Abstract:
:Context Syzygium densiflorum Wall. ex Wight & Arn (Myrtaceae) has been traditionally used by local tribes of the Nilgiris, Tamil Nadu, India, for the treatment of diabetes, however, no definitive experimental studies are available. Objective This study investigates the antidiabetic, antihyperlipidaemic and antioxidant activities of ethanol extract of S. densiflorum (EFSD) fruits in streptozotocin (STZ) and nicotinamide (NA)-induced diabetic rats. Materials and methods Acute oral toxicity and oral glucose tolerance were assessed in normal rats. The antidiabetic, antihyperlipidaemic and antioxidant activities were investigated in STZ - NA-induced diabetic rats. Diabetic rats were orally administered with glibenclamide (10 mg/kg b.wt), EFSD (200, 400 and 800 mg/kg b.wt) for 28 d. Further, changes in the blood glucose level (BGL), biochemical parameters, antioxidants were observed and histology of pancreas was performed. Results No toxicity and lethality were observed. Results of the following parameters are represented by treated versus disease control (STZ + NA) groups. BGL (161.33 ± 22.8 versus 476.17 ± 56.58 mg/dl), glycosylated haemoglobin (5.285 ± 0.19 versus 8.05 ± 0.55%), urea (40.32 ± 1.96 versus 75.37 ± 2.91 mg/dl), uric acid (1.2 ± 0.07 versus 2.16 ± 0.05 mg/dl), total cholesterol (89.3 ± 5.14 versus 139.7 ± 5.95 mg/dl) and triglycerides (79.65 ± 2.52 versus 108.9 ± 3.61 mg/dl) were significantly decreased, whereas haemoglobin (11.75 ± 0.73 versus 7.95 ± 0.42 g/dl), high-density lipoprotein cholesterol (14.2 ± 1.11 versus 6.97 ± 0.84 mg/dl), total protein (45%) and liver glycogen (87%) were significantly increased in EFSD-treated diabetic group. Significant changes were observed in the enzymatic and non-enzymatic antioxidants in EFSD-treated groups (p < 0.001). Histopathological examination showed the regeneration of β-cells in Islets of Langerhans. Conclusion This study confirms the antidiabetic, antihyperlipidaemic and antioxidant activities of S. densiflorum fruits.
journal_name
Pharm Bioljournal_title
Pharmaceutical biologyauthors
Krishnasamy G,Muthusamy K,Chellappan DR,Subbiah Ndoi
10.3109/13880209.2015.1125932subject
Has Abstractpub_date
2016-09-01 00:00:00pages
1716-26issue
9eissn
1388-0209issn
1744-5116journal_volume
54pub_type
杂志文章abstract:CONTEXT AND OBJECTIVE:The Sisala traditional healers of northwest Ghana have a rich ethnomedical tradition. The purpose of this study was to collect and analyse data on medicinal plants commonly used by Sisala traditional healers. METHODS:A total of 30 traditional healers were interviewed using a mixture of open- and ...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2011.633920
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pub_type: 杂志文章
doi:10.3109/13880209.2014.920396
更新日期:2015-03-01 00:00:00
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更新日期:2017-12-01 00:00:00
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doi:10.3109/13880209.2014.962058
更新日期:2015-08-01 00:00:00
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更新日期:2001-01-01 00:00:00
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更新日期:2016-08-01 00:00:00
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更新日期:2016-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-03-01 00:00:00
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更新日期:2011-07-01 00:00:00
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更新日期:2017-12-01 00:00:00
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更新日期:2017-12-01 00:00:00
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更新日期:2015-01-01 00:00:00
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更新日期:2016-11-01 00:00:00
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更新日期:2012-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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更新日期:2020-12-01 00:00:00
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更新日期:2016-11-01 00:00:00