Anemarsaponin BII inhibits the activity of CYP3A4, 2D6, and 2E1 with human liver microsomes.

abstract：:Context Diabetes is a global health challenge. Although large prospective clinical trials have shown that intensive control of blood glucose or blood pressure reduces the risk for development and progression of vascular complications in diabetes, a substantial number of diabetic patients still experience renal failure...

journal_title：Pharmaceutical biology

authors： Yamagishi S,Matsui T

更新日期：2016-10-01 00:00:00

abstract：CONTEXT:The failure of modern anthelmintics to control nematode parasites of sheep and goats is a reality on many farms in the tropical/subtropical regions of the world. This necessitates chemotherapeutic control alternatives and plant secondary metabolite with activity is one of those potential solutions. OBJECTIVE:T...

journal_title：Pharmaceutical biology

authors： Ademola IO,Eloff JN

更新日期：2011-05-01 00:00:00

abstract：:Eugenia jambolana Lam. (Myrtaceae) is widely used in folk medicine as an antidiabetic, but there is a lack of information about its toxicity, especially for the stem bark. The present study evaluated acute oral and repeated-dose toxicity of the stem bark aqueous extract of Eugenia jambolana (EJ) in albino mice and Wis...

journal_title：Pharmaceutical biology

authors： Yele SU,Veeranjaneyulu A

更新日期：2010-08-01 00:00:00

abstract：CONTEXT:Melatonin, a pineal hormone and a potent antioxidant, has important roles in metabolic regulation. OBJECTIVE:This study investigated serum asymmetric dimethylarginine (ADMA), homocysteine (Hcy), nitric oxide (NO) levels, known to be reliable markers of cardiovascular diseases, and determined possible protectiv...

journal_title：Pharmaceutical biology

authors： Kantar Ş,Türközkan N,Bircan FS,Paşaoğlu ÖT

更新日期：2015-07-01 00:00:00

abstract：CONTEXT:The extraction method and the crude wound healing effects of sacchachitin from Ganoderma tsugae Murr. (Ganodermataceae) has been cited. However, its purity is still largely limited. OBJECTIVE:An improvement of the fractionation protocol to purify the sacchachitin from Ganoderma lucidum L. (Ganodermataceae) (SG...

journal_title：Pharmaceutical biology

authors： Chuang CM,Wang HE,Chang CH,Peng CC,Ker YB,Lai JE,Chen KC,Peng RY

更新日期：2013-01-01 00:00:00

abstract：CONTEXT:Hypertrophic scarring, a common proliferative disorder of dermal fibroblasts, results from an overproduction of collagen and excessive deposition of extracellular matrix. Although the treatment with surgical excisions or steroid hormones can modify the symptoms, numerous treatment-related complications have als...

journal_title：Pharmaceutical biology

authors： Wu JG,Wei YJ,Ran X,Zhang H,Nian H,Qin LP

更新日期：2011-07-01 00:00:00

abstract：CONTEXT:Glycosmis pentaphylla (Retz.) DC (Rutaceae) is a shrub, traditionally used to treat anemia, rheumatism, as an anthelmintic, febrifuge and vermifuge, for jaundice, and liver complaints. OBJECTIVE:This study evaluated the hepatoprotective activity of G. pentaphylla against paracetamol-induced hepatotoxicity in S...

journal_title：Pharmaceutical biology

authors： Nayak SS,Jain R,Sahoo AK

更新日期：2011-02-01 00:00:00

abstract：CONTEXT:Alpinia oxyphylla Miquel (Zingiberaceae) is a traditional Chinese herbal medicine widely used for the treatment of intestinal disorders, urosis and diuresis. However, information about antioxidant and cytotoxic properties of its fruits remains to be elucidated. OBJECTIVE:The ethanol crude extract (CE) and its ...

journal_title：Pharmaceutical biology

authors： Wang CZ,Yuan HH,Bao XL,Lan MB

更新日期：2013-11-01 00:00:00

abstract：CONTEXT:Dexamethasone (DXM) has an anti-immunoinflammatory effect, and is often used in acute kidney injury (AKI). However, the effects of DXM on albumin (ALB) have not been fully studied. OBJECTIVE:To investigate the effects of DXM on ALB production and renal function. MATERIALS AND METHODS:Male Wistar rats were div...

journal_title：Pharmaceutical biology

authors： Gong Q,Yin J,Wang M,He L,Lei F,Luo Y,Yang S,Feng Y,Li J,Du L

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:Angelica sinensis (Oliv.) Diels (Apiaceae) (syn. Angelica polymorpha Maxim var. sinensis Oliver) processed with yellow rice wine (WAS) has a blood-supplementing effect. OBJECTIVE:To establish an optimal technology for preparing water decoction of WAS (WASD), and screen blood-supplementing fractions. MATERIALS...

journal_title：Pharmaceutical biology

authors： Ji P,Li C,Wei Y,Wu F,Liu S,Hua Y,Yao W,Zhang X,Yuan Z,Wen Y

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:Buchenavia tetraphylla (Aubl.) RA Howard (Combretaceae: Combretoideae) is an ethnomedicinal plant with reported antifungal action. OBJECTIVE:This study evaluates the antimicrobial activity of B. tetraphylla leaf extracts against clinical isolates of Candida albicans. The morphological alterations, combinatory ...

journal_title：Pharmaceutical biology

authors： Cavalcanti Filho JR,Silva TF,Nobre WQ,Oliveira de Souza LI,Silva E Silva Figueiredo CS,Figueiredo RC,de Gusmão NB,Silva MV,Nascimento da Silva LC,Correia MT

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:The filtrate of Staphylococcus aureus culture, named staphylococcal enterotoxin C injection, has been used for 10 years in China. SEC2 has been claimed to be the only staphylococcal enterotoxins (SEs) without certifiable evidence. OBJECTIVES:To present an efficient procedure for the expression and purification...

journal_title：Pharmaceutical biology

authors： Chen B,Akash MS,Rehman K,Sun H,Chen S

更新日期：2014-01-01 00:00:00

abstract：CONTEXT:The resistance of bacteria to antibiotics is raising serious concern globally. Asian medicinal plants could improve the current treatment strategies for bacterial infections. The antibacterial properties of medicinal plants used by the Khyang tribe in Bangladesh have not been investigated. OBJECTIVE:The presen...

journal_title：Pharmaceutical biology

authors： Hossan MS,Jindal H,Maisha S,Samudi Raju C,Devi Sekaran S,Nissapatorn V,Kaharudin F,Su Yi L,Khoo TJ,Rahmatullah M,Wiart C

更新日期：2018-12-01 00:00:00

abstract：CONTEXT:The biotransformation of lilial results in an acid that is used in the dairy industry, in perfumery, as an intermediate in the manufacture of pharmaceuticals and cosmetics, and as a food additive for enhancing taste. OBJECTIVE:This study investigates the biotransformation of lilial by Staphylococcus aureus and...

journal_title：Pharmaceutical biology

authors： Esmaeili A,Afshari S,Esmaeili D

更新日期：2015-01-01 00:00:00

abstract：CONTEXT:MOTILIPERM was prepared as a mixture of extracts of three medicinal herbs [roots of Morinda officinalis How (Rubiaceae), outer scales of Allium cepa L. (Liliaceae) and seeds of Cuscuta chinensis Lamark (Convolvulaceae)]. OBJECTIVE:To investigate the role of reactive oxygen species (ROS)-based endoplasmic retic...

journal_title：Pharmaceutical biology

authors： Soni KK,Zhang LT,Choi BR,Karna KK,You JH,Shin YS,Lee SW,Kim CY,Zhao C,Chae HJ,Kim HK,Park JK

更新日期：2018-12-01 00:00:00

abstract：CONTEXT:The fruit of the Prunus mume Sieb. et Zucc (Rosaceae) is used as a health food or medicinal material in traditional herb medicine for a long time in Eastern Asian countries. OBJECTIVE:Our present study investigated the hypouricemic effect of the methanol extract from P. mume fruit (MPMF) in mice with potassium...

journal_title：Pharmaceutical biology

authors： Yi LT,Li J,Su DX,Dong JF,Li CF

更新日期：2012-11-01 00:00:00

abstract：CONTEXT:Schumanniophyton magnificum Harms (Rubiaceae) is used traditionally in Nigeria for the treatment of snake bites. Snake venom contains phospholipase A2 (PLA2) which plays a key role in causing inflammation and pain. OBJECTIVE:To assess the anti-inflammatory effect of the methanol extract of Schumanniophyton mag...

journal_title：Pharmaceutical biology

authors： Joshua PE,Anosike CJ,Asomadu RO,Ekpo DE,Uhuo EN,Nwodo OFC

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:Cancer, being a cause of death for major fraction of population worldwide, is one of the most studied diseases and is being investigated for the development of new technologies and more accurate therapies. Still the currently available therapies for cancer have many lacunae which affect the patient's health sev...

journal_title：Pharmaceutical biology

authors： Rai M,Jogee PS,Agarkar G,dos Santos CA

更新日期：2016-01-01 00:00:00

abstract：:Context: Puerarin and triptolide are sometimes used together for the treatment of disease in Chinese clinics; however, the drug-drug interaction between puerarin and triptolide is still unknown. Objective: This study investigates the effects of puerarin on the pharmacokinetics of triptolide in rats and clarifies its m...

journal_title：Pharmaceutical biology

authors： Wang Q,Wu Y,Xiang F,Feng Y,Li Z,Ding Y

更新日期：2019-12-01 00:00:00

abstract：CONTEXT:Seaweeds of the genera Turbinaria and Padina have long been used as food and in traditional medicine for treating several diseases. OBJECTIVE:The current study determines the protective efficacy of the brown seaweeds Turbinaria ornata (Turner) J. Agardh (Sargassaceae) and Padina pavonia (Linnaeus) J.V. Lamouro...

journal_title：Pharmaceutical biology

authors： Abdella EM,Mahmoud AM,El-Derby AM

更新日期：2016-11-01 00:00:00

abstract：CONTEXT:Silymarin, a flavonolignan from Silybum marianum (L.) Gaertn. (Asteraceae), has been reported to have antioxidant and anti-inflammatory properties. Therefore, it may be worthwhile to study the effect of silymarin on wound healing. OBJECTIVE:To evaluate the effect of silymarin on human fibroblast cells in an in...

journal_title：Pharmaceutical biology

authors： Sharifi R,Pasalar P,Kamalinejad M,Dehpour AR,Tavangar SM,Paknejad M,Mehrabani Natanzi M,Nourbakhsh M,Ahmadi Ashtiani HR,Akbari M,Rastegar H

更新日期：2013-03-01 00:00:00

abstract：CONTEXT:For years, natural products from microbes have been used as drugs. Endophytes are the most important fungi that produce many novel metabolites for potential use in pharmacology and agriculture. OBJECTIVE:The objective of the present study was to explore new endophytes for novel natural products. MATERIALS AND...

journal_title：Pharmaceutical biology

authors： Katoch M,Khajuria A,Sharma PR,Saxena AK

更新日期：2015-01-01 00:00:00

abstract：CONTEXT:Arecoline is an effective constituent of Areca catechu L. (Arecaceae) with various pharmacological effects. However, investigations also revealed that long use of arecoline could arouse some oral diseases. OBJECTIVE:The present review gathers the fragmented information available in the literature (before 1 Oct...

journal_title：Pharmaceutical biology

authors： Liu YJ,Peng W,Hu MB,Xu M,Wu CJ

更新日期：2016-11-01 00:00:00

abstract：CONTEXT:Dicranopteris linearis (Burm.f.) Underw. (Gleicheniaceae) has been scientifically proven to exert various pharmacological activities. Nevertheless, its anti-proliferative potential has not been extensively investigated. OBJECTIVE:To investigate the anti-proliferative potential of D. linearis leaves and determi...

journal_title：Pharmaceutical biology

authors： Baharuddin AA,Roosli RAJ,Zakaria ZA,Md Tohid SF

更新日期：2018-12-01 00:00:00

abstract：CONTEXT:Growing adipose tissue is thought to require adipogenesis, angiogenesis, and extracellular matrix (ECM) remodeling. Close examination of developing adipose tissue microvasculature reveals that angiogenesis often precedes adipogenesis. Since our previous study demonstrated that Ob-X, the anti-angiogenic herbal c...

journal_title：Pharmaceutical biology

authors： Hong Y,Kim MY,Yoon M

更新日期：2011-08-01 00:00:00

abstract：CONTEXT:1 D is a novel derivative of curcumin and shows very promising antitumor activities in various cancer cell lines. OBJECTIVE:To characterize its preclinical pharmacokinetic profiles, a novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantification of 1 ...

journal_title：Pharmaceutical biology

authors： Sun J,Jiang T,Xu W,Feng Z,Quan X,Leng P,Sun W,Zhao J,Jing F,Li J

更新日期：2019-12-01 00:00:00

abstract：:Context:Mitrephora sirikitiae Weeras., Chalermglin & R.M.K. Saunders (Annonaceae) is a plant endemic to Thailand. Its constituents and their biological activities are unknown.Objective: Isolation and identification of the compounds in the leaves and stems of M. sirikitiae and determination of their cytotoxicity.Materi...

journal_title：Pharmaceutical biology

authors： Anantachoke N,Lovacharaporn D,Reutrakul V,Michel S,Gaslonde T,Piyachaturawat P,Suksen K,Prabpai S,Nuntasaen N

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:Neuropsychiatric disorders, like anxiety and depression, are global problems for clinical researchers in neurology. Recently, some authors have shown neuroprotective and anti-inflammatory effects of Scrophularia striata Boiss (Scrophulariaceae) extract in rodents. OBJECTIVE:The purpose of the current study was...

journal_title：Pharmaceutical biology

authors： Kosari-Nasab M,Babri S,Fatehi-Gharehlar L,Doosti MH,Pakzad S

更新日期：2013-05-01 00:00:00

abstract：:Different extracts from the stem bark of Berberis asiatica L. , a plant traditionally used to hasten the process of wound healing, and the alkaloid fractions derived from the commonly used aqueous extract, were tested for their putative antimicrobial activity against a battery of microorganisms by disk diffusion and a...

journal_title：Pharmaceutical biology

authors： Bhandari DK,Nath G,Ray AB,Tewari PV

更新日期：2000-01-01 00:00:00

abstract：CONTEXT:Propranolol, atenolol, and ICI118,551 are non-selective β-adrenergic receptor (AR), β1-AR, and β2-AR antagonists, respectively. OBJECTIVE:We investigated the efficacy of propranolol, atenolol, and ICI118,551 on proliferation, migration, and invasion of non-stimulated breast (MCF7), colon (HT-29), and hepatocel...

journal_title：Pharmaceutical biology

authors： Işeri OD,Sahin FI,Terzi YK,Yurtcu E,Erdem SR,Sarialioglu F

更新日期：2014-11-01 00:00:00