Abstract:
CONTEXT:Scrophularia genus (Scrophulariaceae) includes about 350 species commonly known as figwort. Many species of this genus grow wild in nature and have not been cultivated yet. However, some species are in danger of extinction. OBJECTIVE:This paper reviews the chemical compounds, biological activities and the ethnopharmacology of some Scrophularia species. MATERIALS AND METHODS:All information was obtained through reported data on bibliographic database such as Scopus, United States National Agricultural Library, Biological Abstracts, EMBASE, PubMed, MedlinePlus, PubChem and Springer Link (1934-2017). The information in different Pharmacopoeias on this genus was also gathered from 1957 to 2007. RESULTS:The structures of 204 compounds and their biological activity were presented in the manuscript: glycoside esters, iridoid glycosides and triterpenoids are the most common compounds in this genus. Among them, scropolioside like iridoids have shown potential for anti-inflammatory, hepatoprotective and wound healing activity. Among the less frequently isolated compounds, resin glycosides such as crypthophilic acids have shown potent antiprotozoal and antimicrobial activities. CONCLUSION:The Scrophularia genus seems to be a rich source of iridoids and terpenoids, but isolation and identification of its alkaloids have been a neglected area of scientific study. The diverse chemical compounds and biological activities of this genus will motivate further investigation on Scrophularia genus as a source of new therapeutic medications.
journal_name
Pharm Bioljournal_title
Pharmaceutical biologyauthors
Pasdaran A,Hamedi Adoi
10.1080/13880209.2017.1397178subject
Has Abstractpub_date
2017-12-01 00:00:00pages
2211-2233issue
1eissn
1388-0209issn
1744-5116journal_volume
55pub_type
杂志文章,评审abstract:CONTEXT:Agastache mexicana (Kunth) Lint & Epling (Lamiaceae) is a plant used in Mexican traditional medicine for the treatment of hypertension, anxiety and so on. OBJECTIVE:To determine the vasorelaxant effect and functional mode of action of dichloromethane-soluble extract from A. mexicana (DEAm) and isolate the cons...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2016.1184690
更新日期:2016-12-01 00:00:00
abstract:CONTEXT:Glutathione reductase (GR, NADPH:oxidized glutathione oxidoreductase, E.C 1.6.4.2) is a flavoprotein that catalyzes the NADPH-dependent reduction of oxidized glutathione (GSSG). GR is a crucial enzyme in the antioxidant system by maintaining reduced glutathione (GSH). Glucose 6-phosphate dehydrogenase (G6PD, gl...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2010.533187
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2017.1296000
更新日期:2017-12-01 00:00:00
abstract:CONTEXT:Salvicine is a pharmacologically active derivative from Chinese medicinal plant Salvia prionitis Hance (Labiatae). It has been reported that salvicine inactivates β1 integrin and inhibits integrin-mediated cell adhesion to fibronectin. Given the emerging correlation between integrins and angiogenesis, we propos...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2012.673628
更新日期:2012-10-01 00:00:00
abstract:CONTEXT:The extraction method and the crude wound healing effects of sacchachitin from Ganoderma tsugae Murr. (Ganodermataceae) has been cited. However, its purity is still largely limited. OBJECTIVE:An improvement of the fractionation protocol to purify the sacchachitin from Ganoderma lucidum L. (Ganodermataceae) (SG...
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pub_type: 杂志文章
doi:10.3109/13880209.2012.711840
更新日期:2013-01-01 00:00:00
abstract::Escin, a group of chemically related triterpenic glycosides, is widely used in commercial preparations for the treatment of venous insufficiency. Since the zygotic embryo cotyledons accumulate the highest amount of escin, it is currently extracted from the seeds of horse chestnut, Aesculus hippocastanum L. (Hippocasta...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880200903204000
更新日期:2010-05-01 00:00:00
abstract:CONTEXT:(-)-α-Bisabolol (BISA) is a sesquiterpene alcohol widely used as scent in cosmetic preparations, perfumes, shampoos, toilet soaps and other toiletries with potential for use in the pharmaceutical area. OBJECTIVE:To evaluate the corneal antinociceptive efficacy of BISA and to analyze the best solubilizing agent...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2017.1285944
更新日期:2017-12-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2018.1501705
更新日期:2018-12-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2016.1190764
更新日期:2016-12-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.771375
更新日期:2013-07-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2011-07-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2012.698288
更新日期:2013-01-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.803579
更新日期:2013-12-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.962058
更新日期:2015-08-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
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更新日期:2019-12-01 00:00:00
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更新日期:2014-06-01 00:00:00
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pub_type: 杂志文章
doi:10.3109/13880209.2010.550054
更新日期:2011-08-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章,随机对照试验
doi:10.1080/13880209.2019.1569696
更新日期:2019-12-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2013-03-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2010-09-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2012.721789
更新日期:2013-03-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章,评审
doi:10.3109/13880209.2016.1138314
更新日期:2016-10-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2015.1055635
更新日期:2016-07-01 00:00:00