiji AT,Akanji MA,Okogun JI

    更新日期：2010-12-01 00:00:00

  • In vitro effects of rosmarinic acid on glutathione reductase and glucose 6-phosphate dehydrogenase.

    abstract：CONTEXT:Glutathione reductase (GR, NADPH:oxidized glutathione oxidoreductase, E.C 1.6.4.2) is a flavoprotein that catalyzes the NADPH-dependent reduction of oxidized glutathione (GSSG). GR is a crucial enzyme in the antioxidant system by maintaining reduced glutathione (GSH). Glucose 6-phosphate dehydrogenase (G6PD, gl...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.3109/13880209.2010.533187

    authors： Tandogan B,Kuruüzüm-Uz A,Sengezer C,Güvenalp Z,Demirezer LÖ,Ulusu NN

    更新日期：2011-06-01 00:00:00

  • Anticancer effect of 2,7-dihydroxy-3-methylanthraquinone on human gastric cancer SGC-7901 cells in vitro and in vivo.

    abstract：CONTEXT:2,7-Dihydroxy-3-methylanthraquinone (DDMN) is reported to have a remarkable anticancer activity against gastric cancer SGC-7901 cells. OBJECTIVE:The objective of this study is to study the anticancer effect and mechanism of DDMN on SGC-7901 cells. MATERIALS AND METHODS:The MTT assay was used to determine the ...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.3109/13880209.2015.1033563

    authors： Zhu H,Zheng Z,Zhang J,Liu X,Liu Y,Yang W,Liu Y,Zhang T,Zhao Y,Liu Y,Su X,Gu X

    更新日期：2016-01-01 00:00:00

  • Hydroalcoholic extract of red propolis promotes functional recovery and axon repair after sciatic nerve injury in rats.

    abstract：CONTEXT:Peripheral axon injury and degeneration are often mediated by oxidative stress and inflammation. The hydroalcoholic extract of the red propolis (HERP) has attracted great attention because of its antioxidant and anti-inflammatory activities. OBJECTIVE:The objective of this work is to study the effect of HERP o...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.3109/13880209.2015.1091844

    authors： Barbosa RA,Nunes TL,Nunes TL,da Paixão AO,Belo Neto R,Moura S,Albuquerque Junior RL,Cândido EA,Padilha FF,Quintans-Júnior LJ,Gomes MZ,Cardoso JC

    更新日期：2016-01-01 00:00:00

  • Determination of escin content in androgenic embryos and hairy root culture of Aesculus hippocastanum.

    abstract：:Escin, a group of chemically related triterpenic glycosides, is widely used in commercial preparations for the treatment of venous insufficiency. Since the zygotic embryo cotyledons accumulate the highest amount of escin, it is currently extracted from the seeds of horse chestnut, Aesculus hippocastanum L. (Hippocasta...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.3109/13880200903204000

    authors： Calić-Dragosavac D,Zdravković-Korać S,Savikin-Fodulović K,Radojević L,Vinterhalter B

    更新日期：2010-05-01 00:00:00

  • Enhanced memory in Wistar rats by virgin coconut oil is associated with increased antioxidative, cholinergic activities and reduced oxidative stress.

    abstract：CONTEXT:Virgin coconut oil (VCO) has been reported to possess antioxidative, anti-inflammatory and anti-stress properties. OBJECTIVE:Capitalizing on these therapeutic effects, this study investigated for the first time the potential of VCO on memory improvement in vivo. MATERIALS AND METHODS:Thirty male Wistar rats (...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.1080/13880209.2017.1280688

    authors： Rahim NS,Lim SM,Mani V,Abdul Majeed AB,Ramasamy K

    更新日期：2017-12-01 00:00:00

  • Emodin in Rheum undulatum inhibits oxidative stress in the liver via AMPK with Hippo/Yap signalling pathway.

    abstract：:Context: Emodin is a compound in Rheum undulatum Linne (Polygonaceae) that has been reported to exert anti-inflammatory, antibacterial, and antiallergic effects.Objective: Oxidative stress is a causative agent of liver inflammation that may lead to fibrosis and hepato-carcinoma. In this study, we investigated the anti...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.1080/13880209.2020.1750658

    authors： Lee EH,Baek SY,Park JY,Kim YW

    更新日期：2020-12-01 00:00:00

  • The effect of silymarin (Silybum marianum) on human skin fibroblasts in an in vitro wound healing model.

    abstract：CONTEXT:Silymarin, a flavonolignan from Silybum marianum (L.) Gaertn. (Asteraceae), has been reported to have antioxidant and anti-inflammatory properties. Therefore, it may be worthwhile to study the effect of silymarin on wound healing. OBJECTIVE:To evaluate the effect of silymarin on human fibroblast cells in an in...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.3109/13880209.2012.721789

    authors： Sharifi R,Pasalar P,Kamalinejad M,Dehpour AR,Tavangar SM,Paknejad M,Mehrabani Natanzi M,Nourbakhsh M,Ahmadi Ashtiani HR,Akbari M,Rastegar H

    更新日期：2013-03-01 00:00:00

  • Improvement of superoxide dismutase and catalase in streptozotocin-nicotinamide-induced type 2-diabetes in mice by berberine and glibenclamide.

    abstract：:Abstract Context: Diabetes mellitus (DM) type 2 is a chronic disease characterized by hyperglycemia and insulin resistance. Oxidative stress participates in development and progression of DM, in which changes of superoxide dismutase (SOD) and catalase (CAT) were noted in DM mice. Berberine has been widely used as an a...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.3109/13880209.2013.839714

    authors： Chatuphonprasert W,Lao-Ong T,Jarukamjorn K

    更新日期：2013-11-05 00:00:00

  • In vitro antioxidant and cytotoxic properties of ethanol extract of Alpinia oxyphylla fruits.

    abstract：CONTEXT:Alpinia oxyphylla Miquel (Zingiberaceae) is a traditional Chinese herbal medicine widely used for the treatment of intestinal disorders, urosis and diuresis. However, information about antioxidant and cytotoxic properties of its fruits remains to be elucidated. OBJECTIVE:The ethanol crude extract (CE) and its ...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.3109/13880209.2013.794844

    authors： Wang CZ,Yuan HH,Bao XL,Lan MB

    更新日期：2013-11-01 00:00:00

  • Amino acid content and acetylcholinesterase inhibition of Huperzia saururus infusion and decoction.

    abstract：UNLABELLED:CONTEXT. Huperzia saururus (Lam.) Trevis. (Lycopodiaceae), an autochthonous plant species in Argentina, is used as a memory improver in traditional medicine. It was studied for this reason and the purified alkaloid extract did show significant activity on learning and memory. The species is mostly consumed i...

    journal_title：Pharmaceutical biology

    pub_type： 杂志文章

    doi：10.3109/13880209.2013.784921

    authors： Vallejo MG,Dimmer JA,Ortega MG,Cabrera JL,Agnese AM

    更新日期：2013-10-01 00:00:00