Anticancer activities of Withania somnifera: Current research, formulations, and future perspectives.

abstract：CONTEXT:The Boraginaceae family comprises plants that have important therapeutic and cosmetic applications. Their pharmacological effect is related to the presence of naphthaquinones, flavonoids, terpenoids, phenols, or purine derivative - allantoin. OBJECTIVE:In the present study, comparison of some secondary metabol...

journal_title：Pharmaceutical biology

authors： Dresler S,Szymczak G,Wójcik M

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:Hypertrophic scarring, a common proliferative disorder of dermal fibroblasts, results from an overproduction of collagen and excessive deposition of extracellular matrix. Although the treatment with surgical excisions or steroid hormones can modify the symptoms, numerous treatment-related complications have als...

journal_title：Pharmaceutical biology

authors： Wu JG,Wei YJ,Ran X,Zhang H,Nian H,Qin LP

更新日期：2011-07-01 00:00:00

abstract：:Clitoria ternatea , commonly known as Shankpushpi, is widely used in the traditional Indian system of medicine as a brain tonic and is believed to promote memory and intelligence. We examined the effectiveness of alcoholic extracts of aerial and root parts of C. ternatea at 300 and 500 mg/kg doses orally in rats in at...

journal_title：Pharmaceutical biology

authors： Taranalli AD,Cheeramkuzhy TC

更新日期：2000-01-01 00:00:00

abstract：CONTEXT:Dyslipidemia is one of the major risk factors for cardiovascular disease in diabetes mellitus (DM). The availability of multiple lipid-lowering drugs and supplements provides new opportunities for patients to regulate lipid levels. OBJECTIVE:The present study was designed to evaluate the effect of Butea monosp...

journal_title：Pharmaceutical biology

authors： Divya BT,Mini S

更新日期：2014-08-01 00:00:00

abstract：CONTEXT:Several plant-derived natural products have been used in clinical phase for applications in neurological, cardiovascular, and inflammatory diseases. Arbutus andrachne L. (Ericacea) is an evergreen shrub native to the Mediterranean region. Traditionally, the fruits and leaves of Arbutus tree are well known and u...

journal_title：Pharmaceutical biology

authors： Abidi E,Habib J,Yassine A,Chahine N,Mahjoub T,Elkak A

更新日期：2016-01-01 00:00:00

abstract：CONTEXT:MOTILIPERM was prepared as a mixture of extracts of three medicinal herbs [roots of Morinda officinalis How (Rubiaceae), outer scales of Allium cepa L. (Liliaceae) and seeds of Cuscuta chinensis Lamark (Convolvulaceae)]. OBJECTIVE:To investigate the role of reactive oxygen species (ROS)-based endoplasmic retic...

journal_title：Pharmaceutical biology

authors： Soni KK,Zhang LT,Choi BR,Karna KK,You JH,Shin YS,Lee SW,Kim CY,Zhao C,Chae HJ,Kim HK,Park JK

更新日期：2018-12-01 00:00:00

abstract：CONTEXT:Glutathione reductase (GR, NADPH:oxidized glutathione oxidoreductase, E.C 1.6.4.2) is a flavoprotein that catalyzes the NADPH-dependent reduction of oxidized glutathione (GSSG). GR is a crucial enzyme in the antioxidant system by maintaining reduced glutathione (GSH). Glucose 6-phosphate dehydrogenase (G6PD, gl...

journal_title：Pharmaceutical biology

authors： Tandogan B,Kuruüzüm-Uz A,Sengezer C,Güvenalp Z,Demirezer LÖ,Ulusu NN

更新日期：2011-06-01 00:00:00

abstract：:Context Previous studies have shown that Scutellariae Radix, the dried root of Scutellaria baicalensis Georgi (Labiatae), has a certain inhibitory effect on P-glycoprotein (P-gp), but the effects of its main active constituents on P-gp are still ambiguous. Objectives In vitro studies were performed to investigate the ...

journal_title：Pharmaceutical biology

authors： Miao Q,Wang Z,Zhang Y,Miao P,Zhao Y,Zhang Y,Ma S

更新日期：2016-09-01 00:00:00

abstract：CONTEXT:Eryngium maritimum L. and the endemic Eryngium kotschyi Boiss. of the Apiaceae family are used for antiinflammatory, antivenom, antinociceptive and diuretic purposes in folk medicine in Turkey. OBJECTIVE:This study investigated the cytotoxic effects of the plant extracts belonging to Eryngium L. genus on vario...

journal_title：Pharmaceutical biology

authors： Yurdakök B,Baydan E

更新日期：2013-12-01 00:00:00

abstract：:Context Phyllanthus emblica L. (Euphorbiaceae) (amla), Manilkara zapota L.P. Royen (Sapotaceae) (sapota) and silymarin are reported to contain antioxidant effects. However, information on other biological activities relating to the anti-aging properties is limited. Objective To compare in vitro antioxidants, anti-coll...

journal_title：Pharmaceutical biology

authors： Pientaweeratch S,Panapisal V,Tansirikongkol A

更新日期：2016-09-01 00:00:00

abstract：CONTEXT:Liver disease is a serious ailment and the scenario is worsened by the lack of precise therapeutic regimens. Currently available therapies for liver ailments are not apposite and systemic toxicity inhibits their long term use. Medicinal plants have been traditionally used for treating liver diseases since centu...

journal_title：Pharmaceutical biology

authors： Ghosh N,Ghosh R,Mandal V,Mandal SC

更新日期：2011-09-01 00:00:00

abstract：:Context:Mitrephora sirikitiae Weeras., Chalermglin & R.M.K. Saunders (Annonaceae) is a plant endemic to Thailand. Its constituents and their biological activities are unknown.Objective: Isolation and identification of the compounds in the leaves and stems of M. sirikitiae and determination of their cytotoxicity.Materi...

journal_title：Pharmaceutical biology

authors： Anantachoke N,Lovacharaporn D,Reutrakul V,Michel S,Gaslonde T,Piyachaturawat P,Suksen K,Prabpai S,Nuntasaen N

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:A previous study demonstrated that the chloroform extract of Salvia connivens Epling (Lamiaceae) has anti-inflammatory activity. OBJECTIVE:Identification of the active components in the dicholorometane extract (DESC), and, standardization of the extract based in ursolic acid. MATERIAL AND METHODS:DESC was pre...

journal_title：Pharmaceutical biology

authors： González-Chávez MM,Ramos-Velázquez CS,Serrano-Vega R,Pérez-González C,Sánchez-Mendoza E,Pérez-Gutiérrez S

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:Despite phytochemical studies of Agrimonia pilosa Ledeb. (Rosaceae), the antidiabetic effects of this plant are unknown. OBJECTIVE:This study characterizes the isolated compounds from the aerial parts of A. pilosa and evaluates their PTP1B and α-glucosidase inhibitory properties. MATERIALS AND METHODS:Ethanol...

journal_title：Pharmaceutical biology

authors： Na B,Nguyen PH,Zhao BT,Vo QH,Min BS,Woo MH

更新日期：2016-01-01 00:00:00

abstract：:Context: Cisplatin-based chemotherapy was widely used in treating human malignancies. However, side effects and chemoresistance remains the major obstacle.Objective: To verify whether natural borneol (NB) can enhance cisplatin-induced glioma cell apoptosis and explore the mechanism.Materials and methods: Cytotoxicity ...

journal_title：Pharmaceutical biology

authors： Cao WQ,Zhai XQ,Ma JW,Fu XQ,Zhao BS,Zhang P,Fu XY

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:Panax ginseng C. A. Mey (Araliaceae) has been widely used in clinic for treatment of cardiovascular diseases in China. Ginsenoside Rb3 is the main chemical component of Panax ginseng. OBJECTIVE:The aim of this study was to evaluate the effect of ginsenoside Rb3 on myocardial ischemia-reperfusion injury in rats...

journal_title：Pharmaceutical biology

authors： Shi Y,Han B,Yu X,Qu S,Sui D

更新日期：2011-09-01 00:00:00

abstract：CONTEXT:Light microscopy is in most cases a quick method for the identification and discrimination of medicinally used plant drugs; moreover, this technique is very inexpensive. Reliable descriptions of the anatomy of plants and their adulterations are prerequisites for necessary purity controls. OBJECTIVE:The anatomy...

journal_title：Pharmaceutical biology

authors： Fritz E,Saukel J

更新日期：2011-08-01 00:00:00

abstract：CONTEXT:Andrographis paniculata (Burm.f.) Nees (Acanthaceae) is widely used in tribal medicine in India and some other countries for multiple clinical applications. It contains andrographolide (AG) (diterpenoid lactone), a major phytomarker which probably accounts for its medicinal properties. OBJECTIVE:This study inv...

journal_title：Pharmaceutical biology

authors： Bera R,Ahmed SK,Sarkar L,Sen T,Karmakar S

更新日期：2014-03-01 00:00:00

abstract：CONTEXT:One traditional medicines, Hypericum perforatum L. (Hypericaceae), possesses several beneficial effects against depression, ulcers, dyspepsia, abdominal pains, burns, bacterial infections, migraine headaches, and sciatica. OBJECTIVE:The present study investigates the antimicrobial activity of the ethanol extra...

journal_title：Pharmaceutical biology

authors： Süntar I,Oyardı O,Akkol EK,Ozçelik B

更新日期：2016-01-01 00:00:00

abstract：CONTEXT:Angelica sinensis (Oliv.) Diels (Apiaceae) (syn. Angelica polymorpha Maxim var. sinensis Oliver) processed with yellow rice wine (WAS) has a blood-supplementing effect. OBJECTIVE:To establish an optimal technology for preparing water decoction of WAS (WASD), and screen blood-supplementing fractions. MATERIALS...

journal_title：Pharmaceutical biology

authors： Ji P,Li C,Wei Y,Wu F,Liu S,Hua Y,Yao W,Zhang X,Yuan Z,Wen Y

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:Brassicaceae plants are associated with protection against cancers due to their glucosinolate contents. OBJECTIVES:We investigate fresh leaves, roots and ripe seeds of Lobularia libyca (Viv.) C.F.W. Meissn. (Brassicaceae) to identify their glucosinolate constituents, antimicrobial and cytotoxic activities Mate...

journal_title：Pharmaceutical biology

authors： Al-Gendy AA,Nematallah KA,Zaghloul SS,Ayoub NA

更新日期：2016-12-01 00:00:00

abstract：CONTEXT:1 D is a novel derivative of curcumin and shows very promising antitumor activities in various cancer cell lines. OBJECTIVE:To characterize its preclinical pharmacokinetic profiles, a novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantification of 1 ...

journal_title：Pharmaceutical biology

authors： Sun J,Jiang T,Xu W,Feng Z,Quan X,Leng P,Sun W,Zhao J,Jing F,Li J

更新日期：2019-12-01 00:00:00

abstract：CONTEXT:Seaweeds of the genera Turbinaria and Padina have long been used as food and in traditional medicine for treating several diseases. OBJECTIVE:The current study determines the protective efficacy of the brown seaweeds Turbinaria ornata (Turner) J. Agardh (Sargassaceae) and Padina pavonia (Linnaeus) J.V. Lamouro...

journal_title：Pharmaceutical biology

authors： Abdella EM,Mahmoud AM,El-Derby AM

更新日期：2016-11-01 00:00:00

abstract：:Context: Naringenin and tofacitinib are often used together for treatment of rheumatoid arthritis in Chinese clinics.Objective: This experiment investigates the effect of naringenin on the pharmacokinetics of tofacitinib in rats.Materials and methods: Twelve Sprague-Dawley rats were randomly divided into two groups (e...

journal_title：Pharmaceutical biology

authors： Wang B,Shen J,Zhou Q,Meng D,He Y,Chen F,Wang S,Ji W

更新日期：2020-12-01 00:00:00

abstract：:Context: Fuzheng Huayu recipe (FZHY) combined with entecavir (ETV) is used to treat the cirrhosis caused by chronic hepatitis B (CHB) infection.Objective: To investigate the effect of FZHY on ETV pharmacokinetics under different conditions.Materials and methods: A model of liver fibrosis was created by intraperitoneal...

journal_title：Pharmaceutical biology

authors： Yang T,Zheng TH,Zhao Q,Liu W,Li SP,Tao YY,Wang CH,Liu CH

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:Salvia semiatrata Zucc. (Lamiaceae) is a species used as a tranquilizer and to relieve pain in folk medicine in Santiago Huauclilla, Oaxaca, Mexico. OBJECTIVE:To evaluate the antinociceptive and anxiolytic-like effects of S. semiatrata extracts and identify a bioactive metabolite. MATERIALS AND METHODS:The ex...

journal_title：Pharmaceutical biology

authors： Ortiz-Mendoza N,Zavala-Ocampo LM,Martínez-Gordillo MJ,González-Trujano ME,Peña FAB,Rodríguez IJB,Chávez JAR,Dorazco-González A,Aguirre-Hernández E

更新日期：2020-12-01 00:00:00

abstract：:In this study, branchlets, fruit, or bark of Taxus baccata. L. as well as branchlets or fruits of two other species of Iranian conifers, namely, Platycladus orientalis. France and Cupressus sempervirens. L. var. horizentalis. (Mill) Gunde were collected, identified, and the cytotoxic effects of hydroalcoholic extracts...

journal_title：Pharmaceutical biology

authors： Emami SA,Sadeghi-Aliabadi H,Saeidi M,Jafarian A

更新日期：2005-01-01 00:00:00

abstract：CONTEXT:Biotransformation systems are profitable tools for structural modification of bioactive natural compounds into valuable biologically active terpenoids. OBJECTIVE:This study determines the biological effect of (R)-(+)-limonene and (-)-α-pinene, and their oxygenated derivatives, (a) perillyl alcohol and (S)-(+)-...

journal_title：Pharmaceutical biology

authors： Paduch R,Trytek M,Król SK,Kud J,Frant M,Kandefer-Szerszeń M,Fiedurek J

更新日期：2016-01-01 00:00:00

abstract：:Escin, a group of chemically related triterpenic glycosides, is widely used in commercial preparations for the treatment of venous insufficiency. Since the zygotic embryo cotyledons accumulate the highest amount of escin, it is currently extracted from the seeds of horse chestnut, Aesculus hippocastanum L. (Hippocasta...

journal_title：Pharmaceutical biology

authors： Calić-Dragosavac D,Zdravković-Korać S,Savikin-Fodulović K,Radojević L,Vinterhalter B

更新日期：2010-05-01 00:00:00

abstract：CONTEXT:Rabdosia rubescens (Hemsl.) Hara (Lamiaceae) is widely used in traditional Chinese medicines for the treatment of antitumor, antimicrobial, anti-inflammatory and antioxidation. It is also used as a supplement in the treatment of many cancers, such as esophagus, mammary gland, liver and prostate cancers. OBJECT...

journal_title：Pharmaceutical biology

authors： Li F,Fan J,Wu Z,Liu RY,Guo L,Dong Z,Wang Z

更新日期：2013-09-01 00:00:00