Abstract:
CONTEXT:Baohuoside-I was reported to induce apoptosis in non-small-cell lung cancer and inhibit the growth of multiple myeloma cells. The antitumour potential of baohuoside-I has not been demonstrated in melanoma yet. OBJECTIVE:To investigate the potential antitumour activity of baohuoside-I against melanoma and elucidate its underlying molecular mechanism. MATERIALS AND METHODS:Cell viability was evaluated by MTT assay. The malignant invasion capacity was measured with trans-well assay. The relative expression change of microRNAs was profiled with microarray. TargetScan was utilized for prediction of target gene of miR-144. Regulatory effect of miR-144 on SMAD1 was determined by dual luciferase reporter assay. Endogenous SMAD1 protein in response to ectopic expression of miR-144 was determined by immunoblotting. Xenograft mice were employed to evaluate antitumour potential of baohuoside-I (25 mg/kg by tail intravenous injection every two days) in vivo. RESULTS:Baohuoside-I significantly inhibited proliferation (45 ± 4% reduction in M14 and 35 ± 3% reduction in MV3 at 24 h) and migration (70 ± 4% reduction in M14 and 72 ± 3% reduction in MV3) in melanoma cells. Mechanistically, baohuoside-I up-regulated miR-144 expression levels (3 ± 0.2-fold). Silence of miR-144 reversed the inhibition of baohuoside-I in melanoma. We have identified that SMAD1 was the novel target of miR-144. Moreover, baohuoside-I suppressed melanoma in vivo (52 ± 8% reduction in xenograft tumour size at day 20). CONCLUSIONS:Our data suggested significant antitumour potential of baohuoside-I against melanoma both in vitro and in vivo, which warrants further laboratory investigation and clinical trial.
journal_name
Pharm Bioljournal_title
Pharmaceutical biologyauthors
Peng YG,Zhang Ldoi
10.1080/13880209.2017.1418391subject
Has Abstractpub_date
2018-12-01 00:00:00pages
43-50issue
1eissn
1388-0209issn
1744-5116journal_volume
56pub_type
杂志文章abstract:CONTEXT:Lycopene is a phytonutrient under considerable investigation for its antioxidant benefits in treating diseases like cancer, cardiovascular diseases, osteoporosis and diabetes. OBJECTIVE:This study explores the effect of lycopene against oxidative damage during experimental hepatitis, induced by D-galactosamine...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.803579
更新日期:2013-12-01 00:00:00
abstract:CONTEXT:Virgin coconut oil (VCO) has been reported to possess antioxidative, anti-inflammatory and anti-stress properties. OBJECTIVE:Capitalizing on these therapeutic effects, this study investigated for the first time the potential of VCO on memory improvement in vivo. MATERIALS AND METHODS:Thirty male Wistar rats (...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2017.1280688
更新日期:2017-12-01 00:00:00
abstract:CONTEXT:Neuroprotective therapy to rescue dopaminergic neurons is an important trait in the management of Parkinson's disease (PD). OBJECTIVE:The present study identified and evaluated SFSE-T, a standardized hydroalcoholic extract of Trigonella foenum-graecum L. seeds (Fabaceae), in animal models of PD. MATERIALS AND...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2012.747547
更新日期:2013-05-01 00:00:00
abstract:CONTEXT:Tagetes patula L. is one of the French marigold group of the Asteraceae family. It is recognized in folklore for its medicinal and pesticidal properties. OBJECTIVE:In search of more effective, but non-toxic compounds with antioxidative potential led to the bioassay guided isolation studies on the extracts of T...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2010.523006
更新日期:2011-05-01 00:00:00
abstract:CONTEXT:Dexamethasone (DXM) has an anti-immunoinflammatory effect, and is often used in acute kidney injury (AKI). However, the effects of DXM on albumin (ALB) have not been fully studied. OBJECTIVE:To investigate the effects of DXM on ALB production and renal function. MATERIALS AND METHODS:Male Wistar rats were div...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2020.1855214
更新日期:2020-12-01 00:00:00
abstract:CONTEXT:Calotropis procera (Ait.) R. Br. (Asclepiadaceae), Ficus elastica Roxb. (Moraceae) and Zingiber officinale Roscoe (Zingiberaceae) have been traditionally used to treat many diseases. OBJECTIVE:The antischistosomal activity of these plant extracts was evaluated against Schistosoma mansoni. MATERIALS AND METHOD...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.818041
更新日期:2014-02-01 00:00:00
abstract:CONTEXT:Withania (Solanaceae) species are known to be a rich source of withanolides, which have shown several biological properties. OBJECTIVE:To identify the compounds responsible for Withania adpressa Coss. antioxidant activity and further test them for their NF-κB inhibition and antiproliferative activity in multip...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2018.1499781
更新日期:2018-12-01 00:00:00
abstract:CONTEXT:Citronellal is a monoterpene present in the oil of many species, including Cymbopogon winterianus Jowitt (Poaceae). OBJECTIVE:The present study investigated the effect of citronellal on inflammatory nociception induced by different stimuli and examined the involvement of the NO-cGMP-ATP-sensitive K⁺ channel pa...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.781656
更新日期:2013-09-01 00:00:00
abstract:CONTEXT:Total glucosides of peony (TGP), compounds extracted from the dried roots of Paeonia lactiflora Pall, have been reported to have anti-inflammatory and antioxidative activities. However, the protective effect of TGP on liver injury and the underlying mechanisms remains unknown in diabetic rats. OBJECTIVES:Curre...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2017.1390589
更新日期:2017-12-01 00:00:00
abstract:CONTEXT:Hesperidin is a flavonoid that has various pharmacological activities including anti-inflammatory, antimicrobial and antiviral activities. OBJECTIVE:The aim of the study is the isolation of hesperidin from the peel of Citrus sinensis L. (Rutaceae), and the evaluation of its antioxidant capacity and cytotoxicit...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2010.509734
更新日期:2011-03-01 00:00:00
abstract:CONTEXT:Schizophrenia is a chronic disabling psychiatric disorder affecting 1% of the population worldwide. Due to the adverse effects of available antipsychotic medications, recent investigations have focused on the search for well-tolerated, safe molecules from natural resources to control the severity and progressio...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.976350
更新日期:2015-01-01 00:00:00
abstract:CONTEXT:Oysters [Crassostrea plicatula Gmelin (Ostreidae)] are widely used for food in coastal areas. It is reported to have several qualities such as improving sexual and immune function. They has been approved by Chinese Ministry of Health as a functional food. OBJECTIVE:The effects of five types of oyster component...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.866966
更新日期:2014-06-01 00:00:00
abstract::Escin, a group of chemically related triterpenic glycosides, is widely used in commercial preparations for the treatment of venous insufficiency. Since the zygotic embryo cotyledons accumulate the highest amount of escin, it is currently extracted from the seeds of horse chestnut, Aesculus hippocastanum L. (Hippocasta...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880200903204000
更新日期:2010-05-01 00:00:00
abstract::Several drugs of herbal origin are known to possess anxiolytic and antidepressant effects. In a recent study, we showed that extracts from Euphorbia hirta L. (Euphorbiaceae) (Eh) demonstrated anxiolytic effects in rats subjected to chronic immobilization stress (CIS) but not in rats that underwent forced swim stress (...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880200903188534
更新日期:2010-05-01 00:00:00
abstract:CONTEXT:The Boraginaceae family comprises plants that have important therapeutic and cosmetic applications. Their pharmacological effect is related to the presence of naphthaquinones, flavonoids, terpenoids, phenols, or purine derivative - allantoin. OBJECTIVE:In the present study, comparison of some secondary metabol...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2016.1265986
更新日期:2017-12-01 00:00:00
abstract:CONTEXT:Linum usitatissimum L. (Linaceae), commonly known as flaxseed, is a good source of dietary fiber and lignans. Earlier we reported cardioprotective, antihyperlipidemic, and in vitro antioxidant activity of flax lignan concentrate (FLC) obtained from flaxseed. OBJECTIVES:To isolate secoisolariciresinol diglucosi...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.877492
更新日期:2014-09-01 00:00:00
abstract::Context Ginseng is a widely used herbal medicine in China but its mechanism of action remains unclear. Objective The objectives of this work were to study the protective effect of ginsenoside Rg1 on subacute murine renal damage induced by d-galactose and its mechanism. Materials and methods C57BL/6J mice were injected...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2015.1129543
更新日期:2016-09-01 00:00:00
abstract:CONTEXT:Felicia muricata Thunb. (Nees) (Asteraceae) leaves are used in folklore medicine of South Africa as an oral remedy for pain and inflammation. However, the efficacy of the plant part is yet to be validated with scientific experiments. OBJECTIVE:The current study is an effort to investigate the anti-inflammatory...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880200903373664
更新日期:2010-09-01 00:00:00
abstract::Tuberculosis remains a serious public health problem, with nine million cases being reported annually. Treatment with antibiotics is the most effective mechanism to control this disease, although the increase in cases with resistant strains, co-infection with HIV, and the long duration of treatment has established the...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880200903085490
更新日期:2010-03-01 00:00:00
abstract:CONTEXT: Despite the myriad uses of Annona senegalensis Pers. (Annonaceae) leaves in folklore medicine of Nigeria, the basis is yet to be substantiated by scientific investigations. OBJECTIVES: To investigate the antioxidant (in vitro and in vivo) and drug detoxification potential of aqueous extract of A. senegalensis...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2010.483247
更新日期:2010-12-01 00:00:00
abstract:CONTEXT:Cranberry has numerous biological activities, including antioxidation, anticancer, cardioprotection, as well as treatment of urinary tract infection (UTI), attributed to abundant phenolic contents. OBJECTIVE:The current study focused on the effect of cranberry juice (CJ) on blue light exposed human retinal pig...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2016.1263344
更新日期:2017-12-01 00:00:00
abstract::Physalis alkekengi L. (Solanaceae) is a popular plant in traditional European and Chinese folk medicine, and it has been reported to have many ethnopharmacological properties including antifungal, anti-cough, anti-inflammatory, analgesic, and febricide activities. Some active components from Physalis species have been...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880200903062606
更新日期:2010-02-01 00:00:00
abstract:CONTEXT:Liposomes are increasingly employed to deliver chemotherapeutic agents, antisense oligonucleotides, and genes to various therapeutic targets. OBJECTIVE:The present investigation evaluates the ability of fusogenic pH-sensitive liposomes of rapamycin in increasing its antiproliferative effect on human breast ade...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.871640
更新日期:2014-07-01 00:00:00
abstract:CONTEXT:Agastache mexicana (Kunth) Lint & Epling (Lamiaceae) is a plant used in Mexican traditional medicine for the treatment of hypertension, anxiety and so on. OBJECTIVE:To determine the vasorelaxant effect and functional mode of action of dichloromethane-soluble extract from A. mexicana (DEAm) and isolate the cons...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2016.1184690
更新日期:2016-12-01 00:00:00
abstract:CONTEXT:Portulacerebroside A (PCA) is a novel cerebroside compound isolated from Portulaca oleracea L. (Portulacaceae), an edible and medicinal plant distributed in the temperate and tropical zones worldwide. OBJECTIVE:This study investigates the effects of PCA in human liver cancer HCCLM3 cells on metastasis and inva...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2014.941505
更新日期:2015-05-01 00:00:00
abstract::Eugenia jambolana Lam. (Myrtaceae) is widely used in folk medicine as an antidiabetic, but there is a lack of information about its toxicity, especially for the stem bark. The present study evaluated acute oral and repeated-dose toxicity of the stem bark aqueous extract of Eugenia jambolana (EJ) in albino mice and Wis...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880200903300204
更新日期:2010-08-01 00:00:00
abstract:CONTEXT:(-)-α-Bisabolol (BISA) is a sesquiterpene alcohol widely used as scent in cosmetic preparations, perfumes, shampoos, toilet soaps and other toiletries with potential for use in the pharmaceutical area. OBJECTIVE:To evaluate the corneal antinociceptive efficacy of BISA and to analyze the best solubilizing agent...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2017.1285944
更新日期:2017-12-01 00:00:00
abstract:CONTEXT:Commiphora myrrha (Burseraceae), a shrub resembling a small tree, has been used for several centuries for the treatment of various diseases. OBJECTIVE:This study investigates the hepatoprotective activity of C. myrrha ethanol extract against d-galactosamine/lipopolysaccharide (d-GalN/LPS)-induced acute hepatic...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2015.1005754
更新日期:2015-01-01 00:00:00
abstract::Context: Emodin is a compound in Rheum undulatum Linne (Polygonaceae) that has been reported to exert anti-inflammatory, antibacterial, and antiallergic effects.Objective: Oxidative stress is a causative agent of liver inflammation that may lead to fibrosis and hepato-carcinoma. In this study, we investigated the anti...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.1080/13880209.2020.1750658
更新日期:2020-12-01 00:00:00
abstract:CONTEXT:Rabdosia rubescens (Hemsl.) Hara (Lamiaceae) is widely used in traditional Chinese medicines for the treatment of antitumor, antimicrobial, anti-inflammatory and antioxidation. It is also used as a supplement in the treatment of many cancers, such as esophagus, mammary gland, liver and prostate cancers. OBJECT...
journal_title:Pharmaceutical biology
pub_type: 杂志文章
doi:10.3109/13880209.2013.784342
更新日期:2013-09-01 00:00:00