Abstract:
:Context:Mitrephora sirikitiae Weeras., Chalermglin & R.M.K. Saunders (Annonaceae) is a plant endemic to Thailand. Its constituents and their biological activities are unknown.Objective: Isolation and identification of the compounds in the leaves and stems of M. sirikitiae and determination of their cytotoxicity.Materials and methods: Methanol extracts of the leaves and stems of M. sirikitiae were separated by chromatography, and spectroscopic methods were used to determine the structures of the components. The cytotoxicity of the extracts and pure compounds was evaluated using the sulforhodamine B assay with several cell lines. The cells were treated with the compounds at concentrations of 0.16-20 µg/mL for 48 or 72 h.Results: The investigation of the extracts of M. sirikitiae leaves and stems resulted in the isolation of a new lignan, mitrephoran, and 15 known compounds. Among these compounds, 2-(3,4-dimethoxyphenyl)-6-(3,5-dimethoxyphenyl)-3,7-dioxabicyclo[3.3.0]octane, ciliaric acid, 6-methoxymarcanine A, and stepharanine were isolated from this genus for the first time. The alkaloids liriodenine and oxoputerine exhibited strong cytotoxicity against all tested cells (IC50 values of 6.59-11.02 µM). In contrast, magnone A, 3',4-O-dimethylcedrusin, and 6-methoxymarcanine A inhibited the growth of some of the tested cells (IC50 values of 2.03-19.73 µM). Magnone A and 6-methoxymarcanine A showed low toxicity for Hek 293 cells (IC50 >20 µM).Discussion and conclusions:M. sirikitiae is a source of cytotoxic lignans and alkaloids. Among the cytotoxic compounds, magnone A and 6-methoxymarcanine A are potentially useful lead compounds for the further development of anticancer agents because of their selective inhibitory effects on cancer cell lines.
journal_name
Pharm Bioljournal_title
Pharmaceutical biologyauthors
Anantachoke N,Lovacharaporn D,Reutrakul V,Michel S,Gaslonde T,Piyachaturawat P,Suksen K,Prabpai S,Nuntasaen Ndoi
10.1080/13880209.2020.1765813subject
Has Abstractpub_date
2020-12-01 00:00:00pages
490-497issue
1eissn
1388-0209issn
1744-5116journal_volume
58pub_type
杂志文章abstract:CONTEXT:Polygonum multiflorum is known as a medicinal plant. It has been used as a folk medicine which showed antioxidative property. OBJECTIVE:Protective effects of the water extracts (w/v:1/10) from fresh P. multiflorum (WEP) on carbon tetrachloride (CCl(4))-induced liver damage in rats were investigated. MATERIALS...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2011.604335
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.942787
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2017.1296000
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abstract:UNLABELLED:Context Murraya paniculata (L.) Jack (Rutaceae), Qianlixiang in Chinese, is distributed in China. As an important traditional Chinese medicine (TCM), it demonstrates many bioactivities, such as febrifuge, astringent, anti-dysenteric, and tonic. OBJECTIVE:The objective of this study is to evaluate the anti-i...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2015.1089294
更新日期:2016-01-01 00:00:00
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journal_title:Pharmaceutical biology
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journal_title:Pharmaceutical biology
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doi:10.3109/13880209.2016.1155625
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2015.1068337
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journal_title:Pharmaceutical biology
pub_type: 杂志文章,评审
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2012.751616
更新日期:2013-05-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.846916
更新日期:2013-12-13 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2012.738333
更新日期:2013-04-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.776612
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2016.1181660
更新日期:2016-11-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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journal_title:Pharmaceutical biology
pub_type: 杂志文章,评审
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更新日期:2013-07-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2015.1125932
更新日期:2016-09-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2010-02-01 00:00:00
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doi:10.3109/13880209.2014.957782
更新日期:2015-07-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2010.501084
更新日期:2011-02-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章,评审
doi:10.3109/13880209.2012.698286
更新日期:2013-01-01 00:00:00
abstract::The activity of an (8-hydroxymethylen)-trieicosanyl acetate compound obtained from chloroform extracts of Senna villosa (Mill.) H.S. Irwin & Barneby (Leguminosae) against Trypanosoma cruzi was evaluated in vivo. Oral doses of 2.1, 8.4, and 33.6 microg/g were tested for 28 days in BALB/c mice infected with T. cruzi. Re...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880200903241853
更新日期:2010-06-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2010.548390
更新日期:2011-08-01 00:00:00