Cytotoxic effects of Eryngium kotschyi and Eryngium maritimum on Hep2, HepG2, Vero and U138 MG cell lines.

abstract：CONTEXT:Brassicaceae plants are associated with protection against cancers due to their glucosinolate contents. OBJECTIVES:We investigate fresh leaves, roots and ripe seeds of Lobularia libyca (Viv.) C.F.W. Meissn. (Brassicaceae) to identify their glucosinolate constituents, antimicrobial and cytotoxic activities Mate...

journal_title：Pharmaceutical biology

authors： Al-Gendy AA,Nematallah KA,Zaghloul SS,Ayoub NA

更新日期：2016-12-01 00:00:00

abstract：CONTEXT:Sheng-Mai-San (SMS) has been used for the treatment of cardiovascular disease for many years in China. OBJECTIVES:This study investigated the protective effects and active ingredients of SMS on myocardial injury (MI) in mice. MATERIALS AND METHODS:SMS and n-butanol extraction of SMS (SMS-Bu) were prepared and...

journal_title：Pharmaceutical biology

authors： Wang YQ,Zhang JQ,Liu CH,Zhu DN,Yu BY

更新日期：2013-10-01 00:00:00

abstract：CONTEXT:The roots of Phytolacca americana L. (Phytolaccaceae) may be toxic. Despite heated controversy over the toxic compounds of P. americana, especially esculentosides, relevant studies remain scarce. OBJECTIVE:The objective of this study is to screen the toxic fractions and compounds of P. americana, to determine ...

journal_title：Pharmaceutical biology

authors： Yu H,Gong L,Wang X,Wu H,Zhao T,Wang K,Cui X,Chen L

更新日期：2016-01-01 00:00:00

abstract：CONTEXT:Hippocratea africana (Willd.) Loes. ex Engl. (Celastraceae) root is used traditionally as an antipoison or antidote to treat liver diseases. OBJECTIVE:To evaluate antioxidative burst and hepatoprotective potentials of H. africana against paracetamol-induced liver injury in rats. MATERIALS AND METHOD:Antioxida...

journal_title：Pharmaceutical biology

authors： Okokon JE,Nwafor PA,Charles U,Dar A,Choudhary MI

更新日期：2013-07-01 00:00:00

abstract：CONTEXT:The failure of modern anthelmintics to control nematode parasites of sheep and goats is a reality on many farms in the tropical/subtropical regions of the world. This necessitates chemotherapeutic control alternatives and plant secondary metabolite with activity is one of those potential solutions. OBJECTIVE:T...

journal_title：Pharmaceutical biology

authors： Ademola IO,Eloff JN

更新日期：2011-05-01 00:00:00

abstract：CONTEXT:Granulocyte colony stimulating factor (G-CSF) has been commonly used to treat neutropenia caused by chemotherapy, radiotherapy, and organ transplants. Improved in vitro efficacy of G-CSF has already been observed by conjugating it to polyethylene glycol (PEG). OBJECTIVE:The in vivo bioassay using tetrazolium d...

journal_title：Pharmaceutical biology

authors： Tiwari K,Wavdhane M,Haque S,Govender T,Kruger HG,Mishra MK,Chandra R,Tiwari D

更新日期：2015-06-01 00:00:00

abstract：CONTEXT:The poor prognostic outcome of breast cancer is largely due to its resistance to cancer therapies. Development of therapeutic agents that can inhibit growth and induce apoptosis in breast cancer cells can help solve the problem. Emodin is an active anthraquinone that has been reported to have diverse biological...

journal_title：Pharmaceutical biology

authors： Li WY,Chan RY,Yu PH,Chan SW

更新日期：2013-09-01 00:00:00

abstract：CONTEXT:Hyperthermia causes detrimental effects on the testes leading to fertility problems. Mallotus roxbhurghianus Muell. Arg. (Euphorbiaceae) is used in traditional medicine and possesses antioxidant property. However, the mechanisms remain unknown in the context of alleviative action of M. roxburghianus against hea...

journal_title：Pharmaceutical biology

authors： Kumar Roy V,Marak TR,Gurusubramanian G

更新日期：2016-01-01 00:00:00

abstract：:Breast cancer (BCa) is the most commonly occurring cancer in women, comprising almost one third of all malignancies. Previously we reported that the n-hexane fraction (hSL) of the Siddha herbal medicine, Semecarpus Lehyam, relatively sensitized estrogen receptor-negative (ER(-)) BCa when compared to estrogen receptor-...

journal_title：Pharmaceutical biology

authors： Zhao W,Zhu L,Srinivasan S,Damodaran C,Rohr J

更新日期：2009-09-01 00:00:00

abstract：CONTEXT:Phytochemical and pharmacological data on Ducrosia anethifolia (DC.) Boiss. (Apiaceae), an Iranian medicinal plant, are scarce; however, furocoumarins are characteristic compounds of D. anethifolia. OBJECTIVE:Our experiments identify the secondary metabolites of D. anethifolia and assess their antitumor and an...

journal_title：Pharmaceutical biology

authors： Mottaghipisheh J,Nové M,Spengler G,Kúsz N,Hohmann J,Csupor D

更新日期：2018-12-01 00:00:00

abstract：:Context:Melastoma dodecandrum Lour. (Melastomataceae) is a traditional Chinese medicine. This is the first study to report a protective effect of the ethanol extract from M. dodecandrum (MDE) in type 2 diabetic (T2DM) rats.Objective: To investigate the therapeutic mechanism of MDE in T2DM rats.Materials and methods: S...

journal_title：Pharmaceutical biology

authors： Weng J,Zhou J,Liang L,Li L

更新日期：2019-12-01 00:00:00

abstract：CONTEXT:Obesity is the main risk factor for type 2 diabetes mellitus. Secondary metabolites with biological activities and pharmacological potential have been identified in species of the Baccharis genus that are specifically distributed in the Americas. OBJECTIVE:This study evaluated the effects of methanol extracts ...

journal_title：Pharmaceutical biology

authors： Hocayen Pde A,Grassiolli S,Leite NC,Pochapski MT,Pereira RA,da Silva LA,Snack AL,Michel RG,Kagimura FY,da Cunha MA,Malfatti CR

更新日期：2016-07-01 00:00:00

abstract：CONTEXT AND OBJECTIVE:The Sisala traditional healers of northwest Ghana have a rich ethnomedical tradition. The purpose of this study was to collect and analyse data on medicinal plants commonly used by Sisala traditional healers. METHODS:A total of 30 traditional healers were interviewed using a mixture of open- and ...

journal_title：Pharmaceutical biology

authors： Wodah D,Asase A

更新日期：2012-07-01 00:00:00

abstract：CONTEXT:Sepsis continues to be a significant problem for critical care patients. OBJECTIVE:To evaluate the protective effects of IgM-enriched immunoglobulin and erythropoietin on pulmonary and small intestine tissues in a rat model of intra-abdominal sepsis induced via the cecal ligation and puncture (CLP) method. MA...

journal_title：Pharmaceutical biology

authors： Ates I,Dogan N,Aksoy M,Halıcı Z,Gündogdu C,Keles MS

更新日期：2015-01-01 00:00:00

abstract：CONTEXT:Baohuoside-I was reported to induce apoptosis in non-small-cell lung cancer and inhibit the growth of multiple myeloma cells. The antitumour potential of baohuoside-I has not been demonstrated in melanoma yet. OBJECTIVE:To investigate the potential antitumour activity of baohuoside-I against melanoma and eluci...

journal_title：Pharmaceutical biology

authors： Peng YG,Zhang L

更新日期：2018-12-01 00:00:00

abstract：CONTEXT:Termitomyces clypeatus (Lyophyllaceae) is a filamentous edible mushroom, having ethnomedicinal uses. However, information about the antioxidant, anticancer and antitumour properties of this mushroom remains to be elucidated. OBJECTIVE:The study examines the in vitro antioxidant, anticancer and in vivo antitumo...

journal_title：Pharmaceutical biology

authors： Mondal A,Banerjee D,Majumder R,Maity TK,Khowala S

更新日期：2016-11-01 00:00:00

abstract：CONTEXT:Peripheral axon injury and degeneration are often mediated by oxidative stress and inflammation. The hydroalcoholic extract of the red propolis (HERP) has attracted great attention because of its antioxidant and anti-inflammatory activities. OBJECTIVE:The objective of this work is to study the effect of HERP o...

journal_title：Pharmaceutical biology

authors： Barbosa RA,Nunes TL,Nunes TL,da Paixão AO,Belo Neto R,Moura S,Albuquerque Junior RL,Cândido EA,Padilha FF,Quintans-Júnior LJ,Gomes MZ,Cardoso JC

更新日期：2016-01-01 00:00:00

abstract：CONTEXT:The resistance of bacteria to antibiotics is raising serious concern globally. Asian medicinal plants could improve the current treatment strategies for bacterial infections. The antibacterial properties of medicinal plants used by the Khyang tribe in Bangladesh have not been investigated. OBJECTIVE:The presen...

journal_title：Pharmaceutical biology

authors： Hossan MS,Jindal H,Maisha S,Samudi Raju C,Devi Sekaran S,Nissapatorn V,Kaharudin F,Su Yi L,Khoo TJ,Rahmatullah M,Wiart C

更新日期：2018-12-01 00:00:00

abstract：CONTEXT:Amla [Emblica officinalis Gaertn. (Euphorbiaceae)], a major constituent of several herbal formulations, is a well-known hepatoprotectant. Despite its extensive use, mechanistic understanding of its antioxidant action is rather limited. OBJECTIVE:In the current study, we investigated the effects of E. officinal...

journal_title：Pharmaceutical biology

authors： Shivananjappa MM,Joshi MK

更新日期：2012-04-01 00:00:00

abstract：CONTEXT:Eupatorium triplinerve Vahl (Asteraceae), popularly known as Japana, is widely used in folk medicine, due its analgesic, anticoagulant, antianorexic, antiparasitic, anthelmintic, sedative, antifungal, and antibacterial properties. OBJECTIVE:The present study evaluated the chemical composition and antimicrobial...

journal_title：Pharmaceutical biology

authors： Matos Lopes TR,de Oliveira FR,Malheiros FF,de Andrade MA,Monteiro MC,Baetas Gonçalves AC

更新日期：2015-06-01 00:00:00

abstract：CONTEXT:Pomegranate [Punica granatum L. (Lythraceae)] is rich in antioxidants. OBJECTIVE:The present work was undertaken to evaluate the protective effects of methanol extract of pomegranate peel extract (PPE) against a rat model of oxidative stress generated by treatment with mercuric chloride (HgCl(2)). MATERIALS A...

journal_title：Pharmaceutical biology

authors： Kumar D,Singh S,Singh AK,Rizvi SI

更新日期：2013-04-01 00:00:00

abstract：CONTEXT:Vernonia amygdalina Del. (VA; Asteraceae or Compositae) is a small tree growing throughout tropical Africa. It is widely used for food and medicinal purposes by local people. It was reported that it had several qualities, including anticancer activity. OBJECTIVE:A sesquiterpene lactone, vernodalinol, was isola...

journal_title：Pharmaceutical biology

authors： Luo X,Jiang Y,Fronczek FR,Lin C,Izevbigie EB,Lee KS

更新日期：2011-05-01 00:00:00

abstract：CONTEXT:Neuropsychiatric disorders, like anxiety and depression, are global problems for clinical researchers in neurology. Recently, some authors have shown neuroprotective and anti-inflammatory effects of Scrophularia striata Boiss (Scrophulariaceae) extract in rodents. OBJECTIVE:The purpose of the current study was...

journal_title：Pharmaceutical biology

authors： Kosari-Nasab M,Babri S,Fatehi-Gharehlar L,Doosti MH,Pakzad S

更新日期：2013-05-01 00:00:00

abstract：CONTEXT:The plant Hygrophila auriculata (K. Schum) Heine. (Acanthaceae) is widely used in the Indian System of Medicine as "Rasayana" for treating brain and liver diseases. OBJECTIVES:The present study evaluated the in vivo antioxidant and neuroprotective effect of aterpenoid rich fraction (TF) from Hygrophila auricul...

journal_title：Pharmaceutical biology

authors： Kanhere R,Anjana A,Anbu J,Sumithra M,K F H NA

更新日期：2013-02-01 00:00:00

abstract：:In this study, branchlets, fruit, or bark of Taxus baccata. L. as well as branchlets or fruits of two other species of Iranian conifers, namely, Platycladus orientalis. France and Cupressus sempervirens. L. var. horizentalis. (Mill) Gunde were collected, identified, and the cytotoxic effects of hydroalcoholic extracts...

journal_title：Pharmaceutical biology

authors： Emami SA,Sadeghi-Aliabadi H,Saeidi M,Jafarian A

更新日期：2005-01-01 00:00:00

abstract：CONTEXT:Aloe has been used for the prevention and cure of various diseases and symptoms including burns, injuries, oedema and pain. OBJECTIVE:This study determines the specific inhibitory activity of matrix metalloproteinase (MMP)-9 induced by the low molecular-weight gel fraction of Aloe vera (L.) Burm.f. (lgfAv) on ...

journal_title：Pharmaceutical biology

authors： Park CH,Son HU,Yoo CY,Lee SH

更新日期：2017-12-01 00:00:00

abstract：CONTEXT:Medical therapies for alcohol-induced liver disease are often difficult to handle and limited in efficacy. OBJECTIVE:In an attempt to find natural therapeutics, here, we investigate the preventive effect of persimmon vinegar (PV) and its fractions against alcohol-induced hepatic injury, in addition to the unde...

journal_title：Pharmaceutical biology

authors： Lee HM,Park MY,Kim J,Shin JH,Park KS,Kwon O

更新日期：2016-11-01 00:00:00

abstract：CONTEXT:Augmented renal clearance (ARC) refers to enhanced renal elimination of circulating solute, and has attracted wide attention in recent years. OBJECTIVE:This study evaluates the effects of ARC on serum vancomycin concentration in patients administered vancomycin. MATERIALS AND METHODS:This was a retrospective ...

journal_title：Pharmaceutical biology

authors： Chu Y,Luo Y,Qu L,Zhao C,Jiang M

更新日期：2016-12-01 00:00:00

abstract：CONTEXT:To date, there are no reports to validate the Indian traditional and folklore claims of Artemisia maderaspatana L. (syn. Grangea maderaspatana L.) (Asteraceae) for the treatment of Alzheimer's disease. OBJECTIVE:The present study characterizes the volatile components (non-polar compounds) of A. maderaspatana a...

journal_title：Pharmaceutical biology

authors： Jyotshna,Srivastava N,Singh B,Chanda D,Shanker K

更新日期：2015-01-01 00:00:00

abstract：CONTEXT:Pisonia aculeata leaves (Nyctagenaceae), a Folk medicinal plant used in the treatment of several inflammation, pain, and oxidative stress associated diseases. OBJECTIVE:To evaluate anti-inflammatory, analgesic, and antioxidant potential of crude methanol extract of P. aculeata leaves (MEPA). MATERIALS AND MET...

journal_title：Pharmaceutical biology

authors： Sen S,Chakraborty R,Rekha B,Revathi D,Ayyanna SC,Hemalatha G,Kumar Reddy GA,Hyndavi S,Ikhyatha Babu PJ,Prakash PR,Sridhar C

更新日期：2013-04-01 00:00:00