Cytotoxic compounds from the leaves and stems of the endemic Thai plant Mitrephora sirikitiae.

abstract：CONTEXT:Polygonum multiflorum is known as a medicinal plant. It has been used as a folk medicine which showed antioxidative property. OBJECTIVE:Protective effects of the water extracts (w/v:1/10) from fresh P. multiflorum (WEP) on carbon tetrachloride (CCl(4))-induced liver damage in rats were investigated. MATERIALS...

journal_title：Pharmaceutical biology

authors： Lee BH,Huang YY,Duh PD,Wu SC

更新日期：2012-03-01 00:00:00

abstract：CONTEXT:Silymarin (SM) is extracted from milk thistle Silybum marianum L. [Asteraceae (Compositae)] and known for antioxidative and anti-inflammatory effects. OBJECTIVE:The potential antidepressant-like effect of acute SM and possible involvement of nitric oxide (NO) were determined in male mice. MATERIAL AND METHODS...

journal_title：Pharmaceutical biology

authors： Khoshnoodi M,Fakhraei N,Dehpour AR

更新日期：2015-05-01 00:00:00

abstract：CONTEXT:Tranexamic acid is commonly used for curing abnormal bleeding in a variety of diseases. In a previous study, 12 different tetrahydro-2H-1,3,5-thiadiazine derivatives were synthesized from the amine group of tranexamic acid. Their antifibrinolytic and antimicrobial activities were compared with tranexamic acid. ...

journal_title：Pharmaceutical biology

authors： Avuloğlu-Yılmaz E,Yüzbaşıoğlu D,Özçelik AB,Ersan S,Ünal F

更新日期：2017-12-01 00:00:00

abstract：UNLABELLED:Context Murraya paniculata (L.) Jack (Rutaceae), Qianlixiang in Chinese, is distributed in China. As an important traditional Chinese medicine (TCM), it demonstrates many bioactivities, such as febrifuge, astringent, anti-dysenteric, and tonic. OBJECTIVE:The objective of this study is to evaluate the anti-i...

journal_title：Pharmaceutical biology

authors： Wu J,Liu K,Shi X

更新日期：2016-01-01 00:00:00

abstract：CONTEXT:Salvia semiatrata Zucc. (Lamiaceae) is a species used as a tranquilizer and to relieve pain in folk medicine in Santiago Huauclilla, Oaxaca, Mexico. OBJECTIVE:To evaluate the antinociceptive and anxiolytic-like effects of S. semiatrata extracts and identify a bioactive metabolite. MATERIALS AND METHODS:The ex...

journal_title：Pharmaceutical biology

authors： Ortiz-Mendoza N,Zavala-Ocampo LM,Martínez-Gordillo MJ,González-Trujano ME,Peña FAB,Rodríguez IJB,Chávez JAR,Dorazco-González A,Aguirre-Hernández E

更新日期：2020-12-01 00:00:00

abstract：:Context Shengmai injection (SMI) is a patented Chinese medicine originated from the ancient Chinese herbal compound Shengmai san, which is used extensively for the treatment of cardiovascular and cerebrovascular disease in the clinic. Objective To determine the neuroprotective effect of SMI, we investigated the effect...

journal_title：Pharmaceutical biology

authors： Yang H,Li L,Zhou K,Wang Y,Guan T,Chai C,Kou J,Yu B,Yan Y

更新日期：2016-10-01 00:00:00

abstract：CONTEXT:The nephron-protective efficacy of Abelmoschus manihot (Linn.) Medicus (Malvaceae) has been proved by randomized controlled clinical trial. OBJECTIVE:Flavonoids are main active components of A. manihot, which can be transformed into glucuronide/sulfate conjugates in vivo. Exploring the pharmacokinetic profile ...

journal_title：Pharmaceutical biology

authors： Guo J,Du L,Shang E,Li T,Liu Y,Qian D,Tang Y,Duan J

更新日期：2016-01-01 00:00:00

abstract：CONTEXT:Scutellaria baicalensis Georgi (Lamiaceae) is a popular medicinal plant. Its roots are used as the famous traditional Chinese medicine Huang-Qin, which is recorded in Chinese Pharmacopoeia, European Pharmacopoeia, and British Pharmacopoeia. OBJECTIVE:This review comprehensively summarizes research progress in ...

journal_title：Pharmaceutical biology

authors： Wang ZL,Wang S,Kuang Y,Hu ZM,Qiao X,Ye M

更新日期：2018-12-01 00:00:00

abstract：CONTEXT:Many plant extracts and compounds are being investigated for their cytotoxicity and hence their medicinal or therapeutic properties. Reports of toxicity studies with limonoid analogs have been sparse and have involved mainly crude extracts. In this study, individual natural limonoids have been isolated and thei...

journal_title：Pharmaceutical biology

authors： Fowles RG,Mootoo BS,Ramsewak RS,Khan A

更新日期：2012-02-01 00:00:00

abstract：:Context 3,4-Oxo-isopropylidene-shikimic acid (ISA) is an analog of shikimic acid (SA). SA is extracted from the dry fruit of Illicium verum Hook. f. (Magnoliaceae), which has been used for treating stomachaches, skin inflammation and rheumatic pain. Objective To investigate the anti-inflammatory, analgesic and antioxi...

journal_title：Pharmaceutical biology

authors： Sun JY,You CY,Dong K,You HS,Xing JF

更新日期：2016-10-01 00:00:00

abstract：CONTEXT:Depression is one of the most common psychiatric diseases. Acorus tatarinowii Schott (Araceae) has shown many bioactivities in treatment of senile dementia and epilepsy. However, there is no report on antidepressant-like effects of the essential oil (EO) and its major components on animals under standardized ex...

journal_title：Pharmaceutical biology

authors： Han P,Han T,Peng W,Wang XR

更新日期：2013-05-01 00:00:00

abstract：:Abstract Context: Galbanic acid (GA) is a biologically active sesquiterpene coumarin from Ferula species (Apiaceae). This compound showed various biological properties including anticancer, cancer chemopreventive, anticoagulant, antiviral, and antileishmanial activities. Objectives: This article is a review on the syn...

journal_title：Pharmaceutical biology

authors： Kasaian J,Iranshahy M,Iranshahi M

更新日期：2013-12-13 00:00:00

abstract：CONTEXT:Pomegranate [Punica granatum L. (Lythraceae)] is rich in antioxidants. OBJECTIVE:The present work was undertaken to evaluate the protective effects of methanol extract of pomegranate peel extract (PPE) against a rat model of oxidative stress generated by treatment with mercuric chloride (HgCl(2)). MATERIALS A...

journal_title：Pharmaceutical biology

authors： Kumar D,Singh S,Singh AK,Rizvi SI

更新日期：2013-04-01 00:00:00

abstract：CONTEXT:Salvicine is a pharmacologically active derivative from Chinese medicinal plant Salvia prionitis Hance (Labiatae). It has been reported that salvicine inactivates β1 integrin and inhibits integrin-mediated cell adhesion to fibronectin. Given the emerging correlation between integrins and angiogenesis, we propos...

journal_title：Pharmaceutical biology

authors： Zhang Y,Wang L,Chen Y,Qing C

更新日期：2013-08-01 00:00:00

abstract：CONTEXT:Cotinus coggygria Scop. (Anacardiaceae) leaves that were used as wound healing in traditional Balkan and Anatolian folk medicine, could be potentially effective in treating diabetic wounds. OBJECTIVE:This study investigates biochemical and histological effects of ethanol extract of C. coggygria (CCE) on excisi...

journal_title：Pharmaceutical biology

authors： Aksoy H,Sen A,Sancar M,Sekerler T,Akakin D,Bitis L,Uras F,Kultur S,Izzettin FV

更新日期：2016-11-01 00:00:00

abstract：CONTEXT:Anemarsaponin BII is one of the most active saponins isolated from Anemarrhena asphodeloides Bunge (Asparagaceae), a commonly used Chinese traditional paediatric medicine. OBJECTIVE:This study investigates the effects of anemarsaponin BII on the activity of CYP450s to provide more guidance for the clinical use...

journal_title：Pharmaceutical biology

authors： Wang M,Jiang W,Zhou J,Xue X,Yin C

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:Cancer dramatically impacts human life expectancy and quality of life. Natural substances from vegetables, herbs and spices could be beneficial in the prevention or treatment of a variety of cancers. Crocus sativus (Iridaceae), which has been used as a folk medicine for treating diseases for ages, showed obviou...

journal_title：Pharmaceutical biology

authors： Zhang Z,Wang CZ,Wen XD,Shoyama Y,Yuan CS

更新日期：2013-07-01 00:00:00

abstract：CONTEXT:Alismatis rhizome (RA) (Water Plantain Family, also called "Zexie" in Chinese), one of the commonly used components of traditional Chinese medicines, is derived from the dried rhizomes of Alisma orientalis (Sam.) Juzep. (Alismataceae). OBJECTIVE:This study explores the RA influences on rat cytochrome P450 (CYP...

journal_title：Pharmaceutical biology

authors： Huang Y,Zheng SL,Xu ZS,Hou Y

更新日期：2014-06-01 00:00:00

abstract：CONTEXT:Panax ginseng C. A. Mey (Araliaceae) has been widely used in clinic for treatment of cardiovascular diseases in China. Ginsenoside Rb3 is the main chemical component of Panax ginseng. OBJECTIVE:The aim of this study was to evaluate the effect of ginsenoside Rb3 on myocardial ischemia-reperfusion injury in rats...

journal_title：Pharmaceutical biology

authors： Shi Y,Han B,Yu X,Qu S,Sui D

更新日期：2011-09-01 00:00:00

abstract：CONTEXT:Medical therapies for alcohol-induced liver disease are often difficult to handle and limited in efficacy. OBJECTIVE:In an attempt to find natural therapeutics, here, we investigate the preventive effect of persimmon vinegar (PV) and its fractions against alcohol-induced hepatic injury, in addition to the unde...

journal_title：Pharmaceutical biology

authors： Lee HM,Park MY,Kim J,Shin JH,Park KS,Kwon O

更新日期：2016-11-01 00:00:00

abstract：:Context Syzygium densiflorum Wall. ex Wight & Arn (Myrtaceae) has been traditionally used by local tribes of the Nilgiris, Tamil Nadu, India, for the treatment of diabetes, however, no definitive experimental studies are available. Objective This study investigates the antidiabetic, antihyperlipidaemic and antioxidant...

journal_title：Pharmaceutical biology

authors： Krishnasamy G,Muthusamy K,Chellappan DR,Subbiah N

更新日期：2016-09-01 00:00:00

abstract：:Physalis alkekengi L. (Solanaceae) is a popular plant in traditional European and Chinese folk medicine, and it has been reported to have many ethnopharmacological properties including antifungal, anti-cough, anti-inflammatory, analgesic, and febricide activities. Some active components from Physalis species have been...

journal_title：Pharmaceutical biology

authors： Helvaci S,Kökdil G,Kawai M,Duran N,Duran G,Güvenç A

更新日期：2010-02-01 00:00:00

abstract：CONTEXT:Melatonin, a pineal hormone and a potent antioxidant, has important roles in metabolic regulation. OBJECTIVE:This study investigated serum asymmetric dimethylarginine (ADMA), homocysteine (Hcy), nitric oxide (NO) levels, known to be reliable markers of cardiovascular diseases, and determined possible protectiv...

journal_title：Pharmaceutical biology

authors： Kantar Ş,Türközkan N,Bircan FS,Paşaoğlu ÖT

更新日期：2015-07-01 00:00:00

abstract：CONTEXT:Cataract is the clouding of eye lens which causes impairment in vision and accounts for the leading factor of global blindness. Functional food-based prevention of cataract finds application in vision research because of its availability and easy access to all classes of the society. Cassia tora Linn. (Caesalpi...

journal_title：Pharmaceutical biology

authors： Sreelakshmi V,Abraham A

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:2,7-Dihydroxy-3-methylanthraquinone (DDMN) is reported to have a remarkable anticancer activity against gastric cancer SGC-7901 cells. OBJECTIVE:The objective of this study is to study the anticancer effect and mechanism of DDMN on SGC-7901 cells. MATERIALS AND METHODS:The MTT assay was used to determine the ...

journal_title：Pharmaceutical biology

authors： Zhu H,Zheng Z,Zhang J,Liu X,Liu Y,Yang W,Liu Y,Zhang T,Zhao Y,Liu Y,Su X,Gu X

更新日期：2016-01-01 00:00:00

abstract：CONTEXT:Carissa edulis Vahl (Apocynaceae) is used in Nigerian folk medicine to manage a plethora of diseases including epilepsy, cancer, and inflammation; its efficacy is widely acclaimed among communities of northern Nigeria. OBJECTIVE:This study establishes anticonvulsant activities of aqueous fraction of ethanol ro...

journal_title：Pharmaceutical biology

authors： Ya'u J,Yaro AH,Malami S,Musa MA,Abubakar A,Yahaya SM,Chindo BA,Anuka JA,Hussaini IM

更新日期：2015-01-01 00:00:00

abstract：CONTEXT:Glycosmis pentaphylla (Retz.) DC (Rutaceae) is a shrub, traditionally used to treat anemia, rheumatism, as an anthelmintic, febrifuge and vermifuge, for jaundice, and liver complaints. OBJECTIVE:This study evaluated the hepatoprotective activity of G. pentaphylla against paracetamol-induced hepatotoxicity in S...

journal_title：Pharmaceutical biology

authors： Nayak SS,Jain R,Sahoo AK

更新日期：2011-02-01 00:00:00

abstract：CONTEXT:Bombacaceae is a small family of the order Malvales and contains about 28 genera and 200 species. Members of this family are not only showy ornamentals but they possess significant economical and commercial reputation as well. In addition, various plant parts of several species are widely used as foods and trad...

journal_title：Pharmaceutical biology

authors： Refaat J,Desoky SY,Ramadan MA,Kamel MS

更新日期：2013-01-01 00:00:00

abstract：:The activity of an (8-hydroxymethylen)-trieicosanyl acetate compound obtained from chloroform extracts of Senna villosa (Mill.) H.S. Irwin & Barneby (Leguminosae) against Trypanosoma cruzi was evaluated in vivo. Oral doses of 2.1, 8.4, and 33.6 microg/g were tested for 28 days in BALB/c mice infected with T. cruzi. Re...

journal_title：Pharmaceutical biology

authors： Jimenez-Coello M,Acosta-Viana KY,Guzman-Marin E,Perez Gonzalez C,Salud Perez Gutierrez M

更新日期：2010-06-01 00:00:00

abstract：CONTEXT:Light microscopy is in most cases a quick method for the identification and discrimination of medicinally used plant drugs; moreover, this technique is very inexpensive. Reliable descriptions of the anatomy of plants and their adulterations are prerequisites for necessary purity controls. OBJECTIVE:The anatomy...

journal_title：Pharmaceutical biology

authors： Fritz E,Saukel J

更新日期：2011-08-01 00:00:00