Abstract:
CONTEXT:The failure of modern anthelmintics to control nematode parasites of sheep and goats is a reality on many farms in the tropical/subtropical regions of the world. This necessitates chemotherapeutic control alternatives and plant secondary metabolite with activity is one of those potential solutions. OBJECTIVE:This study was design to evaluate the efficacy of solvent: solvent fractions of Cassia alata Gelenggang Besar (Leguminosae) leaf acetone extract against Heamonchus contortus Rudolphi (Trichostrongylidae). MATERIALS AND METHODS:C. alata leaf was extracted with 70% acetone and fractions were obtained by solvent: solvent group separation procedures. The acetone extract and the fractions were tested by egg hatch assay (EHA) and larval development and viability assay to assess relative bioactivity against H. contortus eggs and larvae. RESULTS:The extracts inhibited egg hatchability and killed infective larvae of H. contortus in a concentration-dependent manner. The best-fit LC(50) values were 0.562, 0.243, 0.490, 0.314, and 0.119 mg/mL for the acetone extract, chloroform, hexane, butanol and 35% water in methanol fractions, respectively, when tested against nematode eggs. The best-fit LC(50) values were 0.191, 0.505, 1.444, 0.306, and 0.040 mg/mL for acetone extract, chloroform, hexane, butanol and 35% water in methanol fractions, respectively, when tested against larvae. The 35% water in methanol fraction was the most active against the larvae and eggs of H. contortus demonstrating the lowest LC(50) values DISCUSSION AND CONCLUSION:This study demonstrates that the leaf extracts of C. alata have anthelmintic activity; therefore it could find application in the control of helminths in livestock.
journal_name
Pharm Bioljournal_title
Pharmaceutical biologyauthors
Ademola IO,Eloff JNdoi
10.3109/13880209.2010.526948subject
Has Abstractpub_date
2011-05-01 00:00:00pages
539-44issue
5eissn
1388-0209issn
1744-5116journal_volume
49pub_type
杂志文章abstract:CONTEXT:Red ginseng (heat-processed Panax ginseng) is a well-known alternative medicine with pharmacological antidiabetic activity. It exerts pharmacological effects through the transformation of saponin into metabolites by the intestinal microbiota. Given that intestinal conditions and intestinal microflora vary among...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2016.1237978
更新日期:2017-12-01 00:00:00
abstract::Context: Er Miao San (EMS) is a traditional Chinese medicine composed of Atractylodis Rhizoma and Phellodendri Cortex in a 1:1 weight ratio. EMS has been used to treat rheumatism in China for many years.Objective: To evaluate the anti-arthritic activity of EMS extract on adjuvant-induced arthritis (AA) in Sprague-Dawl...
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journal_title:Pharmaceutical biology
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更新日期:2013-03-01 00:00:00
abstract:CONTEXT:Ginger has been used commonly in the traditional system of medicine for the treatment of respiratory disorders. OBJECTIVE:The present study investigates the immunosuppressive activity of ginger by using the mouse model of ovalbumin-induced allergic asthma. MATERIALS AND METHODS:Treatment with ethanol extract ...
journal_title:Pharmaceutical biology
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journal_title:Pharmaceutical biology
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doi:10.3109/13880209.2012.738331
更新日期:2013-04-01 00:00:00
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更新日期:2016-10-01 00:00:00
abstract:CONTEXT:Fructus Meliae toosendan extracts (FMTE) have a good therapeutic effect on coccidiosis, but there is no relevant research on its prophylactic effect on coccidiosis. OBJECTIVE:This study comprehensively evaluates the anticoccidial effect of FMTE. MATERIALS AND METHODS:In vitro, the unsporulated oocysts were tr...
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更新日期:2020-12-01 00:00:00
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abstract::Context: Curcumin, a polyphenolic compound extracted from the rhizome of the tropical plant Curcuma longa L. (Zingiberaceae), has been considered as a cancer chemopreventive drug by American National Cancer Institute.Objective: To examine the effect of curcumin on acute monocytic leukaemia SHI-1 cells in vivo.Material...
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更新日期:2014-03-01 00:00:00
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更新日期:2016-01-01 00:00:00
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journal_title:Pharmaceutical biology
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doi:10.3109/13880209.2015.1129545
更新日期:2016-09-01 00:00:00
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更新日期:2014-02-01 00:00:00
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更新日期:2014-03-01 00:00:00
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更新日期:2016-11-01 00:00:00
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更新日期:2016-01-01 00:00:00
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更新日期:2014-06-01 00:00:00
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更新日期:2012-03-01 00:00:00
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更新日期:2013-02-01 00:00:00
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更新日期:2016-01-01 00:00:00
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更新日期:2011-08-01 00:00:00