Pomegranate (Punica granatum) peel extract provides protection against mercuric chloride-induced oxidative stress in Wistar strain rats.

abstract：CONTEXT:Amla [Emblica officinalis Gaertn. (Euphorbiaceae)], a major constituent of several herbal formulations, is a well-known hepatoprotectant. Despite its extensive use, mechanistic understanding of its antioxidant action is rather limited. OBJECTIVE:In the current study, we investigated the effects of E. officinal...

journal_title：Pharmaceutical biology

authors： Shivananjappa MM,Joshi MK

更新日期：2012-04-01 00:00:00

abstract：CONTEXT:Phytochemical and pharmacological data on Ducrosia anethifolia (DC.) Boiss. (Apiaceae), an Iranian medicinal plant, are scarce; however, furocoumarins are characteristic compounds of D. anethifolia. OBJECTIVE:Our experiments identify the secondary metabolites of D. anethifolia and assess their antitumor and an...

journal_title：Pharmaceutical biology

authors： Mottaghipisheh J,Nové M,Spengler G,Kúsz N,Hohmann J,Csupor D

更新日期：2018-12-01 00:00:00

abstract：CONTEXT:Marine cyanobacteria offer a robust resource for natural products drug discovery due to the secondary metabolites they produce. OBJECTIVE:To identify novel cyanobacterial compounds that exhibit CNS psychoactive effects. MATERIALS AND METHODS:Cyanobacteria were collected from Las Perlas Archipelago, Panama and...

journal_title：Pharmaceutical biology

authors： Lax NC,Ahmed KT,Ignatz CM,Spadafora C,Kolber BJ,Tidgewell KJ

更新日期：2016-11-01 00:00:00

abstract：CONTEXT:Polygonum multiflorum is known as a medicinal plant. It has been used as a folk medicine which showed antioxidative property. OBJECTIVE:Protective effects of the water extracts (w/v:1/10) from fresh P. multiflorum (WEP) on carbon tetrachloride (CCl(4))-induced liver damage in rats were investigated. MATERIALS...

journal_title：Pharmaceutical biology

authors： Lee BH,Huang YY,Duh PD,Wu SC

更新日期：2012-03-01 00:00:00

abstract：CONTEXT:Safranal (SAF) is verified to have potential effects in promoting nerve growth. OBJECTIVES:This study verifies the role of SAF in promoting dopaminergic neurons growth in vitro and in vivo. MATERIAL AND METHODS:Rat neural stem cells (NSC) were treated with 1, 20, or 100 ng/mL of SAF, and the expression levels...

journal_title：Pharmaceutical biology

authors： Zhao Y,Xi G

更新日期：2018-12-01 00:00:00

abstract：CONTEXT:Sheng-Mai-San (SMS) has been used for the treatment of cardiovascular disease for many years in China. OBJECTIVES:This study investigated the protective effects and active ingredients of SMS on myocardial injury (MI) in mice. MATERIALS AND METHODS:SMS and n-butanol extraction of SMS (SMS-Bu) were prepared and...

journal_title：Pharmaceutical biology

authors： Wang YQ,Zhang JQ,Liu CH,Zhu DN,Yu BY

更新日期：2013-10-01 00:00:00

abstract：:Context: Emodin is a compound in Rheum undulatum Linne (Polygonaceae) that has been reported to exert anti-inflammatory, antibacterial, and antiallergic effects.Objective: Oxidative stress is a causative agent of liver inflammation that may lead to fibrosis and hepato-carcinoma. In this study, we investigated the anti...

journal_title：Pharmaceutical biology

authors： Lee EH,Baek SY,Park JY,Kim YW

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:Panax ginseng C. A. Mey (Araliaceae) has been widely used in clinic for treatment of cardiovascular diseases in China. Ginsenoside Rb3 is the main chemical component of Panax ginseng. OBJECTIVE:The aim of this study was to evaluate the effect of ginsenoside Rb3 on myocardial ischemia-reperfusion injury in rats...

journal_title：Pharmaceutical biology

authors： Shi Y,Han B,Yu X,Qu S,Sui D

更新日期：2011-09-01 00:00:00

abstract：:Context:Caragana pruinosa Kom. (Fabaceae), a commonly used folk medicine, has been found to possess antitumor effects. However, the antiproliferative effect of 2,4-dihydroxy-3'-methoxy-4'-ethoxychalcone (DMEC) derived from C. pruinosa against multiple myeloma (MM) has never been investigated. Objective: This study sys...

journal_title：Pharmaceutical biology

authors： Zhu F,Jiang D,Zhang M,Zhao B

更新日期：2019-12-01 00:00:00

abstract：CONTEXT:Diabetes mellitus is characterized by oxidative stress, which in turn induces endothelial dysfunction. As a potent antioxidant compound, lycopene might rescue diabetic endothelial dysfunction by reducing oxidative stress. OBJECTIVE:The present study investigated whether lycopene could lower oxidative stress an...

journal_title：Pharmaceutical biology

authors： Zhu J,Wang CG,Xu YG

更新日期：2011-11-01 00:00:00

abstract：CONTEXT:Cataract is the clouding of eye lens which causes impairment in vision and accounts for the leading factor of global blindness. Functional food-based prevention of cataract finds application in vision research because of its availability and easy access to all classes of the society. Cassia tora Linn. (Caesalpi...

journal_title：Pharmaceutical biology

authors： Sreelakshmi V,Abraham A

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:Urtica dioica L. (Urticaceae), stinging nettle, has been employed as a folklore remedy for a wide spectrum of ailments, including urinary disorders, prostatic hyperplasia, and liver diseases. It has been also used traditionally for cancer treatment. OBJECT:To evaluate the potential chemopreventive properties o...

journal_title：Pharmaceutical biology

authors： Di Sotto A,Mazzanti G,Savickiene N,Staršelskytė R,Baksenskaite V,Di Giacomo S,Vitalone A

更新日期：2015-06-01 00:00:00

abstract：CONTEXT:The failure of modern anthelmintics to control nematode parasites of sheep and goats is a reality on many farms in the tropical/subtropical regions of the world. This necessitates chemotherapeutic control alternatives and plant secondary metabolite with activity is one of those potential solutions. OBJECTIVE:T...

journal_title：Pharmaceutical biology

authors： Ademola IO,Eloff JN

更新日期：2011-05-01 00:00:00

abstract：CONTEXT:The persistence of fascioliasis in many developing countries urges the search for simple, cheap, and effective substances. In this view, plants provide interesting molluscicidal activities thanks to the secondary metabolites they produce. The genus Solanum is known for its potent effect on vector snails. OBJEC...

journal_title：Pharmaceutical biology

authors： Njeh F,Feki H,Koubaa I,Hamed N,Damak M,Ayadi A,Hammami H,Mezghani-Jarraya R

更新日期：2016-01-01 00:00:00

abstract：CONTEXT:Fructus Meliae toosendan extracts (FMTE) have a good therapeutic effect on coccidiosis, but there is no relevant research on its prophylactic effect on coccidiosis. OBJECTIVE:This study comprehensively evaluates the anticoccidial effect of FMTE. MATERIALS AND METHODS:In vitro, the unsporulated oocysts were tr...

journal_title：Pharmaceutical biology

authors： Yong T,Chen M,Li Y,Song X,Huang Y,Chen Y,Jia R,Zou Y,Li L,Yin L,He C,Lv C,Liang X,Ye G,Yin Z

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:Glutathione reductase (GR, NADPH:oxidized glutathione oxidoreductase, E.C 1.6.4.2) is a flavoprotein that catalyzes the NADPH-dependent reduction of oxidized glutathione (GSSG). GR is a crucial enzyme in the antioxidant system by maintaining reduced glutathione (GSH). Glucose 6-phosphate dehydrogenase (G6PD, gl...

journal_title：Pharmaceutical biology

authors： Tandogan B,Kuruüzüm-Uz A,Sengezer C,Güvenalp Z,Demirezer LÖ,Ulusu NN

更新日期：2011-06-01 00:00:00

abstract：CONTEXT:Brassicaceae plants are associated with protection against cancers due to their glucosinolate contents. OBJECTIVES:We investigate fresh leaves, roots and ripe seeds of Lobularia libyca (Viv.) C.F.W. Meissn. (Brassicaceae) to identify their glucosinolate constituents, antimicrobial and cytotoxic activities Mate...

journal_title：Pharmaceutical biology

authors： Al-Gendy AA,Nematallah KA,Zaghloul SS,Ayoub NA

更新日期：2016-12-01 00:00:00

abstract：CONTEXT:The genus Hypericum (Guttiferae) has received considerable scientific interest as a source of biologically active compounds. OBJECTIVE:The study determined the morphogenetic and ontogenetic variation in the main bioactive compounds of two Hypericum species, namely, Hypericum aviculariifolium subsp. depilatum v...

journal_title：Pharmaceutical biology

authors： Cirak C,Radusiene J,Camas N,Caliskan O,Odabas MS

更新日期：2013-03-01 00:00:00

abstract：CONTEXT:Eupatorium triplinerve Vahl (Asteraceae), popularly known as Japana, is widely used in folk medicine, due its analgesic, anticoagulant, antianorexic, antiparasitic, anthelmintic, sedative, antifungal, and antibacterial properties. OBJECTIVE:The present study evaluated the chemical composition and antimicrobial...

journal_title：Pharmaceutical biology

authors： Matos Lopes TR,de Oliveira FR,Malheiros FF,de Andrade MA,Monteiro MC,Baetas Gonçalves AC

更新日期：2015-06-01 00:00:00

abstract：:Nine species belonging to the genus Lippia - Verbenaceae - are used in Argentine folk medicine. Four of them are known under the trivial name "poleo": L. turbinata Griseb., L. fissicalyx Troncoso, L. integrifolia (Griseb.) Hieron. and L. grisebachiana Mold. Mainly, their leaves are employed as digestive, stomaquique, ...

journal_title：Pharmaceutical biology

authors： Bassols GB,Gurni AA

更新日期：2000-01-01 00:00:00

abstract：:Context: Er Miao San (EMS) is a traditional Chinese medicine composed of Atractylodis Rhizoma and Phellodendri Cortex in a 1:1 weight ratio. EMS has been used to treat rheumatism in China for many years.Objective: To evaluate the anti-arthritic activity of EMS extract on adjuvant-induced arthritis (AA) in Sprague-Dawl...

journal_title：Pharmaceutical biology

authors： Dai X,Yang D,Bao J,Zhang Q,Ding J,Liu M,Ding M,Liu M,Liang J,Jia X

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:Psoralen and anastrozole are always used together for breast cancer patients in Chinese clinics. OBJECTIVE:This study investigates the effects of psoralen on the pharmacokinetics of anastrozole in rats and its potential mechanism. MATERIALS AND METHODS:The pharmacokinetics of orally administered anastrozole (...

journal_title：Pharmaceutical biology

authors： Zhang Y,Wu J,Zhou Y,Yin Y,Chen H

更新日期：2018-12-01 00:00:00

abstract：CONTEXT:The roots of Phytolacca americana L. (Phytolaccaceae) may be toxic. Despite heated controversy over the toxic compounds of P. americana, especially esculentosides, relevant studies remain scarce. OBJECTIVE:The objective of this study is to screen the toxic fractions and compounds of P. americana, to determine ...

journal_title：Pharmaceutical biology

authors： Yu H,Gong L,Wang X,Wu H,Zhao T,Wang K,Cui X,Chen L

更新日期：2016-01-01 00:00:00

abstract：CONTEXT:Rabdosia rubescens (Hemsl.) Hara (Lamiaceae) is widely used in traditional Chinese medicines for the treatment of antitumor, antimicrobial, anti-inflammatory and antioxidation. It is also used as a supplement in the treatment of many cancers, such as esophagus, mammary gland, liver and prostate cancers. OBJECT...

journal_title：Pharmaceutical biology

authors： Li F,Fan J,Wu Z,Liu RY,Guo L,Dong Z,Wang Z

更新日期：2013-09-01 00:00:00

abstract：CONTEXT:Sepsis continues to be a significant problem for critical care patients. OBJECTIVE:To evaluate the protective effects of IgM-enriched immunoglobulin and erythropoietin on pulmonary and small intestine tissues in a rat model of intra-abdominal sepsis induced via the cecal ligation and puncture (CLP) method. MA...

journal_title：Pharmaceutical biology

authors： Ates I,Dogan N,Aksoy M,Halıcı Z,Gündogdu C,Keles MS

更新日期：2015-01-01 00:00:00

abstract：:Context:Mitrephora sirikitiae Weeras., Chalermglin & R.M.K. Saunders (Annonaceae) is a plant endemic to Thailand. Its constituents and their biological activities are unknown.Objective: Isolation and identification of the compounds in the leaves and stems of M. sirikitiae and determination of their cytotoxicity.Materi...

journal_title：Pharmaceutical biology

authors： Anantachoke N,Lovacharaporn D,Reutrakul V,Michel S,Gaslonde T,Piyachaturawat P,Suksen K,Prabpai S,Nuntasaen N

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:During the last few decades, the prevalence of obesity in the western world has dramatically increased with epidemic proportions. Hand in hand with this statistic, the incidences of obesity-linked diseases such as diabetes are increasing with pandemic rate. The search for novel drugs and nutritional interventio...

journal_title：Pharmaceutical biology

authors： Habtemariam S

更新日期：2012-12-01 00:00:00

abstract：CONTEXT:Angelica sinensis (Oliv.) Diels (Apiaceae) (syn. Angelica polymorpha Maxim var. sinensis Oliver) processed with yellow rice wine (WAS) has a blood-supplementing effect. OBJECTIVE:To establish an optimal technology for preparing water decoction of WAS (WASD), and screen blood-supplementing fractions. MATERIALS...

journal_title：Pharmaceutical biology

authors： Ji P,Li C,Wei Y,Wu F,Liu S,Hua Y,Yao W,Zhang X,Yuan Z,Wen Y

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:Oysters [Crassostrea plicatula Gmelin (Ostreidae)] are widely used for food in coastal areas. It is reported to have several qualities such as improving sexual and immune function. They has been approved by Chinese Ministry of Health as a functional food. OBJECTIVE:The effects of five types of oyster component...

journal_title：Pharmaceutical biology

authors： Hao G,Zhang C,Cao W,Hao J

更新日期：2014-06-01 00:00:00

abstract：CONTEXT:Alpinia oxyphylla Miquel (Zingiberaceae) is a traditional Chinese herbal medicine widely used for the treatment of intestinal disorders, urosis and diuresis. However, information about antioxidant and cytotoxic properties of its fruits remains to be elucidated. OBJECTIVE:The ethanol crude extract (CE) and its ...

journal_title：Pharmaceutical biology

authors： Wang CZ,Yuan HH,Bao XL,Lan MB

更新日期：2013-11-01 00:00:00