Abstract:
CONTEXT:Fructus Meliae toosendan extracts (FMTE) have a good therapeutic effect on coccidiosis, but there is no relevant research on its prophylactic effect on coccidiosis. OBJECTIVE:This study comprehensively evaluates the anticoccidial effect of FMTE. MATERIALS AND METHODS:In vitro, the unsporulated oocysts were treated with serial dilutions of FMTE and incubated for 7 d, and the sporulated oocysts were counted for calculating the median lethal concentration (LC50) of FMTE. In vivo, 180 10-day-old broiler chickens free of coccidiosis were weighted and randomly distributed into six groups: normal group, untreated group, 4 protective groups (positive group and three FMTE groups). From day 10 to day 21, chickens in the three FMTE groups were pre-treated with FMTE at the dosage of 2.5, 5 and 10 g/kg/d, respectively, and chickens in the positive group were pre-treated with qiuliling (10 g/kg/d). On day 14, chickens in all groups except the normal group were orally infected with 1.5 × 104 sporulated oocysts. The clinical symptoms were observed from day 10 to day 21, the anticoccidial index (ACI), tissue lesions, and intestinal microflora were determined on day 21. RESULTS:FMTE showed anti-sporulation effect against E. tenella and the LC50 value was 245.83 µg/mL in vitro. In vivo, FMTE at the dosage of 10 g/kg/d was effective against E. tenella infection, and its ACI value was 162.56, which was higher than the value of positive drug qiuliling (128.81). Discussion and conclusions: FMTE have potent anticoccidial effects, and it presents an alternative anticoccidial agent for avian coccidiosis control.
journal_name
Pharm Bioljournal_title
Pharmaceutical biologyauthors
Yong T,Chen M,Li Y,Song X,Huang Y,Chen Y,Jia R,Zou Y,Li L,Yin L,He C,Lv C,Liang X,Ye G,Yin Zdoi
10.1080/13880209.2020.1784234subject
Has Abstractpub_date
2020-12-01 00:00:00pages
636-645issue
1eissn
1388-0209issn
1744-5116journal_volume
58pub_type
杂志文章abstract:CONTEXT:In traditional medicine propolis is widely used for the treatment of various ailments including ulcer and wound healing. The phytochemical screening of Indian propolis indicates the presence of biologically active ingredients in appreciable amounts. In the absence of systematic evaluation of wound healing prope...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880200903578754
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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abstract:CONTEXT:Liposomes are increasingly employed to deliver chemotherapeutic agents, antisense oligonucleotides, and genes to various therapeutic targets. OBJECTIVE:The present investigation evaluates the ability of fusogenic pH-sensitive liposomes of rapamycin in increasing its antiproliferative effect on human breast ade...
journal_title:Pharmaceutical biology
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.976350
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abstract::Rhinacanthus nasutus (L.) Kurz (Acanthaceae) has long been used in Thai traditional medicine for treatment of tinea versicolor, ringworm, pruritic rash, and abscess. The active constituents are known as a group of naphthoquinone esters, rhinacanthins. This work focused on establishment of R. nasutus root cultures and ...
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pub_type: 杂志文章
doi:10.1080/13880200590951766
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2010.533187
更新日期:2011-06-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2011-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-06-01 00:00:00
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journal_title:Pharmaceutical biology
pub_type: 杂志文章
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更新日期:2010-02-01 00:00:00
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